Gluten-free diet induces rapid changes in phenotype and survival properties of gluten-specific T cells in celiac disease
The treatment of celiac disease (CeD) with gluten-free diet (GFD) normalizes gut inflammation and disease-specific antibodies. CeD patients have HLA-restricted, gluten-specific T cells persisting in the blood and gut even after decades of GFD, which are re-activated and disease driving upon gluten exposure. Our aim was to examine the transition of activated gluten-specific T cells into a pool of persisting memory T cells concurrent with normalization of clinically relevant biomarkers during the first year of treatment.
Source: Gastroenterology - Category: Gastroenterology Authors: Louise F. Risnes, Henrik M. Reims, Ronan M. Doyle, Shuo-Wang Qiao, Ludvig M. Sollid, Knut E.A. Lundin, Asbj ørn Christophersen Tags: Basic and Translational - Alimentary Tract Source Type: research