Association between Head and Neck Cancer and Increased Risk of Ischemic Heart Disease: A Retrospective Cohort Study Using National Population Data
Cancers (Basel). 2024 Mar 29;16(7):1352. doi: 10.3390/cancers16071352.ABSTRACTAlthough cancer and ischemic heart disease (IHD) frequently manifest in the same individual, the risk of IHD events in cancer, especially head and neck cancer (HNC), remains unclear. We aimed to examine the incidence and risk of IHD events in patients with HNC using a population-based cohort dataset in South Korea (2002-2013). Through rigorous propensity score matching, we compared data from 2816 individuals without HNC and 704 individuals with HNC. Key independent variables were matched between groups, and the Charlson Comorbidity Index was used...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Chulho Kim Hyunjae Yu Dong-Kyu Kim Source Type: research
Evaluating automatically generated normal tissue contours for safe use in head and neck and cervical cancer treatment planning
CONCLUSIONS: This study shows that dosimetrically equivalent normal tissue contours can be created for HN and cervical cancers using deep learning techniques. In general, differences between the contours did not affect the passing or failing of clinical dose tolerances.PMID:38610118 | DOI:10.1002/acm2.14338 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - April 13, 2024 Category: Physics Authors: Raphael Douglas Adenike Olanrewaju Raymond Mumme Lifei Zhang Beth M Beadle Laurence Edward Court Source Type: research
Targeting BRD4: Potential therapeutic strategy for head and neck squamous cell carcinoma (Review)
Oncol Rep. 2024 Jun;51(6):74. doi: 10.3892/or.2024.8733. Epub 2024 Apr 12.ABSTRACTAs a member of BET (bromodomain and extra-terminal) protein family, BRD4 (bromodomain‑containing protein 4) is a chromatin‑associated protein that interacts with acetylated histones and actively recruits regulatory proteins, leading to the modulation of gene expression and chromatin remodeling. The cellular and epigenetic functions of BRD4 implicate normal development, fibrosis and inflammation. BRD4 has been suggested as a potential therapeutic target as it is often overexpressed and plays a critical role in regulating gene expression pr...
Source: Oncology Reports - April 12, 2024 Category: Cancer & Oncology Authors: Voraporn Yongprayoon Napasporn Wattanakul Winnada Khomate Nathakrit Apithanangsiri Tarathip Kasitipradit Danupon Nantajit Mahvash Tavassoli Source Type: research
Ganoderma spore lipid ameliorates docetaxel, cisplatin, and 5-fluorouracil chemotherapy-induced damage to bone marrow mesenchymal stem cells and hematopoiesis
CONCLUSIONS: GSL efficiently protected BMSCs from damage caused by TPF and recovered hematopoiesis.PMID:38610025 | DOI:10.1186/s12906-024-04445-x (Source: Cancer Control)
Source: Cancer Control - April 12, 2024 Category: Cancer & Oncology Authors: Haohui Lin Manhon Chung Jingchun Sun Yi Yang Li Zhang Xiaohua Pan Minghui Wei Sa Cai Yu Pan Source Type: research
Targeting BRD4: Potential therapeutic strategy for head and neck squamous cell carcinoma (Review)
Oncol Rep. 2024 Jun;51(6):74. doi: 10.3892/or.2024.8733. Epub 2024 Apr 12.ABSTRACTAs a member of BET (bromodomain and extra-terminal) protein family, BRD4 (bromodomain‑containing protein 4) is a chromatin‑associated protein that interacts with acetylated histones and actively recruits regulatory proteins, leading to the modulation of gene expression and chromatin remodeling. The cellular and epigenetic functions of BRD4 implicate normal development, fibrosis and inflammation. BRD4 has been suggested as a potential therapeutic target as it is often overexpressed and plays a critical role in regulating gene expression pr...
Source: Oncology Reports - April 12, 2024 Category: Cancer & Oncology Authors: Voraporn Yongprayoon Napasporn Wattanakul Winnada Khomate Nathakrit Apithanangsiri Tarathip Kasitipradit Danupon Nantajit Mahvash Tavassoli Source Type: research
Are statins onco- suppressive agents for every type of tumor? A systematic review of literature
Expert Rev Anticancer Ther. 2024 Apr 15:1-11. doi: 10.1080/14737140.2024.2343338. Online ahead of print.ABSTRACTINTRODUCTION: Statins, in the role of anti-cancer agents, have been used in many types of cancers with results in some cases promising while, in others, disappointing.AREAS COVERED: The purpose of this review is to identify and highlight data from literature on the successes or failure of using statins as anti-cancer agents. We asked ourselves the following two questions:1. Could statins, which are taken mostly to reduce cardiovascular risk, guarantee a lower incidence or a better cancer disease prognosis, concer...
Source: Expert Review of Anticancer Therapy - April 12, 2024 Category: Cancer & Oncology Authors: Luca Filaferro Fabiana Zaccarelli Giovanni Francesco Niccolini Andrea Colizza Federica Zoccali Michele Grasso Massimo Fusconi Source Type: research
Cancers, Vol. 16, Pages 1484: Plasma IL-1 and IL-6 Family Cytokines with Soluble Receptor Levels at Diagnosis in Head and Neck Squamous Cell Carcinoma: High Levels Predict Decreased Five-Year Disease-Specific and Overall Survival
In conclusion, high plasma levels of IL-6, IL-31, and IL-1RA, as well as the soluble receptors IL-6Rα, gp130, and IL33Rα, predicted clinical outcome. This shows their potential as candidates for both general therapy and immune therapy stratification, as well as being future platforms for the development of new immunotherapy. (Source: Cancers)
Source: Cancers - April 12, 2024 Category: Cancer & Oncology Authors: Helene Hersvik Aarstad Svein Erik Emblem Moe Stein Lybak Øystein Bruserud Tor Henrik Anderson Tvedt Hans J ørgen Aarstad Tags: Article Source Type: research
Prophylactic Central Compartment Dissection on the Long-Term Outcome of Advanced (N0-T3/T4) Papillary Thyroid Cancer
ConclusionProphylactic central compartment dissection did not influence the 10-year outcome of advanced node-negative papillary thyroid cancers. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 12, 2024 Category: ENT & OMF Source Type: research
Prognostic Role of Tumor Budding and Worst Pattern of Invasion in Lymph Node Metastasis and Disease-Free Survival in Oral Squamous Cell Cancer Patients: Result from Central India ’s Regional Cancer Centre
ConclusionBased on the findings of the present study and review of previous articles tumor budding, worst pattern of invasion, host lymphocyte response should also be included in routine histopathology reporting of OSCC. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 12, 2024 Category: ENT & OMF Source Type: research
Quality of Life Assessment and Comparative Analysis of Anterolateral Thigh Flap and Pectoralis Major Myo-cutaneous Flap for Reconstruction of Post Excision Defects of Oral Squamous Cell Carcinoma
AbstractPresent study is a comparative evaluation of the financial impact on choice of flap, clinical results as well as post resection quality of life assessment of cancer patients reconstructed with anterolateral thigh(ALT) flap and pectoralis major myo-cutaneous(PMMC) flap. Ethical clearance was obtained from institutional ethical committee. In this non-randomised, prospective study design among 49 oral squamous cell carcinoma cases, 39 cases were reconstructed using PMMC flap and 10 using ALT flap from year 2020 to 2022. These 2 flaps were compared in terms of parameters like time utilised for reconstruction, hospital ...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 12, 2024 Category: ENT & OMF Source Type: research
Application of Natural Medicinal Plants Active Ingredients in Oral Squamous Cell Carcinoma
AbstractOral squamous cell carcinoma (OSCC) is the most common malignant cancer of the head and neck, with high morbidity and mortality, ranking as the sixth most common cancer in the world. The treatment of OSCC is mainly radiotherapy, chemotherapy and surgery, however, the prognosis of patients is still poor and the recurrence rate is high. This paper reviews the range of effects of natural medicinal plant active ingredients (NMPAIs) on OSCC cancer, including the types of NMPAIs, anti-cancer mechanisms, involved signaling pathways, and clinical trials. The NMPAIs include terpenoids, phenols, flavonoids, glycosides, alkal...
Source: Chinese Journal of Integrative Medicine - April 12, 2024 Category: Internal Medicine Source Type: research
Macrophage membrane-camouflaged pH-sensitive nanoparticles for targeted therapy of oral squamous cell carcinoma
Oral cancer is the most common malignant tumor of the head and neck, and 90% of cases are oral squamous cell carcinoma (OSCC). Chemotherapy is an important component of comprehensive treatment for OSCC. Howeve... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 12, 2024 Category: Nanotechnology Authors: Lin Yang, Hongjiao Li, Aihua Luo, Yao Zhang, Hong Chen, Li Zhu and Deqin Yang Tags: Research Source Type: research
Partial recovery of peripheral blood monocyte subsets in head and neck squamous cell carcinoma patients upon radio(chemo)therapy is associated with decreased plasma CXCL11
Head and neck squamous cell carcinoma (HNSCC) represents a common and heterogeneous malignancy of the oral cavity, pharynx and larynx. Surgery and radio(chemo)therapy are the standard treatment options and als... (Source: BMC Cancer)
Source: BMC Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Christian Idel, Jonas Fleckner, Kirstin Pl ötze-Martin, Lotte Werner, Dirk Rades, Marie-Nicole Theodoraki, Linda Hofmann, Diana Huber, Anke Leichtle, Thomas K. Hoffmann, Karl-Ludwig Bruchhage and Ralph Pries Tags: Research Source Type: research
