Comparison of liver exposure in CT-guided high-dose rate (HDR) interstitial brachytherapy versus SBRT in hepatocellular carcinoma
In unresectable hepatocellular carcinoma several local ablative treatments are available. Among others, radiation based treatments such as stereotactic body radiotherapy (SBRT) and high-dose rate interstitial ... (Source: Radiation Oncology)
Source: Radiation Oncology - May 6, 2021 Category: Cancer & Oncology Authors: Franziska Walter, Lukas Nierer, Maya Rottler, Anna Sophie Duque, Helmut Weingandt, Justus Well, Roel Shpani, Guillaume Landry, Max Seidensticker, Florian Streitparth, Jens Ricke, Claus Belka and Stefanie Corradini Tags: Research Source Type: research

An external validation of the Candiolo nomogram in a cohort of prostate cancer patients treated by external ‐beam radiotherapy
the aim of this study is to perform an external validation for the Candiolo nomogram, a predictive algorithm of biochemical and clinical recurrences in prostate cancer patients treated by radical Radiotherapy,... (Source: Radiation Oncology)
Source: Radiation Oncology - May 5, 2021 Category: Cancer & Oncology Authors: Domenico Gabriele, Alessia Guarneri, Sara Bartoncini, Fernando Munoz, Matteo Tamponi, Filippo Russo, Georgios Stamatakos, Caterina Guiot, Daniele Regge and Umberto Ricardi Tags: Research Source Type: research

Benefit of replanning in MR-guided online adaptive radiation therapy in the treatment of liver metastasis
To assess the effects of daily adaptive MR-guided replanning in stereotactic body radiation therapy (SBRT) of liver metastases based on a patient individual longitudinal dosimetric analysis. (Source: Radiation Oncology)
Source: Radiation Oncology - May 4, 2021 Category: Cancer & Oncology Authors: Michael Mayinger, Roman Ludwig, Sebastian M. Christ, Riccardo Dal Bello, Alex Ryu, Nienke Weitkamp, Matea Pavic, Helena Garcia Sch üler, Lotte Wilke, Matthias Guckenberger, Jan Unkelbach, Stephanie Tanadini-Lang and Nicolaus Andratschke Tags: Research Source Type: research

An ionising radiation-induced specific transcriptional signature of inflammation-associated genes in whole blood from radiotherapy patients: a pilot study
This communication reports the identification of a new panel of transcriptional changes in inflammation-associated genes observed in response to ionising radiation received by radiotherapy patients. (Source: Radiation Oncology)
Source: Radiation Oncology - May 3, 2021 Category: Cancer & Oncology Authors: Lourdes Cruz-Garcia, Christophe Badie, Selvakumar Anbalagan, Jayne Moquet, Lone Gothard, Grainne O ’Brien, Navita Somaiah and Elizabeth A. Ainsbury Tags: Research Source Type: research

Quality assurance of radiotherapy in the ongoing EORTC 1420 “Best of” trial for early stage oropharyngeal, supraglottic and hypopharyngeal carcinoma: results of the benchmark case procedure
The current phase III EORTC 1420 Best-of trial (NCT02984410) compares the swallowing function after transoral surgery versus intensity modulated radiotherapy (RT) in patients with early-stage carcinoma of the ... (Source: Radiation Oncology)
Source: Radiation Oncology - May 1, 2021 Category: Cancer & Oncology Authors: J-J Stelmes, E. Vu, V. Gr égoire, C. Simon, E. Clementel, J. Kazmierska, W. Grant, M. Ozsahin, M. Tomsej, L. Vieillevigne, C. Fortpied, E. C. Hurkmans, A. Branquinho, N. Andratschke, F. Zimmermann and D.-C. Weber Tags: Research Source Type: research

A survey among German-speaking radiation oncologists on PET-based radiotherapy of prostate cancer
Positron emission tomography-(PET) has evolved as a powerful tool to guide treatment for prostate cancer (PC). The aim of this survey was to evaluate the acceptance and use of PET —especially with prostate-spec... (Source: Radiation Oncology)
Source: Radiation Oncology - May 1, 2021 Category: Cancer & Oncology Authors: Marco M. E. Vogel, Sabrina Dewes, Eva K. Sage, Michal Devecka, J ürgen E. Gschwend, Matthias Eiber, Stephanie E. Combs and Kilian Schiller Tags: Research Source Type: research

Impact of feature selection methods and subgroup factors on prognostic analysis with CT-based radiomics in non-small cell lung cancer patients
Radiomics is a new technology to noninvasively predict survival prognosis with quantitative features extracted from medical images. Most radiomics-based prognostic studies of non-small-cell lung cancer (NSCLC)... (Source: Radiation Oncology)
Source: Radiation Oncology - April 30, 2021 Category: Cancer & Oncology Authors: Yuto Sugai, Noriyuki Kadoya, Shohei Tanaka, Shunpei Tanabe, Mariko Umeda, Takaya Yamamoto, Kazuya Takeda, Suguru Dobashi, Haruna Ohashi, Ken Takeda and Keiichi Jingu Tags: Research Source Type: research

Optimal stereotactic body radiotherapy dosage for hepatocellular carcinoma: a multicenter study
The optimal dose and fractionation scheme of stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC) remains unclear due to different tolerated liver volumes and degrees of cirrhosis. In ... (Source: Radiation Oncology)
Source: Radiation Oncology - April 21, 2021 Category: Cancer & Oncology Authors: Ting-Shi Su, Qiu-Hua Liu, Xiao-Fei Zhu, Ping Liang, Shi-Xiong Liang, Lin Lai, Ying Zhou, Yong Huang, Tao Cheng and Le-Qun Li Tags: Research Source Type: research

Split-VMAT technique to control the deep inspiration breath hold time for breast cancer radiotherapy
To improve split-VMAT technique by optimizing treatment delivery time for deep-inspiration breath hold (DIBH) radiotherapy in left-sided breast cancer patients, when automatic beam-interruption devices are not... (Source: Radiation Oncology)
Source: Radiation Oncology - April 20, 2021 Category: Cancer & Oncology Authors: Sara Poeta, Younes Jourani, Alex De Caluw é, Robbe Van den Begin, Dirk Van Gestel and Nick Reynaert Tags: Research Source Type: research

Variation of heart and lung radiation doses according to setup uncertainty in left breast cancer
The objective of this study was to investigate such difference in do... (Source: Radiation Oncology)
Source: Radiation Oncology - April 20, 2021 Category: Cancer & Oncology Authors: Sunmin Park, Chai Hong Rim and Won Sup Yoon Tags: Research Source Type: research

External application of liver compresses to reduce fatigue in patients with metastatic cancer undergoing radiation therapy, a randomized clinical trial
Liver compresses are frequently used in integrative medicine as supportive therapy during cancer treatment in order to reduce fatigue. We performed a pilot study to test whether the external application of yar... (Source: Radiation Oncology)
Source: Radiation Oncology - April 19, 2021 Category: Cancer & Oncology Authors: Pirus Ghadjar, Wiebke Stritter, Irina von Mackensen, Felix Mehrhof, Clara Foucr é, Vincent H. Ehrhardt, Marcus Beck, Pimrapat Gebert, Goda Kalinauskaite, Jacqueline S. Luchte, Carmen Stromberger, Volker Budach, Angelika Eggert and Georg Seifert Tags: Research Source Type: research

3D-printed individualized tooth-borne tissue retraction devices compared to conventional dental splints for head and neck cancer radiotherapy: a randomized controlled trial
Despite modern treatment techniques, radiotherapy (RT) in patients with head and neck cancer (HNC) may be associated with high rates of acute and late treatment-related toxicity. The most effective approach to... (Source: Radiation Oncology)
Source: Radiation Oncology - April 17, 2021 Category: Cancer & Oncology Authors: Thomas Held, Christopher Herpel, Franz Sebastian Schwindling, Leo Christ, Kristin Lang, Sebastian Regnery, Tanja Eichkorn, Adriane Hommertgen, Cornelia Jaekel, Johannes Krisam, Julius Moratin, Jan Mrosek, Karl Metzger, Karim Zaoui, Tracy Moutsis, Semi Har Tags: Study protocol Source Type: research

Radiomics for prediction of radiation-induced lung injury and oncologic outcome after robotic stereotactic body radiotherapy of lung cancer: results from two independent institutions
To generate and validate state-of-the-art radiomics models for prediction of radiation-induced lung injury and oncologic outcome in non-small cell lung cancer (NSCLC) patients treated with robotic stereotactic... (Source: Radiation Oncology)
Source: Radiation Oncology - April 16, 2021 Category: Cancer & Oncology Authors: Khaled Bousabarah, Oliver Blanck, Susanne Temming, Maria-Lisa Wilhelm, Mauritius Hoevels, Wolfgang W. Baus, Daniel Ruess, Veerle Visser-Vandewalle, Maximilian I. Ruge, Harald Treuer and Martin Kocher Tags: Research Source Type: research

Current status and recent advances in resection cavity irradiation of brain metastases
Despite complete surgical resection brain metastases are at significant risk of local recurrence without additional radiation therapy. Traditionally, the addition of postoperative whole brain radiotherapy (WBR... (Source: Radiation Oncology)
Source: Radiation Oncology - April 15, 2021 Category: Cancer & Oncology Authors: Giuseppe Minniti, Maximilian Niyazi, Nicolaus Andratschke, Matthias Guckenberger, Joshua D. Palmer, Helen A. Shih, Simon S. Lo, Scott Soltys, Ivana Russo, Paul D. Brown and Claus Belka Tags: Review Source Type: research

Risk factors for radiation pneumonitis in lung cancer patients with subclinical interstitial lung disease after thoracic radiation therapy
Previous studies have found that patients with subclinical interstitial lung disease (ILD) are highly susceptible to developing radiation pneumonitis (RP) after thoracic radiation therapy. In the present study... (Source: Radiation Oncology)
Source: Radiation Oncology - April 13, 2021 Category: Cancer & Oncology Authors: Fangjuan Li, Hui Liu, Hongyu Wu, Shixiong Liang and Yaping Xu Tags: Research Source Type: research

Method of computing direction-dependent margins for the development of consensus contouring guidelines
Clinical target volume (CTV) contouring guidelines are frequently developed through studies in which experts contour the CTV for a representative set of cases for a given treatment site and the consensus CTVs ... (Source: Radiation Oncology)
Source: Radiation Oncology - April 13, 2021 Category: Cancer & Oncology Authors: Liam S. P. Lawrence, Lee C. L. Chin, Rachel W. Chan, Timothy K. Nguyen, Arjun Sahgal, Chia-Lin Tseng and Angus Z. Lau Tags: Methodology Source Type: research

Conversion and validation of rectal constraints for prostate carcinoma receiving hypofractionated carbon-ion radiotherapy with a local effect model
The study objective was to establish the local effect model (LEM) rectum constraints for 12-, 8-, and 4-fraction carbon-ion radiotherapy (CIRT) in patients with localized prostate carcinoma (PCA) using microdo... (Source: Radiation Oncology)
Source: Radiation Oncology - April 13, 2021 Category: Cancer & Oncology Authors: Weiwei Wang, Ping Li, Yinxiangzi Sheng, Zhijie Huang, Jingfang Zhao, Zhengshan Hong, Kambiz Shahnazi, Guo-Liang Jiang and Qing Zhang Tags: Research Source Type: research

A prospective study investigating the efficacy and toxicity of definitive ChemoRadiation and ImmunOtherapy (CRIO) in locally and/or regionally advanced unresectable cutaneous squamous cell carcinoma
Patients with unresectable advanced cutaneous squamous cell carcinoma (cSCC) are generally treated with palliative intent. Immune checkpoint blockade has significant activity in the palliative setting in patie... (Source: Radiation Oncology)
Source: Radiation Oncology - April 9, 2021 Category: Cancer & Oncology Authors: Charles Lin, Trishna Ballah, Michelle Nottage, Karen Hay, Benjamin Chua, Lizbeth Kenny, Paul Thomas, Michele Teng, Jacqui Keller, Trang Le, Jennifer Edmunds and Brett Hughes Tags: Study protocol Source Type: research

Therapeutic outcome and related predictors of stereotactic body radiotherapy for small liver-confined HCC: a systematic review and meta-analysis of observational studies
This study aimed to synthesize available d... (Source: Radiation Oncology)
Source: Radiation Oncology - April 8, 2021 Category: Cancer & Oncology Authors: Yanyan Long, Yan Liang, Shujie Li, Jing Guo, Ying Wang, Yan Luo and Yongzhong Wu Tags: Research Source Type: research

Clinical validation of a commercially available deep learning software for synthetic CT generation for brain
Most studies on synthetic computed tomography (sCT) generation for brain rely on in-house developed methods. They often focus on performance rather than clinical feasibility. Therefore, the aim of this work wa... (Source: Radiation Oncology)
Source: Radiation Oncology - April 7, 2021 Category: Cancer & Oncology Authors: Minna Lerner, Joakim Medin, Christian Jamtheim Gustafsson, Sara Alkner, Carl Siversson and Lars E. Olsson Tags: Research Source Type: research

Correction to: Correlation of dosimetric factors with the development of symptomatic radiation pneumonitis in stereotactic body radiotherapy
An amendment to this paper has been published and can be accessed via the original article. (Source: Radiation Oncology)
Source: Radiation Oncology - April 7, 2021 Category: Cancer & Oncology Authors: Jeffrey M. Ryckman, Michael Baine, Joseph Carmicheal, Ferdinand Osayande, Richard Sleightholm, Kaeli Samson, Dandan Zheng, Weining Zhen, Chi Lin and Chi Zhang Tags: Correction Source Type: research

Biologically consistent dose accumulation using daily patient imaging
This work addresses a basic inconsistency in the way dose is accumulated in radiotherapy when predicting the biological effect based on the linear quadratic model (LQM). To overcome this inconsistency, we intr... (Source: Radiation Oncology)
Source: Radiation Oncology - April 6, 2021 Category: Cancer & Oncology Authors: Nina I. Niebuhr, Mona Splinter, Tilman Bostel, Joao Seco, Clemens M. Hentschke, Ralf O. Floca, Juliane H örner-Rieber, Markus Alber, Peter Huber, Nils H. Nicolay and Asja Pfaffenberger Tags: Methodology Source Type: research

Cochlea sparing optimized radiotherapy for nasopharyngeal carcinoma
Definitive chemoradiotherapy (CRT) is standard of care for nasopharyngeal carcinoma. Due to the tumor localization and concomitant platinum-based chemotherapy, hearing impairment is a frequent complication, wi... (Source: Radiation Oncology)
Source: Radiation Oncology - April 1, 2021 Category: Cancer & Oncology Authors: Enkelejda Lamaj, Erwin Vu, Janita E. van Timmeren, Chiara Leonardi, Louise Marc, Izabela Pytko, Matthias Guckenberger and Panagiotis Balermpas Tags: Research Source Type: research

Oligometastatic head and neck cancer: Which patients benefit from radical local treatment of all tumour sites?
There is a large lack of evidence for optimal treatment in oligometastatic head and neck cancer and it is especially unclear which patients benefit from radical local treatment of all tumour sites. (Source: Radiation Oncology)
Source: Radiation Oncology - March 31, 2021 Category: Cancer & Oncology Authors: Thomas Weissmann, Daniel H öfler, Markus Hecht, Sabine Semrau, Marlen Haderlein, Irina Filimonova, Benjamin Frey, Christoph Bert, Sebastian Lettmaier, Konstantinos Mantsopoulos, Heinrich Iro, Rainer Fietkau and Florian Putz Tags: Research Source Type: research

Longitudinal MRI study after carbon ion and photon irradiation: shorter latency time for myelopathy is not associated with differential morphological changes
Radiation-induced myelopathy is a severe and irreversible complication that occurs after a long symptom-free latency time if the spinal cord was exposed to a significant irradiation dose during tumor treatment... (Source: Radiation Oncology)
Source: Radiation Oncology - March 31, 2021 Category: Cancer & Oncology Authors: Thomas Welzel, Alina L. Bendinger, Christin Glowa, Inna Babushkina, Manfred Jugold, Peter Peschke, J ürgen Debus, Christian P. Karger and Maria Saager Tags: Research Source Type: research

MR-guided stereotactic body radiation therapy for primary cardiac sarcomas
Primary cardiac tumors are an extremely rare disease with limited prognosis. The treatment of choice is surgery. Other treatment options include chemotherapy and radiation therapy, which historically represent... (Source: Radiation Oncology)
Source: Radiation Oncology - March 26, 2021 Category: Cancer & Oncology Authors: Stefanie Corradini, Rieke von Bestenbostel, Angela Romano, Adrian Curta, Dorit Di Gioia, Lorenzo Placidi, Maximilian Niyazi and Luca Boldrini Tags: Case report Source Type: research

Vestibular dose correlates with dizziness after radiosurgery for the treatment of vestibular schwannoma
Stereotactic radiosurgery (SRS) has been recognized as a first-line treatment option for small to moderate sized vestibular schwannoma (VS). Our aim is to evaluate the impact of SRS doses and other patient and... (Source: Radiation Oncology)
Source: Radiation Oncology - March 26, 2021 Category: Cancer & Oncology Authors: Ekin Ermi ş, Lukas Anschuetz, Dominic Leiser, Robert Poel, Andreas Raabe, Peter Manser, Daniel M. Aebersold, Marco Caversaccio, Georgios Mantokoudis, Janine Abu-Isa, Franca Wagner and Evelyn Herrmann Tags: Research Source Type: research

Dose-escalated radiotherapy with PET/CT based treatment planning in combination with induction and concurrent chemotherapy in locally advanced (uT3/T4) squamous cell cancer of the esophagus: mature results of a phase I/II trial
This prospective phase I/II trial assessed feasibility and efficacy of dose-escalated definitive chemoradiation after induction chemotherapy in locally advanced esophageal cancer. Primary study endpoint was lo... (Source: Radiation Oncology)
Source: Radiation Oncology - March 23, 2021 Category: Cancer & Oncology Authors: C. P öttgen, E. Gkika, M. Stahl, J. Abu Jawad, T. Gauler, S. Kasper, T. Trarbach, K. Herrmann, N. Lehmann, K.-H. Jöckel, H. Lax and M. Stuschke Tags: Research Source Type: research

Evaluation of a highly refined prediction model in knowledge-based volumetric modulated arc therapy planning for cervical cancer
To explore whether a highly refined dose volume histograms (DVH) prediction model can improve the accuracy and reliability of knowledge-based volumetric modulated arc therapy (VMAT) planning for cervical cancer. (Source: Radiation Oncology)
Source: Radiation Oncology - March 22, 2021 Category: Cancer & Oncology Authors: Mingli Wang, Huikuan Gu, Jiang Hu, Jian Liang, Sisi Xu and Zhenyu Qi Tags: Research Source Type: research

NTCP modeling and dose –volume correlations for acute xerostomia and dry eye after whole brain radiation
Whole brain radiation (WBRT) may lead to acute xerostomia and dry eye from incidental parotid and lacrimal exposure, respectively. We performed a prospective observational study to assess the incidence/severit... (Source: Radiation Oncology)
Source: Radiation Oncology - March 21, 2021 Category: Cancer & Oncology Authors: Panayiotis Mavroidis, Kevin A. Pearlstein, Dominic H. Moon, Victoria Xu, Trevor J. Royce, Ashley A. Weiner, Colette J. Shen, Lawrence B. Marks, Bhishamjit S. Chera, Shiva K. Das and Kyle Wang Tags: Research Source Type: research

Correlation of [18F] FDG-PET/CT with dosimetry data: recurrence pattern after radiotherapy for head and neck carcinoma
To analyze the pattern of failure in relation to pre-treatment [18F] FDG-PET/CT uptake in head and neck squamous cell carcinoma (HNSCC) patients treated with definitive radio-chemotherapy (RT-CHT). (Source: Radiation Oncology)
Source: Radiation Oncology - March 21, 2021 Category: Cancer & Oncology Authors: C. Pisani, L. Vigna, F. Mastroleo, G. Loi, V. Amisano, L. Masini, L. Deantonio, P. Aluffi Valletti, G. Sacchetti and M. Krengli Tags: Research Source Type: research

Topographic distribution of lymph node metastasis in patients with stage IB1 cervical cancer: an analysis of 8314 lymph nodes
Systematic pelvic lymphadenectomy or whole pelvic irradiation is recommended for the patients with stage IB1 cervical cancer. However, the precise pattern of lymphatic tumor spread in cervical cancer is unknow... (Source: Radiation Oncology)
Source: Radiation Oncology - March 20, 2021 Category: Cancer & Oncology Authors: Jing Cai, Xiaoqi He, Hongbo Wang, Weihong Dong, Yuan Zhang, Jing Zhao, Kay C. Willborn, Bangxing Huang, Zehua Wang and Ping Jiang Tags: Research Source Type: research

Current status and developments of German curriculum-based residency training programmes in radiation oncology
The current status of German residency training in the field of radiation oncology is provided and compared to programmes in other countries. In particular, we present the DEGRO-Academy within the internationa... (Source: Radiation Oncology)
Source: Radiation Oncology - March 20, 2021 Category: Cancer & Oncology Authors: Marcel B üttner, Nils Cordes, Tobias Gauer, Daniel Habermehl, Gunther Klautke, Oliver Micke, Matthias Mäurer, Jan Sokoll, Esther Gera Cornelia Troost, Hans Christiansen and Maximilian Niyazi Tags: Research Source Type: research

Fiducial-based image-guided SBRT for pancreatic adenocarcinoma: Does inter-and intra-fraction treatment variation warrant adaptive therapy?
Variation in target positioning represents a challenge to set-up reproducibility and reliability of dose delivery with stereotactic body radiation therapy (SBRT) for pancreatic adenocarcinoma (PDAC). While on-... (Source: Radiation Oncology)
Source: Radiation Oncology - March 19, 2021 Category: Cancer & Oncology Authors: Colin S. Hill, Sarah Han-Oh, Zhi Cheng, Ken Kang-Hsin Wang, Jeffrey J. Meyer, Joseph M. Herman and Amol K. Narang Tags: Research Source Type: research

Chemoradiotherapy for limited-stage small-cell lung cancer and interstitial lung abnormalities
Patients with lung cancer and interstitial lung disease treated with radiotherapy are at risk of developing radiation pneumonitis. However, the association between interstitial lung abnormalities (ILAs) and ra... (Source: Radiation Oncology)
Source: Radiation Oncology - March 17, 2021 Category: Cancer & Oncology Authors: Haruki Kobayashi, Kazushige Wakuda, Tateaki Naito, Nobuaki Mamesaya, Shota Omori, Akira Ono, Hirotsugu Kenmotsu, Haruyasu Murakami, Masahiro Endo, Hideyuki Harada, Yasuhiro Gon and Toshiaki Takahashi Tags: Research Source Type: research

Radiotherapeutic treatment options for oligotopic malignant liver lesions
Several radiotherapeutic approaches for patients with oligotopic malignant liver lesions unfit for surgical resection exist. The most advanced competitive techniques are high-dose-rate (HDR) brachytherapy, Cyb... (Source: Radiation Oncology)
Source: Radiation Oncology - March 16, 2021 Category: Cancer & Oncology Authors: Peter Wust, Marcus Beck, Robert Dabrowski, Oliver Neumann, Sebastian Zschaeck, David Kaul, Dominik P. Modest, Carmen Stromberger, Bernhard Gebauer and Pirus Ghadjar Tags: Research Source Type: research

Radiotherapy of oligometastatic prostate cancer: a systematic review
Due to improved imaging sensitivity, the term “oligometastatic” prostate cancer disease is diagnosed more often, leading to an increasing interest in metastasis-directed therapy (MDT). There are two types of r... (Source: Radiation Oncology)
Source: Radiation Oncology - March 9, 2021 Category: Cancer & Oncology Authors: Paul Rogowski, Mack Roach III, Nina-Sophie Schmidt-Hegemann, Christian Trapp, Rieke von Bestenbostel, Run Shi, Alexander Buchner, Christian Stief, Claus Belka and Minglun Li Tags: Review Source Type: research

Appropriate margin for planning target volume for breast radiotherapy during deep inspiration breath-hold by variance component analysis
This study aimed to quantify errors by using a cine electronic portal imaging device (cine EPID) during deep inspiration breath-hold (DIBH) for left-sided breast cancer and to estimate the planning target volu... (Source: Radiation Oncology)
Source: Radiation Oncology - March 6, 2021 Category: Cancer & Oncology Authors: Yuka Ono, Michio Yoshimura, Tomohiro Ono, Takahiro Fujimoto, Yuki Miyabe, Yukinori Matsuo and Takashi Mizowaki Tags: Research Source Type: research

Clinical outcomes of extensive-stage small cell lung cancer patients treated with thoracic radiotherapy at different times and fractionations
The purpose of this study was to assess whether thoracic radiotherapy (TRT) combined with chemotherapy (CHT) showed promising anti-tumour activity in extensive-stage small cell lung cancer (ES-SCLC), to explor... (Source: Radiation Oncology)
Source: Radiation Oncology - March 4, 2021 Category: Cancer & Oncology Authors: Jinmin Han, Chengrui Fu and Baosheng Li Tags: Research Source Type: research

Combining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model
Patients with metastatic HER2/neu-positive (HER2/neu  +) breast cancer (BC) often experience treatment resistance, disease recurrences and metastases. Thus, new approaches for improving the treatment of HER2/ne... (Source: Radiation Oncology)
Source: Radiation Oncology - March 4, 2021 Category: Cancer & Oncology Authors: Wende Li, Sen Li, Ivy X. Chen, Yujiao Liu, Rakesh R. Ramjiawan, Chi-Ho Leung, Leo E. Gerweck, Dai Fukumura, Jay S. Loeffler, Rakesh K. Jain, Dan G. Duda and Peigen Huang Tags: Research Source Type: research

FET-PET radiomics in recurrent glioblastoma: prognostic value for outcome after re-irradiation?
The value of O-(2-[18F]fluoroethyl)-L-tyrosine (FET)-positron emission tomography (PET)-radiomics in the outcome assessment of patients with recurrent glioblastoma (rGBM) has not been evaluated until now. The... (Source: Radiation Oncology)
Source: Radiation Oncology - March 3, 2021 Category: Cancer & Oncology Authors: Montserrat Carles, Ilinca Popp, Michael Maximilian Starke, Michael Mix, Horst Urbach, Tanja Schimek-Jasch, Franziska Eckert, Maximilian Niyazi, Dimos Baltas and Anca L. Grosu Tags: Research Source Type: research

Dosimetric study between a single isocenter dynamic conformal arc therapy technique and Gamma Knife radiosurgery for multiple brain metastases treatment: impact of target volume geometrical characteristics
To compare linac-based mono-isocentric radiosurgery with Brainlab Elements Multiple Brain Mets (MBM) SRS and the Gamma Knife using a specific statistical method and to analyze the dosimetric impact of the targ... (Source: Radiation Oncology)
Source: Radiation Oncology - February 27, 2021 Category: Cancer & Oncology Authors: Michel Chea, Karen Fezzani, Julian Jacob, Marguerite Cuttat, Mathilde Crois é, Jean-Marc Simon, Loïc Feuvret, Charles-Ambroise Valery, Philippe Maingon, Mohamed-Amine Benadjaoud and Catherine Jenny Tags: Research Source Type: research

Radiation-induced kidney toxicity: molecular and cellular pathogenesis
Radiation nephropathy (RN) is a kidney injury induced by ionizing radiation. In a clinical setting, ionizing radiation is used in radiotherapy (RT). The use and the intensity of radiation therapy is limited by... (Source: Radiation Oncology)
Source: Radiation Oncology - February 25, 2021 Category: Cancer & Oncology Authors: Richard Klaus, Maximilian Niyazi and B ärbel Lange-Sperandio Tags: Review Source Type: research

Clinical feasibility of deep learning-based auto-segmentation of target volumes and organs-at-risk in breast cancer patients after breast-conserving surgery
In breast cancer patients receiving radiotherapy (RT), accurate target delineation and reduction of radiation doses to the nearby normal organs is important. However, manual clinical target volume (CTV) and or... (Source: Radiation Oncology)
Source: Radiation Oncology - February 25, 2021 Category: Cancer & Oncology Authors: Seung Yeun Chung, Jee Suk Chang, Min Seo Choi, Yongjin Chang, Byong Su Choi, Jaehee Chun, Ki Chang Keum, Jin Sung Kim and Yong Bae Kim Tags: Research Source Type: research

Lung stereotactic body radiation therapy for elderly patients aged  ≥ 80 years with pathologically proven early-stage non-small cell lung cancer: a retrospective cohort study
Stereotactic body radiation therapy (SBRT) is an established therapy for medically inoperable early-stage non-small cell lung cancer (NSCLC). Many elderly patients are medically inoperable owing to comorbiditi... (Source: Radiation Oncology)
Source: Radiation Oncology - February 23, 2021 Category: Cancer & Oncology Authors: Kenta Watanabe, Kuniaki Katsui, Soichiro Sugiyama, Kotaro Yoshio, Masahiro Kuroda, Takao Hiraki, Katsuyuki Kiura, Yoshinobu Maeda, Shinichi Toyooka and Susumu Kanazawa Tags: Research Source Type: research

Radiation necrosis after a combination of external beam radiotherapy and iodine-125 brachytherapy in gliomas
Frequency and risk profile of radiation necrosis (RN) in patients with glioma undergoing either upfront stereotactic brachytherapy (SBT) and additional salvage external beam radiotherapy (EBRT) after tumor rec... (Source: Radiation Oncology)
Source: Radiation Oncology - February 23, 2021 Category: Cancer & Oncology Authors: Indrawati Hadi, Daniel Reitz, Raphael Bodensohn, Olarn Roengvoraphoj, Stefanie Lietke, Maximilian Niyazi, J örg-Christian Tonn, Claus Belka, Niklas Thon and Silke Birgit Nachbichler Tags: Research Source Type: research

Overlap time is an independent risk factor of radiation pneumonitis for patients treated with simultaneous EGFR-TKI and thoracic radiotherapy
The exact rate and relevant risk factors of radiation pneumonitis (RP) for non-small-cell cancer (NSCLC) patients treated with the combination of epidermal growth factor receptor-tyrosine kinase inhibitors (EG... (Source: Radiation Oncology)
Source: Radiation Oncology - February 23, 2021 Category: Cancer & Oncology Authors: Wenxiao Jia, Qianqian Gao, Min Wang, Ji Li, Wang Jing, Jinming Yu and Hui Zhu Tags: Research Source Type: research

Can internal mammary lymph nodes irradiation bring survival benefits for breast cancer patients? A systematic review and meta-analysis of 12,705 patients in 12 studies
To evaluate the effect of prophylactic irradiation of internal mammary lymph nodes in breast cancer patients. (Source: Radiation Oncology)
Source: Radiation Oncology - February 23, 2021 Category: Cancer & Oncology Authors: Sicong Jia, Zhikun Liu, Jun Zhang, Chenguang Zhao, Longyu Zhu, Jie Kong, Huina Han, Yuguang Shang, Dongxing Shen and Xuejuan Duan Tags: Review Source Type: research

Accuracy of an MR-only workflow for prostate radiotherapy using semi-automatically burned-in fiducial markers
The benefit of MR-only workflow compared to current CT-based workflow for prostate radiotherapy is reduction of systematic errors in the radiotherapy chain by 2 –3 mm. Nowadays, MRI is used for target delineati... (Source: Radiation Oncology)
Source: Radiation Oncology - February 19, 2021 Category: Cancer & Oncology Authors: Karin Goudschaal, F. Beeksma, M. Boon, M. Bijveld, J. Visser, K. Hinnen and Z. van Kesteren Tags: Research Source Type: research

Clinical features, treatment and outcomes in patients with tracheal adenoid cystic carcinoma: a systematic literature review
Primary tracheal adenoid cystic carcinoma (TACC) is rare and originates from the minor salivary gland. Biologically, TACC results in delayed presentation, and the therapeutic effects of multimodal treatment di... (Source: Radiation Oncology)
Source: Radiation Oncology - February 19, 2021 Category: Cancer & Oncology Authors: Juntao Ran, Guofeng Qu, Xiaohua Chen and Da Zhao Tags: Review Source Type: research