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Outcomes of Neoadjuvant Cemiplimab for Squamous Cell Carcinoma of the Head and Neck
This secondary analysis of a phase 2 clinical trial examines long-term survival for resectable cutaneous squamous cell carcinoma of the head and neck according to pathologic response. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - August 3, 2023 Category: ENT & OMF Source Type: research

Setting the Stage for Olfactory Neuroblastoma
In this issue of JAMA Otolaryngology –Head and Neck Surgery, Choby et al present a novel approach to staging olfactory neuroblastoma (ONB) that may well lead to a paradigm shift in the approach to this complex disorder. As the authors expound, current staging systems fall short not only in prognosticating patient outcomes and surviva l but also in guiding appropriate surgical approach and adjuvant therapy recommendations. The Kadish system and its modifications, the Dulguerov system, and the American Joint Committee on Cancer (AJCC) system all poorly estimate overall 10-year survival. Hyams grading of tumor histopatholog...
Source: JAMA Otolaryngology - Head and Neck Surgery - August 3, 2023 Category: ENT & OMF Source Type: research

Omission in Methods and Supplement
This article has been corrected. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - August 3, 2023 Category: ENT & OMF Source Type: research

JAMA Otolaryngology –Head & amp; Neck Surgery
Mission Statement:  JAMA Otolaryngology–Head& Neck Surgery provides timely information for physicians and scientists concerned with diseases of the head and neck. Given the diversity of structure and function based in this anatomic region, JAMA Otolaryngology –Head& Neck Surgery publishes clinical, translational, and population health research from an array of disciplines. We place a high priority on strong study designs that accurately identify etiologies, evaluate diagnostic strategies, and distinguish among treatment options and outcomes. Our objectives are to (1) publish original contributions that will ...
Source: JAMA Otolaryngology - Head and Neck Surgery - August 1, 2023 Category: ENT & OMF Source Type: research

Gender Equality in Facial Plastic Surgery
This Viewpoint reviews the history, obstacles, and progress in equity for women in facial plastic surgery with the goal of promoting continued progress. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - July 27, 2023 Category: ENT & OMF Source Type: research

Olfactory Dysfunction as a Marker of Frailty and Postoperative Outcomes in Head and Neck Cancer
This cohort study assesses the prevalence of olfactory dysfunction and its association with frailty and postoperative outcomes in head and neck cancer. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - July 27, 2023 Category: ENT & OMF Source Type: research

Recurrence After Posttreatment Plasma and Saliva HPV DNA Testing in Low-Risk HPV Oropharynx Cancer
This cohort study examines patients with low-risk human papillomavirus –positive oropharynx cancer at risk for recurrence by detection of HPV16 DNA in plasma and salivary rinses. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - July 27, 2023 Category: ENT & OMF Source Type: research

Time for Acute Bacterial Rhinosinusitis Point-of-Care Testing
The diagnosis of acute bacterial rhinosinusitis in children is clinically challenging due to symptom overlap with acute viral upper respiratory illnesses. To help address this frequent conundrum, Shaikh and colleagues designed a study to identify children who are likely to benefit from antibiotics for acute rhinosinusitis. The investigators included 510 children (2-11 years old) who met inclusion criteria to receive amoxicillin, 90 mg/kg/d, and clavulanate, 6.4 mg/kg/d, or placebo, then further stratified the patients based on nasopharyngeal culture for Streptococcus pneumoniae, nontypeable Haemophilus influenzae, or Morax...
Source: JAMA Otolaryngology - Head and Neck Surgery - July 25, 2023 Category: ENT & OMF Source Type: research

The Role of ENT Specialists in the Nose-to-Brain Pathway
This Viewpoint discusses the role of ear, nose, and throat specialists in the understanding, development, growth, and administration of direct nose-to-brain delivery route devices and therapies. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - July 20, 2023 Category: ENT & OMF Source Type: research

Atypical Activation of Laryngeal Somatosensory-Motor Cortex and Chronic Cough
This cross-sectional study of patients with unexplained chronic cough and healthy individuals assesses neural processing over laryngeal sensorimotor cortex during voluntary laryngeal motor activity such as vocalization. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - July 20, 2023 Category: ENT & OMF Source Type: research

Identifying Factors of Operative Efficiency in Head and Neck Free Flap Reconstruction
This cohort study examines the association of head and neck cancer resection and reconstruction interventions with operative time. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - July 20, 2023 Category: ENT & OMF Source Type: research

Residential Proximity to Commercial Pesticides and Chronic Rhinosinusitis
This retrospective cohort study explores the association between residential proximity to a commercial pesticide application site and chronic rhinosinusitis. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - July 13, 2023 Category: ENT & OMF Source Type: research

Novel PAX3::INO80D Fusion in Biphenotypic Sinonasal Sarcoma in an Adult
This case report describes a novel gene fusion of PAX3::INO80D in a biphenotypic sinonasal carcinoma in a woman in her 40s. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - July 13, 2023 Category: ENT & OMF Source Type: research

Long-Term Environmental Exposures and Chronic Rhinosinusitis
In this issue of JAMA Otolaryngology –Head and Neck Surgery, Dr Yang and colleagues investigate the association of residential proximity to a commercial pesticide application site with the prevalence of chronic rhinosinusitis (CRS) in a retrospective cohort study. The study included 310 participants—90 patients with CRS and nasal p olyps (CRSwNP), 90 patients with CRS and without nasal polyps (CRSwoNP), and 130 control participants—who presented to a tertiary rhinology clinic in Los Angeles (California) from March 2018 to December 2022. Utilizing residential addresses, the authors determined pesticide exposure status...
Source: JAMA Otolaryngology - Head and Neck Surgery - July 13, 2023 Category: ENT & OMF Source Type: research

How to Fully Leverage the Power of Electronic Health Records for Research
Clinical research studies are essential for advancing medical knowledge and improving patient care. However, because conducting research studies can be time consuming and costly, researchers are incentivized to complete the study even if conclusions cannot be drawn. Before embarking, it is important to conduct a feasibility analysis to ensure that the study is possible and worthwhile. Self-service analytical (SSA) tools are a new avenue to improve the research experience; however, these tools are considerably underused by many physicians. This Editorial will go over what SSA tools are, how to use them, best practices, and ...
Source: JAMA Otolaryngology - Head and Neck Surgery - July 13, 2023 Category: ENT & OMF Source Type: research