Neoadjuvant chemoimmunotherapy shows major pathological response and low recurrence in head and neck squamous cell carcinoma
ConclusionNeoadjuvant chemoimmunotherapy of HNSCC showed high rate of pathological response and low recurrence rate, holding promise for becoming the new standard of care for resectable HNSCC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
In vivo EPID-based daily treatment error identification for volumetric-modulated arc therapy in head and neck cancers with a hierarchical convolutional neural network: a feasibility study
AbstractWe proposed a deep learning approach to classify various error types in daily VMAT treatment of head and neck cancer patients based on EPID dosimetry, which could provide additional information to support clinical decisions for adaptive planning. 146 arcs from 42 head and neck patients were analyzed. Anatomical changes and setup errors were simulated in 17,820 EPID images of 99 arcs obtained from 30 patients using in-house software for model training, validation, and testing. Subsequently, 141 clinical EPID images from 47 arcs belonging to the remaining 12 patients were utilized for clinical testing. The hierarchic...
Source: Australasian Physical and Engineering Sciences in Medicine - April 22, 2024 Category: Biomedical Engineering Source Type: research
Cancers, Vol. 16, Pages 1586: Th2 Cells Are Associated with Tumor Recurrence Following Radiation
This study analyzed the relationship between immune function and outcomes following radiation in HPV/p16-negative tumors to identify mechanisms of radiation resistance and prognostic immune biomarkers. A discovery cohort of 94 patients with HNSCC treated uniformly with surgery and adjuvant radiation and a validation cohort of 97 similarly treated patients were utilized. Tumor immune infiltrates were derived from RNAseq gene expression. The immune cell types significantly associated with outcomes in the discovery cohort were examined in the independent validation cohort. A positive association between high Th2 infiltration ...
Source: Cancers - April 20, 2024 Category: Cancer & Oncology Authors: Mohamed K. Abdelhakiem Riyue Bao Phillip M. Pifer David Molkentine Jessica Molkentine Andrew Hefner Beth Beadle John V. Heymach Jason J. Luke Robert L. Ferris Curtis R. Pickering Jing H. Wang Ravi B. Patel Heath D. Skinner Tags: Article Source Type: research
The current status and future perspectives of clinical boron neutron capture therapy trials
ConclusionsMost of the existing studies have been performed with reactor-based facilities, but there is now a rapidly increasing number of linear accelerator-based BNCT sites, and the clinical research is apparently activating again. This, combined with the increased knowledge on cancer biology and novel types of oncological therapies, opens possibilities to study innovative boron carriers and to combine BNCT with modern oncological therapies in the future clinical trials. To conduct larger phase III trials, multicenter approaches are encouraged to be applied, keeping in mind the importance of joint instructions and qual...
Source: Health and Technology - April 20, 2024 Category: Information Technology Source Type: research
Navigating therapeutic strategies: HPV classification in head and neck cancer
British Journal of Cancer, Published online: 20 April 2024; doi:10.1038/s41416-024-02655-1Navigating therapeutic strategies: HPV classification in head and neck cancer (Source: British Journal of Cancer)
Source: British Journal of Cancer - April 20, 2024 Category: Cancer & Oncology Authors: Hossein Tabatabaeian Yuchen Bai Ruihong Huang Akhilanand Chaurasia Charbel Darido Source Type: research
Multi-omics analysis of immune-related microbiome and prognostic model in head and neck squamous cell carcinoma
ConclusionsThis study offers a comprehensive exploration of the ICI landscape in HNSCC. We provide a detailed scenario of immune regulation in HNSCC and report a correlation between differing ICI patterns, intratumor microbiome, and prognosis. This research aids in identifying prime candidates for optimizing treatment strategies in HNSCC.Clinical relevanceThis study revealed the microbial signatures associated with immunophenotyping of HNSCC and further found the microbial signatures associated with prognosis. The prognostic model based on IRM microbes is helpful for early prediction of patient prognosis and assisting clin...
Source: Clinical Oral Investigations - April 20, 2024 Category: Dentistry Source Type: research
Velopalatine and Bilateral Vocal Cord Paralysis Associated with Atezolizumab Treatment: A Severe and Previously Undocumented Side Effect in Cancer Immunotherapy
This study identifies a novel unreported adverse effect —bilateral vocal cord and velopalatine paralysis—associated with atezolizumab use. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 20, 2024 Category: ENT & OMF Source Type: research
The current status and future perspectives of clinical boron neutron capture therapy trials
ConclusionsMost of the existing studies have been performed with reactor-based facilities, but there is now a rapidly increasing number of linear accelerator-based BNCT sites, and the clinical research is apparently activating again. This, combined with the increased knowledge on cancer biology and novel types of oncological therapies, opens possibilities to study innovative boron carriers and to combine BNCT with modern oncological therapies in the future clinical trials. To conduct larger phase III trials, multicenter approaches are encouraged to be applied, keeping in mind the importance of joint instructions and qual...
Source: Health and Technology - April 20, 2024 Category: Information Technology Source Type: research
The indirect costs of human papillomavirus-related cancer in Central and Eastern Europe: years of life lost and productivity costs
CONCLUSIONS: There is a high disease burden of HPV-related cancer-related deaths in the CEE region, with a large economic impact to society due to substantial productivity losses. It is critical to implement and reinforce public health measures with the aim to reduce the incidence of HPV-related diseases, and the subsequent premature cancer deaths. Improving HPV screening and increasing vaccination programs, in both male and female populations, could help reduce this burden.PMID:38638098 | DOI:10.1080/13696998.2024.2341572 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 19, 2024 Category: Health Management Authors: Ugne Sabale Eugenia Karamousouli Lazar Popovic Zo árd Tibor Krasznai Daniel Harrop Anne Meiwald Robert Hughes Georgie Weston Goran Bencina Source Type: research
Temporal characterization of acute pain and toxicity kinetics during radiation therapy for head and neck cancer. A retrospective study
CONCLUSION: This study provides insight on in-depth characterization and associations between dynamic pain, physiologic, and toxicity kinetics. Our findings support further needs of optimized pain control through temporal data-driven clinical decision support systems for acute pain management.PMID:38638130 | PMC:PMC11025722 | DOI:10.1016/j.oor.2023.100092 (Source: Pain Physician)
Source: Pain Physician - April 19, 2024 Category: Anesthesiology Authors: Vivian Salama Sara Youssef Tianlin Xu Kareem A Wahid Jaime Chen Jillian Rigert Anna Lee Katherine A Hutcheson Brandon Gunn Jack Phan Adam S Garden Steven J Frank William Morrison Jay P Reddy Michael T Spiotto Mohamed A Naser Cem Dede Renjie He Abdallah S Source Type: research
Oxcarbazepine for Head and Neck Cancer-Related Pain in Ambulatory Patients Receiving Palliative Care
1. Recognize the opportunities of utilizing oxcarbazepine for the management of head and neck cancer-related pain.2. Recognize the limitations of utilizing oxcarbazepine for the management of head and neck cancer-related pain. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Lorin Fisher, Bryce Andry, Sara Carr, Kylie Juenger, Hsin Lan Lin Source Type: research
Neoadjuvant chemoimmunotherapy shows major pathological response and low recurrence in head and neck squamous cell carcinoma
ConclusionNeoadjuvant chemoimmunotherapy of HNSCC showed high rate of pathological response and low recurrence rate, holding promise for becoming the new standard of care for resectable HNSCC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1572: The Genomic, Transcriptomic, and Immunologic Landscape of HRAS Mutations in Solid Tumors
In conclusion, this study provides new insights into the unique molecular profiles of HRASmt tumors that may help to identify new targets and guide future clinical trial design. (Source: Cancers)
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Samuel A. Kareff Asaad Trabolsi Harris B. Krause Timothy Samec Andrew Elliott Estelamari Rodriguez Coral Olazagasti Dionysios C. Watson Matias A. Bustos Dave S. B. Hoon Stephanie L. Graff Emmanuel S. Antonarakis Sanjay Goel George Sledge Gilberto Lopes Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1575: The Role of Estrogen and Estrogen Receptors in Head and Neck Tumors
etić
Head and neck squamous cell carcinoma (HNSCC) is the most common histological form of head and neck tumors (HNTs), which originate from the epithelium of the lips and oral cavity, pharynx, larynx, salivary glands, nasal cavity, and sinuses. The main risk factors include consumption of tobacco in all forms and alcohol, as well as infections with high-risk human papillomaviruses or the Epstein–Barr virus. Regardless of the etiological agent, the risk of developing different types of HNTs is from two to more than six times higher in males than in females. The reason for such disparities probably lies i...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Kranj čević Čonkaš Ozreti ć Tags: Review Source Type: research
Introduction
This edition of Operative Techniques is dedicated to surgical therapy for laryngeal cancer. Surgery for cancer of the larynx enjoys a long and robust evolutionary history, highlighted by milestones involving the development of innovative surgical techniques aimed at partial laryngeal preservation, implementation of advanced technology utilizing laser and robotic instrumentation, and the restoration of voice following laryngectomy. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
Source: Operative Techniques in Otolaryngology - Head and Neck Surgery - April 19, 2024 Category: ENT & OMF Authors: Phillip K Pellitteri Source Type: research
