PLAU promotes cell proliferation and migration of head and neck cancer via STAT3 signaling pathway
Exp Cell Res. 2024 Apr 23:114056. doi: 10.1016/j.yexcr.2024.114056. Online ahead of print.ABSTRACTIt was reported that within the head and neck cancer (HNC) cell line CAL21 the epithelial-mesenchymal transition (EMT) and cell proliferation were promoted by Urokinase-Type Plasminogen Activator (PLAU) proteinase through TNFRSF12A. Additionally, in this paper HNC cell lines refer to Fadu and Tu686. A novel PLAU-STAT3 axis was found to be involved in HNC cell line proliferation and metastasis. PLAU expression in HNC samples was upregulated, besides, the elevated expression of PLAU was linked to the lower overall survival (OS) ...
Source: Cell Research - April 25, 2024 Category: Cytology Authors: Xiaobo Cui Hongyang Sun Xiaoqing Liu Yunfei Bai Yanping Bai Yanru Cui Boqian Wang Shu Zhang Xin Li Source Type: research
Quantitative ultrasound radiomics analysis to evaluate lymph nodes in patients with cancer: a systematic review
Ultraschall Med. 2024 Apr 25. doi: 10.1055/a-2275-8342. Online ahead of print.ABSTRACTThis systematic review aims to evaluate the role of ultrasound (US) radiomics in assessing lymphadenopathy in patients with cancer and the ability of radiomics to predict metastatic lymph node involvement. A systematic literature search was performed in the PubMed (MEDLINE), Cochrane Central Register of Controlled Trials (CENTRAL), and EMBASE (Ovid) databases up to June 13, 2023. 42 articles were included in which the lymph node mass was assessed with a US exam, and the analysis was performed using radiomics methods. From the survey of th...
Source: Ultraschall in der Medizin - April 25, 2024 Category: Radiology Authors: Antonio Guerrisi Ludovica Miseo Italia Falcone Claudia Messina Sara Ungania Fulvia Elia Flora Desiderio Fabio Valenti Vito Cantisani Antonella Soriani Mauro Caterino Source Type: research
PLAU promotes cell proliferation and migration of head and neck cancer via STAT3 signaling pathway
Exp Cell Res. 2024 Apr 23:114056. doi: 10.1016/j.yexcr.2024.114056. Online ahead of print.ABSTRACTIt was reported that within the head and neck cancer (HNC) cell line CAL21 the epithelial-mesenchymal transition (EMT) and cell proliferation were promoted by Urokinase-Type Plasminogen Activator (PLAU) proteinase through TNFRSF12A. Additionally, in this paper HNC cell lines refer to Fadu and Tu686. A novel PLAU-STAT3 axis was found to be involved in HNC cell line proliferation and metastasis. PLAU expression in HNC samples was upregulated, besides, the elevated expression of PLAU was linked to the lower overall survival (OS) ...
Source: Experimental Cell Research - April 25, 2024 Category: Cytology Authors: Xiaobo Cui Hongyang Sun Xiaoqing Liu Yunfei Bai Yanping Bai Yanru Cui Boqian Wang Shu Zhang Xin Li Source Type: research
Quantitative ultrasound radiomics analysis to evaluate lymph nodes in patients with cancer: a systematic review
Ultraschall Med. 2024 Apr 25. doi: 10.1055/a-2275-8342. Online ahead of print.ABSTRACTThis systematic review aims to evaluate the role of ultrasound (US) radiomics in assessing lymphadenopathy in patients with cancer and the ability of radiomics to predict metastatic lymph node involvement. A systematic literature search was performed in the PubMed (MEDLINE), Cochrane Central Register of Controlled Trials (CENTRAL), and EMBASE (Ovid) databases up to June 13, 2023. 42 articles were included in which the lymph node mass was assessed with a US exam, and the analysis was performed using radiomics methods. From the survey of th...
Source: Ultraschall in der Medizin - April 25, 2024 Category: Radiology Authors: Antonio Guerrisi Ludovica Miseo Italia Falcone Claudia Messina Sara Ungania Fulvia Elia Flora Desiderio Fabio Valenti Vito Cantisani Antonella Soriani Mauro Caterino Source Type: research
PLAU promotes cell proliferation and migration of head and neck cancer via STAT3 signaling pathway
Exp Cell Res. 2024 Apr 23:114056. doi: 10.1016/j.yexcr.2024.114056. Online ahead of print.ABSTRACTIt was reported that within the head and neck cancer (HNC) cell line CAL21 the epithelial-mesenchymal transition (EMT) and cell proliferation were promoted by Urokinase-Type Plasminogen Activator (PLAU) proteinase through TNFRSF12A. Additionally, in this paper HNC cell lines refer to Fadu and Tu686. A novel PLAU-STAT3 axis was found to be involved in HNC cell line proliferation and metastasis. PLAU expression in HNC samples was upregulated, besides, the elevated expression of PLAU was linked to the lower overall survival (OS) ...
Source: Experimental Cell Research - April 25, 2024 Category: Cytology Authors: Xiaobo Cui Hongyang Sun Xiaoqing Liu Yunfei Bai Yanping Bai Yanru Cui Boqian Wang Shu Zhang Xin Li Source Type: research
Quantitative ultrasound radiomics analysis to evaluate lymph nodes in patients with cancer: a systematic review
Ultraschall Med. 2024 Apr 25. doi: 10.1055/a-2275-8342. Online ahead of print.ABSTRACTThis systematic review aims to evaluate the role of ultrasound (US) radiomics in assessing lymphadenopathy in patients with cancer and the ability of radiomics to predict metastatic lymph node involvement. A systematic literature search was performed in the PubMed (MEDLINE), Cochrane Central Register of Controlled Trials (CENTRAL), and EMBASE (Ovid) databases up to June 13, 2023. 42 articles were included in which the lymph node mass was assessed with a US exam, and the analysis was performed using radiomics methods. From the survey of th...
Source: Ultraschall in der Medizin - April 25, 2024 Category: Radiology Authors: Antonio Guerrisi Ludovica Miseo Italia Falcone Claudia Messina Sara Ungania Fulvia Elia Flora Desiderio Fabio Valenti Vito Cantisani Antonella Soriani Mauro Caterino Source Type: research
Quantitative ultrasound radiomics analysis to evaluate lymph nodes in patients with cancer: a systematic review
Ultraschall Med. 2024 Apr 25. doi: 10.1055/a-2275-8342. Online ahead of print.ABSTRACTThis systematic review aims to evaluate the role of ultrasound (US) radiomics in assessing lymphadenopathy in patients with cancer and the ability of radiomics to predict metastatic lymph node involvement. A systematic literature search was performed in the PubMed (MEDLINE), Cochrane Central Register of Controlled Trials (CENTRAL), and EMBASE (Ovid) databases up to June 13, 2023. 42 articles were included in which the lymph node mass was assessed with a US exam, and the analysis was performed using radiomics methods. From the survey of th...
Source: Ultraschall in der Medizin - April 25, 2024 Category: Radiology Authors: Antonio Guerrisi Ludovica Miseo Italia Falcone Claudia Messina Sara Ungania Fulvia Elia Flora Desiderio Fabio Valenti Vito Cantisani Antonella Soriani Mauro Caterino Source Type: research
Quantitative ultrasound radiomics analysis to evaluate lymph nodes in patients with cancer: a systematic review
Ultraschall Med. 2024 Apr 25. doi: 10.1055/a-2275-8342. Online ahead of print.ABSTRACTThis systematic review aims to evaluate the role of ultrasound (US) radiomics in assessing lymphadenopathy in patients with cancer and the ability of radiomics to predict metastatic lymph node involvement. A systematic literature search was performed in the PubMed (MEDLINE), Cochrane Central Register of Controlled Trials (CENTRAL), and EMBASE (Ovid) databases up to June 13, 2023. 42 articles were included in which the lymph node mass was assessed with a US exam, and the analysis was performed using radiomics methods. From the survey of th...
Source: Ultraschall in der Medizin - April 25, 2024 Category: Radiology Authors: Antonio Guerrisi Ludovica Miseo Italia Falcone Claudia Messina Sara Ungania Fulvia Elia Flora Desiderio Fabio Valenti Vito Cantisani Antonella Soriani Mauro Caterino Source Type: research
Medical students ’ knowledge about human papillomavirus (HPV), HPV vaccine and head and neck cancer
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - April 25, 2024 Category: Allergy & Immunology Authors: Norangelys Solis-TorresIsardo Braverman-DiazLuis A. Rivera-MoralesJose J. Perez-SanchezValeria S. Perez-BravoAngel J. Neris-SanchezAlexis VeraYaritza Diaz-AlgorriMaster of Public Health Program, San Juan Bautista School of Medicine, Caguas, Puerto Rico Source Type: research
Randomized self-controlled study comparing open-face vs. closed immobilization masks in fractionated cranial radiotherapy
Radiotherapy is an essential part in the management of primary and metastatic brain tumors. To ensure safe and reproducible delivery of radiotherapy, accurate patient positioning and immobilization is required. The standard-of-care immobilization for fractionated brain irradiation, as for head-and-neck cancer, is an individually made thermoplastic mask which is closed around the patient ’s face. Closed masks provide stability, accuracy and reproducibility of each treatment fraction [1,2,3]. The inter- and intrafraction accuracy described by setup and head motion uncertainties for intracranial radiotherapy are reportedly ...
Source: Radiotherapy and Oncology - April 25, 2024 Category: Radiology Authors: Mich èle Keane, Nienke Weitkamp, Indira Madani, Jonathan Day, Riccardo Dal Bello, Mariangela Zamburlini, Antonia Schiess, Amanda Moreira, Sophie Perryck, Katja Tomuschat, Marilyn Spencer, Stephanie Tanadini-Lang, Matthias Guckenberger, Michelle Brown Tags: Original Article Source Type: research
ctHPVDNA in Patients With HPV-Associated Head and Neck Cancer After Surgery
This cohort study examines the association of posttreatment circulating tumor human papillomavirus DNA (ctHPVDNA) with residual disease and 2-year overall survival and recurrence-free survival in patients with HPV-associated head and neck cancer. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - April 25, 2024 Category: ENT & OMF Source Type: research
Neighborhood-Level Disadvantage and Delayed Adjuvant Therapy in Head and Neck Cancer
This multicenter cohort study examines if living in a socioeconomically disadvantaged neighborhood is associated with an increased likelihood of delays in initiating guideline-adherent adjuvant radiation therapy among patients with head and neck cancer. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - April 25, 2024 Category: ENT & OMF Source Type: research
The role of interventional radiology and molecular imaging for near infrared photoimmunotherapy
AbstractNear infrared photoimmunotherapy (NIR-PIT) is a recently approved cancer therapy for recurrent head and neck cancer. It involves the intravenous administration of an antibody-photoabsorber (IRDye700DX: IR700) conjugate (APC) to target cancer cells, followed 24 h later by exposure to near infrared light to activate cell-specific cytotoxicity. NIR-PIT selectively targets cancer cells for destruction and activates a strong anticancer host immunity. The fluorescent signal emitted by IR700 enables the visualization of the APC in vivo using fluorescence imagi ng. Similarly, the activation of IR700 during therapy can be...
Source: Japanese Journal of Radiology - April 25, 2024 Category: Radiology Source Type: research
Interleukin 33 supports squamous cell carcinoma growth via a dual effect on tumour proliferation, migration and invasion, and T cell activation
AbstractInterleukin (IL)-33 is an important cytokine in the tumour microenvironment; it is known to promote the growth and metastasis of solid cancers, such as gastric, colorectal, ovarian and breast cancer. Our group demonstrated that the IL-33/ST2 pathway enhances the development of squamous cell carcinoma (SCC). Conversely, other researchers have reported that IL-33 inhibits tumour progression. In addition, the crosstalk between IL-33, cancer cells and immune cells in SCC remains unknown. The aim of this study was to investigate the effect of IL-33 on the biology of head and neck SCC lines and to evaluate the impact of ...
Source: Cancer Immunology, Immunotherapy - April 25, 2024 Category: Cancer & Oncology Source Type: research
The role of interventional radiology and molecular imaging for near infrared photoimmunotherapy
AbstractNear infrared photoimmunotherapy (NIR-PIT) is a recently approved cancer therapy for recurrent head and neck cancer. It involves the intravenous administration of an antibody-photoabsorber (IRDye700DX: IR700) conjugate (APC) to target cancer cells, followed 24 h later by exposure to near infrared light to activate cell-specific cytotoxicity. NIR-PIT selectively targets cancer cells for destruction and activates a strong anticancer host immunity. The fluorescent signal emitted by IR700 enables the visualization of the APC in vivo using fluorescence imagi ng. Similarly, the activation of IR700 during therapy can be...
Source: Japanese Journal of Radiology - April 25, 2024 Category: Radiology Source Type: research
