Imaging For Larynx Cancer Assessment
Imaging is critical in the evaluation and accurate staging of the patient with laryngeal cancer. Knowledge of relevant anatomy and characteristic patterns of tumor spread guides prognosis and facilitates treatment planning. Furthermore, imaging plays an important role in follow-up of the patient who has undergone successful treatment of their primary laryngeal cancer to detect recurrence and assess treatment-related complications. This review highlights the common imaging modalities used in laryngeal cancer imaging, unique anatomic considerations for each laryngeal subsite, and provides an overview of post-treatment survei...
Source: Operative Techniques in Otolaryngology - Head and Neck Surgery - April 16, 2024 Category: ENT & OMF Authors: Gino J Mongelluzzo, Edward C Fourgas, Gino Mongelluzzo Source Type: research
Operative Techniques in Otolaryngology: Head and Neck Surgery. Geisinger Medical Center Experience for Whole Mount Laryngectomy Specimen.
This study examines the pathological features of laryngectomy specimens and their significance in the diagnosis and management of laryngeal cancer. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
Source: Operative Techniques in Otolaryngology - Head and Neck Surgery - April 16, 2024 Category: ENT & OMF Authors: Mohammed Amer Swid, Hayden Idom, William Quinones Source Type: research
Re-irradiation versus systemic therapy for the management of local-regionally recurrent head and neck cancer
Despite advances in the multi-disciplinary management of squamous cell carcinoma of the head and neck, a significant proportion of patients still experience local –regional recurrence after radiation therapy. For patients who are not candidates for salvage surgery, re-irradiation has long been suggested to improve outcomes [1–3]. However, the evidence in favor of re-irradiation is based almost entirely on single-arm studies, most of which have established relatively modest rates of local control [4–6]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - April 16, 2024 Category: Radiology Authors: Allen M. Chen, Jeremy P. Harris, Rupali Nabar, Tjoson Tjoa, Yarah Haidar, William B. Armstrong Tags: Original Article Source Type: research
Comparison of 3-year local control using DAHANCA radiotherapy guidelines before and after implementation of five millimetres geometrical GTV to high-dose CTV margin
Primary radiotherapy is the preferred anatomy-preserving treatment for squamous cell carcinomas in the head and neck region (HNSCC), excluding carcinomas in the oral cavity or certain localised oropharyngeal/laryngeal cancers amenable to surgery[1,2]. Platinum-based chemo-radiotherapy (CRT) using IMRT/VMAT techniques is the contemporary standard for loco-regionally advanced HNSCC, with a five-year risk of local and regional failures of 23.5 % and 20.2 %, respectively, using altered fractionation regimes [3]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - April 16, 2024 Category: Radiology Authors: Ruta Zukauskaite Ruta, Morten Horsholt Kristensen, Jesper Grau Eriksen, J ørgen Johansen, Eva Samsøe, Lars Johnsen, Camilla Kjær Lønkvist, Cai Grau, Christian Rønn Hansen Tags: Original Article Source Type: research
A Prospective Cohort Study on Neck Lymph Node Mapping in Oral Cancers Using Methylene Blue Dye
AbstractIn the current scenario, the management of N0 neck in early-stage oral cancer is debatable, whether or not they should undergo elective neck dissection. Most of the time these patients are either over-treated or under-treated. Sentinel lymph node (SLN) biopsy is a good option to identify occult LN in this cohort of patients for guiding neck dissection. With a focus on SLN biopsy using methylene blue dye, this study aims to evaluate its feasibility and accuracy in node-negative oral squamous cell carcinoma. A prospective observational study was conducted involving operable squamous cell carcinoma patients with clini...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 16, 2024 Category: ENT & OMF Source Type: research
Putting the Brakes on Xerostomia in Oropharyngeal Cancer: Can Brachytherapy Be the Key?
There is no question as to the efficacy of brachytherapy in the management of de novo and recurrent head and neck cancers. It has been shown to contribute to both excellent oncologic outcomes in the upfront setting and durable local control and symptom relief in the recurrent setting.1-3 (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Shauna McVorran, Arash Naghavi, Philip Schaner Tags: Editorial Source Type: research
In Regard to Dupere et al.
We present several key points that could affect neutron dose and risk assessments in pregnant patients receiving PBS-PT. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Haibo Lin, Hang Qi, Minglei Kang, Charles B. Simone Tags: Letters to the Editor Source Type: research
Homeobox B2 promotes malignant behavior and contributes to the radioresistance of nasopharyngeal carcinoma by regulating forkhead box protein O1
Conclusion: Our findings showed that HOXB2 acts as a tumor promoter in NPC, activating malignant behaviors and radioresistance of tumors via FOXO1 regulation. Moreover, the inactivation of HOXB2 or activation of FOXO1 are potential strategies to inhibit tumor progression and overcome radioresistance in NPC.PMID:38617001 | PMC:PMC11008478 | DOI:10.7150/ijms.93128 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Jinhai Chen Min Mao Zhaoen Ma Jie Liu Minqiong Jiang Guangui Chen Yali Xu Source Type: research
Identification of an immune-related signature as a prognostic classifier for patients with early-stage head and neck squamous cell carcinoma
CONCLUSIONS: Our novel IRGS is a reliable and robust classifier for accurate patient stratification and prognostic evaluation. Future studies will attempt to affirm the signature's clinical application to early-stage HNSCC.PMID:38617526 | PMC:PMC11009812 | DOI:10.21037/tcr-23-1791 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Le Wang Yulin Zhang Hongmin Li Jilin Peng Changhui Gao Qiuning Yu Pei Gao Ling Li Kuisheng Chen Fanglei Ye Source Type: research
Identification of muc1-c as a target for suppressing progression of head and neck squamous cell carcinomas
Cancer Res Commun. 2024 Apr 15. doi: 10.1158/2767-9764.CRC-24-0011. Online ahead of print.ABSTRACTThe MUC1-C protein is aberrantly expressed in adenocarcinomas of epithelial barrier tissues and contributes to their progression. Less is known about involvement of MUC1-C in the pathogenesis of squamous cell carcinomas (SCCs). Here, we report that the MUC1 gene is upregulated in advanced head and neck SCCs (HNSCCs). Studies of HNSCC cell lines demonstrate that the MUC1-C subunit regulates expression of (i) RIG-I and MDA5 pattern recognition receptors, (ii) STAT1 and interferon (IFN) regulatory factors, and (iii) downstream IF...
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Ayako Nakashoji Naoki Haratake Atrayee Bhattacharya Weipu Mao Kangjie Xu Keyi Wang Tatsuaki Daimon Hiroki Ozawa Keisuke Shigeta Atsushi Fushimi Nami Yamashita Yoshihiro Morimoto Mototsugu Shimokawa Shin Saito Ann Marie Egloff Ravindra Uppaluri Mark D Long Source Type: research
Head and neck cancer in times of COVID-19: Emotion-based medicine
Acta Otorrinolaringol Esp. 2021 Jan-Feb;72(1):1-2. doi: 10.1016/j.otorri.2020.08.001. Epub 2020 Oct 1.NO ABSTRACTPMID:38620342 | PMC:PMC7528842 | DOI:10.1016/j.otorri.2020.08.001 (Source: Acta Otorrinolaringologica Espanola)
Source: Acta Otorrinolaringologica Espanola - April 15, 2024 Category: ENT & OMF Authors: J Alexander Sistiaga Su árez Fernando L ópez Álvarez Eduardo Ferrandis Perep érez Pablo Parente Arias Pedro D íaz de Cerio Canduela en representaci ón de la Comisión de Cabeza y Cuello y Base de Cráneo de la SEORL-CCC Source Type: research
Homeobox B2 promotes malignant behavior and contributes to the radioresistance of nasopharyngeal carcinoma by regulating forkhead box protein O1
Conclusion: Our findings showed that HOXB2 acts as a tumor promoter in NPC, activating malignant behaviors and radioresistance of tumors via FOXO1 regulation. Moreover, the inactivation of HOXB2 or activation of FOXO1 are potential strategies to inhibit tumor progression and overcome radioresistance in NPC.PMID:38617001 | PMC:PMC11008478 | DOI:10.7150/ijms.93128 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Jinhai Chen Min Mao Zhaoen Ma Jie Liu Minqiong Jiang Guangui Chen Yali Xu Source Type: research
Head and neck cancer in times of COVID-19: Emotion-based medicine
Acta Otorrinolaringol Esp. 2021 Jan-Feb;72(1):1-2. doi: 10.1016/j.otorri.2020.08.001. Epub 2020 Oct 1.NO ABSTRACTPMID:38620342 | PMC:PMC7528842 | DOI:10.1016/j.otorri.2020.08.001 (Source: Acta Otorrinolaringologica Espanola)
Source: Acta Otorrinolaringologica Espanola - April 15, 2024 Category: ENT & OMF Authors: J Alexander Sistiaga Su árez Fernando L ópez Álvarez Eduardo Ferrandis Perep érez Pablo Parente Arias Pedro D íaz de Cerio Canduela en representaci ón de la Comisión de Cabeza y Cuello y Base de Cráneo de la SEORL-CCC Source Type: research
Homeobox B2 promotes malignant behavior and contributes to the radioresistance of nasopharyngeal carcinoma by regulating forkhead box protein O1
Conclusion: Our findings showed that HOXB2 acts as a tumor promoter in NPC, activating malignant behaviors and radioresistance of tumors via FOXO1 regulation. Moreover, the inactivation of HOXB2 or activation of FOXO1 are potential strategies to inhibit tumor progression and overcome radioresistance in NPC.PMID:38617001 | PMC:PMC11008478 | DOI:10.7150/ijms.93128 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Jinhai Chen Min Mao Zhaoen Ma Jie Liu Minqiong Jiang Guangui Chen Yali Xu Source Type: research
