Early tumor necrosis factor antagonist treatment prevents perianal fistula in pediatric crohn ’s disease
Perianal fistulizing complications (PFCs) develop amongst approximately 1/3 of children with Crohn ’s disease (CD), are difficult to treat, and commonly recur. Recent retrospective studies suggested PFCs may be preventable with early therapy. We aimed to evaluate PFC prevention in a prospective cohort. Based on prior work, we hypothesized early tumor necrosis antagonist (anti-TNF) treatment wou ld be associated with reduced risk of PFC development. (Source: Gastroenterology)
Source: Gastroenterology - January 25, 2024 Category: Gastroenterology Authors: Jeremy Adler, Samir Gadepalli, Moshiur Rahman, Sandra Kim Source Type: research
Fecal urgency associated with poor quality of life in quiescent ibd: a cross-sectional study of sparc ibd cohort
Fecal urgency (FU) is common in patients with active inflammatory bowel disease (IBD) and has been associated with reduced well-being and poor quality of life (QOL). Despite greater therapeutic options, clinical symptoms may persist in some patients. Data is lacking regarding FU in patients with objectively documented quiescent disease. (Source: Gastroenterology)
Source: Gastroenterology - January 25, 2024 Category: Gastroenterology Authors: Katie Dunleavy, Saam Dilmaghani, Tara Fehlmann, Laura Raffals, Victor Chedid Source Type: research
Free air from where? spontaneous pneumomediastinum and subcutaneous emphysema in a patient with ulcerative colitis in the absence of colonic or esophageal perforation
We describe a case of Ulcerative Colitis complicated by Clostridium difficile (C diff) colitis in which Spontaneous Pneumomediastinum and Subcutaneous Emphysema developed without any evidence of perforation. (Source: Gastroenterology)
Source: Gastroenterology - January 25, 2024 Category: Gastroenterology Authors: Lorraine Chong Tai, Edwin Makarevich, Andrea Alvarez, Ivana Rubenstein, Satya Singh Source Type: research
Hermansky-pudlak syndrome-associated inflammatory bowel disease: a systematic review on clinical manifestations and investigations into optimal management
Hermansky-Pudlak Syndrome (HPS) is a rare autosomal condition resulting from a mutation in 1 of at least 7 different genes leading to the triad of tyrosine-positive oculocutaneous albinism, platelet dysfunction leading to prolonged bleeding time, and ceroid lipofuscin within the reticuloendothelial system. The latter of these can result in systemic derangements including renal failure, pulmonary fibrosis, cardiomyopathy, and a disabling granulomatous colitis. This colitis is a unique type of inflammatory bowel disease (IBD) with complications such as intestinal fistulization, ileitis, enterocolitis and perianal disease. (S...
Source: Gastroenterology - January 25, 2024 Category: Gastroenterology Authors: Clive Miranda, Nariman Javaheri, Alexander Carlson, Ali Aijaz, Naren Nallapeta Source Type: research
Indolent systemic mastocytosis masquerading as chronic anemia in ulcerative colitis: a case study
Anemia is a frequent systemic/extra-intestinal manifestation of inflammatory bowel disease (IBD). It has a complex multifactorial etiology which suppresses erythropoiesis due to pro-inflammatory mediators, myelosuppression, iron and micronutrient deficiency. It significantly impacts quality of life (QoL) and increases hospitalizations, length of hospital stays and mortality rates. It Is commonly thought to arise as a consequence of IBD or it ’s related therapy. Current strategies are aimed at correction of anemia with low priority towards identifying a specific cause. (Source: Gastroenterology)
Source: Gastroenterology - January 25, 2024 Category: Gastroenterology Authors: Syed Adeel Hassan, Deborah Flomenhoft Source Type: research
Infectious complications in patients with primary sclerosing cholangitis and inflammatory bowel disease: a systematic review and meta-analysis
Primary sclerosing cholangitis (PSC) is a cholestatic immune-mediated liver disease that can be associated with inflammatory bowel disease (IBD) in up to 80% of patients. Those with concurrent PSC-IBD exhibit a distinct disease phenotype with increased risk of complications such as malignancy and pouchitis; however, the risk of infections is not yet clearly defined in this population. (Source: Gastroenterology)
Source: Gastroenterology - January 25, 2024 Category: Gastroenterology Authors: Navneet Natt, Tyrel May, Gurpreet Malhi, Jennifer Dumond, Parul Tandon Source Type: research
Inflammatory bowel disease and rheumatoid arthritis
Inflammatory bowel disease has been associated with arthritis since the late 20th century, but it was not until a few decades ago that IBD-associated arthritis was recognized as a distinct pathology independent from rheumatoid arthritis (RA). There is evidence that RA and other autoimmune conditions exist in higher rates in patients with IBD compared to the general population. This is an important distinction because of the different pathophysiology, clinical manifestations, management, complications, and prognosis of both diseases. (Source: Gastroenterology)
Source: Gastroenterology - January 25, 2024 Category: Gastroenterology Authors: Evelyn Calderon Martinez, Esmeralda Vilchez, Wern Lynn Ng, Seema Sharma Gautam, Diana Gavilanes, Maria Joseph, Christian Zevallos-Delgado Source Type: research
Prevalence of frailty in patients with inflammatory bowel disease. a pilot study.
Frailty is a multidimensional syndrome that leads to greater vulnerability to stress, increasing the risk of adverse health outcomes. It is a dynamic process, with transitions between being robust, pre-fragile and fragile over time, suggesting that it is modifiable. (Source: Gastroenterology)
Source: Gastroenterology - January 25, 2024 Category: Gastroenterology Authors: Maria Jesus Ballart, Francisca Grandon, Rodrigo Nieto, Manuel Alvarez Source Type: research
The impact of obesity on the prevalence and severity of perianal complications of crohn's disease
In this study, we aim to examine the relationship between obesity and the prevalence and severity of perianal complications in patients with Crohn ’s disease (CD). (Source: Gastroenterology)
Source: Gastroenterology - January 25, 2024 Category: Gastroenterology Authors: Jennifer Youn, Katie Hsia, Surya Khadilkar, Tanya Zeina, Puja Rai, Akash Rastogi, Pranay Adavelly, Sureya Hussani, Jason Yanes, Jacob Kotlier, Samara Spence, Alexander Levy, Sonia Friedman Source Type: research
The role of alcohol use in the development of crohn ’s disease complications: a retrospective analysis
Crohn ’s disease (CD) is a type of inflammatory bowel disease (IBD) characterized by transmural inflammation that can occur anywhere along the gastrointestinal (GI) tract. Complications of CD include fistulization, abscess formation, and GI bleed. Many social and environmental factors have been associat ed with CD. The role of alcohol use remains unclear, with some studies suggesting that it may increase the risk of CD and worsen symptoms, and others showing no relationship between alcohol and CD. (Source: Gastroenterology)
Source: Gastroenterology - January 25, 2024 Category: Gastroenterology Authors: Humzah Iqbal, Rakahn Haddadin, Hasib Haidary, Patrick Zhang, Devang Prajapati Source Type: research
Association of inflammatory bowel disease and autoimmune primary adrenal insufficiency
To assess the prevalence and association of inflammatory bowel disease (IBD) with autoimmune primary adrenal insufficiency (APAI). (Source: Gastroenterology)
Source: Gastroenterology - January 25, 2024 Category: Gastroenterology Authors: Salman Haider, Daryl Ramai, Saira Shah, Asad Ur Rahman, Moazzam Hussain, Iyad Al-Bustami, Praneeth Bandaru, Denzil Etienne Source Type: research
Deciphering the burden of inflammatory bowel disease landscape (1990-2019) in high income north america: projections, temporal shifts, and a glimpse beyond to 2040
In High-Income North America, IBD ranks as the 6th leading cause of disability and the 9th primary cause of mortality among all digestive diseases. The increasing prevalence in this region underscores the urgent need to address both the clinical and socio-economic challenges of managing this chronic condition in a developed setting. (Source: Gastroenterology)
Source: Gastroenterology - January 25, 2024 Category: Gastroenterology Authors: Rahul Patel, Vivek Roy, Sashank Sai Bollu, Sai Nitya Tejaswi Anne, Pranathi Royal Naradasu, Sneh Patel, Hardik Dineshbhai Desai Source Type: research
Evolving burden of inflammatory bowel disease in women from 1990-2019: global, regional, national variations, age dynamics, and implications for global health
Inflammatory Bowel Disease (IBD), encompassing conditions such as Crohn's disease and ulcerative colitis, has been a growing concern globally. While its burden has been studied extensively, the specific impact on women, who face unique physiological and socio-cultural challenges, remains underexplored. Grasping the global, national, and regional implications of IBD in women across 204 countries and territories provides a comprehensive understanding to guide healthcare strategies and tailor patient management. (Source: Gastroenterology)
Source: Gastroenterology - January 25, 2024 Category: Gastroenterology Authors: Vani Sojitra, Pranathi Royal Naradasu, Krina Manojbhai Patel, Rahul Patel, Sneh Patel, Hardik Dineshbhai Desai Source Type: research
Evolving landscape of inflammatory bowel disease in g20 nations (1990-2019): a comprehensive global assessment
As pivotal players in the global economy, the G20 countries not only lead in economic dynamics but also in health challenges. Recent data reveals an escalating burden of Inflammatory Bowel Disease (IBD) in these nations. Understanding this trend is crucial to frame healthcare strategies and ensure the well-being of a significant portion of the global population. (Source: Gastroenterology)
Source: Gastroenterology - January 25, 2024 Category: Gastroenterology Authors: Rahul Patel, Krishna Sajeev, Vani Sojitra, Krina Manojbhai Patel, Pranathi Royal Naradasu, Sneh Patel, Hardik Dineshbhai Desai Source Type: research
Exploring factors associated with serological response to sars-cov-2 vaccines in individuals with inflammatory bowel disease: interactive visualization methods for multidimensional data
SARS-CoV-2 vaccine response may be reduced in seniors (age 65+) with inflammatory bowel disease (IBD) and those on anti-TNF therapy. A challenge of the COVID-19 era has been conveying rapid-evolving health information, especially for groups with higher risk of poor outcomes of COVID-19 such as seniors and immunocompromised individuals. (Source: Gastroenterology)
Source: Gastroenterology - January 25, 2024 Category: Gastroenterology Authors: Lindsay Hracs, Joshua Quan, Christopher Ma, Remo Panaccione, Nastaran Sharifi, Michelle Herauf, Ante Markovinovic, Stephanie Coward, Joseph Windsor, Lea Caplan, Julia Gorospe, Kenneth Ernest-Suarez, Richard Ingram, Jessalyn Holodinsky, Charles Bernstein, Source Type: research
