ΔNp63α transcriptionally represses p53 target genes involved in the radiation-induced DNA damage response
The DNA damage response (DDR) is a mechanism that protects cells against radiation-induced oxidative DNA damage by causing cell cycle arrest and apoptosis. TP63 is a member of the tumour suppressor TP53 gene fami... (Source: Radiation Oncology)
Source: Radiation Oncology - November 15, 2022 Category: Cancer & Oncology Authors: Ken-ichi Kudo, Naohiro Tsuyama, Kento Nagata, Tatsuhiko Imaoka, Daisuke Iizuka, Misaki Sugai-Takahashi, Moe Muramatsu and Akira Sakai Tags: Research Source Type: research
A dual deep neural network for auto-delineation in cervical cancer radiotherapy with clinical validation
Artificial intelligence (AI) algorithms are capable of automatically detecting contouring boundaries in medical images. However, the algorithms impact on clinical practice of cervical cancer are unclear. We ai... (Source: Radiation Oncology)
Source: Radiation Oncology - November 15, 2022 Category: Cancer & Oncology Authors: Shihong Nie, Yuanfeng Wei, Fen Zhao, Ya Dong, Yan Chen, Qiaoqi Li, Wei Du, Xin Li, Xi Yang and Zhiping Li Tags: Research Source Type: research
Prognostic value of tumor-infiltrating immune cells and immune checkpoints in elderly head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiotherapy
Tumor-infiltrating lymphocytes (TILs) are associated with locoregional control (LRC) in head-and-neck squamous cell carcinoma (HNSCC) patients undergoing (chemo)radiotherapy. As immunosenescence results in red... (Source: Radiation Oncology)
Source: Radiation Oncology - November 14, 2022 Category: Cancer & Oncology Authors: Alexander R ühle, Jovan Todorovic, Simon S. K. Spohn, Eleni Gkika, Christoph Becker, Andreas Knopf, Constantinos Zamboglou, Tanja Sprave, Martin Werner, Anca-Ligia Grosu, Gian Kayser and Nils H. Nicolay Tags: Research Source Type: research
Dose prediction for cervical cancer VMAT patients with a full-scale 3D-cGAN-based model and the comparison of different input data on the prediction results
(Source: Radiation Oncology)
Source: Radiation Oncology - November 13, 2022 Category: Cancer & Oncology Authors: Gongsen Zhang, Zejun Jiang, Jian Zhu and Linlin Wang Tags: Research Source Type: research
Role of postoperative chemoradiotherapy in head and neck cancer without positive margins or extracapsular extension: a propensity score-matching analysis
The aim of this work was to determine whether patients with intermediate-risk head and neck squamous cell carcinoma (HNSCC) can benefit from postoperative chemoradiotherapy (POCRT). (Source: Radiation Oncology)
Source: Radiation Oncology - November 13, 2022 Category: Cancer & Oncology Authors: Zhi-Qiao Liu, Pu-Yun OuYang, Bao-Yu Zhang, En-Ni Chen, Su-Ming Xiao, Shan-Shan Yang, Zhong-Yuan Yang and Fang-Yun Xie Tags: Research Source Type: research
