Early tumor necrosis factor antagonist treatment prevents perianal fistula in pediatric crohn ’s disease

Perianal fistulizing complications (PFCs) develop amongst approximately 1/3 of children with Crohn ’s disease (CD), are difficult to treat, and commonly recur. Recent retrospective studies suggested PFCs may be preventable with early therapy. We aimed to evaluate PFC prevention in a prospective cohort. Based on prior work, we hypothesized early tumor necrosis antagonist (anti-TNF) treatment wou ld be associated with reduced risk of PFC development.
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research