A strategy combining solid-phase extraction, multiple mass defect filtering and molecular networking for rapid structural classification and annotation of natural products: characterization of chemical diversity in Citrus aurantium as a case study
Anal Bioanal Chem. 2021 Apr 6. doi: 10.1007/s00216-021-03201-1. Online ahead of print.ABSTRACTMedicinal plants are complex chemical systems containing thousands of secondary metabolites. The rapid classification and characterization of the components in medicinal plants using mass spectrometry (MS) remains an immense challenge. Herein, a novel strategy is presented for MS through the combination of solid-phase extraction (SPE), multiple mass defect filtering (MMDF) and molecular networking (MN). This strategy enables efficient classification and annotation of natural products. When combined with SPE and MMDF, the improved ...
Source: Analytical and Bioanalytical Chemistry - April 6, 2021 Category: Chemistry Authors: Yi-Kun Wang Xue-Rong Xiao Zi-Meng Zhou Yao Xiao Wei-Feng Zhu Hong-Ning Liu Fei Li Source Type: research

A strategy combining solid-phase extraction, multiple mass defect filtering and molecular networking for rapid structural classification and annotation of natural products: characterization of chemical diversity in Citrus aurantium as a case study
Anal Bioanal Chem. 2021 Apr 6. doi: 10.1007/s00216-021-03201-1. Online ahead of print.ABSTRACTMedicinal plants are complex chemical systems containing thousands of secondary metabolites. The rapid classification and characterization of the components in medicinal plants using mass spectrometry (MS) remains an immense challenge. Herein, a novel strategy is presented for MS through the combination of solid-phase extraction (SPE), multiple mass defect filtering (MMDF) and molecular networking (MN). This strategy enables efficient classification and annotation of natural products. When combined with SPE and MMDF, the improved ...
Source: Analytical and Bioanalytical Chemistry - April 6, 2021 Category: Chemistry Authors: Yi-Kun Wang Xue-Rong Xiao Zi-Meng Zhou Yao Xiao Wei-Feng Zhu Hong-Ning Liu Fei Li Source Type: research

Anti-anxiety properties of selected medicinal plants.
The objective of this review is to provide information about the healing outcomes of anxiety treatment with natural products. Valeriana officinalis, Citrus aurantium, Commelina benghalensis, Achyranthes aspera, Mimosa pudica, Achillea millefolium, Nymphaea alba, Leonurus cardiac, Camellia sinensis, Turnera aphrodisiaca, Crataegus oxyacantha and Piper methysticum showed promising effects on anxiety in animal models. In clinical studies, passion flower, kava, valerian, St John's wort, and ashwagandha showed the most positive results. More studies are needed for the exploration of the anti-anxiety of medicinal plants. In drug...
Source: Current Pharmaceutical Biotechnology - January 22, 2021 Category: Biotechnology Authors: Khan A, Akram M, Thiruvengadam M, Daniyal M, Zakki SA, Munir N, Zainab R, Heydari M, Mosavat SH, Rebezov M, Shariati MA Tags: Curr Pharm Biotechnol Source Type: research

Effects of lavender and Citrus aurantium on pain of conscious intensive care unit patients: A parallel randomized placebo-controlled trial
Publication date: Available online 14 January 2021Source: Journal of Integrative MedicineAuthor(s): Zahra Karimzadeh, Mansooreh Azizzadeh Forouzi, Haleh Tajadini, Mehdi Ahmadinejad, Callista Roy, Mahlagha Dehghan (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - January 14, 2021 Category: Complementary Medicine Source Type: research

Growth sites and their impacts on sour orange ʽCitrus aurantium (Tournef.)ʼ essential oil
Publication date: Available online 9 January 2021Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Khalid A. Khalid (Source: Biocatalysis and Agricultural Biotechnology)
Source: Biocatalysis and Agricultural Biotechnology - January 9, 2021 Category: Biotechnology Source Type: research

Botanical illustration of Citrus vulgaris, 1880
Traditionally, the leaves and fruit of bitter orange were used to alleviate nausea and aid digestion. (Source: The Pharmaceutical Journal)
Source: The Pharmaceutical Journal - December 3, 2020 Category: Drugs & Pharmacology Source Type: research

A Combined Phytochemistry and Network Pharmacology Approach to Reveal the Effective Substances and Mechanisms of Wei-Fu-Chun Tablet in the Treatment of Precancerous Lesions of Gastric Cancer
This study offers an applicable approach to identify chemical components, absorbed compounds, and metabolic compounds in WFC, and provides a method to explore bioactive ingredients and action mechanisms of WFC. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 18, 2020 Category: Drugs & Pharmacology Source Type: research

HPLC-UV-QDa analysis of Citrus aurantium-labelled pre-workout supplements suggest only a minority contain the plant extract
Publication date: Available online 5 November 2020Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Andy Hsien Wei Koh, Russ Chess-Williams, Anna Elizabeth Lohning (Source: Journal of Pharmaceutical and Biomedical Analysis)
Source: Journal of Pharmaceutical and Biomedical Analysis - November 6, 2020 Category: Drugs & Pharmacology Source Type: research

Effects of Citrus aurantium L. on Gastrointestinal Motility and Gastric Cancer Cell Proliferation
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Source: Cancer Biotherapy and Radiopharmaceuticals - October 28, 2020 Category: Cancer & Oncology Authors: Meng Gao Wuliang Yang Source Type: research

The Effect of Aromatherapy Massage with Lavender and Citrus Aurantium Essential Oil on Quality of Life of Patients on Chronic Hemodialysis: A Parallel Randomized Clinical Trial Study
Poor quality of life are major problems in hemodialysis patients. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - August 30, 2020 Category: Palliative Care Authors: Reza Mohammadpourhodki, Hosein Sadeghnezhad, Hossein Ebrahimi, Mohammad Hasan Basirinezhad, Maryam Maleki, Maurizio Bossola Source Type: research

Molecules, Vol. 25, Pages 3956: Biological Activity and Antibiofilm Molecular Profile of Citrus aurantium Essential Oil and Its Application in a Food Model
enáta Benda Prokeinová Nenad Vukovic The main aim of the study was to investigate the chemical composition, antioxidant, antimicrobial, and antibiofilm activity of Citrus aurantium essential oil (CAEO). The biofilm profile of Stenotrophonomonas maltophilia and Bacillus subtilis were assessed using the mass spectrometry MALDI-TOF MS Biotyper and the antibiofilm activity of Citrus aurantium (CAEO) was studied on wood and glass surfaces. A semi-quantitative composition using a modified version was applied for the CAEO characterization. The antioxidant activity of CAEO was determined using the DPPH method. The antimicr...
Source: Molecules - August 29, 2020 Category: Chemistry Authors: Miroslava Ka čániová Margarita Terentjeva Lucia Galovi čová Eva Ivani šová Jana Štefániková Veronika Valkov á Petra Borotov á Przemys ław Łukasz Kowalczewski Simona Kunov á So ňa Felšöciová Eva Tvrd á Jana Žiarovská Ren áta Benda Pr Tags: Article Source Type: research

Synergistic potential of Citrus aurantium L. essential oil with antibiotics against Candida albicans
Publication date: 15 November 2020Source: Journal of Ethnopharmacology, Volume 262Author(s): Prakriti Nidhi, Rajan Rolta, Vikas Kumar, Kamal Dev, Anuradha Sourirajan (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 20, 2020 Category: Drugs & Pharmacology Source Type: research

Facile green and one-pot synthesis of seville orange derived carbon dots as a fluorescent sensor for Fe3+ ions
Publication date: December 2020Source: Microchemical Journal, Volume 159Author(s): Ayse Merve Senol, Ebru Bozkurt (Source: Microchemical Journal)
Source: Microchemical Journal - August 13, 2020 Category: Chemistry Source Type: research

Analysis of bitter orange dietary supplements for natural and synthetic phenethylamines by LC –MS/MS
In this study, an LC –MS/MS method was established to quantify five natural amines (synephrine, octopamine, tyramine,N‐methyltyramine, and hordenine) and four synthetic phenethylamines (phenylephrine, methylsynephrine, etilefrine, and isopropyloctopamine) in dietary supplements sold in the US. The method was validated and found to have acceptable performance to accurately measure analytes in complex botanical pro ducts. The average recoveries from a blank matrix were 88–125% with an RSD of 0.5–7.0%. Fifty‐nine products labeled to contain bitter orange peel, extract, or its amines were purchased and their amine co...
Source: Drug Testing and Analysis - June 27, 2020 Category: Drugs & Pharmacology Authors: Rahul S. Pawar, Satyanarayanaraju Sagi, Dmitry Leontyev Tags: RESEARCH ARTICLE Source Type: research

Essential Oil from Citrus aurantium Alleviates Anxiety of Patients Undergoing Coronary Angiography: A Single-Blind, Randomized Controlled Trial
ConclusionInhalation of the essential oil fromCitrus aurantium was effective in reducing anxiety and stress levels in patients undergoing coronary angiography. Trial registration: IRCT2016040816797N2 (retrospectively registered on 21 April 2016,https://en.irct.ir/trial/15600) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - June 21, 2020 Category: Internal Medicine Source Type: research