Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Yuan Tian, Robert G. Nichols, Pratiti Roy, Wei Gui, Philip B. Smith, Jingtao Zhang, Yangding Lin, Veronika Weaver, Jingwei Cai, Andrew D. Patterson, Margherita T. Cantorna The mechanisms by which white button (WB) mushrooms (Agaricus bisporus) may influence health are unclear. WB feeding (1%) resulted in changes in the composition of microbiota in conventional (CV) mice to expand a population of Prevotella that produce propionate and succinate. Microbial propionate and succinate production induced expression of genes important for intesti...
Source: Journal of Functional Foods - May 21, 2018 Category: Nutrition Source Type: research

Apiaceous vegetable intake modulates expression of DNA damage response genes and microRNA in the rat colon
In conclusion, apiaceous vegetable intake may be chemopreventive through modification of miRNA expression as well as P-glycoprotein expression in colon. Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - May 21, 2018 Category: Nutrition Source Type: research

Whole sorghum flour improves glucose tolerance, insulin resistance and preserved pancreatic islets function in obesity diet-induced rats
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Érica Aguiar Moraes, Rafaela da Silva Marineli, Sabrina Alves Lenquiste, Valéria Aparecida Vieira Queiroz, Rafael Ludemann Camargo, Patricia Cristine Borck, Everardo Magalhães Carneiro, Mário Roberto Maróstica Júnior The effects of sorghum flour fractions (whole and decorticated flours and bran) were evaluated for oxidative stress and obesity parameters in diet-induced obese rats. Compared to high fat-fructose groups, sorghum flour fractions reduced liver fat and whole sorghum flour decreased fast...
Source: Journal of Functional Foods - May 21, 2018 Category: Nutrition Source Type: research

Omega-3 LCPUFA supplementation improves neonatal and maternal bone turnover: A randomized controlled trial
Publication date: July 2018 Source:Journal of Functional Foods, Volume 46 Author(s): Naroa Kajarabille, Manuela Peña, Javier Díaz-Castro, Jose A. Hurtado, Luis Peña-Quintana, Carmen Iznaola, Yessica Rodríguez-Santana, Estefanía Martin-Alvarez, Magdalena López-Frias, Federico Lara-Villoslada, Julio J. Ochoa The aim of this study was to evaluate for the first time the effect of omega-3 LC PUFA supplementation during pregnancy and lactation on bone metabolism in mothers and neonates. 110 pregnant women were divided in two groups: control group (400 mL/day of the control dairy drink...
Source: Journal of Functional Foods - May 5, 2018 Category: Nutrition Source Type: research

Treatment of Dendropanax morbifera leaves extract improves diabetic phenotype and inhibits diabetes induced retinal degeneration in db/db mice
Publication date: July 2018 Source:Journal of Functional Foods, Volume 46 Author(s): Myeong-Gang Heo, Jae-Hyuk Byun, Jun Kim, Se-Young Choung To appraise the effects and involved mechanism of Dendropanax morbifera leaves extract (DLE) on diabetes and retinal degeneration, in this study, male C57BLKS/J-m+/db and five groups of db/db mice were treated with 0.5% CMC or metformin or three doses of DLE for 6 weeks. Administration of DLE stimulated AMP-activated protein kinase in the liver, skeletal muscle and adipose tissue, leading to the improvement of gene and protein expression related with insulin resistance and glucose...
Source: Journal of Functional Foods - May 5, 2018 Category: Nutrition Source Type: research

Mackerel-derived fermented fish oil protects skin against UVB-induced cellular damage by inhibiting oxidative stress
This study investigated the protective effect of mackerel-derived fermented fish oil (FFO) against UVB radiation-induced oxidative stress in human HaCaT keratinocytes and mouse skin tissue. FFO treatment scavenged UVB-induced intracellular reactive oxygen species and attenuated oxidative modifications including lipid peroxidation, protein carbonylation, and DNA damage. FFO treatment reduced UVB-induced apoptosis by reducing DNA fragmentation, caspase activation, and proapoptotic protein expression. UVB radiation activated phospho-extracellular signal-regulated kinase, phospho-c-Jun N-terminal kinase, and phospho-p38, where...
Source: Journal of Functional Foods - May 5, 2018 Category: Nutrition Source Type: research

Antihyperglycemic property and insulin secreting activity of hydroalcoholic shoot extract of Thymus caramanicus Jalas: A wild predominant source of food additive in folk medicine
Publication date: July 2018 Source:Journal of Functional Foods, Volume 46 Author(s): Najmeh Honari, Iran Pouraboli, Sedigheh Gharbi Thymus caramanicus Jalas is a plant that is widely used in the Iranian folk medicine; it serves as spices, tea, and herbal medicine. The present research was carried out to investigate its antidiabetic properties. Oral hydroalcoholic shoot extract of T. caramanicus Jalas (TCE; 300 and 500 mg/kg body weight) 30 min before glucose loading have be observed to improve oral glucose tolerance test in diabetic rats at 240 min. Daily TCE administration for 14 days also showed antihyperglycemi...
Source: Journal of Functional Foods - May 5, 2018 Category: Nutrition Source Type: research

The ginsenoside metabolite compound K inhibits hormone-independent breast cancer through downregulation of cyclin D1
Publication date: July 2018 Source:Journal of Functional Foods, Volume 46 Author(s): Seung Joon Lee, Ji Su Lee, Eunjung Lee, Tae-Gyu Lim, Sanguine Byun Various types of ginsenosides are present in ginseng and have been recognized for their health-promoting effects.Compound K (CK) is a metabolite ofginsenoside Rb1 and reportedly exerts chemotherapeutic effects against several types of cancers. However, the anti-cancer effect and the molecular mechanism of CK against hormone-independent breast cancer is unknown. Through a direct comparison, it was discovered that CK elicits the strongest anti-cancer effect against breast ca...
Source: Journal of Functional Foods - May 5, 2018 Category: Nutrition Source Type: research

Neuritogenic effect of sea cucumber glucocerebrosides on NGF-induced PC12 cells via activation of the TrkA/CREB/BDNF signalling pathway
In conclusion, SCGs possess a marked neuritogenic effect that promotes the signalling downstream from TrkA, likely via the MEK/ERK1/2/CREB/BDNF pathway. (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - May 5, 2018 Category: Nutrition Source Type: research

Effects of garlic-derived lipid soluble organosulfur compounds on hematological parameters in mice
Publication date: July 2018 Source:Journal of Functional Foods, Volume 46 Author(s): Ning Zhao, Min-Jie Guan, Ming-Jun Li, Tao Zeng The effects of garlic oil (GO) and 5 lipid soluble organosulfur compounds on hematological parameters were investigated. SPF male ICR mice were treated with 100 mg/kg body weight of GO, diallyl trisulfide (DATS), diallyl disulfide (DADS), diallyl sulfide (DAS), allyl methyl trisulfide (AMT), or allyl methyl disulfide (AMD) for 4 weeks. We found that 1 and 2 weeks of GO, DATS, and AMT treatment led to significant increase of the blood white blood cell (WBC) counts and a slight decrease o...
Source: Journal of Functional Foods - May 4, 2018 Category: Nutrition Source Type: research

The protective effects of mangiferin on metabolic and organs functions in the adolescent rat model of alcohol abuse
This study was carried out to investigate the beneficial effects and potential mechanism of mangiferin (MG) against the disorders of metabolic and organs functionsinduced by alcoholabuse (40% alcohol, 10 mL/kg day−1 BW, ig) in adolescent rats. MG administration (100 mg/kg·day−1 BW, ig) can effectively prevent the above disorders. The mechanisms of potential effect of MG were related to scavenged free radicals, increased the levels of serum calcium, estradiol, testosterone and bone density, and up-regulated brain GFAP, testes IRS-2 and ovaries GDF-9 expression levels. In addition, lipid accumulation...
Source: Journal of Functional Foods - May 4, 2018 Category: Nutrition Source Type: research

Brain uptake of hydroxytyrosol and its main circulating metabolites: Protective potential in neuronal cells
Publication date: July 2018 Source:Journal of Functional Foods, Volume 46 Author(s): María-Carmen López de las Hazas, Joana Godinho-Pereira, Alba Macià, A. Filipa Almeida, M. Rita Ventura, Maria-José Motilva, Cláudia N. Santos Hydroxytyrosol (HT) and oleuropein derivatives are the main phenolic compounds in virgin olive oil (VOO). After VOO intake, HT is extensively metabolized being hydroxytyrosol-sulphate (HT-S) and hydroxytyrosol-acetate sulphate (HT-AC-S) the main circulating metabolites detected in human plasma. The brain uptake and accumulation of HT and its metabolites were observ...
Source: Journal of Functional Foods - May 4, 2018 Category: Nutrition Source Type: research

Gallotannin derivatives from mango (Mangifera indica L.) suppress adipogenesis and increase thermogenesis in 3T3-L1 adipocytes in part through the AMPK pathway
In this study, 3T3-L1 preadipocytes were differentiated into adipocytes and treated with mango polyphenols (MG), or pyrogallol (PG) for 6 days. The anti-adipogenic activity of PG was demonstrated by reduced number of lipid droplets and expressions of adipogenic markers, such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα). In mature adipocytes, PG promoted adipocyte browning and increased the expressions of uncoupling protein 1 (UCP1) and sirtuin 1 (Sirt1). Knockdown of AMP-activated protein kinase (AMPK) α1 with siRNA partially abolished...
Source: Journal of Functional Foods - May 4, 2018 Category: Nutrition Source Type: research

A systematic review and meta-analysis of the probiotics and synbiotics effects on oxidative stress
Publication date: July 2018 Source:Journal of Functional Foods, Volume 46 Author(s): Javad Heshmati, Farnaz Farsi, Fatemeh Shokri, Mahroo Rezaeinejad, Amir Almasi-Hashiani, Samira Vesali, Mahdi Sepidarkish We performed a comprehensive search of medical bibliographic databases to identify interventional studies reporting the effect of probiotics (or synbiotics) supplementation on biomarkers of oxidative stress. Twenty seven articles that included 1363 subjects (709 cases and 699 controls) were included to our analyses. Oxidative stress parameters levels, including total antioxidant capacity (TAC) (0.31 mmol/L, 95% CI: 0....
Source: Journal of Functional Foods - April 28, 2018 Category: Nutrition Source Type: research

Potential protective effect of Trans-10-hydroxy-2-decenoic acid on the inflammation induced by Lipoteichoic acid
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Yi-Fan Chen, Meng-Meng You, Yi-Chen Liu, Yi-Zhen Shi, Kai Wang, Yuan-Yuan Lu, Fu-Liang Hu Royal jelly (RJ) is known as a functional food for its diverse health-beneficial properties and complicated chemical compositions. Trans-10-hydroxy-2-decenoic acid (10-HDA) is the exclusive lipid component in RJ. In the present study, the in vitro anti-inflammatory effect of 10-HDA in LTA (Lipoteichoic acid from Staphylococcus aureus) induced RAW 264.7 macrophages are evaluated. The results showed that 10-HDA had potent, dose-dependent inhibitory eff...
Source: Journal of Functional Foods - April 27, 2018 Category: Nutrition Source Type: research

( −)-Epicatechin and the colonic metabolite 3,4-dihydroxyphenylacetic acid protect renal proximal tubular cell against high glucose-induced oxidative stress by modulating NOX-4/SIRT-1 signalling
Publication date: July 2018 Source:Journal of Functional Foods, Volume 46 Author(s): David Álvarez-Cilleros, María Ángeles Martín, Luis Goya, Sonia Ramos Oxidative stress plays a main role in the pathogenesis of the diabetic nephropathy. The present study investigated the effect of (−)-epicatechin (EC) and the colonic-derived flavonoid metabolites 2,3-dihydroxybenzoic acid, 3,4-dihydroxyphenylacetic acid (DHPAA), and 3-hydroxyphenylpropionic acid on the redox status in high-glucose-exposed renal proximal tubular NRK-52E cells. EC and DHPAA (10 µM) alleviated the redox imbalance in...
Source: Journal of Functional Foods - April 27, 2018 Category: Nutrition Source Type: research

Effect of long-term administration of mangiferin from Belamcanda chinensis on bone metabolism in ovariectomized rats
In this study we evaluated the effect of mangiferin on ovariectomy-induced osteopenia in rats. Animals were randomized into four groups: SHAM (“sham” operated group) and three ovariectomized groups (OVX-C – controls; OVX-M10 – mangiferin 10 mg/kg/day and OVX-M30 – mangiferin 30 mg/kg/day). Mangiferin administration began 3 months after ovariectomy and was continued for 6 consecutive months. In mangiferin-treated rats we demonstrated decrease in bCTX (beta C-terminated telopeptide of type I collagen) level and increase in BMD (bone mineral density) comparing to OVX-C. Bone histomorphometr...
Source: Journal of Functional Foods - April 27, 2018 Category: Nutrition Source Type: research

Impact of thermal treatments on the bioaccessibility of phytoene and phytofluene in relation to changes in the microstructure and size of orange juice particles
In this study their bioaccessibility from thermally treated orange juices was analysed. Other carotenoids were also considered for comparison. Fresh, pasteurized, and ultrafrozen juices thawed at room temperature (UF-RT), in microwave oven (UF-MW), and in fridge (UF-FG) were investigated. Colourless carotenoids suffered less degradation as a result of ultrafreezing than xanthophylls. The carotenoid with highest bioaccessibility in the fresh juice was phytoene (10%). Total carotenoid bioaccessibility followed the order: Pasteurized > UF-MW > UF-RT > UF-FG > Fresh. The cells degrad...
Source: Journal of Functional Foods - April 27, 2018 Category: Nutrition Source Type: research

The beneficial effects of Gracilaria lemaneiformis polysaccharides on obesity and the gut microbiota in high fat diet-fed mice
This study indicated that dietary supplementation with GLPs reduced weight gain and improved body composition in high fat diet (HFD)-fed mice without reduced food consumption. Fat accumulation in the liver and adipose tissues was reduced by GLPs, and the damages of HFD on the intestine were repaired. These effects could be associated with the modulation of the gut microbiota, resulting in a specific microbiota that similar to normal microbiota. Changes in the gut microbiota may affect the expression of lipid-related genes via short chain fatty acids-dependent pathways. It revealed that GLPs can alleviate HFD-induced obesit...
Source: Journal of Functional Foods - April 27, 2018 Category: Nutrition Source Type: research

Traditional kefir reduces weight gain and improves plasma and liver lipid profiles more successfully than a commercial equivalent in a mouse model of obesity
This study investigated the ability of four traditional and one commercial kefir to control weight gain, plasma cholesterol, and liver triglycerides in a high fat diet-induced obesity mouse model. Two traditional kefirs decreased weight gain and plasma cholesterol levels. Conversely, commercial kefir had no beneficial effect. Additionally, one of the four traditional kefirs lowered liver triglycerides, which corresponded with decreases in the expression of fatty acid synthase, a gene involved in liver lipogenesis. Together with evidence of gut microbiome modulation, this study shows that traditional kefir has the potential...
Source: Journal of Functional Foods - April 27, 2018 Category: Nutrition Source Type: research

Synergistic effect of black tea polyphenol, theaflavin-3,3 ′-digallate with cisplatin against cisplatin resistant human ovarian cancer cells
Publication date: July 2018 Source:Journal of Functional Foods, Volume 46 Author(s): Haibo Pan, Jin Li, Gary O. Rankin, Yon Rojanasakul, Youying Tu, Yi Charlie Chen Theaflavin-3,3′-digallate (TF3) is a phenolic compound extracted from black tea. We previously demonstrated that TF3 selectively inhibited ovarian cancer cells. Ovarian cancer has high death rate because of acquired cisplatin resistance. We aimed to investigate the synergistic effect of TF3 and cisplatin (CDDP) against cisplatin resistant ovarian cancer cells. In the present study, combination treatment with TF3 and CDDP showed a synergistic cytotoxic ef...
Source: Journal of Functional Foods - April 27, 2018 Category: Nutrition Source Type: research

Myricetin prevents dopaminergic neurons from undergoing neuroinflammation-mediated degeneration in a lipopolysaccharide-induced Parkinson ’s disease model
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Bingxu Huang, Juxiong Liu, Dongxu Ma, Guangxin Chen, Wei Wang, Shoupeng Fu Myricetin, one of the lipophenolic compounds present in red wine, has been reported to pass through blood–brain barriers and reduce dopaminergic neuron degeneration, but the mechanism remains unclear. We thoroughly investigated the underlying mechanisms in Parkinson’s disease models both in vivo and in vitro. The neuroprotective effects of myricetin were assessed by performing behavioural test, immunohistochemistry and western blotting in vivo. The expr...
Source: Journal of Functional Foods - April 26, 2018 Category: Nutrition Source Type: research

Dietary functional flavonoids as natural hepatoprotective agents against acute liver injury from hop (Humulus lupulus L.)
This study reported the hepatoprotective effect of HF and the action could be through reducing oxidative stress, suppressing inflammation and apoptosis firsly. So HF could be a potential functional food against acute liver injury. Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - April 26, 2018 Category: Nutrition Source Type: research

Design cocoa processing towards healthy cocoa products: The role of phenolics and melanoidins
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Cinthya Nathaly Quiroz-Reyes, Vincenzo Fogliano Roasting and fermentation are key steps in cocoa processing that can be modulated to optimize the presence of health-promoting compounds in the final product. Roasting promote melanoidins formation and polyphenols depolymerization. Results of Forastero and Criollo cocoa beans were processed in different conditions showed that higher fat content and high phenolic content could promote melanoidins formation. Forastero variety had the highest melanoidins and phenols concentration under severe r...
Source: Journal of Functional Foods - April 26, 2018 Category: Nutrition Source Type: research

Brazilian insulin plant as a bifunctional food: Dual high-resolution PTP1B and α-glucosidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of antidiabetic compounds in Myrcia rubella Cambess
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Rita de Cássia Lemos Lima, Lucília Kato, Kenneth Thermann Kongstad, Dan Staerk Six species of Myrcia, commonly known as 'insulin plants' in Brazil, were assessed for their potential as functional foods. Thus, dual high-resolution α-glucosidase/PTP1B inhibition profiling and HPLC-HRMS-SPE-NMR analysis were used to identify the antidiabetic constituents of the crude ethyl acetate extract of M. rubella Cambess. A total of 31 compounds were identified, including seven α-glucosidase inhibitors with IC50 values between...
Source: Journal of Functional Foods - April 25, 2018 Category: Nutrition Source Type: research

Probiotic Minas Frescal cheese added with L. casei 01: Physicochemical and bioactivity characterization and effects on hematological/biochemical parameters of hypertensive overweighted women – A randomized double-blind pilot trial
This study aimed to evaluate the effects of Lactobacillus casei 01 on quality parameters of Minas Frescal cheese and to investigate the hematological and clinical effects of its regular consumption on hypertensive overweighed women (n = 30, 50 g, 28 days). Microbiological (lactic acid bacteria and probiotic counts), physicochemical parameters (proximate composition, pH, proteolysis, organic acid levels, and fatty acid profile), water mobility (TD-NMR), bioactivity [antioxidant and angiotensin I-converting enzyme (ACE) inhibitory activity], and microstructure were evaluated. The addition of L. casei 01 (108 CFU/g) did n...
Source: Journal of Functional Foods - April 23, 2018 Category: Nutrition Source Type: research

Endogenous synthesis of n-3 polyunsaturated fatty acids in fat-1 transgenic mice ameliorates streptozocin-induced diabetic nephropathy
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Yuan-Ming Zhang, Xiao-Hong Zhang, Pan Zhu, Rong-Hui Tan, Jin-Shun Zhao, Feng Wang, Jin-Jie Zhang, Wang Yan, Yang Xi, Jian-Bo Wan, Jing-Xuan Kang, Zu-Quan Zou, Shi-Zhong Bu Although n-3 polyunsaturated fatty acids (PUFAs) exhibit biological activity in many inflammatory diseases, their renoprotective effects against diabetic nephropathy (DN) have been controversial. Here, fat-1 transgenic mice were used to investigate the effects of n-3 PUFAs on streptozocin (STZ)-induced DN. Fat-1 mice exhibited increased renal n-3 PUFAs and n-3 PUFA-deri...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

DHA enriched phospholipids with different polar groups (PC and PS) had different improvements on MPTP-induced mice with Parkinson ’s disease
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Chengcheng Wang, Dan Wang, Jie Xu, Teruyoshi Yanagita, Changhu Xue, Tiantian Zhang, Yuming Wang Docosahexaenoic acid (DHA) enriched phospholipids such as phosphatidylcholine (PC) and phosphatidylserine (PS) are important bioactive components and widely distributed in multifarious marine products. In the present study, we investigated the effects of DHA enriched phospholipids with different polar groups (DHA-PC and DHA-PS) on MPTP-induced PD mice by behavioral experiments including rotarod test and open field test as well as immunohistoche...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

Coffee, type 2 diabetes and pancreatic islet function – A mini-review
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Adele Costabile, Kittiwadee Sarnsamak, Astrid C. Hauge-Evans Caffeinated and decaffeinated coffee consumption has increasingly been linked to reduced risks of type 2 diabetes. The condition is characterised by insulin resistance and pancreatic beta cell loss and dysfunction, leading to hyperglycaemia. Recent research has indicated that coffee components such as chlorogenic acid derivatives and cafestol positively modify the regulation of blood glucose levels in peripheral tissues. Taking into consideration bioavailability of coffee bioact...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

Transepithelial transport and structural changes of chicken angiotensin I-converting enzyme (ACE) inhibitory peptides through Caco-2 cell monolayers
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Papungkorn Sangsawad, Kiattawee Choowongkomon, David D. Kitts, Xiu-Min Chen, Eunice C.Y. Li-Chan, Jirawat Yongsawatdigul Permeability of angiotensin I-converting enzyme (ACE) inhibitory peptides (KPLLCS, ELFTT, and KPLL) identified from the in vitro gastrointestinal digest of cooked chicken breast was investigated using the Caco-2 cell model system. KPLLCS was originally the most effective ACE inhibitor (IC50 0.37 μM), but it was degraded during permeation through Caco-2 cells. Among these peptides, KPLL showed the highest permeabili...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

Anti-inflammatory and antioxidant effect of fermented whole wheat on TNF α-stimulated HT-29 and NF-κB signaling pathway activation
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Morena Gabriele, Laura Pucci, Julius Árvay, Vincenzo Longo The present study compared the phenolic profile, the in vitro and ex vivo antioxidant activity, as well as the anti-inflammatory effect of fermented (LG) and unfermented (FG) whole wheat flour from Triticum aestivum on tumor necrosis factor alpha (TNFα)-inflamed human intestinal epithelial cells (HT-29). Gallic acid, 3-hydroxybenzoic acid, and vanillic acid were identified by HPLC-DAD as the main polyphenols increased by fermentation. LG showed a higher antioxidant ac...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

Influence of acute ingestion and regular intake of green tea catechins on resting oxidative stress biomarkers assays in a paralleled randomized controlled crossover supplementation study in healthy men
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Mahendra P. Kapoor, Masaaki Sugita, Akinobu Nishimura, Akihiro Sudo, Tsutomu Okubo In this paralleled randomized controlled crossover study, we examined the hypothesis whether acute or regular green tea catechins (GTC) supplements have the potential to stimulate resting oxidative stress metabolites in healthy individuals. Sixteen subjects were randomly divided equally and assigned into regular intake (GTC-RI) or control group (GTC-CG) after the screening. GTC-RI group consumed 780 mg/day EGCG-enriched GTC (506 mg EGCG). While GTC-CG r...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

Bioactive constituents from Medicago sativa L. with antioxidant, neuroprotective and acetylcholinesterase inhibitory activities
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Xue-Gui Liu, Ming-Yuan Huang, Pin-Yi Gao, Chang-Feng Liu, Yu-Qiu Sun, Meng-Chao Lv, Guo-Dong Yao, Li-Xin Zhang, Dan-Qi Li Medicago sativa L. is an important source of functional foods and supplements, which can improve human health. The present work was carried out to search for potential antioxidants from M. sativa to treat neurodegeneration. Four new isoflavane glycosides (1–4) were isolated from M. sativa, along with seven known compounds (5–11). Their structures including absolute configurations were elucidated by multi-sp...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

Behavior of three hypocholesterolemic peptides from soy protein in an intestinal model based on differentiated Caco-2 cell
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Gilda Aiello, Simonetta Ferruzza, Giulia Ranaldi, Yula Sambuy, Anna Arnoldi, Giulio Vistoli, Carmen Lammi IAVPGEVA, IAVPTGVA, and LPYP, three peptides deriving from soy protein hydrolysis, inhibit the activity of 3-hydroxy-3-methylglutaryl CoA reductase (HMGCoAR) and modulate cholesterol metabolism in HepG2 cells. In order to assess whether these hypocholesterolemic peptides can be absorbed across the epithelium barrier, experiments were performed using human intestinal Caco-2 cell monolayers grown in two-compartments systems. Each peptid...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

Antioxidant activity of whole grain Qingke (Tibetan Hordeum vulgare L.) toward oxidative stress in d-galactose induced mouse model
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Xuejuan Xia, Yuxiao Xing, Guannan Li, Jinsong Wu, Jianquan Kan The effects of two varieties of Qingke (WGCQ, Changhei Qingke and WGPQ, Purple Qingke) on the oxidative stress-related biochemical indexes of d-galactose-treated mice (DT-mice) were investigated. Results showed that vitamin E (positive control), WGCQ, and WGPQ reduced the fasting plasma glucose, malondialdehyde, reactive oxygen species, plasma cortisol, and brain amyloid beta peptide (1–42) levels and increased the superoxide dismutase and glutathione peroxidase activiti...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

Phloridzin alleviate colitis in mice by protecting the intestinal brush border and improving the expression of sodium glycogen transporter 1
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Ying-yu Lu, Jian Liang, Shu-Xian Chen, Bing-xin Wang, Han Yuan, Can-tao Li, Ya-yun Wu, Yan-fang Wu, Xu-guang Shi, Jie Gao, Shao-zhen Hou Increasing reports showed that artificial food additives might increase the incidence of ulcerative colitis (UC). Phloridzin is a natural food additive and a pharmacologic agent, whether phloridzin could induce or treat UC is not clear. We investigated the effects of phloridzin on acute colitis in mice and elucidated the potential mechanism. Phloridzin was given to mice with acute UC induced by 4% dextra...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

Gamma-conglutin peptides from Andean lupin legume (Lupinus mutabilis Sweet) enhanced glucose uptake and reduced gluconeogenesis in vitro
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Erika B. Muñoz, Diego A. Luna-Vital, Marco Fornasini, Manuel E. Baldeón, Elvira Gonzalez de Mejia The present study aimed to analyze the mechanism of action of a hydrolyzed gamma-conglutin fraction (Cgh) extracted from Andean L. mutabilis legume on glucose metabolism. At 5 mg/mL, Cgh from L. mutabilis inhibited dipeptidyl peptidase IV activity (DPP-IV) (100%), and increased (p < 0.05) 6.5-fold the glucose uptake in a dual-layered enterocyte/adipocyte culture system compared to untreated cells, through an enhance...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

Chemical and nutritional properties of white bread leavened by lactic acid bacteria
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Michela Bottani, Milena Brasca, Anita Ferraretto, Gaetano Cardone, Maria Cristina Casiraghi, Giovanni Lombardi, Ivano De Noni, Stefano Cattaneo, Tiziana Silvetti Four LAB strains belonging to the Lactobacillus and Leuconostoc genera were investigated in experimental bread-making in comparison with Saccharomyces cerevisiae (SC). The derived breads were evaluated for microbiological and technological characteristics. Functional features associated to degradation of starch, release of gluten exorphins were investigated ante and post in vitro...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

Beneficial effects of a selected probiotic mixture administered to high fat-fed mice before and after the development of obesity
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Marianna Roselli, Alberto Finamore, Elisa Brasili, Rita Rami, Fabio Nobili, Carla Orsi, Angelo Vittorio Zambrini, Elena Mengheri We investigated the efficacy of different probiotics and bacteria used in dairy products to prevent the development of obesity and ameliorate established obesity in C57BL/6J mice fed a high fat diet (HFD). For the preventive efficacy, Lactobacillus rhamnosus GG, L. acidophilus LA1/K8, a mixture of Bifidobacterium lactis Bi1, B. breve Bbr8 and B. breve BL10 (B. mix), or a mixture of L. bulgaricus Lb2 and S. termo...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

Triterpene saponins with neuroprotective effects from a wild vegetable Aralia elata
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Yan Zhang, Wei Wang, Huan He, Xiao-yu Song, Guo-dong Yao, Shao-jiang Song Aralia elata (Miq.) Seem. is a highly nutritious wild vegetable widely consumed in China, it can be made into salad, dumplings, pickles and soup for its fresh smell. In the phytochemical investigation of the constituents of Aralia elata, three new triterpene saponins (1–3), named congmusaponin I, II and III, along with twelve known ones (4–15) were isolated from the 70% EtOH extract of buds. Their structures were determined on the basis of spectroscopic ...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

The effect of chewing on oral glucoraphanin hydrolysis in raw and steamed broccoli
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Irmela Sarvan, Michelle van der Klauw, Teresa Oliviero, Matthijs Dekker, Ruud Verkerk Chewing disrupts broccoli cells, and myrosinase can effectively hydrolyze the glucosinolate glucoraphanin into the biological active sulforaphane. The influence of chewing time and steaming time on glucoraphanin hydrolysis as well as sulforaphane and sulforaphane nitrile formation in broccoli was studied. To study the effect of chewing time on differently steamed broccoli, broccoli was chewed for 11 s, 22 s, 30 s and 40 s by volunteers. To determ...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

10-Hydroxy-trans-2-decenoic acid attenuates angiotensin II-induced inflammatory responses in rat vascular smooth muscle cells
In this study, the rat vascular smooth muscle cells (VSMCs) were pretreated with 10-HDA (250 μM, 500 μM, 1000 μM), followed by incubation with Angiotensin II (Ang II, 100 nM). 10-HDA significantly reduced the productions of Ang II induced inflammatory cytokines interleukin 6 and C-reactive protein, through downregulating the nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. 10-HDA also attenuated the Ang II-stimulated reactive oxygen species production and the NADPH oxidase 4 (NOX4) expression. Further mechanistic studies showed that 10-HDA reduced the ele...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

Liensinine suppresses STAT3-dependent HK2 expression through elevating SHP-1 to induce apoptosis in hepatocellular carcinoma cells in vitro and in vivo
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Guangwen Shu, Ji Hao, Wei Li, Lang Zhang, Yunhan Qiu, Xinzhou Yang Liensinine is an alkaloid from the embryos of Nelumbo nucifera Gaertn. Here, we revealed that liensinine induces hepatocellular carcinoma (HCC) cell apoptosis. Accumulation of ROS participates in liensinine-induced apoptosis. Mechanically, liensinine inhibits the expression of hexokinase 2 (HK2) and metabolism of glucose through glycolysis. In addition, liensinine increases SHP-1 expression, impairs STAT3 transactivity, and declines the binding between STAT3 and HK2 promot...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

A novel collagen glycopeptide, Pro-Hyp-CONH-GlcN, stimulates cell proliferation and hyaluronan production in cultured human dermal fibroblasts
This study investigated the effects of POGlcN on dermal fibroblast growth, hyaluronan production, and the underlying mechanism. The results suggest that the plasma digestion-resistant POGlcN stimulated the proliferation of cultured human dermal fibroblasts in a time- and concentration-dependent manner with optimal performance at 200 nmol/mL and 6 days. Comparable to Pro-Hyp, POGlcN increased the cell number to 1.5-fold and HA production to 1.4-fold of control. Edu labeling-assisted cell cycle analysis revealed that POGlcN modulated the cell cycle of fibroblasts by arresting more cells in DNA synthesis phase. Moreover, ...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

Physicochemical differences between malanga (Xanthosoma sagittifolium) and potato (Solanum tuberosum) tubers are associated with differential effects on the gut microbiome
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Brittany L. Graf, Li Zhang, Maria G. Corradini, Peter Kuhn, Susan S. Newman, J. Michael Salbaum, Ilya Raskin Malanga (Xanthosoma sagittifolium) is used as a medicinal food for infant development and gastritis. We compared the physicochemical properties and gut microbial effects of malanga versus potato (Solanum tuberosum) using nutritional analysis, rheometry, in vitro TNO Intestinal Model, and C57Bl/6J mouse models. Malanga was characterized by higher starch (70.7% v. 66.3%), lower amylose:amylopectin (0.33 v. 0.59), higher free sugar (5...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

Calendula L. species polyphenolic profile and in vitro antifungal activity
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Maria V. Faustino, Diana C.G.A. Pinto, Maria José Gonçalves, Lígia Salgueiro, Paulo Silveira, Artur M.S. Silva Calendula officinalis is an edible and medicinal plant with recognised economic value. What about the other Calendula species? This work aims to provide in-depth information about the UHPLC-MS/MS profile of other Portuguese Calendula species and in doing so contribute to answer that question. The knowledge on the metabolic machinery from C. arvensis, C. suffruticosa subsp. algarbiensis and lusitanica growing ...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

Diet containing a polyphenol concentrate from pomegranate juice attenuates contact hypersensitivity in mice
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Takao Nagano, Hideyuki Ito Murine contact hypersensitivity (CHS) is an animal model of allergic contact dermatitis (ACD). We investigated the inhibitory effects of dietary pomegranate polyphenol concentrate (PPC) on CHS. Mice were fed diets containing low or high doses of PPC for 3 weeks prior to CHS induction. Both the low- and high-dose PPC diets attenuated ear swelling and edema, and resulted in reduced infiltration of Gr-1-positive myeloid cells into ear tissues. The ear tissues of PPC-treated mice exhibited reduced mRNA expression ...
Source: Journal of Functional Foods - April 22, 2018 Category: Nutrition Source Type: research

The contribution of α-dicarbonyl compound dependent radical formation to the antiseptic effect of honey
In this study we investigated free radical formation and inhibition in different honeys and the influence on bacterial growth inhibition. α-Oxaldehydes and free amino acids were shown to be present in manuka and non-manuka honeys. With electron spin resonance we measured that methylglyoxal (MG) and glyoxal (GO) form different carbon centered radicals under the influence of either hydrogen peroxide or arginine and lysine. These radicals were also formed in a combination of α-oxaldehydes and amino acids in artificial honey, which was quantified by the cytochrome C assay. Also, a strong bactericidal activity for M...
Source: Journal of Functional Foods - April 17, 2018 Category: Nutrition Source Type: research

Clinical trials using functional foods provide unique challenges
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Lindsay Brown, Stephanie P.B. Caligiuri, Dan Brown, Grant N. Pierce Clinical trials usually evaluate medicines as the intervention of choice to improve health. Changing the intervention to a functional food would appear straightforward, but there are many unique technical issues that will confront the Principal Investigator and research team. These challenges are found in each of the three distinct phases of a trial: the initial organisation of the trial, running the trial, and finally, the dissemination of the data following successful c...
Source: Journal of Functional Foods - April 17, 2018 Category: Nutrition Source Type: research

Immunomodulatory effect of Ganoderma atrum polysaccharides on Th17/Treg balance
Publication date: June 2018 Source:Journal of Functional Foods, Volume 45 Author(s): Quandan Xiang, Qiang Yu, Hui Wang, Mingming Zhao, Shiyu Liu, Shaoping Nie, Mingyong Xie Th17 and regulatory T (Treg) cells are two new subsets of T cells. An increasing number of evidences suggest that Th17/Treg balance plays a vital role in maintenance of immune homeostasis. The present study aims to investigate the immunomodulatory effect of Ganoderma atrum polysaccharide (PSG-1) on Th17/Treg balance. In vitro study found that PSG-1 could inhibit Th17 and Treg cell differentiation from spleen under Th17- and Treg-polarizing condition, r...
Source: Journal of Functional Foods - April 14, 2018 Category: Nutrition Source Type: research