Geriatric Assessment –Identified Deficits and Quality of Life in Patients With Head and Neck Cancer
This cohort study assesses the association of single and accumulated geriatric deficits with health-related quality of life decline after treatment for head and neck cancer. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - October 21, 2021 Category: ENT & OMF Source Type: research

Extranodal Extension and Other Adverse Features After Transoral Robotic Surgery for HPV-Positive Cancer
This cohort study evaluates the risk of adverse histopathologic features that meet indications for possible adjuvant radiotherapy or chemoradiotherapy in patients with human papillomavirus –positive oropharynx squamous cell carcinoma undergoing transoral robotic surgery with neck dissection. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - October 21, 2021 Category: ENT & OMF Source Type: research

Management of Pediatric Graves Disease
This review provides a broad multidisciplinary perspective on the diagnosis and management of Graves disease in children. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - October 14, 2021 Category: ENT & OMF Source Type: research

Association of Bone Conduction Devices for Single-Sided Sensorineural Deafness With QOL
This systematic review and meta-analysis assesses quality of life measures among patients with single-sided sensorineural deafness who received a unilateral bone conduction device. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - October 14, 2021 Category: ENT & OMF Source Type: research

Association of Performance on Dichotic Auditory Tests With Risk for Incident Dementia and Alzheimer Dementia
This cohort study examines associations between signal sensitivity, central auditory processing, and dementia and Alzheimer dementia risk. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - October 14, 2021 Category: ENT & OMF Source Type: research

Clinical Staging to Estimate the Probability of Postoperative Complications in Vestibular Schwannoma
This cohort study presents a staging system to predict severe surgical complications in patients who undergo surgical resection of vestibular schwannoma. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - October 7, 2021 Category: ENT & OMF Source Type: research

Risk of Suicidal Self-directed Violence Among US Veteran Survivors of Head and Neck Cancer
This cohort study examines the associations between precancer mental health and pain and postcancer receipt of mental health, substance use disorder, or palliative care services with risk of suicidal self-directed violence. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - October 7, 2021 Category: ENT & OMF Source Type: research

Persistent Postthyroidectomy Hypoparathyroidism in the Netherlands
This cohort study examines the incidence of postoperative, persistent hypoparathyroidism after total or completion thyroidectomy in Dutch patients. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - October 7, 2021 Category: ENT & OMF Source Type: research

Lethal Suicidal Acts Among Head and Neck Cancer Survivors
Patients treated for head and neck cancer (HNC) often experience inordinate amounts of stress. These cancers occur more frequently in populations with limited resources and high rates of mental illness —even before a life-altering cancer diagnosis and the toxic effects of treatments take their toll. Considering these circumstances, it is perhaps unsurprising, but no less concerning, that in this issue of JAMA Otolaryngology–Head& Neck Surgery Nugent and colleagues found a high rate of suicidal self-directed violence (SSDV) in this population. Importantly, this study highlights that factors beyond depression...
Source: JAMA Otolaryngology - Head and Neck Surgery - October 7, 2021 Category: ENT & OMF Source Type: research

Intraoperative Parathyroid Hormone in Minimally Invasive Parathyroidectomy —Reply
In Reply We thank Dr Chow for their careful review of our recent article on the use of intraoperative parathyroid hormone (ioPTH) in minimally invasive parathyroidectomy (MIP) for primary hyperparathyroidism (PHP). (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - October 1, 2021 Category: ENT & OMF Source Type: research

JAMA Otolaryngology –Head & amp; Neck Surgery
Mission Statement:  JAMA Otolaryngology–Head& Neck Surgery provides timely information for physicians and scientists concerned with diseases of the head and neck. Given the diversity of structure and function based in this anatomic region, JAMA Otolaryngology –Head& Neck Surgery publishes clinical, translational, and population health research from an array of disciplines. We place a high priority on strong study designs that accurately identify etiologies, evaluate diagnostic strategies, and distinguish among treatment options and outcomes. Our objectives are to (1) publish original contributions th...
Source: JAMA Otolaryngology - Head and Neck Surgery - October 1, 2021 Category: ENT & OMF Source Type: research

Levels of Triamcinolone Acetonide in Human Perilymph and Plasma After Intratympanic Application
This randomized clinical trial compares levels of triamcinolone acetonide in perilymph and plasma after intratympanic injection. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 30, 2021 Category: ENT & OMF Source Type: research

Nonsurgical Risk Factors Associated With Pharyngocutaneous Fistula After Laryngectomy
This multicenter cohort study of adult patients with laryngeal cancer uses data from a national database to identify nonclinical risks associated with the formation of pharyngocutaneous fistula after total laryngectomy. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 30, 2021 Category: ENT & OMF Source Type: research

Continuous Intraoperative Vasopressor Use in Head and Neck Free-Flap Reconstruction
This cohort study investigates the association between continuous vasopressor use and the incidence of reoperation in the early postoperative period for patients undergoing free-flap reconstruction. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 30, 2021 Category: ENT & OMF Source Type: research

An Unusual Case of Bilateral Chylothorax After Neck Dissection
This case report describes a woman in her 30s who underwent total thyroidectomy with modified radical neck dissection due to papillary thyroid cancer and was subsequently diagnosed with bilateral chylothorax secondary to cervical thoracic duct injury. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 30, 2021 Category: ENT & OMF Source Type: research

Error in Author Surnames
This article was corrected online. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 30, 2021 Category: ENT & OMF Source Type: research

Error in Author Name
In the Original Investigation “Outcomes of Onabotulinum Toxin A Treatment for Adductor Spasmodic Dysphonia and Laryngeal Tremor,” published online February 2, 2018, and in April 2018 print, there was an error in an author name. The author listed as “Vishnutheert Kulkarni” should have been “Vishnutheertha Kulkarni.” T his article has been corrected online. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 30, 2021 Category: ENT & OMF Source Type: research

Hoarseness and Stridor Following Stem Cell Transplant
A 59-year-old man presented with progressive hoarseness and dyspnea 15 months after an allogeneic stem cell transplant for treatment of acute myeloid leukemia. What is your diagnosis? (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 30, 2021 Category: ENT & OMF Source Type: research

Hearing Loss and Impaired Physical Function, Frailty, and Disability in Older Adults
This cross-sectional study examines the association between hearing loss and impaired lower extremity function, frailty syndrome, and disability in older adults (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 23, 2021 Category: ENT & OMF Source Type: research

Thyroid Lobectomy for T1 Papillary Thyroid Carcinoma in Pediatric Patients
This cohort study assesses the use of thyroid lobectomy for the treatment of papillary thyroid cancer in pediatric patients. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 23, 2021 Category: ENT & OMF Source Type: research

Rapidly Enlarging Neck Mass in a Patient With Testicular Cancer
A 40-year-old man presented with a large left neck mass after recent treatment of mixed testicular nonseminomatous germ cell tumor with metastasis to the retroperitoneal and mediastinal lymph nodes. What is your diagnosis? (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 23, 2021 Category: ENT & OMF Source Type: research

Association of Functional Outcomes in Tracheoesophageal Voicing With Intratracheal Pressures and Esophagram Findings
This cohort study examines the association between intratracheal manometric pressure, speech function, and proximal esophageal abnormalities in patients with tracheoesophageal voice prosthesis. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 16, 2021 Category: ENT & OMF Source Type: research

Sensitivity of Communicative Participation Item Bank for Measuring Unilateral Vocal Fold Immobility
This case series examines differences in patients ’ scores on the Communicative Participation Item Bank before and after treatment of unilateral vocal fold immobility and how the scores compare with qualitative self-reports of treatment outcomes. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 16, 2021 Category: ENT & OMF Source Type: research

A Novel Case of Clofazimine-Induced Purple Nasal Mucosal Discoloration
This case report describes a woman in her 70s with a history of Mycobacterium abscessus pulmonary infection refractory to multiple medication regimens over the preceding decade who presented with clofazimine-induced purple nasal mucosal discoloration. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 16, 2021 Category: ENT & OMF Source Type: research

Cystic Neck Mass
A 44-year-old woman presented with a 6-month history of a right neck mass with compressive symptoms. What is your diagnosis? (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 16, 2021 Category: ENT & OMF Source Type: research

Evaluation of Nocturnal Enuresis After Adenotonsillectomy in Children With Obstructive Sleep Apnea
This secondary analysis of a randomized clinical trial of children who underwent adenotonsillectomy for nonsevere obstructive sleep apnea evaluates the prevalence of nocturnal enuresis after the operation. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 9, 2021 Category: ENT & OMF Source Type: research

Shared Decision-making and Decisional Conflict in Otolaryngologic Surgery
This survey study assesses the prevalence of decisional conflict, patient-specific concerns, and the association between patient factors and decisional conflict in patients undergoing otolaryngologic surgery during the COVID-19 pandemic. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 9, 2021 Category: ENT & OMF Source Type: research

Cribriform Plate Injury After Nasal Swab Testing for COVID-19
This case report describes an otherwise healthy man in his 40s who presented with right-sided clear water rhinorrhea after nasal swab testing that was mistakenly diagnosed as allergic rhinitis. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 9, 2021 Category: ENT & OMF Source Type: research

Neck Mass in an Adolescent
This case report describes a 13-year-old male who presented with a 2-year history of a right neck mass that had slowly increased in size. What is your diagnosis? (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 9, 2021 Category: ENT & OMF Source Type: research

Neoadjuvant PD-1/PD-L1 Inhibitors for Resectable Head and Neck Cancer
This systematic review and meta-analysis assesses the efficacy and safety of neoadjuvant immunotherapy for resectable head and neck squamous cell carcinoma. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 2, 2021 Category: ENT & OMF Source Type: research

Prophylactic Steroids for Postthyroidectomy Hypocalcemia and Voice Dysfunction
This randomized clinical trial investigates the use of dexamethasone to prevent postoperative hypocalcemia and voice dysfunction in patients undergoing thyroidectomy. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 2, 2021 Category: ENT & OMF Source Type: research

Use of Intraoperative Parathyroid Hormone in Minimally Invasive Parathyroidectomy for Primary Hyperparathyroidism —Reply
In Reply We thank Dr Chow for their careful review of our recent article on the use of intraoperative parathyroid hormone (ioPTH) in minimally invasive parathyroidectomy (MIP) for primary hyperparathyroidism (PHP). (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 2, 2021 Category: ENT & OMF Source Type: research

Analyzing Charge Data Systematically Overestimates Health Care Costs —Reply
In Reply We appreciate the thoughtful response from Rathi et al regarding our study on imaging surveillance costs for patients with head and neck cancer. They appropriately highlight the role of payer mix and service mix in accurately estimating costs. Their review of publicly available information on charge data and insurer-specific rates suggests an overestimation of our study ’s potential cost savings. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 2, 2021 Category: ENT & OMF Source Type: research

The Future of Fluorescent-Guided Surgery —Reply
In Reply We appreciate the comments from Hom et al regarding our recent study. Our previous studies showed that fluorescence visualization (FV) can improve the direct visualization of clinical nonapparent changes that are associated with either high-grade histologic findings or high-risk molecular changes (Figure). Although the so-called “gold standard” phase 3 clinical trial did not find a significant difference in the local recurrence rate between FV-guided and conventional white light (WL)-guided surgeries, using quantitative tissue pathologic analysis we found that FV-guided surgery has the potential to spa...
Source: JAMA Otolaryngology - Head and Neck Surgery - September 2, 2021 Category: ENT & OMF Source Type: research

Intraoperative Parathyroid Hormone in Minimally Invasive Parathyroidectomy
To the Editor My attention was arrested by the article by Quinn et al on the use of intraoperative parathyroid hormone (ioPTH) in minimally invasive parathyroidectomy (MIP) for primary hyperparathyroidism (PHP). To our knowledge, it is the first meta-analysis on this topic showing a beneficial association of ioPTH with cure rates —98% vs 94.8% without ioPTH. It will have a considerable effect on surgical treatment for PHP. Nonetheless, I have some comments on the methodology, results, and conclusion of the trial. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 2, 2021 Category: ENT & OMF Source Type: research

Analyzing Charge Data Systematically Overestimates Health Care Costs
To the Editor Nocon et al estimated that the mean total cost associated with imaging surveillance after treatment for head and neck cancer was $36  800 over a median surveillance period of 3.2 years. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 2, 2021 Category: ENT & OMF Source Type: research

The Future of Fluorescent-Guided Surgery
To the Editor Durham and colleagues conducted one of the first large-scale clinical trials using fluorescence to guide surgical resection. The strong data from this large, multicenter, well-conducted trial clearly demonstrated that autofluorescence imaging can be helpful to identify the extent of the mucosal margin. However, the results of this clinical trial did not find a significant difference in key indicators of clinical benefit. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 2, 2021 Category: ENT & OMF Source Type: research

Symptoms With New Loss of Taste or Smell in Adults With or Without SARS-CoV-2 Infection
This cross-sectional study uses data from the Centers for Disease Control and Prevention ’s Coronavirus Self-checker to assess which symptoms are reported with new loss of taste or smell among individuals with and without SARS-CoV-2. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 2, 2021 Category: ENT & OMF Source Type: research

A Not-So-Simple Thyroid Nodule
A 50-year-old woman presents with a 2-month history of a neck mass that was associated with hoarseness of voice and globus sensation and thyromegaly with a palpable nodule in the right lobe. What is your diagnosis? (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 2, 2021 Category: ENT & OMF Source Type: research

Nodular Mass in the Earlobe of an 18-Month-Old Girl
An 18-month-old girl presents with a firm, nodular, angulated, pinkish, nontender mass in the posterior aspect of the right earlobe. What is your diagnosis? (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 1, 2021 Category: ENT & OMF Source Type: research

JAMA Otolaryngology –Head & amp; Neck Surgery
Mission Statement:  JAMA Otolaryngology–Head& Neck Surgery provides timely information for physicians and scientists concerned with diseases of the head and neck. Given the diversity of structure and function based in this anatomic region, JAMA Otolaryngology –Head& Neck Surgery publishes clinical, translational, and population health research from an array of disciplines. We place a high priority on strong study designs that accurately identify etiologies, evaluate diagnostic strategies, and distinguish among treatment options and outcomes. Our objectives are to (1) publish original contributions th...
Source: JAMA Otolaryngology - Head and Neck Surgery - September 1, 2021 Category: ENT & OMF Source Type: research

Assessment of Opioid Use and Analgesic Requirements After Endoscopic Sinus Surgery
This multi-institutional, nonblinded randomized clinical trial compares the efficacy of different analgesic regimens after endoscopic sinus surgery. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 1, 2021 Category: ENT & OMF Source Type: research

Evaluation of the Neuroanatomical Basis of Olfactory Dysfunction
This cross-sectional study evaluates the role of the components of the olfactory pathway structures in impaired olfactory function. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - August 26, 2021 Category: ENT & OMF Source Type: research

Comments on Use of Diagnostic Testing and Intervention for Sensorineural Hearing Loss in US Children —Reply
In Reply In our study, we reported rates of diagnostic workup and intervention of sensorineural hearing loss in a large cohort of children from a commercial insurer identified through insurance claims. We proposed that workup and intervention are underused in this cohort and built predictive models to identify clinical and sociodemographic variables that influence outcomes. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - August 26, 2021 Category: ENT & OMF Source Type: research

Local Anesthetic Wound Infusions as Postoperative Standard of Care in Patients With Head and Neck Cancer —Reply
In Reply We are pleased to respond to the comments by Vishnu et al on our article, “Postoperative Pain Treatment With Continuous Local Anesthetic Wound Infusion in Patients With Head and Neck Cancer: A Nonrandomized Clinical Trial.” (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - August 26, 2021 Category: ENT & OMF Source Type: research

Acute Vision Loss From IgG4-Related and Bacterial Rhinosinusitis After COVID-19
This case report describes a man in his 70s who presented to the emergency department with a headache for 2 weeks and vision loss in the right eye for 2 days and was subsequently diagnosed with IgG4-related and Streptococcus constellatus rhinosinusitis. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - August 26, 2021 Category: ENT & OMF Source Type: research

Comments on Use of Diagnostic Testing and Intervention for Sensorineural Hearing Loss in US Children
To the Editor The article by Qian et al is interesting and has several valid points. But there are some limitations that can influence the interpretation of the findings. First, the authors based the qualifying patient search on International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) codes of which almost half were listed as “unspecified.” It may well be that these unspecified diagnosis codes represent children who had normal hearing outcomes. When the diagnostic conclusion is normal, we are required to code the type of problem that represents either the chief c...
Source: JAMA Otolaryngology - Head and Neck Surgery - August 26, 2021 Category: ENT & OMF Source Type: research

Continuous Local Anesthetic Wound Infusions as Postoperative Standard of Care in Patients With Head and Neck Cancer
To the Editor We thank Gostian et al for their study demonstrating a reduction in postoperative pain when continuous wound infusion (CWI) was used after head and neck oncological resections. The authors call for CWI to be assimilated into the multimodal postoperative analgesic concept in patients. However, prior to widespread implementation, we find it prudent to draw attention to a few caveats to the study ’s conclusions. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - August 26, 2021 Category: ENT & OMF Source Type: research

Olfactory Bulb Volume —A Novel Preclinical Biomarker for Smell Loss and Neurodegenerative Disease
Neurodegenerative disorders, such as Alzheimer dementia and Parkinson disease, are disabling diseases that present a burden on society that rivals the costs of cancer and heart disease. Although current therapies are often unsuccessful at reversing the progression of these diseases, early detection in patients who are at risk of neurodegenerative disease could allow for timely interventions to delay and minimize the loss of brain function over time. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - August 26, 2021 Category: ENT & OMF Source Type: research

Deep Learning for Clinical Image Analyses in Oral Squamous Cell Carcinoma
This review summarizes the use of deep learning models for diagnosis, prognosis, and metastasis detection for oral squamous cell carcinoma by analyzing information from pathological and radiographic images. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - August 19, 2021 Category: ENT & OMF Source Type: research