Open Organ Preservation for Laryngeal Cancer
As the treatment for laryngeal cancer has evolved over several decades, organ preservation has remained one of the goals of treatment. While chemoradiation therapy is the most widely used treatment modality, open surgical preservation techniques for laryngeal cancer continue to be an option in the surgeon's armamentarium. A summary of the history, anatomic considerations, principles of organ preservation and specific partial laryngectomy techniques are discussed in this review. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
Source: Operative Techniques in Otolaryngology - Head and Neck Surgery - April 17, 2024 Category: ENT & OMF Authors: Thomas L. Kennedy, Priscilla F.A. Pichardo Source Type: research
History and Evolution of the Laryngectomy
This article reviews the history of laryngectomy, progression of surgical techniques, concurrent advancements in vocal rehabilitation, and role of complete and partial laryngectomy procedures in the current era. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
Source: Operative Techniques in Otolaryngology - Head and Neck Surgery - April 17, 2024 Category: ENT & OMF Authors: Ryan N. Hellums, John E. Hanks, Kevin J. Kovatch Source Type: research
Trends in ototoxicity monitoring among cisplatin-treated patients with cancer
ConclusionsOtotoxicity monitoring is an inconsistent practice, particularly during chemotherapy and for long-term surveillance of hearing loss. Patients with non –head and neck cancer may be at increased risk for loss of audiologic follow-up.Implications for Cancer SurvivorsCisplatin ototoxicity is a common occurrence that can be effectively managed with auditory rehabilitation. Therefore, referrals to audiology and counseling on treatment-related ototoxicity are recommended throughout chemotherapy and cancer survivorship. (Source: Journal of Cancer Survivorship)
Source: Journal of Cancer Survivorship - April 17, 2024 Category: Cancer & Oncology Source Type: research
Correction: Pembrolizumab-based first-line treatment for PD-L1-positive, recurrent or metastatic head and neck squamous cell carcinoma: a retrospective analysis
(Source: BMC Cancer)
Source: BMC Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Alessio Cirillo, Daniele Marinelli, Umberto Romeo, Daniela Messineo, Francesca De Felice, Marco De Vincentiis, Valentino Valentini, Silvia Mezi, Filippo Valentini, Luca Vivona, Antonella Chiavassa, Bruna Cerbelli, Daniele Santini, Paolo Bossi, Antonella P Tags: Correction Source Type: research
Expansion of tumor-infiltrating lymphocytes from head and neck squamous cell carcinoma to assess the potential of adoptive cell therapy
ConclusionWe could expand TILs from approximately one-third of HNSCC samples. TIL expansion could be applicable in HNSCC samples with diverse clinicopathological characteristics. (Source: Cancer Immunology, Immunotherapy)
Source: Cancer Immunology, Immunotherapy - April 17, 2024 Category: Cancer & Oncology Source Type: research
Platinum-based adjuvant chemoradiotherapy versus adjuvant radiotherapy in patients with head and neck adenoid cystic carcinoma
CONCLUSION: In terms of reducing locoregional failures in HNACC patients, POCRT may potentially offer a more effective therapeutic approach than using PORT alone, although it also entails an augmented burden of treatment-related toxicity.PMID:38625410 | DOI:10.1007/s00432-024-05719-0 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Zichen Qiu Zheng Wu Xiong Zhou Minchuan Lin Yong Su Yalan Tao Source Type: research
The effects of re-irradiation on the chemical and morphological properties of permanent teeth
This study aimed to assess the in vitro effects of re-irradiation on enamel and dentin properties, simulating head and neck cancer radiotherapy retreatment. Forty-five human permanent molars were classified into five groups: non-irradiated; irradiated 60 Gy, and re-irradiated with doses of 30, 40, and 50 Gy. Raman spectroscopy, scanning electron microscopy (SEM), and energy dispersive x-ray spectroscopy (EDS) were employed for analysis. Raman spectroscopy assessed intensity, spectral area, and specific peaks comparatively. Statistical analysis involved Kolmogorov-Smirnov and One-Way ANOVA tests, with Tukey's post-test (sig...
Source: Radiation and Environmental Biophysics - April 16, 2024 Category: Physics Authors: Thais Tedeschi Dos Santos Vicente Silva Mattos Kelly Fernanda Molena Francisco Wanderley Garcia de Paula-Silva Harley Francisco de Oliveira Juliana Jendiroba Faraoni Paulo Nelson-Filho Jarbas Caiado de Castro Neto Regina Guenka Palma-Dibb Alexandra Mussol Source Type: research
The effects of re-irradiation on the chemical and morphological properties of permanent teeth
This study aimed to assess the in vitro effects of re-irradiation on enamel and dentin properties, simulating head and neck cancer radiotherapy retreatment. Forty-five human permanent molars were classified into five groups: non-irradiated; irradiated 60 Gy, and re-irradiated with doses of 30, 40, and 50 Gy. Raman spectroscopy, scanning electron microscopy (SEM), and energy dispersive x-ray spectroscopy (EDS) were employed for analysis. Raman spectroscopy assessed intensity, spectral area, and specific peaks comparatively. Statistical analysis involved Kolmogorov-Smirnov and One-Way ANOVA tests, with Tukey's post-test (sig...
Source: Radiation and Environmental Biophysics - April 16, 2024 Category: Physics Authors: Thais Tedeschi Dos Santos Vicente Silva Mattos Kelly Fernanda Molena Francisco Wanderley Garcia de Paula-Silva Harley Francisco de Oliveira Juliana Jendiroba Faraoni Paulo Nelson-Filho Jarbas Caiado de Castro Neto Regina Guenka Palma-Dibb Alexandra Mussol Source Type: research
The effects of re-irradiation on the chemical and morphological properties of permanent teeth
This study aimed to assess the in vitro effects of re-irradiation on enamel and dentin properties, simulating head and neck cancer radiotherapy retreatment. Forty-five human permanent molars were classified into five groups: non-irradiated; irradiated 60 Gy, and re-irradiated with doses of 30, 40, and 50 Gy. Raman spectroscopy, scanning electron microscopy (SEM), and energy dispersive x-ray spectroscopy (EDS) were employed for analysis. Raman spectroscopy assessed intensity, spectral area, and specific peaks comparatively. Statistical analysis involved Kolmogorov-Smirnov and One-Way ANOVA tests, with Tukey's post-test (sig...
Source: Radiation and Environmental Biophysics - April 16, 2024 Category: Physics Authors: Thais Tedeschi Dos Santos Vicente Silva Mattos Kelly Fernanda Molena Francisco Wanderley Garcia de Paula-Silva Harley Francisco de Oliveira Juliana Jendiroba Faraoni Paulo Nelson-Filho Jarbas Caiado de Castro Neto Regina Guenka Palma-Dibb Alexandra Mussol Source Type: research
The effects of re-irradiation on the chemical and morphological properties of permanent teeth
This study aimed to assess the in vitro effects of re-irradiation on enamel and dentin properties, simulating head and neck cancer radiotherapy retreatment. Forty-five human permanent molars were classified into five groups: non-irradiated; irradiated 60 Gy, and re-irradiated with doses of 30, 40, and 50 Gy. Raman spectroscopy, scanning electron microscopy (SEM), and energy dispersive x-ray spectroscopy (EDS) were employed for analysis. Raman spectroscopy assessed intensity, spectral area, and specific peaks comparatively. Statistical analysis involved Kolmogorov-Smirnov and One-Way ANOVA tests, with Tukey's post-test (sig...
Source: Radiation and Environmental Biophysics - April 16, 2024 Category: Physics Authors: Thais Tedeschi Dos Santos Vicente Silva Mattos Kelly Fernanda Molena Francisco Wanderley Garcia de Paula-Silva Harley Francisco de Oliveira Juliana Jendiroba Faraoni Paulo Nelson-Filho Jarbas Caiado de Castro Neto Regina Guenka Palma-Dibb Alexandra Mussol Source Type: research
Cavernous Sinus Metastasis in Patients of Head & amp; Neck Squamous Cell Carcinoma: A Series of Five Rare Instances and Review of Literature
AbstractHead and neck squamous cell carcinoma (HNSCC) exhibits a higher degree of local aggressiveness as compared to a tendency for distant metastasis. Cavernous sinus metastasis from HNSCC is exceptionally rare, with only a handful of cases reported worldwide. This case series presents five instances showcasing an unusual metastatic pattern of HNSCC to the cavernous sinus, documented over one year in a single tertiary cancer care centre in Northeast India. Typically, the treatment of cavernous sinus metastasis involves radiotherapy and chemotherapy with a palliative intent. Unfortunately, the prognosis for this entity is...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 16, 2024 Category: ENT & OMF Source Type: research
Cancers, Vol. 16, Pages 1520: Identification and In Vivo Validation of Unique Anti-Oncogenic Mechanisms Involving Protein Kinase Signaling and Autophagy Mediated by the Investigational Agent PV-10
Narendran
PV-10 is a 10% formulation of rose bengal sodium that has potent immunotherapeutic and anti-cancer activity against various tumors, including metastatic melanoma and refractory neuroblastoma. Currently, PV-10 is undergoing clinical testing for refractory metastatic neuroendocrine cancer and melanomas. However, preclinical investigation of PV-10 activity and its mechanisms against phenotypically and molecularly diverse adult solid tumors had not been conducted. In a panel of human cell lines derived from breast, colorectal, head and neck, and testicular cancers, we demonstrated that PV-10 induces cytotoxicity ...
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Son Tran Patrick Sipila Satbir Thakur Chunfen Zhang Aru Narendran Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1523: Head and Neck Paragangliomas: Overview of Institutional Experience
Brant
Yonghong Huan
Head and neck paragangliomas (HNPGLs) are rare and have high rates of genetic mutations. We conducted a retrospective review of 187 patients with 296 PGLs diagnosed between 1974 and 2023. The mean age of diagnosis was 48.8 years (range 10 to 82) with 69.0% female and 26.5% patients with multiple PGLs. Among 119 patients undergoing genetic testing, 70 (58.8%) patients had mutations, with SDHB (30) and SDHD (26) being the most common. The rates of metastasis and recurrence were higher among patients with SHDB mutations or SDHD mutations associated with multiple PGLs. Metabolic evaluation showed elev...
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Swar N. Vimawala Alex Z. Graboyes Bonita Bennett Maria Bonanni Aleena Abbasi Tanaya Oliphant Michelle Alonso-Basanta Christopher Rassekh Debbie Cohen Jason A. Brant Yonghong Huan Tags: Article Source Type: research
Platinum-based adjuvant chemoradiotherapy versus adjuvant radiotherapy in patients with head and neck adenoid cystic carcinoma
ConclusionIn terms of reducing locoregional failures in HNACC patients, POCRT may potentially offer a more effective therapeutic approach than using PORT alone, although it also entails an augmented burden of treatment-related toxicity. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 16, 2024 Category: Cancer & Oncology Source Type: research
Construction and validation of a folate metabolism-related gene signature for predicting prognosis in HNSCC
ConclusionsOur study identified a novel and robust folate metabolic signature. A folate metabolic signature comprising six genes was effective in assessing the prognosis and reflecting the immune status of HNSCC patients. The target molecule of folate metabolic reprogramming, SHMT2, probably plays a very important role in HNSCC development and immune escape. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 16, 2024 Category: Cancer & Oncology Source Type: research
