Reply to Vege et al
(Source: Gastroenterology)
Source: Gastroenterology - February 29, 2024 Category: Gastroenterology Authors: Mathias Ellgaard Cook, Niels Henrik Bruun, S øren Schou Olesen Tags: Correspondence Source Type: research
Bridging the Diagnostic Gap: How Autonomous AI Can Assist in Endoscopic Diagnosis of Experts
(Source: Gastroenterology)
Source: Gastroenterology - February 29, 2024 Category: Gastroenterology Authors: Hantong Hu Tags: Correspondence Source Type: research
The optimal duration of vasoconstrictors for acute variceal hemorrhage: longer is safer?
(Source: Gastroenterology)
Source: Gastroenterology - February 29, 2024 Category: Gastroenterology Authors: Gin-Ho Lo Tags: Correspondence Source Type: research
Impact of Longitudinal Alcohol Use Patterns on Long-Term Risk of Cirrhosis Among US Veterans With Steatotic Liver Disease
High-risk alcohol use in adults with steatotic liver disease increases the risk of liver disease progression. Timely alcohol use assessment and early interventions to address high-risk alcohol use are critical, particularly in patients with steatotic liver disease. (Source: Gastroenterology)
Source: Gastroenterology - February 28, 2024 Category: Gastroenterology Authors: Robert J. Wong, Zeyuan Yang, Ramsey Cheung, Ashwani K. Singal, Albert Do, Aijaz Ahmed, Aaron Yeoh Tags: Clinical - Liver Source Type: research
Impact of Longitudinal Alcohol Use Patterns on Long-Term Risk of Cirrhosis Among U.S. Veterans with Steatotic Liver Disease
Conflicting data exists on impact of alcohol use on risk of liver disease progression in patients with steatotic liver disease. We aim to evaluate the effect of longitudinal alcohol use on risk of cirrhosis among Veterans with steatotic liver disease. (Source: Gastroenterology)
Source: Gastroenterology - February 28, 2024 Category: Gastroenterology Authors: Robert J. Wong, Zeyuan Yang, Ramsey Cheung, Ashwani K. Singal, Albert Do, Aijaz Ahmed, Aaron Yeoh Tags: Clinical - Liver Source Type: research
Diagnostic and Prognostic Biomarkers of Chronic Pancreatitis: A Conceptual Framework Based on the PRoBE Design
Chronic pancreatitis (CP) is defined by clinical evidence of chronic fibroinflammatory pancreatic injury usually preceded by acute pancreatitis (AP) or recurrent AP. Clinical manifestations include AP, diabetes, exocrine insufficiency, metabolic bone disease, and pancreatic cancer.1 Abdominal pain, the most common symptom, significantly affects quality of life.2 Diagnosing CP relies on cross-sectional imaging features, which are not apparent until later stages. Additionally, the variable clinical presentation and course of CP make reliable diagnosis challenging. (Source: Gastroenterology)
Source: Gastroenterology - February 27, 2024 Category: Gastroenterology Authors: Dhiraj Yadav, Darwin L. Conwell, Stephen J. Pandol, Hanno Steen, Ziding Feng, Liang Li, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer Tags: Commentary Source Type: research
Diagnostic and Prognostic Biomarkers of Chronic Pancreatitis: A Conceptual Framework Based on PRoBE Design
(Source: Gastroenterology)
Source: Gastroenterology - February 27, 2024 Category: Gastroenterology Authors: Dhiraj Yadav, Darwin L. Conwell, Stephen J. Pandol, Hanno Steen, Ziding Feng, Liang Li, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) Tags: Commentary Source Type: research
TGF- β1-Induced SOX18 Elevation Promotes Hepatocellular Carcinoma Progression and Metastasis Through Transcriptionally Upregulating PD-L1 and CXCL12
We elucidated that SOX18 mediated by the TGF- β1-p-Smad2/3 axis shaped the immunosuppressive microenvironment. CXCR4 inhibitor AMD3100 or TGFβR1 inhibitor Vactosertib may boost anti-PD-L1 efficacy and represent novel combinational strategies. (Source: Gastroenterology)
Source: Gastroenterology - February 26, 2024 Category: Gastroenterology Authors: Jie Chen, Weibo Feng, Mengyu Sun, Wenjie Huang, Guodong Wang, Xilang Chen, Yue Yin, Xiaoping Chen, Bixiang Zhang, Yongzhan Nie, Daiming Fan, Kaichun Wu, Limin Xia Tags: Basic and Translational - Liver Source Type: research
TGF- β1 Induced SOX18 Elevation Promotes Hepatocellular Carcinoma Progression and Metastasis through Transcriptionally Upregulating PD-L1 and CXCL12
Hepatocellular carcinoma (HCC) is characterized by an immune-suppressive microenvironment, which contributes to tumor progression, metastasis and immunotherapy resistance. Identification of HCC-intrinsic factors regulating immunosuppressive microenvironment is urgently needed. Here, we aimed to elucidate the role of SYR-Related High-Mobility Group Box 18 (SOX18) in inducing immunosuppression and to validate novel combination strategies for SOX18-mediated HCC progression and metastasis. (Source: Gastroenterology)
Source: Gastroenterology - February 26, 2024 Category: Gastroenterology Authors: Jie Chen, Weibo Feng, Mengyu Sun, Wenjie Huang, Guodong Wang, Xilang Chen, Yue Yin, Xiaoping Chen, Bixiang Zhang, Yongzhan Nie, Daiming Fan, Kaichun Wu, Limin Xia Tags: Basic and Translational - Liver Source Type: research
Reply
We thank the authors for their letters to the editor regarding our recent publication, in which we describe the association between hepatitis B virus (HBV) DNA and hepatitis B surface antigen (HBsAg) levels at 6 months after therapy cessation with subsequent clinical relapse and HBsAg loss.1 –3 (Source: Gastroenterology)
Source: Gastroenterology - February 24, 2024 Category: Gastroenterology Authors: Milan J. Sonneveld, Benjamin Maasoumy, CREATE study group Tags: Correspondence Source Type: research
Reply to Liaw and Zheng et al
(Source: Gastroenterology)
Source: Gastroenterology - February 24, 2024 Category: Gastroenterology Authors: Milan J. Sonneveld, Benjamin Maasoumy, CREATE study group Tags: Correspondence Source Type: research
Efficacy and findings of a blinded randomized reintroduction phase for the low FODMAP diet in Irritable Bowel Syndrome
The efficacy of a low fermentable oligo-, di-, monosaccharides and polyols (FODMAP) diet in Irritable Bowel Syndrome (IBS) is well established. After the elimination period, a reintroduction phase aims to identify triggers. We studied the impact of a blinded reintroduction using FODMAP-powders to objectively identify triggers and evaluated the effect on symptoms, quality of life (QoL), and psychosocial co-morbidities. (Source: Gastroenterology)
Source: Gastroenterology - February 22, 2024 Category: Gastroenterology Authors: K. Van den Houte, E. Colomier, K. Routhiaux, Z. Mari ën, J. Schol, J. Van den Bergh, J. Vanderstappen, N. Pauwels, A. Joos, J. Arts, Ph. Caenepeel, F. De Clerck, C. Matthys, A. Meulemans, M. Jones, T. Vanuytsel, F. Carbone, J. Tack Tags: Clinical - Alimentary Tract Source Type: research
CME Exam 1: PNPLA3 Risk Allele Association With ALT Response to Semaglutide Treatment
(Source: Gastroenterology)
Source: Gastroenterology - February 21, 2024 Category: Gastroenterology Tags: Continuing Medical Education (CME)/MOC Activities Source Type: research
AGA Clinical Practice Guideline on Fecal Microbiota –Based Therapies for Select Gastrointestinal Diseases
Fecal microbiota –based therapies include conventional fecal microbiota transplant and US Food and Drug Administration–approved therapies, fecal microbiota live-jslm and fecal microbiota spores live-brpk. The American Gastroenterological Association (AGA) developed this guideline to provide recommendations on t he use of fecal microbiota–based therapies in adults with recurrent Clostridioides difficile infection; severe to fulminant C difficile infection; inflammatory bowel diseases, including pouchitis; and irritable bowel syndrome. (Source: Gastroenterology)
Source: Gastroenterology - February 21, 2024 Category: Gastroenterology Authors: Anne F. Peery, Colleen R. Kelly, Dina Kao, Byron P. Vaughn, Benjamin Lebwohl, Siddharth Singh, Aamer Imdad, Osama Altayar, AGA Clinical Guidelines Committee Tags: Guidelines Source Type: research
Approaching Digestive Health Care in Transgender and Gender-Diverse Communities
Transgender and gender-diverse (TGD) people are more likely than cisgender people to experience adverse health outcomes and health care discrimination. These disparities remain uninvestigated in gastroenterology (GI) and hepatology. Here, we describe what is known about digestive clinical care in TGD people. Practical considerations are offered to assist in the provision of culturally humble care to TGD people. (Source: Gastroenterology)
Source: Gastroenterology - February 21, 2024 Category: Gastroenterology Authors: Christopher V élez, Kira L. Newman, Sonali Paul, Jens U. Berli, Vin Tangpricha, Laura E. Targownik Tags: Diversity, Equity, and Inclusion in GI Source Type: research
