Hypoxia as a stimulus for tissue formation: The concept of organogenesis in microsurgically vascularized tissue engineering constructs
J Craniomaxillofac Surg. 2024 Mar 13:S1010-5182(24)00104-5. doi: 10.1016/j.jcms.2024.03.020. Online ahead of print.ABSTRACTAxial vascularization of tissue constructs is essential to maintain an adequate blood supply for a stable regeneration of a clinically relevant tissue size. The versatility of the arterio-venous loop (AVL) has been previously shown in various small and large animal models as well as in clinical reports for bone regeneration. We have previously demonstrated the capability of the AVL to induce axial vascularization and to support the nourishment of tissue constructs in small animal models after applying ...
Source: Hand Surgery - April 6, 2024 Category: Surgery Authors: Ahmad Eweida Elli Sandberg Oliver Ritthaler Jens Fleckenstein Yasser Abo-Madyan Frank Anton Giordano Matthias Schulte Ulrich Kneser Leila Harhaus Source Type: research
Hypoxia as a stimulus for tissue formation: The concept of organogenesis in microsurgically vascularized tissue engineering constructs
J Craniomaxillofac Surg. 2024 Mar 13:S1010-5182(24)00104-5. doi: 10.1016/j.jcms.2024.03.020. Online ahead of print.ABSTRACTAxial vascularization of tissue constructs is essential to maintain an adequate blood supply for a stable regeneration of a clinically relevant tissue size. The versatility of the arterio-venous loop (AVL) has been previously shown in various small and large animal models as well as in clinical reports for bone regeneration. We have previously demonstrated the capability of the AVL to induce axial vascularization and to support the nourishment of tissue constructs in small animal models after applying ...
Source: Hand Surgery - April 6, 2024 Category: Surgery Authors: Ahmad Eweida Elli Sandberg Oliver Ritthaler Jens Fleckenstein Yasser Abo-Madyan Frank Anton Giordano Matthias Schulte Ulrich Kneser Leila Harhaus Source Type: research
New hopes for the breast cancer treatment: perspectives on the oncolytic virus therapy
Front Immunol. 2024 Mar 21;15:1375433. doi: 10.3389/fimmu.2024.1375433. eCollection 2024.ABSTRACTOncolytic virus (OV) therapy has emerged as a promising frontier in cancer treatment, especially for solid tumours. While immunotherapies like immune checkpoint inhibitors and CAR-T cells have demonstrated impressive results, their limitations in inducing complete tumour regression have spurred researchers to explore new approaches targeting tumours resistant to current immunotherapies. OVs, both natural and genetically engineered, selectively replicate within cancer cells, inducing their lysis while sparing normal tissues. Rec...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Hanna Chowaniec Antonina Ślubowska Magdalena Mroczek Martyna Borowczyk Ma łgorzata Braszka Grzegorz Dworacki Paula Dobosz Mateusz Wichtowski Source Type: research
Clinical Results and Prognostic Factors in BNCT for Recurrent Squamous Cell Carcinoma of the Head and Neck under the Japan National Health Insurance System: A Retrospective Study of the Initial 47 Patients
CONCLUSIONS: This study provided valuable insights into the early integration of BNCT into routine clinical practice, highlighting its efficacy and safety. Technical improvements are needed to ensure precise dose administration. Ongoing prospective studies, such as the phase II REBIVAL study, will further elucidate the role of BNCT in recurrent head and neck cancer.PMID:38580084 | DOI:10.1016/j.ijrobp.2024.03.041 (Source: Health Physics)
Source: Health Physics - April 5, 2024 Category: Physics Authors: Katsumi Hirose Mariko Sato Source Type: research
CLO24-081: Induction Chemotherapy in Locally Advanced Squamous Cell Carcinoma of Head and Neck-Biweekly Docetaxel, Cisplatin, 5-Fluorouracil, Leucovorin (TPFL) Versus Triweekly TPF: Response Assessment and Translation Into Survival Benefit
J Natl Compr Canc Netw. 2024 Apr 5;22(2.5):CLO24-081. doi: 10.6004/jnccn.2023.7186.NO ABSTRACTPMID:38580290 | DOI:10.6004/jnccn.2023.7186 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - April 5, 2024 Category: Cancer & Oncology Authors: Sreevalli Anantharamu A Sreevalli Linu Abraham Jacob Lokanatha Dasappa Suresh Babu Mc Iokesh Kn Rudresha Ah R Lakkavalli Krishnappa Saldanha Saldanha Source Type: research
New hopes for the breast cancer treatment: perspectives on the oncolytic virus therapy
Front Immunol. 2024 Mar 21;15:1375433. doi: 10.3389/fimmu.2024.1375433. eCollection 2024.ABSTRACTOncolytic virus (OV) therapy has emerged as a promising frontier in cancer treatment, especially for solid tumours. While immunotherapies like immune checkpoint inhibitors and CAR-T cells have demonstrated impressive results, their limitations in inducing complete tumour regression have spurred researchers to explore new approaches targeting tumours resistant to current immunotherapies. OVs, both natural and genetically engineered, selectively replicate within cancer cells, inducing their lysis while sparing normal tissues. Rec...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Hanna Chowaniec Antonina Ślubowska Magdalena Mroczek Martyna Borowczyk Ma łgorzata Braszka Grzegorz Dworacki Paula Dobosz Mateusz Wichtowski Source Type: research
Clinical Results and Prognostic Factors in BNCT for Recurrent Squamous Cell Carcinoma of the Head and Neck under the Japan National Health Insurance System: A Retrospective Study of the Initial 47 Patients
CONCLUSIONS: This study provided valuable insights into the early integration of BNCT into routine clinical practice, highlighting its efficacy and safety. Technical improvements are needed to ensure precise dose administration. Ongoing prospective studies, such as the phase II REBIVAL study, will further elucidate the role of BNCT in recurrent head and neck cancer.PMID:38580084 | DOI:10.1016/j.ijrobp.2024.03.041 (Source: Health Physics)
Source: Health Physics - April 5, 2024 Category: Physics Authors: Katsumi Hirose Mariko Sato Source Type: research
CLO24-081: Induction Chemotherapy in Locally Advanced Squamous Cell Carcinoma of Head and Neck-Biweekly Docetaxel, Cisplatin, 5-Fluorouracil, Leucovorin (TPFL) Versus Triweekly TPF: Response Assessment and Translation Into Survival Benefit
J Natl Compr Canc Netw. 2024 Apr 5;22(2.5):CLO24-081. doi: 10.6004/jnccn.2023.7186.NO ABSTRACTPMID:38580290 | DOI:10.6004/jnccn.2023.7186 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - April 5, 2024 Category: Cancer & Oncology Authors: Sreevalli Anantharamu A Sreevalli Linu Abraham Jacob Lokanatha Dasappa Suresh Babu Mc Iokesh Kn Rudresha Ah R Lakkavalli Krishnappa Saldanha Saldanha Source Type: research
Carotid Artery Stenosis and Ischemic Stroke in Patients with Head and Neck Cancer Treated with Radiotherapy: A Critical Review
The purpose of this review is to summarize the literature on carotid artery stenosis (CAS) and ischemic stroke (IS) in head and neck cancer (HNC) patients treated with radiotherapy (RT) to guide assessment, screening, and management strategies. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 5, 2024 Category: Radiology Authors: Justin Smith, Danielle Margalit, Jonathan Golledge, Domenico Nastasi, Anju Nohria, Lachlan McDowell Tags: Critical Review Source Type: research
Qualitative study exploring the design of a patient-reported symptom-based risk stratification system for suspected head and neck cancer referrals: protocol for work packages 1 and 2 within the EVEREST-HN programme
Introduction
Between 2009/2010 and 2019/2020, England witnessed an increase in suspected head and neck cancer (sHNC) referrals from 140 to 404 patients per 100 000 population. 1 in 10 patients are not seen within the 2-week target, contributing to patient anxiety. We will develop a pathway for sHNC referrals, based on the Head and Neck Cancer Risk Calculator. The evolution of a patient-reported symptom-based risk stratification system to redesign the sHNC referral pathway (EVEREST-HN) Programme comprises six work packages (WPs). This protocol describes WP1 and WP2. WP1 will obtain an understanding of language to optimise t...
Source: BMJ Open - April 5, 2024 Category: General Medicine Authors: Albutt, A., Hardman, J., McVey, L., Odo, C., Paleri, V., Patterson, J., Webb, S., Rousseau, N., Kellar, I., Randell, R. Tags: Open access, Oncology Source Type: research
Citalopram, an antipsychotic agent, induces G1/G0 phase cell cycle arrest and promotes apoptosis in human laryngeal carcinoma HEP-2 cells
AbstractHuman laryngeal squamous carcinoma (LSCC) is a common malignant tumor in the head and neck. Despite the recently developed therapies for the treatment of LSCC, patients ’ overall survival rate still did not enhance remarkably; this highlights the need to formulate alternative strategies to develop novel treatments. The antitumor effects of antidepressant drugs such as citalopram have been reported on several cancer cells; however, they have yet to be investigated against LSCC. The current study was directed to explore the possible antitumor effects of citalopram on human laryngeal carcinoma cell lines (HEP-2). HE...
Source: Medical Oncology - April 4, 2024 Category: Cancer & Oncology Source Type: research
Error in Author Name
This article was corrected online. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - April 4, 2024 Category: ENT & OMF Source Type: research
Trends in Oral Tongue Cancer Incidence in the US
This cross-sectional study examines US trends in oral tongue cancer incidence and the factors associated with future case burden. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - April 4, 2024 Category: ENT & OMF Source Type: research
Does lower dose pilocarpine have a role in radiation-induced xerostomia in the modern radiotherapy era? A single-center experience based on patient-reported outcome measures
ConclusionPilocarpine may be considered at doses lower for late-term dry mouth. With modern radiotherapy techniques effectively preserving the parotid gland, short-term use may be recommended in these patients. Future studies may enhance the development of a more robust patient selection criteria model. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - April 4, 2024 Category: ENT & OMF Source Type: research
Outcome of Adjuvant Radiotherapy and Adjuvant Chemoradiation for Oral Cancers with Close Margins of Resection
This study aims at documenting the oncological outcome with regards to loco-regional control, disease-free survival, overall survival and complications of adjuvant radiotherapy and adjuvant chemoradiation in operated oral cancer patients having close margins of resection. In this Retrospective cohort study, 163 patients with stage T1-T4 oral cancers operated between 2015 and 2019 who have fulfilled the inclusion and exclusion criteria, received adjuvant treatment and could be followed up for at least one year were included. At the end of 45 months, the overall survival was 74.7% and disease specific survival was 82.7%. Amo...
Source: Cancer Control - April 3, 2024 Category: Cancer & Oncology Authors: Lini Joseph S M Azeem Mohiyuddin G N Manjunath R Kalyani Source Type: research
