Transforming growth factor-beta signals promote progression of squamous cell carcinoma by inducing epithelial-mesenchymal transition and angiogenesis
In this study, we examined the effects of TGF-β signaling on the murine squamous cell carcinoma, SCCVII cells in vitro and in vivo. The incubation of SCCVII cells with TGF-β induced the activation of TGF-β signals and epithelial-mesenchymal transition (EMT). Notably, the motility of SCCVII cells was increased upon the activation of the TGF-β signaling. RNA sequencing revealed upregulation of genes related to EMT and angiogenesis. Consistent with these in vitro results, the inhibition of TGF-β signals in SCCVII cell-derived primary tumors resulted in suppressed angiogenesis. Furthermore, we identified six candidate fac...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Haruka Ibi Kazuki Takahashi Hiroyuki Harada Tetsuro Watabe Katarzyna A Podyma-Inoue Source Type: research
Recent updates in the therapeutic uses of Pembrolizumab: a brief narrative review
CONCLUSION: Evolving research on pembrolizumab allows a deeper clinical understanding, despite challenges as variable patient responses. Pembrolizumab has emerged as a pivotal breakthrough in cancer treatment, improving patient outcomes and safety.PMID:38658461 | DOI:10.1007/s12094-024-03491-8 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 24, 2024 Category: Cancer & Oncology Authors: V ítor Silva Cristiano Matos Source Type: research
Recent updates in the therapeutic uses of Pembrolizumab: a brief narrative review
CONCLUSION: Evolving research on pembrolizumab allows a deeper clinical understanding, despite challenges as variable patient responses. Pembrolizumab has emerged as a pivotal breakthrough in cancer treatment, improving patient outcomes and safety.PMID:38658461 | DOI:10.1007/s12094-024-03491-8 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 24, 2024 Category: Cancer & Oncology Authors: V ítor Silva Cristiano Matos Source Type: research
Letter to Editor: "The Trajectory of Oral Mucositis in Head and Neck Cancer Patients Undergoing Radiotherapy and Its Influencing Factors"
Ear Nose Throat J. 2024 Apr 24:1455613241249268. doi: 10.1177/01455613241249268. Online ahead of print.NO ABSTRACTPMID:38656170 | DOI:10.1177/01455613241249268 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - April 24, 2024 Category: ENT & OMF Authors: Erkan Topkan Efsun Somay Ali Ayberk Besen Huseyin Mertsoylu Source Type: research
Transforming growth factor- β signals promote progression of squamous cell carcinoma by inducing epithelial-mesenchymal transition and angiogenesis
In this study, we examined the effects of TGF-β signaling on the murine squamous cell carcinoma, SCCVII cells in vitro and in vivo. The incubation of SCCVII cells with TGF-β induced the activation of TGF-β signals and epithelial-mesenchymal transition (EMT). Notably, the motility of SCCVII cells was increased upon the activation of the TGF-β signaling. RNA sequencing revealed upregulation of genes related to EMT and angiogenesis. Consistent with these in vitro results, the inhibition of TGF-β signals in SCCVII cell-derived primary tumors resulted in suppressed angiogenesis. Furthermore, we identified six candidate fac...
Source: Biochemical and Biophysical Research communications - April 24, 2024 Category: Biochemistry Authors: Haruka Ibi Kazuki Takahashi Hiroyuki Harada Tetsuro Watabe Katarzyna A Podyma-Inoue Source Type: research
Letter to Editor: "The Trajectory of Oral Mucositis in Head and Neck Cancer Patients Undergoing Radiotherapy and Its Influencing Factors"
Ear Nose Throat J. 2024 Apr 24:1455613241249268. doi: 10.1177/01455613241249268. Online ahead of print.NO ABSTRACTPMID:38656170 | DOI:10.1177/01455613241249268 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - April 24, 2024 Category: ENT & OMF Authors: Erkan Topkan Efsun Somay Ali Ayberk Besen Huseyin Mertsoylu Source Type: research
Recent updates in the therapeutic uses of Pembrolizumab: a brief narrative review
CONCLUSION: Evolving research on pembrolizumab allows a deeper clinical understanding, despite challenges as variable patient responses. Pembrolizumab has emerged as a pivotal breakthrough in cancer treatment, improving patient outcomes and safety.PMID:38658461 | DOI:10.1007/s12094-024-03491-8 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 24, 2024 Category: Cancer & Oncology Authors: V ítor Silva Cristiano Matos Source Type: research
Recent updates in the therapeutic uses of Pembrolizumab: a brief narrative review
CONCLUSION: Evolving research on pembrolizumab allows a deeper clinical understanding, despite challenges as variable patient responses. Pembrolizumab has emerged as a pivotal breakthrough in cancer treatment, improving patient outcomes and safety.PMID:38658461 | DOI:10.1007/s12094-024-03491-8 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 24, 2024 Category: Cancer & Oncology Authors: V ítor Silva Cristiano Matos Source Type: research
Recent updates in the therapeutic uses of Pembrolizumab: a brief narrative review
CONCLUSION: Evolving research on pembrolizumab allows a deeper clinical understanding, despite challenges as variable patient responses. Pembrolizumab has emerged as a pivotal breakthrough in cancer treatment, improving patient outcomes and safety.PMID:38658461 | DOI:10.1007/s12094-024-03491-8 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 24, 2024 Category: Cancer & Oncology Authors: V ítor Silva Cristiano Matos Source Type: research
Human papillomavirus associated oropharyngeal cancer now the most common mucosal head and neck cancer in Queensland
ConclusionOPSCC is now the most common mucosal head and neck cancer diagnosed in Queensland, having surpassed oral cavity cancer. The majority are HPV-associated (p16+), presenting with early-stage disease with a favourable prognosis. (Source: Journal of Medical Imaging and Radiation Oncology)
Source: Journal of Medical Imaging and Radiation Oncology - April 24, 2024 Category: Radiology Authors: Sandro V Porceddu,
Theresa Negrello,
Neal Rawson,
Nathan Dunn,
Martin Batstone,
Michael Collins,
Sam Dowthwaite,
Brett GM Hughes,
Liz Kenny,
Rahul Ladwa,
Ben Panizza,
Danica Cossio Tags: Radiation Oncology —Original Article Source Type: research
Cancers, Vol. 16, Pages 1642: Assessing the Effects of Curcumin and 450 nm Photodynamic Therapy on Oxidative Metabolism and Cell Cycle in Head and Neck Squamous Cell Carcinoma: An In Vitro Study
Andrea Amaroli
Oral cancer is the 16th most common malignant tumor worldwide. The risk of recurrence and mortality is high, and the survival rate is low over the following five years. Recent studies have shown that curcumin causes apoptosis in tumor cells by affecting FoF1-ATP synthase (ATP synthase) activity, which, in turn, hinders cell energy production, leading to a loss of cell viability. Additionally, irradiation of curcumin within cells can intensify its detrimental effects on cancer cell viability and proliferation (photodynamic therapy). We treated the OHSU-974 cell line, a model for human head and neck squam...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Silvia Ravera Claudio Pasquale Isabella Panfoli Matteo Bozzo Dimitrios Agas Silvia Bruno Michael R. Hamblin Andrea Amaroli Tags: Article Source Type: research
Adaptive radiotherapy for head and neck cancer: Pitfalls and possibilities from the radiation oncologist's point of view
CONCLUSION: Although based on mainly non-randomized and retrospective trials, there is accumulating evidence that ART has the potential to reduce toxicity and improve quality of life and tumor control in HNC patients treated with RT. However, several questions remain regarding accurate patient selection, the ideal frequency and timing of replanning, and the appropriate way for image registration and dose calculation. Well-designed randomized prospective trials, with a predetermined protocol for both image registration and dose summation, are urgently needed to further investigate the dosimetric and clinical benefits of ART...
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Sandra Nuyts Heleen Bollen Avrahram Eisbruch Primoz Strojan William M Mendenhall Sweet Ping Ng Alfio Ferlito Source Type: research
Inhibition of SUV39H1 reduces tumor angiogenesis via Notch1 in oral squamous cell carcinoma
This study provides a foundation for SUV39H1 as a potential therapeutic target for OSCC.PMID:38650654 | PMC:PMC11034493 | DOI:10.7717/peerj.17222 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Yan Chen Xiuhong Weng Chuanjie Zhang Simin Wang Xuechen Wu Bo Cheng Source Type: research
Adaptive radiotherapy for head and neck cancer: Pitfalls and possibilities from the radiation oncologist's point of view
ConclusionAlthough based on mainly non-randomized and retrospective trials, there is accumulating evidence that ART has the potential to reduce toxicity and improve quality of life and tumor control in HNC patients treated with RT. However, several questions remain regarding accurate patient selection, the ideal frequency and timing of replanning, and the appropriate way for image registration and dose calculation. Well-designed randomized prospective trials, with a predetermined protocol for both image registration and dose summation, are urgently needed to further investigate the dosimetric and clinical benefits of ART. ...
Source: Cancer Medicine - April 23, 2024 Category: Cancer & Oncology Authors: Sandra Nuyts,
Heleen Bollen,
Avrahram Eisbruch,
Primoz Strojan,
William M. Mendenhall,
Sweet Ping Ng,
Alfio Ferlito Tags: REVIEW Source Type: research
Poorly differentiated neuroendocrine carcinoma originating in the subglottic larynx: A case report with imm unohistochemical study
Laryngoscopic images showing a red mass in the sub glottis (black arrow). Key Clinical MessageLaryngeal neuroendocrine carcinomas are the most common non-squamous neoplasm of the larynx. Due to the rarity of the tumor, pathological diagnosis should be confirmed by immunohistochemistry.AbstractLaryngeal neuroendocrine carcinomas (LNECs) are a rare cancer of the head and neck. Few case reports of poorly differentiated neuroendocrine carcinoma originating in the subglottic larynx exist within the literature. In this case, we discuss a 57-year-old patient with a history of four-month hoarseness with a newly diagnosed of poorly...
Source: Clinical Case Reports - April 23, 2024 Category: General Medicine Authors: Mahboobe Asadi,
Milad Elyasi,
Arvin Shahzamani,
Saeedeh Miri Tags: CASE REPORT Source Type: research
