Chronic visceral pain: new peripheral mechanistic insights and resulting treatments
Chronic visceral pain is one of the most common reasons for patients with gastrointestinal disorders, such as inflammatory bowel disease or disorders of brain-gut interaction, to seek medical attention. It represents a substantial burden to patients, and is associated with anxiety, depression, reductions in quality of life, and impaired social functioning, as well as increased direct and indirect healthcare costs to society. Unfortunately, the diagnosis and treatment of chronic visceral pain is difficult, in part because our understanding of the underlying pathophysiologic basis is incomplete. (Source: Gastroenterology)
Source: Gastroenterology - February 4, 2024 Category: Gastroenterology Authors: Alexander C. Ford, Stephen Vanner, Purna C. Kashyap, Yasmin Nasser Tags: Reviews in Basic and Clinical Gastroenterology and Hepatology Source Type: research
A Randomized Trial of Two Remote Healthcare Delivery Models on the Uptake of Genetic Testing and Impact on Patient-Reported Psychological Outcomes in Families With Pancreatic Cancer: The Genetic Education, Risk Assessment, and Testing (GENERATE) Study
Genetic testing uptake for cancer susceptibility in family members of cancer patients is suboptimal. Among relatives of pancreatic ductal adenocarcinoma (PDAC) patients, The GENetic Education, Risk Assessment, and TEsting (GENERATE) study evaluated two online genetic education/testing delivery models and their impact on patient-reported psychological outcomes (PRPOs). (Source: Gastroenterology)
Source: Gastroenterology - February 4, 2024 Category: Gastroenterology Authors: Nicolette J. Rodriguez, C. Sloane Furniss, Matthew B. Yurgelun, Chinedu Ukaegbu, Pamela E. Constantinou, Ileana Fortes, Alyson Caruso, Alison N. Schwartz, Jill E. Stopfer, Meghan Underhill-Blazey, Barbara Kenner, Scott H. Nelson, Sydney Okumura, Alicia Y. Tags: Clinical - Pancreas Source Type: research
Pembrolizumab-induced Liver Injury: Beyond Immune-Mediated Hepatitis.
(Source: Gastroenterology)
Source: Gastroenterology - February 4, 2024 Category: Gastroenterology Authors: Queralt Herms, Carla Fuster-Anglada, Adri à Juanola Tags: Electronic Gastro Curbside Consult Source Type: research
Does a Rising Tide Lift All Boats? How Institutional Procedural Volume Impacts the Clinical Outcomes of Gastric Endoscopic Submucosal Dissection
(Source: Gastroenterology)
Source: Gastroenterology - February 2, 2024 Category: Gastroenterology Authors: Hiroyuki Aihara, Peter V. Draganov Tags: Editorials Source Type: research
Machine Learning –Based Prediction of Pediatric Ulcerative Colitis Treatment Response Using Diagnostic Histopathology
The initial presentation of ulcerative colitis within the pediatric population exhibits a degree of uniformity, the majority characterized by extensive colitis at the time of diagnosis. However, the response to initial therapy demonstrates marked heterogeneity.1 It is challenging to discriminate which patients would successfully improve on corticosteroids followed by mesalamine therapy maintenance therapy and those who would benefit from early introduction of biologic therapy. The Clinical and Biological Predictors of Response to Standardized Pediatric Colitis Therapy (PROTECT) study, a multicenter inception cohort study, ...
Source: Gastroenterology - February 1, 2024 Category: Gastroenterology Authors: Xiaoxuan Liu, Surya Prasath, Iram Siddiqui, Thomas D. Walters, Lee A. Denson, PROTECT Consortium, Jasbir Dhaliwal Tags: Research Letters Source Type: research
Patient-Reported Outcomes in Disorders of Gut –Brain Interaction
Disorders of gut –brain interaction are characterized by chronic gastrointestinal symptoms in the absence of abnormal endoscopic or radiologic findings or objective biomarkers that can be identified during routine clinical evaluation. The assessment of the symptom pattern and severity, therefore, is the key modali ty to evaluate the presence, impact, and evolution of these conditions, for both clinical and regulatory purposes. Patient-reported outcomes are structured symptom assessment questionnaires designed to evaluate symptom patterns, quantify severity of symptoms, and evaluate response to treatment at fo llow-up. (S...
Source: Gastroenterology - February 1, 2024 Category: Gastroenterology Authors: Jan Tack, Florencia Carbone, Lin Chang, Brian E. Lacy Tags: Reviews in Basic and Clinical Gastroenterology and Hepatology Source Type: research
First Year on the Job as a Gastroenterologist and Hepatologist: Lessons Learned
Over the coming year MET will publish a series of articles focused on topics for early career gastroenterologists and senior fellows. This series is coordinated by Dr. Mohammad Bilal. (Source: Gastroenterology)
Source: Gastroenterology - February 1, 2024 Category: Gastroenterology Authors: Mohammad Bilal, Joshua Steinberg, Jeremy Louissaint, Jennifer Phan Tags: Mentoring, Education, and Training Corner Source Type: research
Has a hundred years of pursuing proteases helped to palliate pain in chronic pancreatitis more than placebo?
(Source: Gastroenterology)
Source: Gastroenterology - February 1, 2024 Category: Gastroenterology Authors: Vijay P. Singh, Fred S. Gorelick Tags: Editorials Source Type: research
Machine Learning-Based Prediction of Pediatric Ulcerative Colitis Treatment Response using Diagnostic Histopathology
(Source: Gastroenterology)
Source: Gastroenterology - February 1, 2024 Category: Gastroenterology Authors: Xiaoxuan Liu, Surya Prasath, Iram Siddiqui, Thomas D. Walters, Lee A. Denson, PROTECT consortium, Jasbir Dhaliwal Tags: Research Letter Source Type: research
Patient and Community Health Global Burden in a World with more Celiac Disease
Celiac disease is one of the commonest life-long disorders worldwide, with a prevalence mostly ranging between 0.7 and 2.9 % in the general population and a higher frequency in females and in well-defined at-risk groups, such as relatives of affected individuals and patients with autoimmune co-morbidities. Increasing clinical detection is facilitated by improving awareness, implementation of a case-finding approach, and serology availability for screening at risk patients, among other factors. Nevertheless, due to huge clinical variability many CeD cases still escape diagnosis in most countries, unless actively searched by...
Source: Gastroenterology - February 1, 2024 Category: Gastroenterology Authors: Simona Gatti, Alberto Rubio-Tapia, Govind Makharia, Carlo Catassi Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research
Moving Away from Biopsy Confirmation of Celiac Disease
(Source: Gastroenterology)
Source: Gastroenterology - February 1, 2024 Category: Gastroenterology Authors: Benjamin Lebwohl Tags: Editorials Source Type: research
Patient reported outcomes in Disorders of Gut-Brain Interaction
Disorders of gut-brain interaction (DGBIs) are characterized by chronic gastrointestinal symptoms, in the absence of abnormal endoscopic or radiologic findings or objective biomarkers that can be identified during routine clinical evaluation. The assessment of the symptom pattern and severity therefore is the key modality to evaluate the presence, impact and evolution of these conditions, both for clinical and regulatory purposes. Patient-reported outcomes (PROs) are structured symptom assessment questionnaires designed to evaluate symptom patterns, quantify severity of symptoms, and evaluate response to treatment at follo...
Source: Gastroenterology - February 1, 2024 Category: Gastroenterology Authors: Jan Tack, Florencia Carbone, Lin Chang, Brian E. Lacy Tags: Reviews in Basic and Clinical Gastroenterology and Hepatology Source Type: research
First Year on the Job as a Gastroenterologist & Hepatologist – Lessons Learned
(Source: Gastroenterology)
Source: Gastroenterology - February 1, 2024 Category: Gastroenterology Authors: Mohammad Bilal, Joshua Steinberg, Jeremy Louissaint, Jennifer Phan Source Type: research
Recurrent Abdominal Pain Associated with Small Intestinal Edema
(Source: Gastroenterology)
Source: Gastroenterology - January 30, 2024 Category: Gastroenterology Authors: Qing Lu, Li Tang, Jinlin Yang Tags: Electronic Gastro Curbside Consul0074 Source Type: research
Opportunities for Improving Biopsy and Non –Biopsy-Based Diagnosis of Celiac Disease
The accumulating data regarding a non-biopsy diagnosis of celiac disease has led to its adoption in certain scenarios, although debate on whether and when to use non-biopsy criteria in clinical practice is ongoing. Despite the growing popularity and evidence basis for a biopsy-free approach to diagnosis in the context of highly elevated serologies, there will continue to be a role for a biopsy in some groups. This review summarizes the current evidence supporting a non-biopsy approach and arguments supporting continued reliance on biopsy, and focuses on opportunities to improve both approaches. (Source: Gastroenterology)
Source: Gastroenterology - January 29, 2024 Category: Gastroenterology Authors: Marie E. Robert, Carolina Ciacci, Benjamin Lebwohl Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research
