Complex interaction of dietary fat and Alaskan bog blueberry supplementation influences manganese mediated neurotoxicity and behavioral impairments
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Malabika Maulik, Swarup Mitra, McKenzie Sweeney, Brianna Lu, Barbara E. Taylor, Abel Bult-ItoAbstractDietary fat modulates neuronal health and contributes to age-related nervous system disorders. However, the complex interaction between dietary fat and supplementation and its consequences on neurotoxic pathophysiology has been sparsely explored. The indigenous Alaskan bog blueberry (BB), Vaccinum uliginosum, is known to have anti-inflammatory properties, mostly attributed to its rich polyphenolic content. Here, we evaluate the interplay...
Source: Journal of Functional Foods - January 18, 2019 Category: Nutrition Source Type: research

Identification of polyphenols that repair the ultraviolet-B-induced DNA damage via SIRT1-dependent XPC/XPA activation
In this study, we established a method of screening foods and food ingredients, which augment the SIRT1 promoter in HaCaT cells, where we used recombinant HaCaT cells transduced with the vector expressing EGFP under the control of SIRT1 promoter. We identified four SIRT1-augmenting pomegranate-derived polyphenols (ellagic acid, punicalin, punicalagin, and urolithin A). All of these contributed to the proliferation of UVB-irradiated HaCaT cells. Punicalagin and urolithin A removed UVB-induced cyclobutane pyrimidine dimers (CPD) by activating nucleotide excision repair (NER). Both punicalagin and urolithin A upregulated NER-...
Source: Journal of Functional Foods - January 18, 2019 Category: Nutrition Source Type: research

Thymus carnosus extracts induce anti-proliferative activity in Caco-2 cells through mechanisms that involve cell cycle arrest and apoptosis
In conclusion, Thymus carnosus anti-proliferative activity against Caco-2 cells highlights the potential of this plant, and its extracts, as functional food/ingredient with nutraceutical and pharmacological value.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - January 18, 2019 Category: Nutrition Source Type: research

Evaluation of hypolipidemic peptide (Val-Phe-Val-Arg-Asn) virtual screened from chickpea peptides by pharmacophore model in high-fat diet-induced obese rat
Publication date: March 2019Source: Journal of Functional Foods, Volume 54Author(s): Wen Shi, Tao Hou, Danjun Guo, Hui HeAbstractChickpea peptides (ChPs) were found to significantly decrease serum total cholesterol (TC), total triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) content, and increase serum high-density lipoprotein cholesterol (HDL-C) content (P 
Source: Journal of Functional Foods - January 18, 2019 Category: Nutrition Source Type: research

Functionality of low digestibility emulsions in cocoa creams. Structural changes during in vitro digestion and sensory perception
The objective of this work was to evaluate the application of low digestibility oil/water emulsions as fat source in a cocoa cream. Emulsions were composed by water, sunflower oil and cellulose ethers or xanthan gum. Back extrusion assays were measured before and after in vitro digestion and free fatty acids release were measured to evaluate the fat digestibility. Finally consumer acceptability was carried out to determine the degree of liking of each system. The results revealed that all the emulsions confer a suitable consistency to the creams and the structure provided by the hydrocolloids was resistant to digestion, re...
Source: Journal of Functional Foods - January 18, 2019 Category: Nutrition Source Type: research

Evaluation of the viability and the preservation of the functionality of microencapsulated Lactobacillus paracasei BGP1 and Lactobacillus rhamnosus 64 in lipid particles coated by polymer electrostatic interaction
This study aimed to evaluate the resistance, viability, and functionality of two strains of probiotics immobilized in solid lipid microparticles covered by a complex of gelatin and gum Arabic. Microcapsules were evaluated regarding their size, morphology, and resistance under stress conditions. Encapsulated microorganisms were evaluated concerning during storage for 120 days. Additionally, the effect of encapsulation on the functionality of the microorganisms was investigated using an in vivo assay. Microcapsules had sizes around 80 μm and extreme pH and temperature of 50 °C destabilized them. Encapsulation im...
Source: Journal of Functional Foods - January 17, 2019 Category: Nutrition Source Type: research

Beer promotes differentiation and mineralization of human osteoblastic cells: Role of silicon
This study showed, for the first time, that beer has evident beneficial effects towards osteoblastic functionality, in respect to OSA alone and this may probably be ascribed to its interrelationship with other elements present in the whole beverage, thus supporting the potential use of beer as nutraceutical to prevent bone omeostastasis unbalance.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - January 17, 2019 Category: Nutrition Source Type: research

Immune-modulatory effects and mechanism of action of l-theanine on ETEC-induced immune-stressed mice via nucleotide-binding oligomerization domain-like receptor signaling pathway
Publication date: March 2019Source: Journal of Functional Foods, Volume 54Author(s): Zhihua Gong, Ling Lin, Zunying Liu, Sheng Zhang, An Liu, Ling Chen, Qiuling Liu, Yanli Deng, Wenjun XiaoAbstractl-Theanine (LTA), a non-protein-derived amino acid, is widely used as a functional ingredient. Here, we established an immune-stressed mouse model by infecting mice with enterotoxigenic Escherichia coli (ETEC) to study the immunomodulatory effects of LTA with respect to nucleotide-binding oligomerization domain (NOD)-like receptor signaling in vivo. Compared to ETEC control group, LTA alleviated ileal tissue lesions, significantl...
Source: Journal of Functional Foods - January 16, 2019 Category: Nutrition Source Type: research

Whey prefermented with beneficial microbes modulates immune response and lowers responsiveness to milk allergens in mouse model
Publication date: March 2019Source: Journal of Functional Foods, Volume 54Author(s): Barbara Wróblewska, Anna Kaliszewska-Suchodoła, Lidia H. Markiewicz, Anna Szyc, Ewa WasilewskaAbstractWhey is a rich dairy by-product emerging mostly during cheese production, with valuable nutritional, functional and bioactive properties and reduced immunogenicity of the protein fractions. The aim of the study was to evaluate therapeutic potential and immunoreactivity with milk antigens of whey prefermented with potentially probiotic bacteria (with Streptococcus salivarius subsp. thermophilus 2 K and Lactobacillus delbrueckii su...
Source: Journal of Functional Foods - January 16, 2019 Category: Nutrition Source Type: research

Intestinal metabolism of baicalein after oral administration in mice: Pharmacokinetics and mechanisms
In conclusion, the intestinal concentration of baicalein can support its intestinal pharmacological activities, and the present study may provide useful information for understanding the bioactivities of flavonoids with limited systemic bioavailability.Graphic abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - January 16, 2019 Category: Nutrition Source Type: research

The chemical structure and biological activities of a novel polysaccharide obtained from Fructus Mori and its zinc derivative
Publication date: March 2019Source: Journal of Functional Foods, Volume 54Author(s): Ping-Ping Wang, Qiang Huang, Chun Chen, Li-Jun You, Rui Hai Liu, Zhi-Gang Luo, Mou-Ming Zhao, Xiong FuAbstractA novel polysaccharide (MFP4P) was isolated from mulberry fruits (Morus alba L.) pulp using a combination of DEAE-Sepharose fast-flow and Sephadex G-100 chromatographic columns. Structural characterization revealed that MFP4P was composed of arabinose, rhamnose, galactose, glucose and galacturonic acid with a molecular weight of 198.2 kDa. The linkage types of MFP4P were proved to be (1 → 6)-linked α-D-Glc, (1 &r...
Source: Journal of Functional Foods - January 16, 2019 Category: Nutrition Source Type: research

Anti-inflammatory and antioxidant jasmonates and flavonoids from lychee seeds
In this study, bioactive phytochemical study of the seeds of lychee led to the isolation and identification of four methyl jasmonate analogs (1–4), one lignanoside (5), together with fifteen flavonoids (6–20). Their chemical structures were established on the basis of spectroscopic analysis including HR-ESI-MS, 1D and 2D NMR spectra. The anti-inflammatory and antioxidant activities were evaluated for the isolated compounds. Compounds 2 and 3 exhibited notable inhibition on NO production induced by lipopolysaccharides (LPS) in macrophages cell line RAW 264.7. Compound 5 and some flavonoids revealed potent antiox...
Source: Journal of Functional Foods - January 16, 2019 Category: Nutrition Source Type: research

Immune-modulating activities of glucans extracted from Pleurotus ostreatus and Pleurotus eryngii
Publication date: March 2019Source: Journal of Functional Foods, Volume 54Author(s): Vaclav Vetvicka, Ofer Gover, Michal Karpovsky, Hilla Hayby, Ofer Danay, Nirit Ezov, Yitzhak Hadar, Betty SchwartzAbstractWe compared the immune-modulating activity of glucans extracted from P. ostreatus and P. eryngii on phagocytosis of peripheral blood neutrophils, and superoxide release from HL-60 cells. The results suggest that the anti-inflammatory properties of these glucans are partially mediated through modulation of neutrophil effector functions (P. eryngii was more effective). Additionally, both glucans dose-dependently competed f...
Source: Journal of Functional Foods - January 16, 2019 Category: Nutrition Source Type: research

Biological effects and potential mechanisms of action of Pistacia lentiscus Chios mastic extract in Caco-2 cell model
Publication date: March 2019Source: Journal of Functional Foods, Volume 54Author(s): Maira Zorzan, Daniela Collazuol, Giovanni Ribaudo, Alberto Ongaro, Carla Scaroni, Giuseppe Zagotto, Decio Armanini, Susi Barollo, Fabio Galeotti, Nicola Volpi, Marco Redaelli, Raffaele PezzaniAbstractPistacia lentiscus L. (PL) is an evergreen shrub from which it is derived a precious aromatic resin called mastic gum or mastic. This extract possesses numerous proprieties, such as antimicrobial, anti-inflammatory, anticancer, etc. The aim of this study was to investigate the biological activities of a patented PL Chios mastic extract in a hu...
Source: Journal of Functional Foods - January 16, 2019 Category: Nutrition Source Type: research

The role of omega 3 fatty acids in suppressing muscle protein catabolism: A possible therapeutic strategy to reverse cancer cachexia?
Publication date: March 2019Source: Journal of Functional Foods, Volume 54Author(s): Felipe Aguiar Pupo Seabra Malta, Debora Estadella, Daniela Caetano GonçalvesAbstractCancer cachexia is a complex multifactorial syndrome which etiology still under discussion, characterized by ongoing loss of skeletal muscle mass, accompanied or not by loss of fat mass. Cachexia cannot be reversed only by energetic-protein adequacy, so, many therapeutic strategies are being investigated. Omega-3 fatty acids are widely used and studied in cancer cachexia and many studies have shown improvement in inflammation status and muscle homeos...
Source: Journal of Functional Foods - January 13, 2019 Category: Nutrition Source Type: research

In-vitro inhibitory effects of flavonoids in Rosa roxburghii and R. sterilis fruits on α-glucosidase: Effect of stomach digestion on flavonoids alone and in combination with acarbose
Publication date: March 2019Source: Journal of Functional Foods, Volume 54Author(s): Jianzhong Zhu, Bin Zhang, Bingxu Wang, Chao Li, Xiong Fu, Qiang HuangAbstractInhibitory effects (IEs) of flavonoids from Rosa roxburghii and R. sterilis fruits against α-glucosidase were investigated. Crude extract of R. roxburghii fruits (RrCE) and R. sterilis fruits (RsCE) were extracted with ethanol. The n-butanol extraction of aqueous RrCE dispersion (RrCE-B) showed the greatest inhibition of α-glucosidase. The most abundant three components in RrCE-B were kaempferol hexose, rutin, and catechin (Cat). The predominant active...
Source: Journal of Functional Foods - January 13, 2019 Category: Nutrition Source Type: research

Sulfated polysaccharides from the edible marine algae Padina tetrastromatica protects heart by ameliorating hyperlipidemia, endothelial dysfunction and inflammation in isoproterenol induced experimental myocardial infarction
Publication date: March 2019Source: Journal of Functional Foods, Volume 54Author(s): V.S. Lekshmi, G. Muraleedhara KurupAbstractThe global concern of cardiovascular diseases (CVDs) has been increased, as it was declared as the top cause of mortality and morbidity worldwide. The edible marine algae are now considered as an important functional food ingredient or nutraceuticals as it contains many bioactive molecules. In the present study, cardioprotective properties of the sulfated polysaccharides from the edible marine algae, Padina tetrastromatica (PSPS) has been evaluated in isoproterenol (ISO) induced myocardial infarct...
Source: Journal of Functional Foods - January 13, 2019 Category: Nutrition Source Type: research

A metabolomic explanation on beneficial effects of dietary Goji on intestine inflammation
This study profiled faecal metabolomic changes of the same cohort of mice. Thirty-four compounds were altered due to Goji supplementation, including polyunsaturated long-chain fatty acids (PUFAs), sugar and sugar alcohols, benzene derivatives, pyridine derivatives, dicarboxylic acids and short-chain hydroxy acids. Pathway analysis showed that α-linolenic acid and linoleic acid metabolism were strongly affected by Goji supplementation. Four ω-6 PUFAs, including linoleic acid and arachidonic acid were reduced due to Goji supplementation. Faecal levels of most amino acids, positively correlated with gut inflammati...
Source: Journal of Functional Foods - January 12, 2019 Category: Nutrition Source Type: research

Microbial transglutaminase-mediated polymerization in the presence of lactic acid bacteria affects antigenicity of soy protein component present in bio-tofu
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Guangliang Xing, Concetta Valeria Lucia Giosafatto, Xin Rui, Mingsheng Dong, Loredana MarinielloAbstractThe aim of this study was to evaluate the antibody (Ab) reactivity of soy proteins present in bio-tofu made of soymilk or soymilk and cow milk mixture polymerized by microbial transglutaminase (MTGase) combined or not with lactic acid bacteria (LAB). Of all samples, the in vitro digestibility studies were also performed, together with Ab reactivity of the digests. In comparison with only MTGase or LAB treated samples, the use of LAB i...
Source: Journal of Functional Foods - January 10, 2019 Category: Nutrition Source Type: research

Effects of equivalent medium-chain diacylglycerol or long-chain triacylglycerol oil intake via muffins on postprandial triglycerides and plasma fatty acids levels
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Ayoung Lee, Hye Jin Yoo, Minkyung Kim, Minjoo Kim, Jong-Hun Choi, Chulyoung Lee, Jong Ho LeeAbstractWe assessed the effects of medium-chain diacylglycerol (MCDG) oil on postprandial triglycerides (TGs) and plasma fatty acids through a clinical trial (NCT03415568; clinicaltrials.gov). Meal tolerance tests using muffins containing 15 g of MCDG oil (MCDG muffins, test) or long-chain triacylglycerol (LCT) oil (LCT muffins, control) were conducted. Blood samples were collected under fasting conditions (0 h) and at 2, 3, 4, and 6 h afte...
Source: Journal of Functional Foods - January 10, 2019 Category: Nutrition Source Type: research

Immune enhancement activity of a novel polysaccharide produced by Dendrobium officinale endophytic fungus Fusarium solani DO7
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Ying-Jie Zeng, Hui-Rong Yang, Hong-Feng Wang, Min-Hua Zong, Wen-Yong LouAbstractA novel polysaccharide DG2 was obtained from the Dendrobium officinale endophytic fungus Fusarium solani DO7. The structural characterization and immunological activity of DG2 were investigated. Results showed that DG2 with the molecular weight of 152.8 kDa was composed of Galp, Manp, Glcp and Araf at a molar ratio of 4.3:1.9:2.8: 1.0. The main linkage types of DG2 were (1 → )-β-D-Glc, (1 → 4)-β-D-Glc, (1 → 3,6)-β-...
Source: Journal of Functional Foods - January 6, 2019 Category: Nutrition Source Type: research

Tryptophan residue enhances in vitro walnut protein-derived peptides exerting xanthine oxidase inhibition and antioxidant activities
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Qingyong Li, Chuanchao Shi, Min Wang, Mao Zhou, Ming Liang, Ting Zhang, Erdong Yuan, Zhi Wang, Maojin Yao, Jiaoyan RenAbstractThe modulation of xanthine oxidase (XO) activity is critical to the treatment of hyperuricemia and oxidative stress-related disease. Although the walnut protein hydrolysates had been reported to inhibit XO, their interaction mechanism remained unclear. Herein, the walnut protein-derived peptides were used to evaluate their in vitro XO-inhibitory activity and their inhibitory mechanism. The results suggested that ...
Source: Journal of Functional Foods - January 6, 2019 Category: Nutrition Source Type: research

Gut fermentation induced by a resistant starch rich whole grain diet explains serum concentration of dihydroferulic acid and hippuric acid in a model of ZDF rats
This study aimed at assessing the influence of an 11 weeks intervention with a resistant starch-enriched whole grain diet (HI-RS-WG, 25% RS) compared to a WG control diet (LOW-RS-WG, 6.9% RS) on serum profile of polyphenols (PPs) in 20 Zucker Diabetic Fatty rats. Five PPs were identified and quantified in serum samples of rats belonging to both intervention groups. HI-RS-WG rats had 2.6 folds higher serum concentrations of total PPs than LOW-RS-WG rats. An explorative data reduction approach, based on the Principal Component Analysis identified two principal components related to the gut microbiota fermentation and food ...
Source: Journal of Functional Foods - January 6, 2019 Category: Nutrition Source Type: research

Phosvitin and its hydrolysate promote differentiation and inhibit TNF-ɑ induced inflammation in MC3T3-E1 cells via ERK and AKT pathways
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Jiandong Ren, Subhadeep Chakrabarti, Jianping WuAbstractPhosvitin and its hydrolysate were reported to show antioxidant, anti-inflammation and antimicrobial activities. Given the critical role of inflammation on bone health, the work was designed to study the effects of phosvitin and its hydrolysate on osteoblast differentiation and inflammation in osteoblastic (MC3T3-E1) cells. Both phosvitin and its hydrolysate promoted osteoblast differentiation by upregulating expression of runt-related transcription factor 2, alkaline phosphatase (...
Source: Journal of Functional Foods - January 4, 2019 Category: Nutrition Source Type: research

Potential application of zerumbone in the prevention and therapy of chronic human diseases
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Yogendra Prakash Singh, Sosmitha Girisa, Kishore Banik, Sharad Ghosh, Pantheerayil Swathi, Manab Deka, Ganesan Padmavathi, Jibon Kotoky, Gautam Sethi, Lu Fan, Xinliang Mao, Clarissa Esmeralda Halim, Frank Arfuso, Ajaikumar B. KunnumakkaraAbstractSeveral active compounds from ‘Mother Nature’ have been found to be tailor-made therapeutics for the better management of numerous chronic ailments, with fewer adverse side effects. Zerumbone is one such molecule isolated from the rhizomes of Zingiber zerumbet (L.) Smith, a Zingibera...
Source: Journal of Functional Foods - December 30, 2018 Category: Nutrition Source Type: research

Protective effect of Lactobacillus delbrueckii subsp. Lactis CIDCA 133 in a model of 5 Fluorouracil-Induced intestinal mucositis
In conclusion, CIDCA 133 is able to prevent the intestinal mucosa damage caused by 5-FU revealing to be a promising strategy for intestinal mucositis treatment.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - December 30, 2018 Category: Nutrition Source Type: research

Modulation of LDL receptor expression and promoter methylation in HepG2 cells treated with a Corylus avellana L. extract
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Barbara Benassi, Chiara Santi, Stefania Santangeli, Maria Giuseppa Grollino, Giuseppe Raschellà, Loretta Bacchetta, Francesca PacchierottiAbstractThe aim of our study was to evaluate the impact of an ethanolic extract of C. avellana on the molecular pathway(s) regulating the low-density lipoprotein receptor (LDLR) in HepG2 cells, mainly in terms of epigenetics. We demonstrated that viability, proliferation and cell cycle distribution were not affected up to 72 h of treatment, whereas LDLR expression was stimulated as early as 2...
Source: Journal of Functional Foods - December 30, 2018 Category: Nutrition Source Type: research

Oleuropein aglycone attenuates the pro-angiogenic phenotype of senescent fibroblasts: A functional study in endothelial cells
In conclusion, OLE can modulate angiogenesis indirectly acting on local senescent fibroblasts, a new mechanism possibly contributing to the beneficial effects of the Mediterranean diet against cancer and cardiovascular diseases.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - December 30, 2018 Category: Nutrition Source Type: research

The immune-modulation and gut microbiome structure modification associated with long-term dietary supplementation of Lactobacillus rhamnosus using 16S rRNA sequencing analysis
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Yaser Gamallat, Xiaomeng Ren, Abdo Meyiah, Meiqi Li, Xinxiu Ren, Yazeed Jamalat, Siyuan Song, Luhan Xie, Bashir Ahmad, Abdullah Shopit, Haithm Mousa, Yufang Ma, Yi Xin, Dapeng DingAbstractProbiotic dietary supplementation plays a crucial role in shaping gut microbiota and boost immune-responses. We herein investigated the potential effect of long-term dietary-supplementation of Lactobacillus rhamnosus (LBR) on gut microbiome structure, metabolome functions, and serum-profile. Our results revealed, LBR long-term supplementation reduces t...
Source: Journal of Functional Foods - December 30, 2018 Category: Nutrition Source Type: research

Detailed chemical composition and functional properties of Ammodaucus leucotrichus Cross. & Dur. and Moringa oleifera Lamarck
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Borhane E.C. Ziani, Wahiba Rached, Khaldoun Bachari, Maria José Alves, Ricardo C. Calhelha, Lillian Barros, Isabel C.F.R. FerreiraAbstractEdible Ammodaucus leucotrichus Cross. & Dur. and Moringa oleifera Lamarck are largely used in the Algerian Sahara. In this context, soluble sugars, fatty acids, organic acids, and tocopherols were characterized. Decoctions and hydroethanolic extracts were studied regarding their phenolic compounds by HPLC-DAD-ESI/MSn, and in-vitro cytotoxic, anti-inflammatory, and antibacterial activities w...
Source: Journal of Functional Foods - December 30, 2018 Category: Nutrition Source Type: research

Polyphenol-rich blue honeysuckle extract alleviates silica-induced lung fibrosis by modulating Th immune response and NRF2/HO-1 MAPK signaling
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Jin Zhao, Jian Zang, Yang Lin, Yuehua Wang, Dongnan Li, Xianjun MengAbstractBlue honeysuckles are rich in polyphenol compounds that exert many beneficial effects. Previously, we demonstrated that polyphenol-rich blue honeysuckle extract (BHE) could alleviate silica-induced lung inflammation; however, its role in anti-fibrosis effects remains unknown. Here, we applied polyphenol-rich BHE to silica-injured mice to investigate its anti-fibrosis effect and the underlying mechanism. The results showed that BHE alleviated silica-induced pulmo...
Source: Journal of Functional Foods - December 29, 2018 Category: Nutrition Source Type: research

Bound polyphenol extracted from jujube pulp triggers mitochondria-mediated apoptosis and cell cycle arrest of HepG2 cell in vitro and in vivo
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Shuhua Shan, Yue Xie, Huiling Zhao, Jinping Niu, Sheng Zhang, Xiaoli Zhang, Zhuoyu LiAbstractChinese jujube which contains many nutrients, contributes to a healthy diet. Jujube pulp extracts are rich in polyphenol compounds exhibiting admirable pharmacological activities. In present, free and bound polyphenols extracted from jujube pulp were named JPFP and JPBP, respectively. Interesting, we found only JPBP exhibited prominent anti-tumor activity in HepG2 cells, and especially, it also had the same effect in nude mice tumor model. Furth...
Source: Journal of Functional Foods - December 29, 2018 Category: Nutrition Source Type: research

Tropical fruit by-products water extracts as sources of soluble fibres and phenolic compounds with potential antioxidant, anti-inflammatory, and functional properties
Publication date: January 2019Source: Journal of Functional Foods, Volume 52Author(s): Marcela Albuquerque Cavalcanti de Albuquerque, Romina Levit, Carolina Beres, Raquel Bedani, Alejandra de Moreno de LeBlanc, Susana Marta Isay Saad, Jean Guy LeBlancAbstractFibre content, phenolic content, antioxidant and anti-inflammatory activities were evaluated for water extracts of fruit by-products (passion fruit, orange, acerola, and mango). The impact of these extracts on microbial growth, folate production, and adhesion ability of Streptococcus thermophilus TH-4 and Lactobacillus rhamnosus LGG was investigated. Mango water extrac...
Source: Journal of Functional Foods - December 22, 2018 Category: Nutrition Source Type: research

Linseed oil improves hepatic insulin resistance in obese mice through modulating mitochondrial quality control
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Xiao Yu, Shasha Huang, Qianchun Deng, Yuhan Tang, Ping Yao, Hu Tang, Xuyan DongAbstractN-3 polyunsaturated fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), mitigate the progression of obesity-associated insulin resistance. However, the knowledge on the metabolic response and underlying mechanism of α-linolenic acid-rich linseed oil (ALA-LO) on insulin resistance was still limited. The results showed that lard-based high fat diet (HFD) feeding for 16 weeks (60% of total calories from fat) led to...
Source: Journal of Functional Foods - December 21, 2018 Category: Nutrition Source Type: research

Colonization and probiotic function of Bifidobacterium longum
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Chengcheng Zhang, Zhiming Yu, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wei ChenAbstractBifidobacterium longum, a common member of the gut microbiota throughout the human lifespan, has been widely reported to play a role in host health and disease. However, colonization of B. longum in the host intestine is the basis for its probiotic function. The colonization and abundance of B. longum in the human gut varies significantly among individuals, which have been suggested to be associated with the delivery mode, feeding type, age, geography, a...
Source: Journal of Functional Foods - December 20, 2018 Category: Nutrition Source Type: research

Probiotic Lactobacillus rhamnosus modulates the gut microbiome composition attenuates preneoplastic colorectal Aberrant crypt foci
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Yaser Gamallat, Xiaomeng Ren, Williams Walana, Abdo Meyiah, Ren Xinxiu, Yanyan Zhu, Meiqi Li, Siyuan Song, Luhan Xie, Yazeed Jamalat, Mohammad Zubair Saleem, Yufang Ma, Yi Xin, Dong ShangAbstractLactobacillus rhamnosus (LGG) is well documented strain with wide clinical applications. We investigated herein the possible protection role of LGG in against early preneoplastic colon carcinogenesis Aberrant crypt foci (ACF) in rat model. Sprague Dawley rats were pre-treated with or without LGG via oral gavage, followed by ACF induction with Di...
Source: Journal of Functional Foods - December 20, 2018 Category: Nutrition Source Type: research

Antioxidant and anti-inflammatory polyphenols and peptides of common bean (Phaseolus vulga L.) milk and yogurt in Caco-2 and HT-29 cell models
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Yuhuan Chen, Hua Zhang, Ronghua Liu, Lili Mats, Honghui Zhu, K. Peter Pauls, Zeyuan Deng, Rong TsaoAbstractCommon bean milks and their corresponding probiotic yogurts were developed and subjected to simulated gastrointestinal digestion before characterization and assessment of bioactivities. Only digestates fractions of molecular weight
Source: Journal of Functional Foods - December 19, 2018 Category: Nutrition Source Type: research

Effects of elicitation on bioactive compounds and biological activities of sprouts
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): HongKai Liu, YuFan Kang, XiaoYan Zhao, YunPeng Liu, XiaoWei Zhang, ShuJie ZhangAbstractFoods high in bioactive compounds become more and more popular and sprouts are an edible food with good nutritional values and health benefits. Elicitation is an effective tool to induce physiological changes in plants, and has been used for improving bioactive compounds of sprouts in many studies. The current review presents the effect of elicitation on bioactive compounds and biological activities of sprouts. Elicitation can enhance the accumulation...
Source: Journal of Functional Foods - December 19, 2018 Category: Nutrition Source Type: research

Tropical fruit by-products water extracts of tropical fruit by-products as sources of soluble fibres and phenolic compounds with potential antioxidant, anti-inflammatory, and functional properties
Publication date: January 2019Source: Journal of Functional Foods, Volume 52Author(s): Marcela Albuquerque Cavalcanti de Albuquerque, Romina Levit, Carolina Beres, Raquel Bedani, Alejandra de Moreno de LeBlanc, Susana Marta Isay Saad, Jean Guy LeBlancAbstractFibre content, phenolic content, antioxidant and anti-inflammatory activities were evaluated for water extracts of fruit by-products (passion fruit, orange, acerola, and mango). The impact of these extracts on microbial growth, folate production, and adhesion ability of Streptococcus thermophilus TH-4 and Lactobacillus rhamnosus LGG was investigated. Mango water extrac...
Source: Journal of Functional Foods - December 17, 2018 Category: Nutrition Source Type: research

Kefir reduces the incidence of pre-neoplastic lesions in an animal model for colorectal cancer
This study aimed to evaluate the effect of regular consumption of milk kefir on the development of pre-neoplastic colonic lesions. Thirty Wistar rats received water (Control group) or milk (Milk group) or kefir (Kefir group) during five weeks. After that, colonic lesions were chemically induced and the treatments continued for more thirteen weeks. The regular consumption of kefir was able to reduce the incidence of aberrant crypt foci by 36%. Also, the consumption of kefir increased the cecal concentration of short chain fatty acids; reduced the lactulose/mannitol ratio; promoted an increase in the colonic concentration of...
Source: Journal of Functional Foods - December 17, 2018 Category: Nutrition Source Type: research

A metabolome explanation on beneficial effects of dietary Goji on intestine inflammation
This study profiled fecal metabolomic changes of the same cohort of mice. Thirty-four compounds were altered due to Goji supplementation, including polyunsaturated long-chain fatty acids (PUFAs), sugar and sugar alcohols, benzene derivatives, pyridine derivatives, dicarboxylic acids and short-chain hydroxy acids. Pathway analysis showed that α-linolenic acid and linoleic acid metabolism were strongly affected by Goji supplementation. Four ω-6 PUFAs, including linoleic acid and arachidonic acid were reduced due to Goji supplementation. Fecal levels of most amino acids, positively correlated with gut inflammation...
Source: Journal of Functional Foods - December 17, 2018 Category: Nutrition Source Type: research

Predisposing factors of type 2 diabetes mellitus and the potential protective role of native plants with functional properties
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Collise Njume, Osaana Donkor, Andrew J. McAinchAbstractType 2 diabetes mellitus (T2DM) affects at least 285 million people globally and is at epidemic proportions within Indigenous communities in Australia. This review creates awareness about populations most at risk of T2DM, factors that accelerate rise of the disease and the potential protective role of plants with functional properties including non-native (Moringa oleifera Lam., Momordica charantia L., Panax ginseng L. and Curcuma longa L.) and native Australian (Terminalia ferdin...
Source: Journal of Functional Foods - December 17, 2018 Category: Nutrition Source Type: research

Effect of Lactobacillus reuteri on intestinal microbiota and immune parameters: Involvement of sex differences
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Jiayi He, Wenwen Wang, Zhen Wu, Daodong Pan, Yuxing Guo, Zhendong Cai, Liwei LianAbstractProbiotic candidate Lactobacillus reuteri DMSZ 8533 was screened out in vitro based on a relatively higher gastrointestinal tolerance and moderate adhesiveness. The organ index (spleen, thymus and liver), Interleukin-12 (IL-12), tumor necrosis factor-α (TNF-α), T-lymphocytes (CD3-, CD4- and CD-8 positive cells) and fecal microbiota composition were also investigated in BALB/c mice. Results showed a significant higher level of IL-12 at lo...
Source: Journal of Functional Foods - December 16, 2018 Category: Nutrition Source Type: research

An in vitro fermentation study on the effects of Dendrobium officinale polysaccharides on human intestinal microbiota from fecal microbiota transplantation donors
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Yousi Fu, Junnan Zhang, Kainan Chen, Chuanxing Xiao, Lina Fan, Bangzhou Zhang, Jianlin Ren, Baishan FangAbstractThe current study investigated the effects of Dendrobium officinale polysaccharides (DOP) on human intestinal microbiota composition and metabolism via in vitro fermentation. Following 48 h of fermentation, 63.88% ± 2.40% of the total carbohydrate in the DOP was consumed and pH decreased from 6.95 to 4.70. Meanwhile, the total short chain fatty acid (SCFA) productions significantly increased, with the major SCFA b...
Source: Journal of Functional Foods - December 16, 2018 Category: Nutrition Source Type: research

Lactobacillus plantarum helps to suppress body weight gain, improve serum lipid profile and ameliorate low-grade inflammation in mice administered with glycerol monolaurate
In this study, male C57BL/6J mice fed normal chow diet with or without GML supplementation were administered with Lactobacillus plantarum strains isolated from Chinese sourdough for 6 weeks to investigate the influence of GML and the L. plantarum strains on body weight, serum lipid profiles, inflammatory responses and gut microbiota. The results showed that L. plantarum could attenuate the adverse effects induced by GML, especially the strain L. plantarum ZJUFT17, which showed good performance in suppressing body weight gain, lowering total cholesterol, reducing the serum tumor necrosis factor (TNF)-α level and enh...
Source: Journal of Functional Foods - December 16, 2018 Category: Nutrition Source Type: research

Probiotic dairy-based beverages: A review
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Nazli Turkmen, Ceren Akal, Barbaros ÖzerAbstractThis review primarily focuses on the technology of commercially available milk-based probiotic beverages including acidophilus milk, bifidus milk, acidophilus-yeast milk, acidophilin, etc. These products have long been enjoying a market success especially in Europe, North America and Asia-Pacific countries. Cheese whey and buttermilk whey also offer suitable matrices for the growth and viability of probiotic microorganisms and, therefore, they are potential sources for the development...
Source: Journal of Functional Foods - December 16, 2018 Category: Nutrition Source Type: research

Chickpea (Cicer arietinum L.) sprouts containing supranutritional levels of selenium decrease tumor growth of colon cancer cells xenografted in immune-suppressed mice
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Daniela Guardado-Félix, Marilena Antunes-Ricardo, María R. Rocha-Pizaña, Ana-Carolina Martínez-Torres, Janet A. Gutiérrez-Uribe, Sergio O. Serna SaldivarAbstractThe effect of selenium enriched chickpea sprouts with and without isoflavonoids (IS) on colorectal cancer (CRC) tumor growth was evaluated in immune-suppressed mice xenografted. Two levels of selenium (0.17 and 2.29 µg/g) and isoflavonoids (0 and 2.34 mg/g) were evaluated in the diets. High intake of Se (2.29 µg/g) with and wi...
Source: Journal of Functional Foods - December 16, 2018 Category: Nutrition Source Type: research

Spent hen-derived ACE inhibitory peptide IWHHT shows antioxidative and anti-inflammatory activities in endothelial cells
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Yuchen Gu, Ying Liang, Jie Bai, Wei Wu, Qinlu Lin, Jianping WuAbstractThe pathophysiology of hypertension involves the interplay among renin-angiotensin system (RAS), oxidative stress and inflammation. Previous studies focused mainly on ACE inhibitory activity; the goals of this study were to characterize ACE inhibitory peptides from chicken and to investigate their potential antioxidative and anti-inflammatory activities. Spent hen muscle protein hydrolysate digested by thermolysin showed an IC50 value of 39.6 ± 2.3 µ...
Source: Journal of Functional Foods - December 16, 2018 Category: Nutrition Source Type: research

Cluster of differentiation 14 and toll-like receptor 4 are involved in the anti-inflammatory effects of tyrosol
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Chao-Yuan Chang, I-Tao Huang, Hung-Jen Shih, Ya-Ying Chang, Ming-Chang Kao, Ping-Chen Shih, Chun-Jen HuangAbstractWe investigated effects of tyrosol on upstream pathway regulating lipopolysaccharide (LPS)-induced inflammatory response, including cluster of differentiation 14 (CD14)-mediated LPS–macrophage binding, toll-like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD2) expression and subsequent myeloid differentiation primary response gene 88 (MyD88) and TIR-domain-containing adapter-inducing interferon-β (TRIF) re...
Source: Journal of Functional Foods - December 16, 2018 Category: Nutrition Source Type: research

Ilex paraguariensis, exercise and cardioprotection: A retrospective analysis
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Fábio Cahuê, José Hamilton Matheus Nascimento, Luciane Barcellos, Veronica P. SalernoAbstractStudies on strategies to generate cardioprotection have been on the rise. Previous work by our group with an ex vivo model of ischemia/reperfusion has shown that both short-term consumption of yerba mate (YM) and exercise can each preserve cardiac function independently. Surprising, the two strategies together do not, with apparent loss of their respective cardioprotection activity. To improve our understanding of mechanisms ...
Source: Journal of Functional Foods - December 16, 2018 Category: Nutrition Source Type: research