Liquid Biopsy for Colorectal Cancer Screening: Not So Bloody Fast
Colorectal cancer (CRC) screening is an integral part of preventive care. Many countries worldwide have adopted centrally administered national programs, and others, like the United States, perform opportunistic screening. Regardless of delivery system or method —predominantly fecal immunochemical test [FIT] or colonoscopy—periodic screening cost-effectively reduces CRC incidence and mortality.1 CRC screening works through the following 2 mechanisms: early identification of colon neoplasia before malignant transformation and detection of cancers at an e arlier stage than unscreened patients. (Source: Gastroenterology)
Source: Gastroenterology - March 28, 2024 Category: Gastroenterology Authors: David S. Weinberg, Alan Barkun Tags: Editorials Source Type: research
Longitudinal Change of Alcohol Use is a Dynamic Contributor to Steatotic Liver Disease Progression
(Source: Gastroenterology)
Source: Gastroenterology - March 28, 2024 Category: Gastroenterology Authors: Brian P. Lee, Alexandre Louvet Tags: Editorials Source Type: research
Gluten-free diet induces rapid changes in phenotype and survival properties of gluten-specific T cells in celiac disease
The treatment of celiac disease (CeD) with gluten-free diet (GFD) normalizes gut inflammation and disease-specific antibodies. CeD patients have HLA-restricted, gluten-specific T cells persisting in the blood and gut even after decades of GFD, which are re-activated and disease driving upon gluten exposure. Our aim was to examine the transition of activated gluten-specific T cells into a pool of persisting memory T cells concurrent with normalization of clinically relevant biomarkers during the first year of treatment. (Source: Gastroenterology)
Source: Gastroenterology - March 27, 2024 Category: Gastroenterology Authors: Louise F. Risnes, Henrik M. Reims, Ronan M. Doyle, Shuo-Wang Qiao, Ludvig M. Sollid, Knut E.A. Lundin, Asbj ørn Christophersen Tags: Basic and Translational - Alimentary Tract Source Type: research
Increased risk of aspiration pneumonia associated with endoscopic procedures among patients with Glucagon-like peptide-1 receptor agonist use
(Source: Gastroenterology)
Source: Gastroenterology - March 27, 2024 Category: Gastroenterology Authors: Yee Hui Yeo, Srinivas Gaddam, Wee Han Ng, Pin-Chia Huang, Gastrointestinal Motility and Metabolic Pharmacoepidemiology Group, Kevin Sheng-Kai Ma, Ali Rezaie Tags: Research Letter Source Type: research
Of Humans and Machines in Endoscopy: Flying Solo, Instrument Aided, or on Autopilot?
Endoscopy is a triumph of science and engineering.1,2 During a busy day of procedures, we rarely stop and marvel at our routine: we delve deep into the tortuous gastrointestinal tract, topologically “outside of our bodies” but viscerally far “inside us”; we examine the barrier between our bodies’ substance and the outside world with high definition, magnification, and enhanced lighting, and we even peer beyond it; we advance instruments to diagnose and treat conditions that afflict hu mankind with substantial morbidity and mortality. (Source: Gastroenterology)
Source: Gastroenterology - March 26, 2024 Category: Gastroenterology Authors: Uri Ladabaum Tags: Editorials Source Type: research
Effectiveness and Cost-Effectiveness of Colorectal Cancer Screening With a Blood Test That Meets the Centers for Medicare & Medicaid Services Coverage Decision
Current test performance characteristics of blood-based colorectal cancer screening tests are insufficient to justify their high costs compared with less expensive and more effective alternatives such as fecal immunochemical testing, triennial stool DNA testing combined with a fecal immunochemical testing assay, and colonoscopy. (Source: Gastroenterology)
Source: Gastroenterology - March 26, 2024 Category: Gastroenterology Authors: Rosita van den Puttelaar, Pedro Nascimento de Lima, Amy B. Knudsen, Carolyn M. Rutter, Karen M. Kuntz, Lucie de Jonge, Fernando Alarid Escudero, David Lieberman, Ann G. Zauber, Anne I. Hahn, John M. Inadomi, Iris Lansdorp-Vogelaar Tags: Clinical - Alimentary Tract Source Type: research
Comparative Effectiveness and Cost-Effectiveness of Colorectal Cancer Screening With Blood-Based Biomarkers (Liquid Biopsy) vs Fecal Tests or Colonoscopy
Blood tests to screen for colorectal cancer could be effective in people who decline stool tests or colonoscopy, but they should not substitute for established methods unless they achieve high detection rates for colorectal cancer and its precursors. (Source: Gastroenterology)
Source: Gastroenterology - March 26, 2024 Category: Gastroenterology Authors: Uri Ladabaum, Ajitha Mannalithara, Yingjie Weng, Robert E. Schoen, Jason A. Dominitz, Manisha Desai, David Lieberman Tags: Clinical - Alimentary Tract Source Type: research
Of Humans and Machines in Endoscopy: Flying Solo, Instrument-Aided, or on Autopilot?
(Source: Gastroenterology)
Source: Gastroenterology - March 26, 2024 Category: Gastroenterology Authors: Uri Ladabaum Tags: Editorials Source Type: research
Recurrent Duodenal Ulceration —More Than Simple Peptic Ulcer Disease?
Question: A 77-year-old man with a pertinent medical history of dementia, recurrent small bowel obstruction resulting in small bowel resection secondary to intraabdominal adhesions related to a previous hernia repair resulting in small bowel resection, and nonsteroidal antiinflammatory drug (NSAID) –associated peptic ulcer disease presented with sharp epigastric abdominal pain, nausea, watery nonbloody diarrhea (approximately 4 bowel movements daily), weight loss, and intolerance to oral intake. Before admission, his medication regimen was 40 mg oral omeprazole daily, 1 g metformin twice dai ly, 1000 U cholecalciferol da...
Source: Gastroenterology - March 24, 2024 Category: Gastroenterology Authors: Govind Kallumkal, Justin McCallen, Michael Contarino Tags: Electronic Curbside Consult Source Type: research
Recurrent Duodenal Ulceration – More Than Simple Peptic Ulcer Disease?
(Source: Gastroenterology)
Source: Gastroenterology - March 24, 2024 Category: Gastroenterology Authors: Govind Kallumkal, Justin McCallen, Michael Contarino Tags: Electronic Gastro Curbside Consult Source Type: research
An Unusual Nodular Hyperplasia in the Rectum
Question: A 23-year-old woman presented with a 1-year history of lower abdominal discomfort. She denied the presence of fever, weight loss, persistent diarrhea, and hematochezia. She was single and employed as a clerk in a corporation within the urban area. No surgical history, drug history, medical history, alcohol abuse, or smoking were noted; she reported a history of anal intercourse. (Source: Gastroenterology)
Source: Gastroenterology - March 23, 2024 Category: Gastroenterology Authors: Ju-Ji Dai, Kai-yan Yang, Wei Xie Tags: Electronic Curbside Consult Source Type: research
Benefits of NSAIDs plus Pancreatic Stenting to Prevent Post-ERCP Pancreatitis
(Source: Gastroenterology)
Source: Gastroenterology - March 23, 2024 Category: Gastroenterology Authors: Mark Hanscom Tags: Gastro Digest Source Type: research
An unusual nodular hyperplasia in the rectum.
(Source: Gastroenterology)
Source: Gastroenterology - March 23, 2024 Category: Gastroenterology Authors: Ju-Ji Dai, Kai-yan Yang, Wei Xie Tags: Electronic Gastro Curbside Consult Source Type: research
Elusive hepatic nodules
(Source: Gastroenterology)
Source: Gastroenterology - March 23, 2024 Category: Gastroenterology Authors: Claudia Campani, Maria Guido, Fabio Marra Tags: Electronic Gastro Curbside Consult Source Type: research
CME Exam 1: Accuracy of the No-Biopsy Approach for the Diagnosis of Celiac Disease in Adults: A Systematic Review and Meta-Analysis
(Source: Gastroenterology)
Source: Gastroenterology - March 21, 2024 Category: Gastroenterology Tags: Continuing Medical Education (CME)/MOC Activities Source Type: research
