Anxiety, depression and quality of life in patients with head and neck cancer undergoing laryngectomy: A long-term prospective evaluation
CONCLUSION: Anxiety, depression and QoL in laryngectomised patients improved at 1 year after surgery and were maintained for up to 5 years.WHAT THIS PAPER ADDS: What is already known on the subject Laryngectomy is associated with prolonged functional and psychological effects and has a major impact on patient quality of life (QoL). Several prospective studies evaluating the QoL in laryngectomised patients have been reported, in which significant deterioration in social functioning was found even 1 year after surgery. What this paper adds to existing knowledge One year is not a sufficient period for laryngectomised patients...
Source: International Journal of Language and Communication Disorders - April 22, 2024 Category: Speech-Language Pathology Authors: Nobuaki Mukoyama Naoki Nishio Hiroyuki Kimura Tatsuya Tokura Shinichi Kishi Kazuyoshi Ogasawara Hidenori Tsuzuki Sayaka Yokoi Akihisa Wada Mayu Shigeyama Norio Ozaki Yasushi Fujimoto Michihiko Sone Source Type: research
In vivo EPID-based daily treatment error identification for volumetric-modulated arc therapy in head and neck cancers with a hierarchical convolutional neural network: a feasibility study
AbstractWe proposed a deep learning approach to classify various error types in daily VMAT treatment of head and neck cancer patients based on EPID dosimetry, which could provide additional information to support clinical decisions for adaptive planning. 146 arcs from 42 head and neck patients were analyzed. Anatomical changes and setup errors were simulated in 17,820 EPID images of 99 arcs obtained from 30 patients using in-house software for model training, validation, and testing. Subsequently, 141 clinical EPID images from 47 arcs belonging to the remaining 12 patients were utilized for clinical testing. The hierarchic...
Source: Australasian Physical and Engineering Sciences in Medicine - April 22, 2024 Category: Biomedical Engineering Source Type: research
Association of Herpes simplex infection with significantly increased risk of head and neck cancer: real-world evidence of about 500,000 patients
CONCLUSION: The surprisingly strong correlation with lip, oral cavity, and pharynx neoplasms sheds new light on supposedly harmless herpes simplex infections, suggesting them as a possible new factor for risk stratification.PMID:38643367 | DOI:10.1111/ijd.17196 (Source: Herpes)
Source: Herpes - April 21, 2024 Category: Infectious Diseases Authors: Jennifer von Stebut Max Heiland Robert Preissner Carsten Rendenbach Saskia Preissner Source Type: research
IP3R1 dysregulation via miR-200c-3p/SSFA2 axis contributes to taxol resistance in head and neck cancer
Eur J Pharmacol. 2024 Apr 18:176592. doi: 10.1016/j.ejphar.2024.176592. Online ahead of print.ABSTRACTHead and neck cancer (HNC) is the sixth most common malignancy worldwide. Although current modalities offer a wide variety of therapy choices, head and neck carcinoma has poor prognosis due to its diagnosis at later stages and development of resistance to current therapeutic tools. In the current study, we aimed at exploring the roles of miR-200c-3p during head and neck carcinogenesis and acquisition of taxol resistance. We analyzed miR-200c-3p levels in HNC clinical samples and cell lines using quantitative real-time poly...
Source: European Journal of Pharmacology - April 20, 2024 Category: Drugs & Pharmacology Authors: Fatma Sanli Arzu Tatar Betul Gundogdu Omer Faruk Karatas Source Type: research
Effect of voice training intervention on swallowing function in patients with head and neck cancer undergoing radiotherapy: A randomized controlled trial
CONCLUSION: Voice training can improve swallowing function and MPT and reduce complications related to swallowing disorders in patients with head and neck cancer.PMID:38642524 | DOI:10.1016/j.ejon.2024.102551 (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - April 20, 2024 Category: Nursing Authors: Yan Liu Ran Hou Qinqin Yu Qiaohong Niu Source Type: research
Cancers, Vol. 16, Pages 1586: Th2 Cells Are Associated with Tumor Recurrence Following Radiation
This study analyzed the relationship between immune function and outcomes following radiation in HPV/p16-negative tumors to identify mechanisms of radiation resistance and prognostic immune biomarkers. A discovery cohort of 94 patients with HNSCC treated uniformly with surgery and adjuvant radiation and a validation cohort of 97 similarly treated patients were utilized. Tumor immune infiltrates were derived from RNAseq gene expression. The immune cell types significantly associated with outcomes in the discovery cohort were examined in the independent validation cohort. A positive association between high Th2 infiltration ...
Source: Cancers - April 20, 2024 Category: Cancer & Oncology Authors: Mohamed K. Abdelhakiem Riyue Bao Phillip M. Pifer David Molkentine Jessica Molkentine Andrew Hefner Beth Beadle John V. Heymach Jason J. Luke Robert L. Ferris Curtis R. Pickering Jing H. Wang Ravi B. Patel Heath D. Skinner Tags: Article Source Type: research
The current status and future perspectives of clinical boron neutron capture therapy trials
ConclusionsMost of the existing studies have been performed with reactor-based facilities, but there is now a rapidly increasing number of linear accelerator-based BNCT sites, and the clinical research is apparently activating again. This, combined with the increased knowledge on cancer biology and novel types of oncological therapies, opens possibilities to study innovative boron carriers and to combine BNCT with modern oncological therapies in the future clinical trials. To conduct larger phase III trials, multicenter approaches are encouraged to be applied, keeping in mind the importance of joint instructions and qual...
Source: Health and Technology - April 20, 2024 Category: Information Technology Source Type: research
Navigating therapeutic strategies: HPV classification in head and neck cancer
British Journal of Cancer, Published online: 20 April 2024; doi:10.1038/s41416-024-02655-1Navigating therapeutic strategies: HPV classification in head and neck cancer (Source: British Journal of Cancer)
Source: British Journal of Cancer - April 20, 2024 Category: Cancer & Oncology Authors: Hossein Tabatabaeian Yuchen Bai Ruihong Huang Akhilanand Chaurasia Charbel Darido Source Type: research
Multi-omics analysis of immune-related microbiome and prognostic model in head and neck squamous cell carcinoma
ConclusionsThis study offers a comprehensive exploration of the ICI landscape in HNSCC. We provide a detailed scenario of immune regulation in HNSCC and report a correlation between differing ICI patterns, intratumor microbiome, and prognosis. This research aids in identifying prime candidates for optimizing treatment strategies in HNSCC.Clinical relevanceThis study revealed the microbial signatures associated with immunophenotyping of HNSCC and further found the microbial signatures associated with prognosis. The prognostic model based on IRM microbes is helpful for early prediction of patient prognosis and assisting clin...
Source: Clinical Oral Investigations - April 20, 2024 Category: Dentistry Source Type: research
Velopalatine and Bilateral Vocal Cord Paralysis Associated with Atezolizumab Treatment: A Severe and Previously Undocumented Side Effect in Cancer Immunotherapy
This study identifies a novel unreported adverse effect —bilateral vocal cord and velopalatine paralysis—associated with atezolizumab use. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 20, 2024 Category: ENT & OMF Source Type: research
The current status and future perspectives of clinical boron neutron capture therapy trials
ConclusionsMost of the existing studies have been performed with reactor-based facilities, but there is now a rapidly increasing number of linear accelerator-based BNCT sites, and the clinical research is apparently activating again. This, combined with the increased knowledge on cancer biology and novel types of oncological therapies, opens possibilities to study innovative boron carriers and to combine BNCT with modern oncological therapies in the future clinical trials. To conduct larger phase III trials, multicenter approaches are encouraged to be applied, keeping in mind the importance of joint instructions and qual...
Source: Health and Technology - April 20, 2024 Category: Information Technology Source Type: research
The indirect costs of human papillomavirus-related cancer in Central and Eastern Europe: years of life lost and productivity costs
CONCLUSIONS: There is a high disease burden of HPV-related cancer-related deaths in the CEE region, with a large economic impact to society due to substantial productivity losses. It is critical to implement and reinforce public health measures with the aim to reduce the incidence of HPV-related diseases, and the subsequent premature cancer deaths. Improving HPV screening and increasing vaccination programs, in both male and female populations, could help reduce this burden.PMID:38638098 | DOI:10.1080/13696998.2024.2341572 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 19, 2024 Category: Health Management Authors: Ugne Sabale Eugenia Karamousouli Lazar Popovic Zo árd Tibor Krasznai Daniel Harrop Anne Meiwald Robert Hughes Georgie Weston Goran Bencina Source Type: research
Temporal characterization of acute pain and toxicity kinetics during radiation therapy for head and neck cancer. A retrospective study
CONCLUSION: This study provides insight on in-depth characterization and associations between dynamic pain, physiologic, and toxicity kinetics. Our findings support further needs of optimized pain control through temporal data-driven clinical decision support systems for acute pain management.PMID:38638130 | PMC:PMC11025722 | DOI:10.1016/j.oor.2023.100092 (Source: Pain Physician)
Source: Pain Physician - April 19, 2024 Category: Anesthesiology Authors: Vivian Salama Sara Youssef Tianlin Xu Kareem A Wahid Jaime Chen Jillian Rigert Anna Lee Katherine A Hutcheson Brandon Gunn Jack Phan Adam S Garden Steven J Frank William Morrison Jay P Reddy Michael T Spiotto Mohamed A Naser Cem Dede Renjie He Abdallah S Source Type: research
Corrigendum to Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture
Transl Oncol. 2024 Jun;44:101927. doi: 10.1016/j.tranon.2024.101927. Epub 2024 Mar 8.NO ABSTRACTPMID:38641374 | DOI:10.1016/j.tranon.2024.101927 (Source: Translational Oncology)
Source: Translational Oncology - April 19, 2024 Category: Cancer & Oncology Authors: Joseph Zenga Musaddiq Awan Anne Frei Jamie Foeckler Rachel Kuehn Oscar Villareal Espinosa Jennifer Bruening Becky Massey Stuart Wong Aditya Shreenivas Monica Shukla Julia Kasprzak Yunguang Sun Md Shaheduzzaman Fanghong Chen Tyce Kearl Heather A Himburg Source Type: research
Temporal characterization of acute pain and toxicity kinetics during radiation therapy for head and neck cancer. A retrospective study
CONCLUSION: This study provides insight on in-depth characterization and associations between dynamic pain, physiologic, and toxicity kinetics. Our findings support further needs of optimized pain control through temporal data-driven clinical decision support systems for acute pain management.PMID:38638130 | PMC:PMC11025722 | DOI:10.1016/j.oor.2023.100092 (Source: Pain Physician)
Source: Pain Physician - April 19, 2024 Category: Anesthesiology Authors: Vivian Salama Sara Youssef Tianlin Xu Kareem A Wahid Jaime Chen Jillian Rigert Anna Lee Katherine A Hutcheson Brandon Gunn Jack Phan Adam S Garden Steven J Frank William Morrison Jay P Reddy Michael T Spiotto Mohamed A Naser Cem Dede Renjie He Abdallah S Source Type: research
