Marine-derived antimicrobial peptide piscidin-1 triggers extrinsic and intrinsic apoptosis in oral squamous cell carcinoma through reactive oxygen species production and inhibits angiogenesis
Free Radic Biol Med. 2024 Apr 26:S0891-5849(24)00422-2. doi: 10.1016/j.freeradbiomed.2024.04.235. Online ahead of print.ABSTRACTCancer of the head and neck encompasses a wide range of cancers, including oral and oropharyngeal cancers. Oral cancer is often diagnosed at advanced stages and has a dismal prognosis. Piscidin-1, a marine antimicrobial peptide (AMP) containing approximately 22 amino acids, also exhibits significant anticancer properties. We investigated the possible anti-oral cancer effects of piscidin-1 and clarified the mechanisms underlying these effects. We treated the oral squamous cell carcinoma cell lines ...
Source: Free Radical Biology and Medicine - April 28, 2024 Category: Biology Authors: Fu-Ching Chiu Hsiao-Mei Kuo Chen-Ling Yu Padhmavathi Selvam I-Li Su Chung-Chih Tseng Chien-Han Yuan Zhi-Hong Wen Source Type: research
Marine-derived antimicrobial peptide piscidin-1 triggers extrinsic and intrinsic apoptosis in oral squamous cell carcinoma through reactive oxygen species production and inhibits angiogenesis
Free Radic Biol Med. 2024 Apr 26;220:28-42. doi: 10.1016/j.freeradbiomed.2024.04.235. Online ahead of print.ABSTRACTCancer of the head and neck encompasses a wide range of cancers, including oral and oropharyngeal cancers. Oral cancer is often diagnosed at advanced stages and has a dismal prognosis. Piscidin-1, a marine antimicrobial peptide (AMP) containing approximately 22 amino acids, also exhibits significant anticancer properties. We investigated the possible anti-oral cancer effects of piscidin-1 and clarified the mechanisms underlying these effects. We treated the oral squamous cell carcinoma cell lines OC2 and SCC4...
Source: Free Radical Biology and Medicine - April 28, 2024 Category: Biology Authors: Fu-Ching Chiu Hsiao-Mei Kuo Chen-Ling Yu Padhmavathi Selvam I-Li Su Chung-Chih Tseng Chien-Han Yuan Zhi-Hong Wen Source Type: research
Cancers, Vol. 16, Pages 1714: Deep Learning Reconstruction for DWIs by EPI and FASE Sequences for Head and Neck Tumors
Conclusion: In comparison with EPI sequence, FASE sequence and DLR can improve image quality and distortion of DWIs without significantly influencing ADC measurements or differentiation capability of malignant from benign head and neck tumors. (Source: Cancers)
Source: Cancers - April 28, 2024 Category: Cancer & Oncology Authors: Hirotaka Ikeda Yoshiharu Ohno Kaori Yamamoto Kazuhiro Murayama Masato Ikedo Masao Yui Yunosuke Kumazawa Yurika Shimamura Yui Takagi Yuhei Nakagaki Satomu Hanamatsu Yuki Obama Takahiro Ueda Hiroyuki Nagata Yoshiyuki Ozawa Akiyoshi Iwase Hiroshi Toyama Tags: Article Source Type: research
The Use of Artificial Intelligence in Head and Neck Cancers: A Multidisciplinary Survey
J Pers Med. 2024 Mar 25;14(4):341. doi: 10.3390/jpm14040341.ABSTRACTArtificial intelligence (AI) approaches have been introduced in various disciplines but remain rather unused in head and neck (H&N) cancers. This survey aimed to infer the current applications of and attitudes toward AI in the multidisciplinary care of H&N cancers. From November 2020 to June 2022, a web-based questionnaire examining the relationship between AI usage and professionals' demographics and attitudes was delivered to different professionals involved in H&N cancers through social media and mailing lists. A total of 139 professionals c...
Source: Cancer Control - April 27, 2024 Category: Cancer & Oncology Authors: Caterina Giannitto Giorgia Carnicelli Stefano Lusi Angela Ammirabile Elena Casiraghi Armando De Virgilio Andrea Alessandro Esposito Davide Farina Fabio Ferreli Ciro Franzese Gian Marco Frigerio Antonio Lo Casto Luca Malvezzi Luigi Lorini Ahmed E Othman Lo Source Type: research
Advancing Postoperative Pain Management in Oral Cancer Patients: A Systematic Review
Pharmaceuticals (Basel). 2024 Apr 22;17(4):542. doi: 10.3390/ph17040542.ABSTRACTThe goal of this review is to shed light on the management of orofacial discomfort after a cancer diagnosis in the head and neck region. A search was conducted on PubMed, Scopus, and Web of Science to identify studies on postoperative pain control in oral cancer. The review included open-access research, investigations into pain management, randomized clinical trials, retrospective studies, case-control studies, prospective studies, English-written studies, and full-text publications. Exclusion criteria included animal studies; in vitro studies...
Source: Cancer Control - April 27, 2024 Category: Cancer & Oncology Authors: Angelo Michele Inchingolo Gianna Dipalma Alessio Danilo Inchingolo Irene Palumbo Mariafrancesca Guglielmo Roberta Morolla Antonio Mancini Francesco Inchingolo Source Type: research
Human Papillomavirus Is Rare and Does Not Correlate with p16 < sup > INK4A < /sup > Expression in Non-Small-Cell Lung Cancer in a Jordanian Subpopulation
Conclusions: This is the first study to assess HPV and p16INK4a expression in a Jordanian population. HPV positivity is rare in NSCLC among a Jordanian subpopulation. P16 INK4a reliability as a surrogate marker for HPV infection in lung cancer must be revisited.PMID:38674306 | DOI:10.3390/medicina60040660 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Ola Abu Al Karsaneh Arwa Al Anber Sahar AlMustafa Hussien AlMa'aitah Batool AlQadri Abir Igbaria Rama Tayem Mustafa Khasawneh Shaima Batayha Tareq Saleh Mohammad ALQudah Maher Sughayer Source Type: research
Human Papillomavirus Is Rare and Does Not Correlate with p16 < sup > INK4A < /sup > Expression in Non-Small-Cell Lung Cancer in a Jordanian Subpopulation
Conclusions: This is the first study to assess HPV and p16INK4a expression in a Jordanian population. HPV positivity is rare in NSCLC among a Jordanian subpopulation. P16 INK4a reliability as a surrogate marker for HPV infection in lung cancer must be revisited.PMID:38674306 | PMC:PMC11052093 | DOI:10.3390/medicina60040660 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Ola Abu Al Karsaneh Arwa Al Anber Sahar AlMustafa Hussien AlMa'aitah Batool AlQadri Abir Igbaria Rama Tayem Mustafa Khasawneh Shaima Batayha Tareq Saleh Mohammad ALQudah Maher Sughayer Source Type: research
Human Papillomavirus Is Rare and Does Not Correlate with p16 < sup > INK4A < /sup > Expression in Non-Small-Cell Lung Cancer in a Jordanian Subpopulation
Conclusions: This is the first study to assess HPV and p16INK4a expression in a Jordanian population. HPV positivity is rare in NSCLC among a Jordanian subpopulation. P16 INK4a reliability as a surrogate marker for HPV infection in lung cancer must be revisited.PMID:38674306 | PMC:PMC11052093 | DOI:10.3390/medicina60040660 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Ola Abu Al Karsaneh Arwa Al Anber Sahar AlMustafa Hussien AlMa'aitah Batool AlQadri Abir Igbaria Rama Tayem Mustafa Khasawneh Shaima Batayha Tareq Saleh Mohammad ALQudah Maher Sughayer Source Type: research
Human Papillomavirus Is Rare and Does Not Correlate with p16 < sup > INK4A < /sup > Expression in Non-Small-Cell Lung Cancer in a Jordanian Subpopulation
Conclusions: This is the first study to assess HPV and p16INK4a expression in a Jordanian population. HPV positivity is rare in NSCLC among a Jordanian subpopulation. P16 INK4a reliability as a surrogate marker for HPV infection in lung cancer must be revisited.PMID:38674306 | PMC:PMC11052093 | DOI:10.3390/medicina60040660 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Ola Abu Al Karsaneh Arwa Al Anber Sahar AlMustafa Hussien AlMa'aitah Batool AlQadri Abir Igbaria Rama Tayem Mustafa Khasawneh Shaima Batayha Tareq Saleh Mohammad ALQudah Maher Sughayer Source Type: research
Genes, Vol. 15, Pages 556: The Relationship between miR-5682 and Nutritional Status of Radiotherapy-Treated Male Laryngeal Cancer Patients
Conclusions: analysis of miR-5682 expression demonstrates a potential clinical utility in selection of LC patients suffering from nutritional deficiencies developing as a consequence of RT-based therapy. (Source: Genes)
Source: Genes - April 27, 2024 Category: Genetics & Stem Cells Authors: Marcin Mazurek Anna Brzozowska Miros ław Maziarz Teresa Ma łecka-Massalska Tomasz Powr ózek Tags: Article Source Type: research
Arenobufagin induces cell apoptosis by modulating the cell cycle regulator claspin and the JNK pathway in nasopharyngeal carcinoma cells
. (Source: Expert Opinion on Therapeutic Targets)
Source: Expert Opinion on Therapeutic Targets - April 27, 2024 Category: Drugs & Pharmacology Authors: Hsin-Yu HoMu-Kuan ChenChia-Chieh LinYu-Sheng LoYi-Ching ChuangMing-Ju Hsieha Oral Cancer Research Center, Changhua Christian Hospital, Changhua, Taiwanb Department of Otorhinolaryngology-Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan Source Type: research
Interdisciplinary Collaboration in Head and Neck Cancer Care: Optimizing Oral Health Management for Patients Undergoing Radiation Therapy
In conclusion, these proactive measures help minimize dental and oral complications before, during, and after treatment.PMID:38668058 | DOI:10.3390/curroncol31040155 (Source: Current Oncology)
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Tugce Kutuk Ece Atak Alessandro Villa Noah S Kalman Adeel Kaiser Source Type: research
Evaluation of Serum and Salivary Lactate Dehydrogenase Levels in Patients with Oral Potentially Malignant Conditions/Lesions: A Clinical and Biochemical Study
CONCLUSION: Higher serum and salivary LDH levels in Oral Potentially malignant lesions/conditions than in control groups signifies the importance of assessing salivary LDH levels, in the prognosis of the same. Further prospective longitudinal studies are required to assess the salivary LDH levels among the patients with malignant transformation of Oral Potentially malignant lesions/conditions to oral cancers.PMID:38665466 | PMC:PMC11042121 | DOI:10.4103/ijcm.ijcm_612_22 (Source: Cancer Control)
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Kumuda Rao Subhas G Babu Shishir Ram Shetty Renita Lorina Castelino Source Type: research
Human papillomavirus infection: Epidemiology, biology, host interactions, cancer development, prevention, and therapeutics
This study aimed to carry out a literature review considering several aspects involving HPV infection: Global distribution, prevalence, biology, host interactions, cancer development, prevention, therapeutics, coinfection with other viruses, coinfection with bacteria, association with head and neck squamous cell carcinomas, and association with anal cancer.PMID:38666757 | DOI:10.1002/rmv.2537 (Source: Cancer Control)
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Jonas Wolf Lucas Felipe Kist Samanta Brangel Pereira Marilze Alves Quessada Helena Petek Arthur Pille Ju çara Gasparetto Maccari Mohamed Parrini Mutlaq Luiz Antonio Nasi Source Type: research
Availability of genome-matched therapy based on clinical practice
CONCLUSION: This study demonstrated the usefulness of CGP for patients with sarcoma and HNC in addition to lung cancer in clinical practice. Performing CGP at the front line has the potential to improve the availability of genome-matched therapy.PMID:38668785 | DOI:10.1007/s10147-024-02533-z (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 26, 2024 Category: Cancer & Oncology Authors: Naomi Hayashi Seiichi Mori Akihiro Ohmoto Ippei Fukada Masumi Yamazaki Mari Hosonaga Xiaofei Wang Arisa Ueki Kazuma Kiyotani Akiko Tonooka Kengo Takeuchi Shunji Takahashi Source Type: research
