Fight Aging! Newsletter, January 8th 2024
This study examined whether the local injection of the supernatant of activated PRP (saPRP) into the salivary gland (SG) could help prevent aging-induced SG dysfunction and explored the mechanisms responsible for the protective effects on the SG hypofunction.
Human salivary gland epithelial cells (hSGEC) were treated with saPRP or PRP after senescence through irradiation. The significant proliferation of hSGEC was observed in saPRP treated group compared to irradiation only group and irradiation + PRP group. Cellular senescence, apoptosis, and inflammation were significantly reduced in the saPRP group.
Th...
Source: Fight Aging! - January 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Platelet Rich Plasma Treatment Rescues Damaged Salivary Gland Function in Aged Mice
This study examined whether the local injection of the supernatant of activated PRP (saPRP) into the salivary gland (SG) could help prevent aging-induced SG dysfunction and explored the mechanisms responsible for the protective effects on the SG hypofunction.
Human salivary gland epithelial cells (hSGEC) were treated with saPRP or PRP after senescence through irradiation. The significant proliferation of hSGEC was observed in saPRP treated group compared to irradiation only group and irradiation + PRP group. Cellular senescence, apoptosis, and inflammation were significantly reduced in the saPRP group.
...
Source: Fight Aging! - January 5, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Patients are Not “Consumers”: My Cancer Story
By JEFF GOLDSMITH
On Christmas Eve 2014, I received a present of some profoundly unwelcome news: a 64 slice CT scan confirming not only the presence of a malignant tumor in my neck, but also a fluid filled mass the size of a man’s finger in my chest cavity outside the lungs. Two days earlier, my ENT surgeon in Charlottesville, Paige Powers, had performed a fine needle aspiration of a suspicious almond-shaped enlarged lymph node, and the lab returned a verdict of “metastatic squamous cell carcinoma of the head and neck with an occult primary tumor”.
I had worked in healthcare for nearly forty years when ca...
Source: The Health Care Blog - December 5, 2023 Category: Consumer Health News Authors: matthew holt Tags: Medical Practice The Business of Health Care Cancer Jeff Goldsmith Medicare Advantage Patient Experience Source Type: blogs
My Cancer Story
By JEFF GOLDSMITH
On Christmas Eve 2014, I received a present of some profoundly unwelcome news: a 64 slice CT scan confirming not only the presence of a malignant tumor in my neck, but also a fluid filled mass the size of a man’s finger in my chest cavity outside the lungs. Two days earlier, my ENT surgeon in Charlottesville, Paige Powers, had performed a fine needle aspiration of a suspicious almond-shaped enlarged lymph node, and the lab returned a verdict of “metastatic squamous cell carcinoma of the head and neck with an occult primary tumor”.
I had worked in healthcare for nearly forty years when ca...
Source: The Health Care Blog - December 5, 2023 Category: Consumer Health News Authors: matthew holt Tags: Medical Practice The Business of Health Care Cancer Jeff Goldsmith Medicare Advantage Patient Experience Source Type: blogs
Cancer Organoids Offer Insights into Treatment Outcomes
Researchers at the Hubrecht Institute in the Netherlands have developed a biobank of cancer organoids using tissue samples obtained from head and neck cancer patients. So far, the team used the biobank to validate tumor biomarkers. Excitingly, they also correlated patient treatment responses with organoid treatment responses, suggesting that the organoids provide a good proxy for testing new treatments and for designing a personalized treatment plan for individual patients. The organoids also revealed that certain drugs work better or worse in combination with other techniques, such as radiotherapy, offering new insights i...
Source: Medgadget - May 26, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Oncology _Hubrecht organoid organoids Source Type: blogs
A Second Cancer
It’s been a long time since I posted anything. Recently I was diagnosed with a second primary cancer. I’ve had surgery and am well on the way to recovery. My hematologist and the head and neck cancer specialist agreed it wasn’t necessary for me to undergo aggressive surgery for this cancer, so I didn’t have … (Source: beth's myeloma blog)
Source: beth's myeloma blog - May 4, 2023 Category: Cancer & Oncology Authors: Beth Tags: Cancer Source Type: blogs
An mRNA Vaccine to Treat Cancer
by Gertrud U. Rey There are several highly effective vaccines that block infection by human papillomaviruses (HPVs) and thereby prevent the cervical, anogenital, and head and neck cancers caused by these viruses. However, none of these vaccines are effective for the treatment of established HPV-induced tumors. The success of the COVID-19 messenger RNA (mRNA) vaccines … An mRNA Vaccine to Treat Cancer Read More » (Source: virology blog)
Source: virology blog - April 7, 2023 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey cancer cancer mRNA vaccines cytotoxic T cells helper T cells HPV HPV E7 human papillomavirus tumor Source Type: blogs
An mRNA Vaccine to Treat Cancer
by Gertrud U. Rey There are several highly effective vaccines that block infection by human papillomaviruses (HPVs) and thereby prevent the cervical, anogenital, and head and neck cancers caused by these viruses. However, none of these vaccines are effective for the treatment of established HPV-induced tumors. The success of the COVID-19 messenger RNA (mRNA) vaccines […] (Source: virology blog)
Source: virology blog - April 6, 2023 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey cancer cancer vaccine cervical cancer cytotoxic T cells helper T cells HPV HPV E7 human papillomavirus mRNA mRNA vaccine non-replicating mRNA vaccine self-replicating mRNA vaccine tumor Source Type: blogs
Alpha TAU Killing Tumors With Highly Targeted Alpha Radiation
Radiation is commonly employed in hospitals around the world to treat tumors, typically using gamma ray beams of high energy photons, with a relatively long range, that penetrate all the tissues on the way to and from the tumor. This leads to substantial damage to healthy tissues and too often results in poor outcomes. An alpha particle, consisting of two protons and two neutrons bound together and akin to a helium-4 nucleus, is much trickier to work with in medicine because it is extremely powerful, yet has a very short effective range.
Ronen Segal
We recently visited the offices of Alpha TAU, a company based in Jeru...
Source: Medgadget - March 2, 2023 Category: Medical Devices Authors: Medgadget Editors Tags: Exclusive Oncology Radiation Oncology TelAvivUni Source Type: blogs
Which chemotherapeutic agent is well known to cause coronary vasospasm?
5-fluorouracil is well known to cause coronary vasospasm. 5-fluorouracil and its orally active prodrug capecitabine are fluoropyrimidines, belonging to the class of antimetabolites used for treatment of malignancies of breast, head and neck tumours and gastrointestinal tumours.
Mechanisms for coronary vasospasm
Endothelial cell damage with cytolysis and denudation
Increased endothelin-1 bioactivity leading to vasoconstriction
When high dose infusions are given, coronary vasospasm with angina, arrhythmia or even sudden death can occur in up to 5% of patients. Vascular toxicity occurs generally within 72 hours of the...
Source: Cardiophile MD - November 13, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Symani Microsurgical Robotic System: Interview with Mark Toland, CEO of Medical Microinstruments
Medical Microinstruments, a medtech company with offices in Pisa, Italy and Delaware, USA, has developed the Symani Microsurgical Robot. The robotic system is designed to assist with microsurgical procedures, and it boasts a variety of advanced features to achieve this goal.
These include a suite of the world’s smallest wristed surgical instruments, tremor reducing technology, and motion scaling (7-20X), to allow surgeons to perform very small and precise movements. The company has also paired with a software company to develop a surgical simulator to help with training surgeons on the system.
Medical Microinstr...
Source: Medgadget - November 3, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Neurosurgery Vascular Surgery @mmimicro_inc microsurgery Source Type: blogs
Nanorattles for Rapid Detection of Multiple mRNA Cancer Biomarkers
Scientists at Duke University have developed a ‘nanorattle’ system that allows for the detection of mRNA biomarkers of cancer. The tiny structures consist of gold nanospheres with a surrounding silver nanocage, forming the so-called rattle. The nanorattles are also loaded with light scattering dyes called Raman reporters. When illuminated with a laser, the rattles emit significant amounts of light. The researchers developed the technology so that they could detect mRNA biomarkers of cancer, which will bind to the nanorattles if present in a patient sample. The researchers can then use a laser to illuminate the nanoratt...
Source: Medgadget - September 28, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Nanomedicine Oncology Pathology Duke Source Type: blogs
Career Conversations: Q & A with Organic Chemist Elizabeth Parkinson
Dr. Elizabeth Parkinson. Credit: Courtesy of Dr. Elizabeth Parkinson.
“Being able to discover new, unexpected things is why you wake up every day and go to work as a scientist. The other part is hopefully to have a positive impact on human health—through combatting conditions ranging from antibiotic resistance to cancer,” says Elizabeth Parkinson, Ph.D., an assistant professor of organic chemistry at Purdue University in West Lafayette, Indiana. In an interview, Dr. Parkinson shared with us her path to a scientific career, research on natural products made by soil-dwelling bacteria, and advice for students.
Q: W...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - August 17, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Bacteria Medicines Microbes Profiles Source Type: blogs
Robotic Brace Measures Neck Mobility in Cancer Patients
Patients with head and neck cancer frequently require surgical removal of lymph nodes from the neck. While this is necessary, it can cause pain and stiffness that can persist for a long time after surgery. Assessing neck mobility of such patients would be useful, as it would allow doctors to identify deficits in range of motion, and design appropriate strategies to help improve them.
However, current techniques to achieve this are somewhat crude and do not produce quantifiable data, or involve equipment that is not easily portable or easy to use, making routine clinical assessments challenging.
Researchers at Columb...
Source: Medgadget - July 21, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Oncology Rehab Surgery columbia Source Type: blogs
The Benefits of Taking a Break from Alcohol
Alcohol abuse and alcoholism are serious issues across the nation. In fact, there are over 95,000 alcohol-related deaths each and every year. Despite how problematic alcohol can be, it is still the most used substance across the country – many don’t realize the risks and health-related problems associated with alcohol.
Before we look at how taking even a short break can help you in the long-term let’s first look at the major risks associated with excessive alcohol use and binge drinking.
Major Risks of Alcohol Use
When it comes to alcohol abuse, there are many issues that can occur – from long-term physica...
Source: PickTheBrain | Motivation and Self Improvement - May 5, 2021 Category: Consumer Health News Authors: Joe Gilmore Tags: depression featured happiness health and fitness productivity tips self-improvement addiction alcohol self improvement Source Type: blogs
