The role of the soft palate dose regarding normal tissue toxicities in older adults with head and neck cancer undergoing definitive radiotherapy
The number of older adults with head and neck squamous cell carcinoma (HNSCC) is continuously increasing. Older HNSCC patients may be more vulnerable to radiotherapy-related toxicities, so that extrapolation o... (Source: Radiation Oncology)
Source: Radiation Oncology - April 30, 2024 Category: Cancer & Oncology Authors: Helena C. Bitz, Ilias Sachpazidis, Jiadai Zou, Daniel Schnell, Dimos Baltas, Anca-Ligia Grosu, Nils H. Nicolay and Alexander R ühle Tags: Research Source Type: research
The Effect of Tumor Resection and Radiotherapy on the Expression of Stem Cell Markers (CD44 and CD133) in Patients with Squamous Cell Carcinoma
Conclusion: The results also indicated that the expression of CD44 significantly decreased after tumor resection and radiotherapy. The upregulation of mRNA level of Bcl-2 and ALDH, and the downregulation of Bax and Bak gene expression were noted in these cases when compared to the healthy control group.PMID:38680713 | PMC:PMC11055418 | DOI:10.18502/ijhoscr.v18i1.14748 (Source: Cell Research)
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Ladan Paya Ali Rafat Mehdi Talebi Amirala Aghbali Nikzad Shahidi Babak Nejati Parya Emamverdizadeh Hojjatollah Nozad Charoudeh Source Type: research
The Effect of Tumor Resection and Radiotherapy on the Expression of Stem Cell Markers (CD44 and CD133) in Patients with Squamous Cell Carcinoma
Conclusion: The results also indicated that the expression of CD44 significantly decreased after tumor resection and radiotherapy. The upregulation of mRNA level of Bcl-2 and ALDH, and the downregulation of Bax and Bak gene expression were noted in these cases when compared to the healthy control group.PMID:38680713 | PMC:PMC11055418 | DOI:10.18502/ijhoscr.v18i1.14748 (Source: Cancer Control)
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Ladan Paya Ali Rafat Mehdi Talebi Amirala Aghbali Nikzad Shahidi Babak Nejati Parya Emamverdizadeh Hojjatollah Nozad Charoudeh Source Type: research
RNA-binding protein HuR reprograms immune T cells and promotes oral squamous cell carcinoma
We examined HuR's effects on oral malignancies and immune cell function in vitro and in vivo using oral carcinoma cells and transgenic HuR knockout (KO) mice. CRISPR/Cas9-mediated HuR deletion in mice syngeneic oral cancer cells eliminated colony formation and tumor development. HuR-KO tumors had a lower tumor volume, fewer CD4+CD25+FoxP3+ regulatory T cells, and more CD8+ T cells, suggesting that HuR may suppress the immune response during oral cancer progression. In contrast, HuR KO oral epithelial tissues are resistant to 4NQO-induced oral malignancies compared to control tumor-bearing mice. HuR KO mice showed fewer Tre...
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Mrinmoyee Majumder Harinarayanan Janakiraman Paramita Chakraborty Anitha Vijayakumar Sari Mayhue Hong Yu Toros Dincman Romeo Martin Elizabeth O'Quinn Shikhar Mehrotra Viswanathan Palanisamy Source Type: research
Insights into metastatic roadmap of head and neck cancer squamous cell carcinoma based on clinical, histopathological and molecular profiles
Mol Biol Rep. 2024 Apr 29;51(1):597. doi: 10.1007/s11033-024-09476-8.ABSTRACTThe incidence of head and neck cancer (HNC), constituting approximately one in ten cancer cases worldwide, affects approximately 644,000 individuals annually. Managing this complex disease involves various treatment modalities such as systemic therapy, radiation, and surgery, particularly for patients with locally advanced disease. HNC treatment necessitates a multidisciplinary approach due to alterations in patients' genomes affecting their functionality. Predominantly, squamous cell carcinomas (SCCs), the majority of HNCs, arise from the upper a...
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Nicholas S Mastronikolis Alexander Delides Efthymios Kyrodimos Zoi Piperigkou Despoina Spyropoulou Evangelos Giotakis Evangelos Tsiambas Nikos K Karamanos Source Type: research
Head and Neck Cancer: United Kingdom National Multidisciplinary Guidelines, Sixth Edition - ERRATUM
J Laryngol Otol. 2024 Apr 29:1-5. doi: 10.1017/S0022215124000628. Online ahead of print.NO ABSTRACTPMID:38682705 | DOI:10.1017/S0022215124000628 (Source: Journal of Laryngology and Otology)
Source: Journal of Laryngology and Otology - April 29, 2024 Category: ENT & OMF Authors: Jarrod J Homer Stuart C Winter Source Type: research
Dysregulation of base excision repair factors associated with low tumor immunogenicity in head and neck cancer: implication for immunotherapy
CONCLUSION: Our analysis suggests that dysregulation of the BER genes panel might be a potential prognosis marker and/or an attractive target for an immune checkpoint blockade in HNSCC cancers. However, our observation still requires further experimental-based scientific validation studies.PMID:38680291 | PMC:PMC11047243 | DOI:10.1177/17588359241248330 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Zackary Shpilman Dawit Kidane Source Type: research
Insights into metastatic roadmap of head and neck cancer squamous cell carcinoma based on clinical, histopathological and molecular profiles
Mol Biol Rep. 2024 Apr 29;51(1):597. doi: 10.1007/s11033-024-09476-8.ABSTRACTThe incidence of head and neck cancer (HNC), constituting approximately one in ten cancer cases worldwide, affects approximately 644,000 individuals annually. Managing this complex disease involves various treatment modalities such as systemic therapy, radiation, and surgery, particularly for patients with locally advanced disease. HNC treatment necessitates a multidisciplinary approach due to alterations in patients' genomes affecting their functionality. Predominantly, squamous cell carcinomas (SCCs), the majority of HNCs, arise from the upper a...
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Nicholas S Mastronikolis Alexander Delides Efthymios Kyrodimos Zoi Piperigkou Despoina Spyropoulou Evangelos Giotakis Evangelos Tsiambas Nikos K Karamanos Source Type: research
Insights into metastatic roadmap of head and neck cancer squamous cell carcinoma based on clinical, histopathological and molecular profiles
Mol Biol Rep. 2024 Apr 29;51(1):597. doi: 10.1007/s11033-024-09476-8.ABSTRACTThe incidence of head and neck cancer (HNC), constituting approximately one in ten cancer cases worldwide, affects approximately 644,000 individuals annually. Managing this complex disease involves various treatment modalities such as systemic therapy, radiation, and surgery, particularly for patients with locally advanced disease. HNC treatment necessitates a multidisciplinary approach due to alterations in patients' genomes affecting their functionality. Predominantly, squamous cell carcinomas (SCCs), the majority of HNCs, arise from the upper a...
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Nicholas S Mastronikolis Alexander Delides Efthymios Kyrodimos Zoi Piperigkou Despoina Spyropoulou Evangelos Giotakis Evangelos Tsiambas Nikos K Karamanos Source Type: research
Head and Neck Cancer: United Kingdom National Multidisciplinary Guidelines, Sixth Edition - ERRATUM
J Laryngol Otol. 2024 Apr 29:1-5. doi: 10.1017/S0022215124000628. Online ahead of print.NO ABSTRACTPMID:38682705 | DOI:10.1017/S0022215124000628 (Source: Journal of Laryngology and Otology)
Source: Journal of Laryngology and Otology - April 29, 2024 Category: ENT & OMF Authors: Jarrod J Homer Stuart C Winter Source Type: research
Dysregulation of base excision repair factors associated with low tumor immunogenicity in head and neck cancer: implication for immunotherapy
CONCLUSION: Our analysis suggests that dysregulation of the BER genes panel might be a potential prognosis marker and/or an attractive target for an immune checkpoint blockade in HNSCC cancers. However, our observation still requires further experimental-based scientific validation studies.PMID:38680291 | PMC:PMC11047243 | DOI:10.1177/17588359241248330 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Zackary Shpilman Dawit Kidane Source Type: research
Insights into metastatic roadmap of head and neck cancer squamous cell carcinoma based on clinical, histopathological and molecular profiles
Mol Biol Rep. 2024 Apr 29;51(1):597. doi: 10.1007/s11033-024-09476-8.ABSTRACTThe incidence of head and neck cancer (HNC), constituting approximately one in ten cancer cases worldwide, affects approximately 644,000 individuals annually. Managing this complex disease involves various treatment modalities such as systemic therapy, radiation, and surgery, particularly for patients with locally advanced disease. HNC treatment necessitates a multidisciplinary approach due to alterations in patients' genomes affecting their functionality. Predominantly, squamous cell carcinomas (SCCs), the majority of HNCs, arise from the upper a...
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Nicholas S Mastronikolis Alexander Delides Efthymios Kyrodimos Zoi Piperigkou Despoina Spyropoulou Evangelos Giotakis Evangelos Tsiambas Nikos K Karamanos Source Type: research
Insights into metastatic roadmap of head and neck cancer squamous cell carcinoma based on clinical, histopathological and molecular profiles
Mol Biol Rep. 2024 Apr 29;51(1):597. doi: 10.1007/s11033-024-09476-8.ABSTRACTThe incidence of head and neck cancer (HNC), constituting approximately one in ten cancer cases worldwide, affects approximately 644,000 individuals annually. Managing this complex disease involves various treatment modalities such as systemic therapy, radiation, and surgery, particularly for patients with locally advanced disease. HNC treatment necessitates a multidisciplinary approach due to alterations in patients' genomes affecting their functionality. Predominantly, squamous cell carcinomas (SCCs), the majority of HNCs, arise from the upper a...
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Nicholas S Mastronikolis Alexander Delides Efthymios Kyrodimos Zoi Piperigkou Despoina Spyropoulou Evangelos Giotakis Evangelos Tsiambas Nikos K Karamanos Source Type: research
Impact of COVID-19 pandemic among patients with lung and head and neck cancer assisted in a public cancer center in Brazil
This study aimed to anal... (Source: BMC Cancer)
Source: BMC Cancer - April 29, 2024 Category: Cancer & Oncology Authors: Gilson Gabriel Viana Veloso, Fl ávia Duarte Amaral and Angélica Nogueira-Rodrigues Tags: Research Source Type: research
Marine-derived antimicrobial peptide piscidin-1 triggers extrinsic and intrinsic apoptosis in oral squamous cell carcinoma through reactive oxygen species production and inhibits angiogenesis
Free Radic Biol Med. 2024 Apr 26:S0891-5849(24)00422-2. doi: 10.1016/j.freeradbiomed.2024.04.235. Online ahead of print.ABSTRACTCancer of the head and neck encompasses a wide range of cancers, including oral and oropharyngeal cancers. Oral cancer is often diagnosed at advanced stages and has a dismal prognosis. Piscidin-1, a marine antimicrobial peptide (AMP) containing approximately 22 amino acids, also exhibits significant anticancer properties. We investigated the possible anti-oral cancer effects of piscidin-1 and clarified the mechanisms underlying these effects. We treated the oral squamous cell carcinoma cell lines ...
Source: Free Radical Biology and Medicine - April 28, 2024 Category: Biology Authors: Fu-Ching Chiu Hsiao-Mei Kuo Chen-Ling Yu Padhmavathi Selvam I-Li Su Chung-Chih Tseng Chien-Han Yuan Zhi-Hong Wen Source Type: research
