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Considerations in Salvage Laryngectomy Reconstruction
Pharyngocutaneous fistula (PCF) is a dreaded complication from total laryngectomy (TL), as it can cause wound issues, lengthen hospitalization, increase costs, and prolong nothing-by-mouth status. In this issue of JAMA Otolaryngology –Head& Neck Surgery, Moreno et al evaluated 309 patients from multiple institutions who underwent salvage TL. This work nicely focuses on the subset of TL with limited pharyngeal defect amenable to primary closure (PC), distinguishing it from other work on this topic. The authors report a PCF rate of 29%. In their study, the investigators evaluated the use of free tissue transfer (FTT) v...
Source: JAMA Otolaryngology - Head and Neck Surgery - April 18, 2024 Category: ENT & OMF Source Type: research

Addressing Financial Toxicity in Head and Neck Cancer
This Viewpoint calls for consideration of the financial costs of head and neck cancer care when choosing treatment strategies for patients who may face severe financial stress or insolvency due to cancer treatment. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - April 11, 2024 Category: ENT & OMF Source Type: research

TORS and Radiation Volume in Unknown Primary Squamous Cell Carcinoma of the Neck
This phase 2 trial assesses whether transoral robotic surgery and tailored radiotherapy are associated with favorable outcomes among patients with unknown primary squamous cell carcinoma. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - April 11, 2024 Category: ENT & OMF Source Type: research

Neoadjuvant Chemotherapy and Transoral Robotic Surgery for Oropharynx Cancer and Quality of Life —Reply
In Reply In reaction to our recent report on quality-of-life outcomes following neoadjuvant chemotherapy and transoral robotic surgery (NECTORS) for human papillomavirus virus –associated oropharyngeal squamous cell carcinoma (HPV-OPSCC), Granell and Gutierrez-Fonseca have raised concerns to which we would like to respond. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - April 11, 2024 Category: ENT & OMF Source Type: research

Complete Clinical Response With Pembrolizumab for Cutaneous Squamous Cell Carcinoma
This case report describes an 89-year-old patient with prior cutaneous squamous cell carcinoma who presented with a new isolated metastasis and was subsequently treated with pembrolizumab, which produced a complete clinical response. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - April 11, 2024 Category: ENT & OMF Source Type: research

Neoadjuvant Chemotherapy and Transoral Robotic Surgery for Oropharynx Cancer and Quality of Life
To the Editor To deintensify treatment (avoid overtreatment) for patients with human papillomavirus virus –associated oropharyngeal squamous cell carcinoma (HPV-OPSCC) is certainly one of the hot topics in head and neck cancer, driven by the goal of enhancing quality of life. Although various strategies are under exploration, the unconventional inclusion of neoadjuvant chemotherapy by Silver et al has captured our attention. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - April 11, 2024 Category: ENT & OMF Source Type: research

Interfacility Transfer Guidelines for Isolated Facial Trauma
This Viewpoint discusses the need to implement proposed guidelines for facial trauma assessment to prevent unnecessary interfacility transfer of patients with facial trauma despite most such patients having injuries that do not require surgical intervention. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - April 4, 2024 Category: ENT & OMF Source Type: research

Preoperative Circulating Tumor HPV DNA and Oropharyngeal Squamous Cell Disease
This cross-sectional study evaluates the association of preoperative circulating tumor HPV DNA levels with disease burden or adverse pathologic features among patients with HPV-associated oropharyngeal squamous cell carcinoma who have undergone primary transoral robotic surgery. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - April 4, 2024 Category: ENT & OMF Source Type: research

Trends in Oral Tongue Cancer Incidence in the US
This cross-sectional study examines US trends in oral tongue cancer incidence and the factors associated with future case burden. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - April 4, 2024 Category: ENT & OMF Source Type: research

Quality of Life and Depression Symptoms After Therapy De-Escalation in HPV+ Oropharyngeal SCC
This nonrandomized clinical trial quantifies quality of life and depression burden variables in patients undergoing de-escalation of human papillomavirus –mediated oropharyngeal squamous cell carcinoma therapy. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - April 4, 2024 Category: ENT & OMF Source Type: research

Response to Hypoglossal Nerve Stimulation Changes With Body Mass Index and Supine Sleep
This cohort study evaluates whether hypoglossal nerve stimulation therapy is effective for patients with obstructive sleep apnea, whether hypoglossal nerve stimulation can treat supine obstructive sleep apnea, and whether there are associations between BMI and treatment response. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - April 4, 2024 Category: ENT & OMF Source Type: research

Error in Author Name
This article was corrected online. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - April 4, 2024 Category: ENT & OMF Source Type: research

JAMA Otolaryngology –Head & amp; Neck Surgery
Mission Statement:  JAMA Otolaryngology–Head& Neck Surgery provides timely information for physicians and scientists concerned with diseases of the head and neck. Given the diversity of structure and function based in this anatomic region, JAMA Otolaryngology –Head& Neck Surgery publishes clinical, translational, and population health research from an array of disciplines. We place a high priority on strong study designs that accurately identify etiologies, evaluate diagnostic strategies, and distinguish among treatment options and outcomes. Our objectives are to (1) publish original contributions that will ...
Source: JAMA Otolaryngology - Head and Neck Surgery - April 1, 2024 Category: ENT & OMF Source Type: research

Neoadjuvant-Intent Immunotherapy in Advanced, Resectable Cutaneous Squamous Cell Carcinoma
This cohort study examines treatment with neoadjuvant-intent cemiplimab or pembrolizumab for patients with locoregionally advanced cutaneous squamous cell carcinoma in a clinical setting. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - March 28, 2024 Category: ENT & OMF Source Type: research

Depressive Symptoms, Inflammation, and Survival in Patients With Head and Neck Cancer
This cohort study assessed the associations of pretreatment depressive symptoms and inflammation with posttreatment tumor response and overall survival among patients with head and neck cancer. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - March 28, 2024 Category: ENT & OMF Source Type: research