Radiation-associated changes in saliva composition of head and neck cancer patients: A systematic review
Head and neck squamous cell cancer accounts for approximately 4.5% of the newly diagnosed malignancies worldwide, with over 878,000 new cases in 2020 (including lip cancer) [1]. The incidence is rising, especially due to HPV associated head and neck cancer and is expected to increase by 30% until 2030 [2]. Compared to non-HPV related head and neck cancer, often induced by heavy alcohol consumption and/or smoking, the HPV-positive patients usually have a good prognosis after therapy, even with advanced stages of disease at diagnosis. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - April 19, 2024 Category: Radiology Authors: Michal Staruch, Marlene M. Speth, Peter Neyer, Oliver Riesterer, Daniel M. Aebersold, Sonja Stieb Tags: Review Article Source Type: research
Therapeutic Targeting of Thioredoxin Reductase 1 Causes Ferroptosis while Potentiating Anti-PD-1 Efficacy in Head and Neck Cancer
This study is the first to highlight TXNRD1 as a crucial factor contributing to resistance to anti-PD-1 treatment in HNSCC. In this study, we identified targetable regulators of resistance to immunotherapy-induced ferroptosis in HNSCC. We observed a link of thioredoxin reductase 1 (TXNRD1) with tumoral PD-L1 expression and ferroptosis suppression in HNSCC. Moreover, HNSCC tumors with aberrant TXNRD1 expression exhibited a lack of PD-1 response, NRF2 overexpression, and PD-L1 upregulation. TXNRD1 inhibition promoted ferroptosis in HNSCC cells with NRF2 activation and in organoid tumors derived from patients lacking a PD-1 r...
Source: Chemico-Biological Interactions - April 18, 2024 Category: Molecular Biology Authors: Ming-Shou Hsieh Hang Huong Ling Syahru Agung Setiawan Mardiah Suci Hardianti Iat-Hang Fong Chi-Tai Yeh Jia-Hong Chen Source Type: research
A multicentric randomized controlled phase III trial of adaptive and 18F-FDG-PET-guided dose-redistribution in locally advanced head and neck squamous cell carcinoma (ARTFORCE)
CONCLUSION: Adaptive and dose redistributed radiotherapy enabled dose-escalation with similar toxicity rates compared to conventional radiotherapy. While FDG-PET-guided dose-escalation did overall not lead to significant tumor control or survival improvements, post-hoc results showed improved locoregional control for patients with N0-1 disease or oropharyngeal cancer treated with rRT.PMID:38636708 | DOI:10.1016/j.radonc.2024.110281 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 18, 2024 Category: Radiology Authors: Anna Liza M P de Leeuw Jordi Giralt Yungan Tao Sergi Benavente Thanh-V ân France Nguyen Frank J P Hoebers Ann Hoeben Chris H J Terhaard Lip Wai Lee Signe Friesland Roel J H M Steenbakkers Lisa Tans Jolien Heukelom Mutamba T Kayembe Simon R van Kranen Har Source Type: research
Re-irradiation versus systemic therapy for the management of local-regionally recurrent head and neck cancer
CONCLUSION: Although re-irradiation improved overall survival compared to systemic therapy for appropriately selected patients with local-regionally recurrent head and neck cancer, the relatively high risk of toxicity must be considered.PMID:38636710 | DOI:10.1016/j.radonc.2024.110278 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 18, 2024 Category: Radiology Authors: Allen M Chen Jeremy P Harris Rupali Nabar Tjoson Tjoa Yarah Haidar William B Armstrong Source Type: research
Therapeutic targeting of thioredoxin reductase 1 causes ferroptosis while potentiating anti-PD-1 efficacy in head and neck cancer
This study is the first to highlight TXNRD1 as a crucial factor contributing to resistance to anti-PD-1 treatment in HNSCC. In this study, we identified targetable regulators of resistance to immunotherapy-induced ferroptosis in HNSCC. We observed a link of thioredoxin reductase 1 (TXNRD1) with tumoral PD-L1 expression and ferroptosis suppression in HNSCC. Moreover, HNSCC tumors with aberrant TXNRD1 expression exhibited a lack of PD-1 response, NRF2 overexpression, and PD-L1 upregulation. TXNRD1 inhibition promoted ferroptosis in HNSCC cells with NRF2 activation and in organoid tumors derived from patients lacking a PD-1 r...
Source: Chemico-Biological Interactions - April 18, 2024 Category: Molecular Biology Authors: Ming-Shou Hsieh Hang Huong Ling Syahru Agung Setiawan Mardiah Suci Hardianti Iat-Hang Fong Chi-Tai Yeh Jia-Hong Chen Source Type: research
The effect of internet-administered support (carer eSupport) on preparedness for caregiving in informal caregivers of patients with head and neck cancer compared with support as usual: a study protocol for a randomized controlled trial
Informal caregivers (ICs) of patients with cancer provide essential and mainly uncompensated care. A self-perceived preparedness to care for the patient is associated with a lower caregiver burden, described a... (Source: BMC Cancer)
Source: BMC Cancer - April 18, 2024 Category: Cancer & Oncology Authors: Birgitta Johansson, Åsa Cajander, Awais Ahmad, Emma Ohlsson-Nevo, Per Fransson, Brith Granström, Louise von Essen, Ulrica Langegård, Mona Pettersson, Anna Henriksson and Ylva Tiblom Ehrsson Tags: Study Protocol Source Type: research
Cancers, Vol. 16, Pages 1554: The Role of Curcumin in Cancer: A Focus on the PI3K/Akt Pathway
os A. Alexiou
Cancer is a life-threatening disease and one of the leading causes of death worldwide. Despite significant advancements in therapeutic options, most available anti-cancer agents have limited efficacy. In this context, natural compounds with diverse chemical structures have been investigated for their multimodal anti-cancer properties. Curcumin is a polyphenol isolated from the rhizomes of Curcuma longa and has been widely studied for its anti-inflammatory, anti-oxidant, and anti-cancer effects. Curcumin acts on the regulation of different aspects of cancer development, including initiation, metastasis, an...
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Vasiliki Zoi Athanassios P. Kyritsis Vasiliki Galani Diamanto Lazari Chrissa Sioka Spyridon Voulgaris Georgios A. Alexiou Tags: Review Source Type: research
Role of Imaging in Predicting the Deep Surgical Margin in Gingivobuccal Complex Cancers: A Pilot Study
AbstractCancers arising from the gingivobuccal complex are one of the most common types of cancer in the oral cavity and are associated with poor prognosis. Among the various prognostic factors, positive surgical margin is the most important one that can be controlled by the operating surgeon. The deep surgical margins for buccal mucosa cancers is normally assessed by palpating the skin for induration and skin pinchability. The present study evaluates the role of imaging in assessing the deep surgical margin and its efficacy for skin preservation in buccal mucosa/ gingivobuccal carcinomas. The patients of gingivobuccal com...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 18, 2024 Category: ENT & OMF Source Type: research
Effect of radiotherapy on the surface roughness and microhardness of contemporary bioactive restorative materials
ConclusionThe effect of radiotherapy might differ according to the type of the restorative material. Although results may differ for other tested materials, giomer tends to exhibit worse behaviour in terms of both surface roughness and microhardness.Clinical relevanceIn patients undergoing head and neck radiotherapy, it should be taken into consideration that the treatment process may also have negative effects on the surface properties of anti-caries restorative materials. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - April 18, 2024 Category: Cancer & Oncology Source Type: research
Synthetic Low-Energy Monochromatic Image Generation in Single-Energy Computed Tomography System Using a Transformer-Based Deep Learning Model
This study proposed a novel method to generate synthetic low-energy virtual monochromatic images at 50 keV (sVMI50keV) from SECT images using a transformer-based deep learning model, SwinUNETR. Data were obtained from 85 patients who underwent head and neck radiotherapy. Among these, the model was built using data from 70 patients for whom only DECT images were available. The remaining 15 patients, for whom both DECT and SECT images were available, were used to predict from the actual SECT images. We used the SwinUNETR model to generate sVMI50keV. The image quality was evaluated, and the results were compared with those ...
Source: Journal of Digital Imaging - April 18, 2024 Category: Radiology Source Type: research
Cancers, Vol. 16, Pages 1525: Dichloroacetate and Quercetin Prevent Cell Proliferation, Induce Cell Death and Slow Tumor Growth in a Mouse Model of HPV-Positive Head and Neck Cancer
h Miskimins
Elevated glucose uptake and production of lactate are common features of cancer cells. Among many tumor-promoting effects, lactate inhibits immune responses and is positively correlated with radioresistance. Dichloroacetate (DCA) is an inhibitor of pyruvate dehydrogenase kinase that decreases lactate production. Quercetin is a flavonoid compound found in fruits and vegetables that inhibits glucose uptake and lactate export. We investigated the potential role and mechanisms of DCA, quercetin, and their combination, in the treatment of HPV-positive head and neck squamous cell carcinoma, an antigenic cancer su...
Source: Cancers - April 17, 2024 Category: Cancer & Oncology Authors: Yongxian Zhuang Joseph D. Coppock Allison B. Haugrud John H. Lee Shanta M. Messerli W. Keith Miskimins Tags: Article Source Type: research
Risk factors associated with the development of osteoradionecrosis (ORN) in Head and Neck cancer patients in Ireland: A 10-year retrospective review
Over 700 cases of Head and Neck cancer (HNC) are diagnosed in Ireland each year [1]. Recommended treatment options for HNC include surgery, radiation therapy (RT), and systemic therapy [2]. One of the most serious long-term complications of radiotherapy in HNC patients is osteoradionecrosis (ORN) [3]. Clinical presentations of ORN include persistent pain, chronic bone exposure, pus secretion, radiographic bone changes, pathological fracture, inflammation, and roughness [4]. Patients suffering from ORN experience considerable deterioration in their quality of life owing to chronic pain, infection, dysphagia, and oro-facial ...
Source: Radiotherapy and Oncology - April 17, 2024 Category: Radiology Authors: Kathleen T. Fitzgerald, Ciara Lyons, Andrew England, Mark F. McEntee, Annemarie Devine, Theresa O'Donovan, Eleanor O'Sullivan Tags: Original Article Source Type: research
Metastatic cutaneous squamous cell carcinoma accounts for nearly all squamous cell carcinomas of the parotid gland
AbstractPrimary squamous cell carcinoma of the parotid gland (pSCCP) has long been recognized as a separate entity and is included in the WHO classifications of salivary gland tumors. However, it is widely accepted among head and neck pathologists that pSCCP is exceptionally rare. Yet, there are many publications describing series of pSCCP and data from SEER and other cancer register databases indicate erroneously an increasing incidence of pSCCP. Importantly, pSCCP and metastatic (secondary) squamous cell carcinoma to the parotid gland (mSCCP) have nearly identical histological features, and the diagnosis of pSCCP should ...
Source: Virchows Archiv - April 17, 2024 Category: Pathology Source Type: research
Assessing radiation-induced carotid artery injury using ultrasound in patients with head and neck cancer
Head and neck cancers (HNC) are among the most prevalent malignant tumors worldwide. They encompass malignancies of the upper respiratory tract and gastrointestinal system, including nasopharyngeal carcinoma, laryngeal carcinoma, tongue carcinoma, parotid gland carcinoma, and others [1]. The development of HNC is closely related to smoking, excessive drinking, chewing of betel nuts, and viral infection (HBV/HPV). The treatment of HNC includes surgery, radiotherapy (RT), chemotherapy, and immunotherapy. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - April 17, 2024 Category: Radiology Authors: Zhuangzhuang Zheng, Yingying Shen, Jing Su, Xiaorui Ji, Qiang Zhang, Qin Zhao, Xin Jiang Tags: Original Article Source Type: research
Open Organ Preservation for Laryngeal Cancer
As the treatment for laryngeal cancer has evolved over several decades, organ preservation has remained one of the goals of treatment. While chemoradiation therapy is the most widely used treatment modality, open surgical preservation techniques for laryngeal cancer continue to be an option in the surgeon's armamentarium. A summary of the history, anatomic considerations, principles of organ preservation and specific partial laryngectomy techniques are discussed in this review. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
Source: Operative Techniques in Otolaryngology - Head and Neck Surgery - April 17, 2024 Category: ENT & OMF Authors: Thomas L. Kennedy, Priscilla F.A. Pichardo Source Type: research
