When Aspirin Causes Damage —Microbes Modulate the Host to Restore Gut Homeostasis
Li T, Ding N, Guo H, et  al. A gut microbiota–bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage. Cell Host Microbe 2024;32:191–208.e9. (Source: Gastroenterology)
Source: Gastroenterology - February 20, 2024 Category: Gastroenterology Authors: Eytan Wine Tags: Digest Source Type: research

When aspirin causes damage - microbes modulate the host to restore gut homeostasis
(Source: Gastroenterology)
Source: Gastroenterology - February 20, 2024 Category: Gastroenterology Authors: Eytan Wine Tags: Gastro Digest Source Type: research

In search of the best second-line therapy for Primary Biliary Cholangitis
(Source: Gastroenterology)
Source: Gastroenterology - February 19, 2024 Category: Gastroenterology Authors: Sabela Lens Tags: Gastro Digest Source Type: research

Commentary on the Epidemiology of Inflammatory Bowel Disease in Compounding Prevalence Nations: Toward Sustaining Healthcare Delivery
Inflammatory bowel disease (IBD), namely Crohn ’s disease and ulcerative colitis, affects millions of individuals worldwide.1 IBD is characterized geographically by epidemiologic stages: Stage 1 (emergence) includes developing regions with low incidence and prevalence; stage 2 (acceleration in incidence) includes newly industrialized regions i n Asia and Latin America with rapidly rising incidence but low prevalence; and stage 3 (compounding prevalence) includes early industrialized regions in North America, Europe, and Oceania with steadily climbing prevalence due to the cumulative effect of incidence greatly exceeding ...
Source: Gastroenterology - February 17, 2024 Category: Gastroenterology Authors: Michelle Herauf, Stephanie Coward, Juan-Nicol ás Peña-Sánchez, Charles N. Bernstein, Eric I. Benchimol, Gilaad G. Kaplan, Canadian Gastro-Intestinal Epidemiology Consortium Tags: Commentary Source Type: research

Metachronous Gastric Cancer Outcomes After Helicobacter pylori Therapy and Endoscopic Dysplasia Resection: Insights From a Global Real-World Study
We read with interest the article by Yoo et  al1 that describes the incidence of metachronous gastric cancer (MGC) after Helicobacter pylori therapy and endoscopic dysplasia resection using data from the Korean nationwide insurance database. The cohort receiving H pylori therapy experienced a significantly lower incidence of MGC compared wit h the untreated cohort, specifically 5.89 vs 6.20 for MGC and 7.23 vs 9.20 for metachronous gastric neoplasm per 1000 person-years. Several points merit further discussion. (Source: Gastroenterology)
Source: Gastroenterology - February 17, 2024 Category: Gastroenterology Authors: Yasutoshi Shiratori, Naoki Ishii, Anthony Kalloo Tags: Correspondence Source Type: research

Esophageal Food Impaction —Cola Can’t Beat the Real Thing
Tibie EG, Boeije T, Lameijer H, Ridderikhof ML. Efficacy of cola ingestion for oesophageal food bolus impaction: open label, multicenter, randomized controlled trial. BMJ 2023;383:e077294. (Source: Gastroenterology)
Source: Gastroenterology - February 17, 2024 Category: Gastroenterology Authors: Rena Yadlapati Tags: Digest Source Type: research

Metachronous Gastric Cancer Outcomes Following H-pylori Therapy after Endoscopic Dysplasia Resection: Insights from a Global Real-World Study
(Source: Gastroenterology)
Source: Gastroenterology - February 17, 2024 Category: Gastroenterology Authors: Yasutoshi Shiratori, Naoki Ishii, Anthony Kalloo Tags: Correspondence Source Type: research

A Commentary on the Epidemiology of Inflammatory Bowel Disease in Compounding Prevalence Nations: Towards Sustaining Healthcare Delivery
(Source: Gastroenterology)
Source: Gastroenterology - February 17, 2024 Category: Gastroenterology Authors: Michelle Herauf, Stephanie Coward, Juan-Nicol ás Peña-Sánchez, Charles N. Bernstein, Eric I. Benchimol, Gilaad G. Kaplan, Canadian Gastro-Intestinal Epidemiology Consortium (CanGIEC) Tags: Commentary Source Type: research

Thalidomide for Recurrent Small Intestinal Gastrointestinal Bleeding
Small intestinal angiodysplasia (SIA) accounts for 5 to 10% of gastrointestinal bleeds and can be managed via blood transfusions, pharmacological therapies (e.g. iron supplementation, octreotide, Bevacizumab, and other antifibrinolytic agents), and invasive interventions (e.g. endoscopic ablation, angiographic embolization, or surgical resection). Thalidomide is an immunomodulatory drug that down-regulates vascular endothelial growth factor and has been used to treat SIA, although its evidence in this setting is limited to observational and open-label trials. (Source: Gastroenterology)
Source: Gastroenterology - February 17, 2024 Category: Gastroenterology Authors: Niranjani Venkateswaran Tags: Gastro Digest Source Type: research

Esophageal Food Impaction - Cola Can ’t Beat the Real Thing
(Source: Gastroenterology)
Source: Gastroenterology - February 17, 2024 Category: Gastroenterology Authors: Rena Yadlapati Tags: Gastro Digest Source Type: research

Developing a Mentoring Network to Navigate Fellowship and Beyond: Moving from “Mentor” to “Mentors”
(Source: Gastroenterology)
Source: Gastroenterology - February 17, 2024 Category: Gastroenterology Authors: Kenzie A. Cameron, Terrance J. Rodrigues, Rajesh N. Keswani Tags: Mentoring, Education, and Training Corner Source Type: research

Reply
We are grateful that the results of our international collaboration solicited debate concerning such a compelling dilemma.1 We proposed that discontinuing surveillance for seniors with presumed branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) (Source: Gastroenterology)
Source: Gastroenterology - February 16, 2024 Category: Gastroenterology Authors: Fabio Casciani, Tommaso Pollini, Roberto Salvia Tags: Correspondence Source Type: research

Reply
We are grateful for the interest in our study examining whether antireflux surgery prevents esophageal adenocarcinoma to a larger degree than antireflux medication in patients with Barrett ’s esophagus.1 In our study, the overall hazard ratio was not decreased in patients having undergone antireflux surgery, as hypothesized, but rather increased. Instead of decreasing, the hazard ratios increased with length of follow-up in the antireflux surgery group compared with the medication g roup. In the following paragraphs we address the comments in 3 letters to the editor regarding our article. (Source: Gastroenterology)
Source: Gastroenterology - February 16, 2024 Category: Gastroenterology Authors: Johan Hardvik Åkerström, Giola Santoni, Jesper Lagergren Tags: Correspondence Source Type: research

Reply to Zhang, Samo and Hamo, and Li and Yang
(Source: Gastroenterology)
Source: Gastroenterology - February 16, 2024 Category: Gastroenterology Authors: Johan Hardvik Åkerström, Giola Santoni, Jesper Lagergren Tags: Correspondence Source Type: research

Dysphagia In A 75-Year-Old Male
(Source: Gastroenterology)
Source: Gastroenterology - February 16, 2024 Category: Gastroenterology Authors: Michael A. Perrin, David Y. Graham, Scott A. Larson Tags: Electronic Gastro Curbside Consult Source Type: research