Exploiting Citrus aurantium seeds and their secondary metabolites in the management of Alzheimer disease
Publication date: Available online 5 June 2020Source: Toxicology ReportsAuthor(s): Doha H. Abou Baker, Bassant M.M. Ibrahim, Nabila S. Hassan, A.F Yousuf, Souad El Gengaihi (Source: Toxicology Reports)
Source: Toxicology Reports - June 5, 2020 Category: Toxicology Source Type: research
Analysis of bitter orange dietary supplements for natural and synthetic phenethylamines by LC ‐MS/MS
In this study, an LC ‐MS/MS method was established to quantify five natural amines (synephrine, octopamine, hordenine, tyramine andN‐methyltyramine) and four synthetic amines (phenylephrine, methylsynephrine, etilefrine and isopropyloctopamine) in dietary supplements sold in the US. The method was validated and found to have acceptable performance to accurately measure analytes in complex botanical products. The average recove ries from a blank matrix were between 88 – 125% with an RSD of 0.5 – 7.0%. Fifty‐nine products labeled to contain bitter orange peel, extract, or its amines were purchased and their amine c...
Source: Drug Testing and Analysis - June 3, 2020 Category: Drugs & Pharmacology Authors: R.S. Pawar,
S. Sagi,
D. Leontyev Tags: RESEARCH ARTICLE Source Type: research
Rapid identification of chemical composition and metabolites of Pingxiao Capsule in vivo using molecular networking and untargeted data-dependent tandem mass spectrometry.
In this study, a ultra-high performance liquid chromatography (UHPLC) system equipped with high resolution Q-Orbitrap mass spectrometry (MS), and comparative global natural product social (GNPS) molecular networking together with the Compound Discoverer (CD) software were used to identify metabolites of PXC in vitro and in vivo. Based on untargeted data-dependent MS2 and data-mining techniques, 89 peaks of alkaloids, flavonoids, organic acid, and phenolic compounds were identified in the PXC 70% methanol extract. Furthermore, 15 absorbed prototype compounds and their metabolites were rapidly confirmed in rat blood. Glucuro...
Source: Biomedical Chromatography : BMC - May 11, 2020 Category: Biomedical Science Authors: Wang D, Fu Z, Xing Y, Tan Y, Han L, Yu H, Wang T Tags: Biomed Chromatogr Source Type: research
The Effects of Low-Dose and High-Dose Decoctions of Fructus aurantii in a Rat Model of Functional Dyspepsia.
CONCLUSIONS In the rat model of FD, low-dose Fructus aurantii with stir-fried wheat bran increased gastrointestinal motility and gastrointestinal hormone levels.
PMID: 32248203 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research
Molecules, Vol. 25, Pages 1485: Protein Extraction, Enrichment and MALDI MS and MS/MS Analysis from Bitter Orange Leaves (Citrus aurantium)
Anna Napoli
Citrus aurantium is a widespread tree in the Mediterranean area, and it is mainly used as rootstock for other citrus. In the present study, a vacuum infiltration centrifugation procedure, followed by solid phase extraction matrix-assisted laser desorption ionization tandem mass spectrometry (SPE MALDI MS/MS) analysis, was adopted to isolate proteins from leaves. The results of mass spectrometry (MS) profiling, combined with the top-down proteomics approach, allowed the identification of 78 proteins. The bioinformatic databases TargetP, SignalP, ChloroP, WallProtDB, and mGOASVM-Loc were used to predict the s...
Source: Molecules - March 24, 2020 Category: Chemistry Authors: Donatella Aiello Carlo Siciliano Fabio Mazzotti Leonardo Di Donna Roberta Risoluti Anna Napoli Tags: Article Source Type: research
Chemical profile and antioxidant potency of Citrus aurantium L. flower extracts with antibacterial effect against foodborne pathogens in rice pudding
Publication date: Available online 16 March 2020Source: LWTAuthor(s): Huseyin Degirmenci, Hatice Erkurt (Source: LWT Food Science and Technology)
Source: LWT Food Science and Technology - March 17, 2020 Category: Food Science Source Type: research
Citrus aurantium L. polymethoxyflavones promote thermogenesis of brown and white adipose tissue in high-fat diet induced C57BL/6J mice
This study demonstrated that citrus PMFs could prevent obesity by activating thermogenesis of BAT and iWAT. PMFs may use as a novel dietary supplemental approach for obesity.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - February 24, 2020 Category: Nutrition Source Type: research
Inducing mutations in Citrus spp.: Sensitivity of different sources of plant material to gamma radiation.
In this study in vitro and ex vitro mutagenesis was induced by gamma radiation in several citrus species ('Alemow' and sour orange as citrus rootstocks, lemon cv. 'Fino 49' and 'Verna 51', mandarin cv. 'Nova' and lime cv. 'Bearss'). Three different sources of materials - seeds, budwoods and nodal segments - from in vitro explants, were tested. Seeds and budwoods were germinated or induced to sprout, and de novo regeneration was obtained from in vitro nodal segments from which preexisting buds were previously removed. Budwoods were tested in summer and winter in order to assess their capacity for mutation and further sprout...
Source: Applied Radiation and Isotopes - February 19, 2020 Category: Radiology Authors: Pérez-Jiménez M, Tallón CI, Pérez-Tornero O Tags: Appl Radiat Isot Source Type: research
Selective pressurized extraction as single-step extraction and clean-up for the determination of organophosphate ester flame retardant in Citrus aurantium leaves by gas chromatography-tandem mass spectrometry.
Abstract
In this work, an analytical method has been developed and validated for the determination of organophosphate esters (OPEs) in urban ornamental tree leaves. OPEs are flame retardants and plasticizers which are classified as health and environmental hazards substances. Their presence in urban air has been previously described. The method proposed in this work would allow the use of urban tree leaves as simple, cheap, and widely distributed in urban areas alternative to the existing active and passive sampler for sample collection. The method was based on sample treatment by selective pressurized liq...
Source: Analytical and Bioanalytical Chemistry - February 17, 2020 Category: Chemistry Authors: Santos JL, Malvar JL, Abril C, Martín J, Aparicio I, Alonso E Tags: Anal Bioanal Chem Source Type: research
Citrus aurantium L.: Cultivar impact on sensory profile
Publication date: Available online 11 February 2020Source: International Journal of Gastronomy and Food ScienceAuthor(s): Diana De Santis, Maria Teresa FrangipaneAbstractThe purpose of this study was to identify the sensory attributes for the evaluation of bitter orange (Citrus aurantium L.) sensory profile, in three different cultivars (Canaliculata, C1; Crispifolia, C2; Salicifolia C3), so that it was possible to highlight their sensory characteristics, through the application of the official procedure. Our results revealed that the odor of C1 was mainly characterized by the citrus flavor, while the aroma of C3 was gover...
Source: International Journal of Gastronomy and Food Science - February 12, 2020 Category: Food Science Source Type: research
Naturally Occurring TPE-CA Maintains Gut Microbiota and Bile Acids Homeostasis via FXR Signaling Modulation of the Liver –Gut Axis
Antibiotics-induced changes in intestinal flora (dysbiosis) may have various effects on the host. Dysbiosis is associated with numerous metabolites including bile acids, which are produced in the liver from cholesterol and metabolized in the gut by intestinal microbiota. Total phenolic extracts of Citrus aurantium L. (TPE-CA) are rich in dietary flavanones and their glycosyl derivatives, including flavones, flavonols, polymethoxyflavones and coumarins, which exert positive health effects on the microbiota. The aim of this study is to elucidate the interplays between the intestinal microbiota and bile acids metabolism attri...
Source: Frontiers in Pharmacology - February 5, 2020 Category: Drugs & Pharmacology Source Type: research
Identification and quantification of limonoid aglycones content of Citrus seeds
ABSTRACT Citrus fruits are recognized as an important source of bioactive molecules such as limonin and nomilin. However, these molecules exhibit low bioavailability, therefore, obtaining these molecules using biotechnological techniques may be an alternative to harvesting them directly from fruits. The aim of this study was to quantify and identify limonoids in the dichloromethane extracts of Citrus seeds of Criolla orange, Oneco tangerine, Tangerine-lemon, Sour orange and Valencia orange from department of Antioquia-Colombia by high performance liquid chromatography with diode array detection, and high-resolution mass sp...
Source: Revista Brasileira de Farmacognosia - February 3, 2020 Category: Drugs & Pharmacology Source Type: research
Metabolites from the citrus extracts inhibit the activity of selected proteins in Indian Cobra (Naja naja) venom
ConclusionThe present study provides new molecular insight and scientific evidence on the utility of the methanolic extracts of citrus peels to neutralize the venom toxins of Naja naja.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - January 15, 2020 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 25, Pages 357: Systematic Detection and Identification of Bioactive Ingredients from Citrus aurantium L. var. amara Using HPLC-Q-TOF-MS Combined with a Screening Method
Qing
Zeng
Bitter orange, Citrus aurantium L. var. amara (CAVA), is an important crop and its flowers and fruits are widely used in China as a food spice, as well as in traditional Chinese medicine, due to its health-promoting properties. The secondary metabolites that are present in plant-derived foods or medicines are, in part, responsible for the health benefits and desirable flavor profiles. Nevertheless, detailed information about the bioactive ingredients in CAVA is scarce. Therefore, this study was aimed at exploring the phytochemicals of CAVA by high performance liquid chromatography/quadrupole time-of-flig...
Source: Molecules - January 14, 2020 Category: Chemistry Authors: Yu Chen Liu Huang He Qing Zeng Tags: Article Source Type: research
The effects of Citrus aurantium aroma on anxiety and fatigue in patients with Acute Myocardial Infarction: A Two-center, randomized, controlled trial
ConclusionAromatherapy with Citrus aurantium can be used as part of holistic care for managing the symptoms of AMI by nurses. (Source: Journal of Herbal Medicine)
Source: Journal of Herbal Medicine - December 25, 2019 Category: Complementary Medicine Source Type: research
