Cancers, Vol. 16, Pages 1523: Head and Neck Paragangliomas: Overview of Institutional Experience

Cancers, Vol. 16, Pages 1523: Head and Neck Paragangliomas: Overview of Institutional Experience Cancers doi: 10.3390/cancers16081523 Authors: Swar N. Vimawala Alex Z. Graboyes Bonita Bennett Maria Bonanni Aleena Abbasi Tanaya Oliphant Michelle Alonso-Basanta Christopher Rassekh Debbie Cohen Jason A. Brant Yonghong Huan Head and neck paragangliomas (HNPGLs) are rare and have high rates of genetic mutations. We conducted a retrospective review of 187 patients with 296 PGLs diagnosed between 1974 and 2023. The mean age of diagnosis was 48.8 years (range 10 to 82) with 69.0% female and 26.5% patients with multiple PGLs. Among 119 patients undergoing genetic testing, 70 (58.8%) patients had mutations, with SDHB (30) and SDHD (26) being the most common. The rates of metastasis and recurrence were higher among patients with SHDB mutations or SDHD mutations associated with multiple PGLs. Metabolic evaluation showed elevated plasma dopamine levels were the most common derangements in HNPGL. MRI and CT were the most common anatomic imaging modalities and DOTATATE was the most common functional scan used in this cohort. Most patients (81.5%) received surgery as the primary definitive treatment, while 22.5% patients received radiation treatment, mostly as an adjuvant therapy or for surgically challenging or inoperable cases. Systemic treatment was rarely used in our cohort. Our single-center experience highlights the need for referral for genetic testing and ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research