Dandelion (Taraxacum officinale L.) root components exhibit anti-oxidative and antiplatelet action in an in vitro study
Publication date: August 2019Source: Journal of Functional Foods, Volume 59Author(s): Bernadetta Lis, Agata Rolnik, Dariusz Jedrejek, Agata Soluch, Anna Stochmal, Beata OlasAbstractThe effect of dandelion root and its various ingredients on the biological functions of blood platelets has not been well investigated. Thus, the objective of our in vitro study was to examine the five root fractions (A–E), differing in chemical composition, for changes induced in the human platelets’ model using selected hemostatic parameters. As a result, the best anti-platelet potential was shown by preparation enriched with hydro...
Source: Journal of Functional Foods - May 21, 2019 Category: Nutrition Source Type: research

Chicoric acid promotes glucose uptake and Akt phosphorylation via AMP-activated protein kinase α-dependent pathway
Publication date: August 2019Source: Journal of Functional Foods, Volume 59Author(s): Ye Peng, Quancai Sun, Yeonhwa ParkAbstractChicoric acid is a naturally-occurring dicaffeoyl ester often found in chicory. Based on previous studies chicoric acid ameliorated insulin resistance in human hepatoma cells, the current study was undertaken to investigate the effects of chicoric acid on glucose homeostasis in C2C12 myotubes and male C57BL/6J mice. Chicoric acid (25 µM) significantly enhanced glucose uptake and the phosphorylation of protein kinase B (Akt) independent of insulin in C2C12 myotubes. Consistently, glucose to...
Source: Journal of Functional Foods - May 19, 2019 Category: Nutrition Source Type: research

Effects of naringenin on renal expression of organic cation transporter 1 and 2 proteins and metformin disposition in diabetic rats
Publication date: August 2019Source: Journal of Functional Foods, Volume 59Author(s): Edith Pascale Mofo Mato, M. Faadiel Essop, Peter Mark Oroma OwiraAbstractModulation of metformin transporters could affect its pharmacokinetics/pharmacodynamics. The effects of naringenin on the renal tubular Organic Cation Transporter 1 (OCT1) and 2 (OCT2) protein expressions and subsequently the metformin clearance in diabetic rats are hereby investigated. Male Sprague Dawley rats were divided into 7 groups. Animals were daily treated orally with metformin (250 mg/kg) or naringenin (60 mg/kg) alone or both for 56 days. Blood gluco...
Source: Journal of Functional Foods - May 19, 2019 Category: Nutrition Source Type: research

(−)-Epicatechin modifies body composition of the male offspring of obese rats
In conclusion, the administration of long Epi protocol elicited better results in decreasing total fat and all fat deposits and increased lean mass. However, only the short Epi protocol increased the total BMD in the male offspring.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - May 17, 2019 Category: Nutrition Source Type: research

Antioxidant and anticancer effects in human hepatocarcinoma (HepG2) cells of papain-hydrolyzed sorghum kafirin hydrolysates
This study reported antioxidant and anticancer properties of papain-hydrolyzed sorghum kafirin. The optimum hydrolysis conditions were determined to be 360 kU/g enzyme-to-substrate ratio, and 4 h of reaction time. After ultrafiltration, the 1–3 kDa hydrolysate fraction demonstrating promising antioxidative activities as well as yield was selected for further analyses. In an oil-in-water emulsion system, the incorporation of the selected fraction of hydrolysates at 10 mg/mL resulted in an average inhibition of primary and secondary oxidation products by 53.7% and 43.0%, respectively, without significantly chan...
Source: Journal of Functional Foods - May 17, 2019 Category: Nutrition Source Type: research

Intake of green tea products and obesity in nondiabetic overweight and obese females: A systematic review and meta-analysis
The objective is to examine its effectiveness in the following indicators of obesity: body mass index (BMI), body weight, waist circumference, waist-to-hip ratio, and % body fat upon the intervention of GT products in nondiabetic overweight and obese females. For review and analysis, multiple databases were searched and a total of six studies was found. The results revealed that the treatment group who received GT products underwent statistically significant reductions in BMI, body weight, waist circumference and % body fat. The placebo group experienced decreases in BMI and body weight. Analyses of the differences in post...
Source: Journal of Functional Foods - May 16, 2019 Category: Nutrition Source Type: research

Systematic evaluation of polyphenols composition and antioxidant activity of mulberry cultivars subjected to gastrointestinal digestion and gut microbiota fermentation
In this study, mulberry cultivars were found to have abundant bioactive compounds such as phenolics (100.97–586.23 mg gallic acid equivalents/100 g fresh weight), flavonoids (16.38–368.16 mg rutin equivalents/100 g fresh weight) and procyanidins (4.20–121.56 mg catechin equivalents/100 g fresh weight) after in vitro digestion. HPLC-TOF-MS analysis revealed that digested mulberry cultivars contained multiple phenolic compounds including cyanidin-3-O-glucoside and cyanidin-3-O-rutinoside. After gut microbiota fermentation, the contents of anthocyanins were increased initially, then decreased wit...
Source: Journal of Functional Foods - May 16, 2019 Category: Nutrition Source Type: research

The postprandial inflammatory response is attenuated by a dietary structured lipid containing behenic acid
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Reginaldo Marques da Silva, Débora Kono Taketa Moreira, Melina Luzzi Zarricueta, Cíntia Rabelo e Paiva Caria, Juliana Alves Macedo, Gabriela Alves Macedo, Alessandra GamberoAbstractA high-fat meal can induce a postprandial inflammatory response, characterized mainly by increased serum levels of interleukin (IL)-6 and endotoxemia. We developed a structured lipid rich in behenic acid via enzymatic interesterification of a blend of soy, olive, and fully hydrogenated crambe oil, and evaluated its ability to induce postprandial inf...
Source: Journal of Functional Foods - May 16, 2019 Category: Nutrition Source Type: research

Sargahydroquinoic acid, a major compound in Sargassum serratifolium (C. Agardh) C. Agardh, widely activates lipid catabolic pathways, contributing to the formation of beige-like adipocytes
In conclusion, SHQA may activate PPARγ, PPARα, and AMPKα, contributing to the stimulation of lipid catabolic pathways and adipocyte browning. Therefore, SHQA may be used as a novel pharmaceutical agent to combat obesity and associated metabolic syndrome.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - May 16, 2019 Category: Nutrition Source Type: research

Editorial Board
Publication date: June 2019Source: Journal of Functional Foods, Volume 57Author(s): (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - May 16, 2019 Category: Nutrition Source Type: research

Bioactive compounds of probiotic Saccharomyces cerevisiae strains isolated from cucumber jangajji
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Na-Kyoung Lee, Ji-Young Hong, Sung-Hun Yi, Sang-Pil Hong, Jang-Eun Lee, Hyun-Dong PaikAbstractThe bioactive compounds and probiotic properties of three Saccharomyces cerevisiae strains isolated from cucumber jangajji were investigated. The β-glucan contents of S. cerevisiae KU200270, KU200280, and KU200284 were 4.09%, 7.45%, and 13.97%, respectively, and the glutathione contents of the strains were in the range of 3.19–6.03 mg/g dry cells. The l-ornithine and spermidine contents were 2.98–4.29 and 4.29–4.55 mg/g d...
Source: Journal of Functional Foods - May 16, 2019 Category: Nutrition Source Type: research

Enterococcus faecalis milk fermentates display antioxidant properties and inhibitory activity towards key enzymes linked to hypertension and hyperglycaemia
In this study, Enterococcus faecalis milk fermentates were assayed for total phenolic content, related antioxidant activity and the inhibition of key enzymes linked to hypertension and hyperglycaemia. Of the 25 isolates, milk fermented with E. faecalis DPC5154 had the highest level of total phenolic compounds (739.06 µg GAE/ml) and demonstrated the highest level of Trolox Equivalent Antioxidant Activity (TEAA) based on DPPH radical scavenging activity and ferric reducing antioxidant power (271.27 TEAA (µM) and 272.75 TEAA (µM), respectively). Inhibition of Angiotensin Converting Enzyme (ACE) and α...
Source: Journal of Functional Foods - May 14, 2019 Category: Nutrition Source Type: research

Anti-pancreatic-cancer effect of a newly bred cabbage line, Amtak-ssamchae, is mediated by a reduction in regulatory-T-cell recruitment
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Sunggun Kim, Soo Jeong Kim, Eun-Sang Jo, Kicheol Gil, Na-Yeon Kim, Ji Sung Park, Dongbok Park, So-Young Park, Kwang Woo HwangAbstractWe aimed to investigate possible anticancer effects of Amtak-ssamchae (a newly bred cabbage line containing more carotenoids) in an in vitro pancreatic-tumor cell model and an in vivo model (Panc02 cells). In an in vitro assay, Amtak-ssamchae significantly reduced the viability of Panc02 cells relative to normal ssamchae. Furthermore, an Amtak-ssamchae extract significantly reduced the tumor size in mice inocu...
Source: Journal of Functional Foods - May 14, 2019 Category: Nutrition Source Type: research

Insulin resistance accelerated the clearance of resveratrol: A note of caution
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Zhixia Qiu, Qiuyan Liu, Jiaojiao Yu, Yu Dai, Xiaonan Li, Fang Huang, Ning LiAbstractTrans-resveratrol (RES), a well-known polyphenol exerts various health-promoting benefits, including glucose homeostasis maintenance. Here, we have investigated the impact of insulin resistance (IR) on RES disposition. Rats were fed with 10%-fructose-water for 8 weeks for developing IR. The systemic exposure to RES significantly decreased (IR vs normal, AUC0-24h, 1.73, 3.79, 9.27 vs 2.50, 6.12, 12.6 μM∙h, 20, 50, 100 mg/kg, p 
Source: Journal of Functional Foods - May 14, 2019 Category: Nutrition Source Type: research

Extruded sorghum (Sorghum bicolor L.) improves gut microbiota, reduces inflammation, and oxidative stress in obese rats fed a high-fat diet
In conclusion, ESF improves the intestinal dysbiosis, inflammation and oxidative stress in obese rats fed a hyperlipid diet.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - May 13, 2019 Category: Nutrition Source Type: research

Modulation of Akt-p38-MAPK/Nrf2/SIRT1 and NF-κB pathways by wine pomace product in hyperglycemic endothelial cell line
This study investigates the pathways involved in the effects of a red wine pomace product (rWPP) against inflammatory and oxidative damage in hyperglycemic EA.hy926 endothelial cells. rWPP-digested fractions showed an inhibitory effect on IKK/IκBα/NF-κB pathway and a stimulatory effect on Akt-p38-MAPK/Nrf2 pathway with an impact on their antioxidant and anti-inflammatory downstream targets. In addition, the pathways regulation was also accompanied by downregulation of the gene expression of superoxide dismutase 2, cyclooxygenase 2 and NADPH oxidase 4. These results suggest the expression of SOD2 as a...
Source: Journal of Functional Foods - May 11, 2019 Category: Nutrition Source Type: research

Metabolic profiling and investigations on crude extract of Olea europaea L. leaves as a potential therapeutic agent against skin cancer
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Debabrata Majumder, Mousumi Debnath, K.V. Libin Kumar, Priyatosh Nath, Rahul Debnath, Chaitali Sarkar, G.B.K.S. Prasad, Yogesh Kumar Verma, Debasish MaitiAbstractOlive (Olea europaea L.) leaf extract (OLE) have shown therapeutic activity against different types of cancer. However, it is less known that olive leaf extract has anti myeloma activity. The in vitro cytotoxic activity of OLE was evaluated against mouse metastatic melanoma B16F10 cell lines. The extracts were analyzed for their antioxidant activity by DPPH radical scaven...
Source: Journal of Functional Foods - May 11, 2019 Category: Nutrition Source Type: research

Enhanced bioavailability of iron from spray dried whey protein concentrate-iron (WPC-Fe) complex in anaemic and weaning conditions
The objective of this study was to assess the bioavailability of iron from spray dried whey protein concentrate-iron (WPC-Fe) complex in weaning and anaemic rats. Blood hemoglobin level, bioavailability, lipid profile, antioxidant status and concentration of iron delivery molecules were analysed under in vivo conditions. Hemoglobin level, % apparent digestibility coefficient and % retention/intake were increased in weaning and anaemic rats on 7th and 28th days. Additionally, WPC-Fe supplementation reduced nitric oxide (NO) production, maintained serum triglycerides, total cholesterol, LDL, VLDL and HDL-cholesterol. Simulta...
Source: Journal of Functional Foods - May 11, 2019 Category: Nutrition Source Type: research

Identification of bioactive peptides from half-fin anchovy (Setipinna taty) hydrolysates and further modification using Maillard reaction to improve antibacterial activities
This study investigated the effect of Maillard reaction (MR) on the antibacterial activity of half-fin anchovy hydrolysates (HAHp)-derived peptides. Eighty-two peptides (450–1400 Da) were identified from the peptidic-fraction F3 and were classified into five groups according to the presence of W, F, Y, K, H, and R residues in sequences. Increases of antibacterial activity and glycosylation contents were found in the Maillard reaction products (MRPs) of synthetic peptides including HLRVGW (Syn-pep1), KWTRPMY (syn-pep2) and KLWHHTF (syn-pep3). Soluble melanoidins (SMs) (
Source: Journal of Functional Foods - May 10, 2019 Category: Nutrition Source Type: research

l-histidine and l-carnosine accelerate wound healing via regulation of corticosterone and PI3K/Akt phosphorylation in d-galactose-induced aging models in vitro and in vivo
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Yerin Kim, Eunju Kim, Yuri KimAbstractImpaired skin wound healing in the elderly can lead to medical issues and increased mortality. Although l-histidine and l-carnosine are potent anti-aging amino acids, the wound healing effects of these amino acids in aging remain to be elucidated. Here, we investigated the regenerative potential of l-histidine and l-carnosine in in vitro and in vivo aging models. l-histidine (1 mM), l-carnosine (10 mM), or a combination improved proliferation, migration, senescence, and epithelial-mesenchymal transi...
Source: Journal of Functional Foods - May 10, 2019 Category: Nutrition Source Type: research

Thelenota ananas saponin extracts attenuate the atherosclerosis in apoE−/− mice by modulating lipid metabolism
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Qi-An Han, Shiliang Jia, Kaifeng Li, Yinqiang Sui, Hui Hong, Xiuping Dong, Yongkang Luo, Beiwei ZhuAbstractAs one of the most nutrient-rich marine species, Thelenota ananas has various effects, but its antiatherosclerosis activity has yet to be plumbed in depths. In this work, T. ananas saponin extracts were used to assess the effect on atherosclerosis development in the apoE−/− mice. In detail, the saponin treated groups clearly showed an inhibitory effect on the size of aortic atheromatous plaque, and the levels of serum lipid...
Source: Journal of Functional Foods - May 10, 2019 Category: Nutrition Source Type: research

Polyphenols from Morchella angusticepes Peck attenuate D-galactosamine/lipopolysaccharide-induced acute hepatic failture in mice
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Qiming Wang, Keke Lu, Fuhua Li, Lin Lei, Jichun Zhao, Surui Wu, Ran Yin, Jian MingAbstractWe investigated the effect of polyphenols extracted from M. angusticepes Peck (PMP) on D-galactosamine/lipopolysaccharide (D-GalN/LPS) induced acute hepatic failure (AHF) in mice. Results indicated that administration of PMP relieved the leakage of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). The level of serum ALT was reduced in groups of P-H (800 mg PMP/kg BW) and P-L (400 mg PMP/kg BW) by 44.6% and 31.8%, respective...
Source: Journal of Functional Foods - May 10, 2019 Category: Nutrition Source Type: research

Protective effect of S-allyl cysteine-enriched black garlic on reflux esophagitis in rats via NF-κB signaling pathway
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Kyeong Jo Kim, Soo Hyun Kim, Mi-Rae Shin, Young Jun Kim, Hae-Jin Park, Seong-Soo RohAbstractThe present study was conducted to determine whether black garlic (BG) which is aged by pectinase treatment with high hydrostatic pressure processing has the protective effects in experimental model of acute reflux esophagitis (RE). BG was orally administered at a dose of 100 mg/kg body weight 2 h prior to induction of RE, and the effects were compared with those of raw garlic (RG). Esophageal pathological changes were analyzed using gross and hi...
Source: Journal of Functional Foods - May 10, 2019 Category: Nutrition Source Type: research

Anti-allergic activity of polyphenolic compounds isolated from olive mill wastes
We report the isolation and anti-allergic activity (degranulation reduction) of six polyphenolic compounds, one of them being novel, from olive mill wastes (OMW). Additionally, we evaluated their ability to reduce; intracellular Ca2+ levels and expression of calcium channel proteins in RBL-2H3 cells, to assist the possible characterization of the mechanisms involved. The novel compound, new hemialdehydic decarboxymethylated oleuropein aglycone, HDOA 1 (IC50 = 108.3 µM), hydroxytyrosol acetate 3 (IC50 = 40.2 µM) and 1-acetoxypinoresinol 4 (IC50 = 43.8 µM) reduced intracellular Ca2+ levels...
Source: Journal of Functional Foods - May 10, 2019 Category: Nutrition Source Type: research

Ethanol extracts of Panax notoginseng increase lifespan and protect against oxidative stress in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Si-Yi Jin, Dang-Qing Li, Shan Lu, Lin-Tao Han, Da-Hui Liu, Zhuang Huang, Bi-Sheng Huang, Yan CaoAbstractPanax notoginseng (Burk.) F.H. Chen (PN) has been widely used as an edible and medicinal resource in China, with PN powder being used in dosage form. The present study aimed to investigate the optimal powder size of PN and evaluate its anti-ageing effect in Caenorhabditis elegans. Firstly, four PN powders of different sizes were prepared and their extracts were obtained. These extracts improved the lifespan of Caenorhabditis elegans, with...
Source: Journal of Functional Foods - May 10, 2019 Category: Nutrition Source Type: research

Allium fistulosum (Welsh onion) and Portulaca oleracea increase longitudinal bone growth in weanling rats possibly by promoting TGF-β and IGF-1 signaling
In conclusion, WO and PO are potential to promote the proliferation of the leg growth plate similar to growth hormone.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - May 8, 2019 Category: Nutrition Source Type: research

Osteoprotective effect of genistein 7-O-phosphate, a derivative of genistein with high bioavailability, in ovariectomized rats
In this study, we assessed the ability of G7P to prevent bone loss in rats with ovariectomy. Twelve-week-old female rats underwent ovariectomy, and genistein or G7P was administered to rats 2 weeks after the surgery by daily oral gavage for another 12 weeks. After sacrifice at the 12th week, the femurs were analyzed by micro computed tomography, histology and biomechanical study. G7P administration prevented the loss of bone mineral density and the reduced Young’s modulus caused by ovariectomy and improved bone architecture observed in histology and tomography. Additionally, G7P treatment resulted in a higher pla...
Source: Journal of Functional Foods - May 8, 2019 Category: Nutrition Source Type: research

Piceatannol effectively counteracts glyceraldehyde-3-phosphate dehydrogenase aggregation and nuclear translocation in hippocampal cells
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Joanna Gerszon, Martyna Wojtala, Sylwia Michlewska, Aleksandra RodackaAbstractThere is increasing evidence that supplementation with superfoods is one of the available solution to prevent or slow down the progression of neurodegenerative diseases. Especially polyphenols have been reported to exert strong neuroprotective properties. Taking into consideration our latest discovery, where we demonstrated that piceatannol inhibits glyceraldehyde-3-phosphate dehydrogenase (GAPDH) aggregation (in tube) we decided to explore its effect on hippocamp...
Source: Journal of Functional Foods - May 8, 2019 Category: Nutrition Source Type: research

Melatonin possesses an anti-influenza potential through its immune modulatory effect
In this study, we found that melatonin treatment significantly decreases the expression of TNF-α, IL-6 and IFN-γ, and increases the production of IL-10 and TGF-β. The induction of IL-10 by melatonin occurs via the upregulation of IL-27 expression in dendritic cells. Melatonin also significantly inhibits the production of TNF-α in CD8 T cells. Co-treatment of melatonin and ribavirin significantly increases the survival of virus-infected mice compared to ribavirin alone. Our study suggests that melatonin possesses a therapeutic potential in influenza-induced pneumonia as an adjuvant treatment with anti...
Source: Journal of Functional Foods - May 8, 2019 Category: Nutrition Source Type: research

The protective effect of piperine on ovariectomy induced bone loss in female mice and its enhancement effect of osteogenic differentiation via Wnt/β-catenin signaling pathway
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Chenrui Li, Yu Li, Lixiu Zhang, Shu Zhang, Weiyun Yao, Zhong ZuoAbstractPiperine (PIP) demonstrates extensive pharmacological effects. Recent studies reported that PIP enhanced osteogenic differentiation and inhibited osteoclast functions. Nevertheless, its effect has not been evaluated in vivo. In the current study, ovariectomised female mice and MC3T3-E1 cells were used to examine its effect on osteoblastogenesis. Oral administration of PIP significantly elevated bone mineral density and suppressed bone remodeling without dose dependence....
Source: Journal of Functional Foods - May 7, 2019 Category: Nutrition Source Type: research

Reduction of blood glucose and HbA1c levels by cyanidin 3,5-diglucoside in KKAy mice
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Takuya Yamane, Momoko Imai, Satoshi Handa, Keiko Yamada, Tatsuji Sakamoto, Testuo Ishida, Hiroshi Inui, Yoshio Yamamoto, Takenori Nakagaki, Yoshihisa NakanoAbstractAronia melanocarpa has beneficial effects on lifestyle-related diseases. Our previous studies showed that dipeptidyl peptidase IV (DPP IV) activity was inhibited by cyanidin 3,5-diglucoside from aronia juice and the weight of adipose tissues of mice given aronia juice was also reduced. The aim of this study is to investigate the effects of cyanidin 3,5-diglucoside, including aron...
Source: Journal of Functional Foods - May 3, 2019 Category: Nutrition Source Type: research

Fat concentration and high-pressure homogenization affect chlorogenic acid bioaccessibility and α-glucosidase inhibitory capacity of milk-based coffee beverages
This study aimed at investigating the effect of coffee formulation and high-pressure homogenization (HPH) on chlorogenic acid bioaccessibility and α-glucosidase inhibition.Coffee was added with milk (1:1) containing 0.1, 3.6 or 7.1% fat, homogenized at increasing pressure (0–150 MPa) and in vitro digested. Using milk with the highest fat concentration (7.1%) promoted the formation of smaller particles after HPH treatment, as well as upon digestion. Digested samples with the highest fat content also presented lower ζ-potential, suggesting higher stability. Chlorogenic acids (CGAs) bioaccessibility and &al...
Source: Journal of Functional Foods - May 3, 2019 Category: Nutrition Source Type: research

Regulatory requirements of bioactive peptides (protein hydrolysates) from food proteins
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Meram Chalamaiah, Sule Keskin Ulug, Hui Hong, Jianping WuAbstractThe global bioactive peptides’ market has been rising steadily due to the increased awareness of consumers about the positive association between functional foods/health foods and health. Bioactive peptides are short sequences of food proteins, mostly composed of 2–20 amino acid residues, with demonstrated positive physiological effects on human health. Different countries have developed various regulatory frameworks in order to protect the consumers from risks, mi...
Source: Journal of Functional Foods - May 2, 2019 Category: Nutrition Source Type: research

Kinetic study of d-limonene release from finger citron essential oil loaded nanoemulsions during simulated digestion in vitro
This study could demonstrate the digestion mechanisms of FCEO loaded nanoemulsion and facilitate the design of hydrophobic nutraceuticals delivery systems in food industry.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - May 2, 2019 Category: Nutrition Source Type: research

Bound phenolics from fresh lotus seeds exert anti-obesity effects in 3T3-L1 adipocytes and high-fat diet-fed mice by activation of AMPK
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Shaoling Lin, Zhenyu Wang, Yilin Lin, Shenghan Ge, Siti Sarah Hamzah, Jiamiao HuAbstractPolyphenols are found in free and bound forms in foods, both of which exert a wide range of pharmacological and therapeutic effects. Here, 3T3-L1 pre-adipocytes and high-fat diet (HFD)-induced mice were used to investigate the potential anti-obesity effect of bound phenolics extracted from lotus seeds (LBP). Phenolic compounds including protocatechuic, caffeic and ellagic acids were identified in LBP. In vitro results showed LBP significantly decreased i...
Source: Journal of Functional Foods - May 2, 2019 Category: Nutrition Source Type: research

Chronic effects of nitrate supplementation with a newly designed beetroot formulation on biochemical and hemodynamic parameters of individuals presenting risk factors for cardiovascular diseases: A pilot study
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Diego dos Santos Baião, Jenifer d'El-Rei, Genilton Alves, Mario Fritsch Neves, Daniel Perrone, Eduardo Mere Del Aguila, Vania M. Flosi PaschoalinAbstractDietary nitrate has been associated with nitric oxide bioconversion and beneficial vascular effects. A randomized, controlled, crossover and placebo 3-week supplementation trial with a beetroot-cereal bar enriched in nitrate (9.5 ± 0.05 mmol) and polyphenols was performed on patients displaying three risk factors for the development of cardiovascular diseases. The beetro...
Source: Journal of Functional Foods - May 2, 2019 Category: Nutrition Source Type: research

Olive secoiridoid oleuropein and its semisynthetic acetyl-derivatives reduce LPS-induced inflammatory response in murine peritoneal macrophages via JAK-STAT and MAPKs signaling pathways
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Maria Luisa Castejon, Marina Sánchez-Hidalgo, Marina Aparicio-Soto, Alejandro González-Benjumea, Jose G. Fernández-Bolaños, Catalina Alarcón-de-la-LastraAbstractThe present study was designed to investigate the potential anti-inflammatory, antioxidant and immunomodulatory activities of three new derivatives from OL in lipopolysaccharide (LPS)-induced mouse peritoneal macrophages in comparison with natural OL. Nitrites levels were analyzed by Griess method and intracellular reactive oxygen species (ROS) by ...
Source: Journal of Functional Foods - May 2, 2019 Category: Nutrition Source Type: research

Nuciferine alleviates acute alcohol-induced liver injury in mice: Roles of suppressing hepatic oxidative stress and inflammation via modulating miR-144/Nrf2/HO-1 cascade
This study aimed to explore the potential efficacy of nuciferine (NCF) in protecting acute alcohol-induced liver injury and the underlying molecular mechanisms. We revealed that NCF activated Nrf2/HO-1 signaling in HepG2 hepatocytes and relieved alcohol-induced ROS generation and subsequent cell death. Mechanistically, suppression of miR-144 expression contributed to NCF-mediated activation of Nrf2/HO-1 signaling. Consistently, NCF modulated hepatic miR-144/Nrf2/HO-1 axis and alleviated acute alcohol-induced liver injury as well as concomitant oxidative stress and inflammation in mice. In addition, suppressing the catalyti...
Source: Journal of Functional Foods - May 2, 2019 Category: Nutrition Source Type: research

Chemical profile and in vitro gut microbiota modulatory, anti-inflammatory and free radical scavenging properties of chrysanthemum morifolium cv. Fubaiju
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Yanfang Li, Yiming Hao, Boyan Gao, Ping Geng, Haiqiu Huang, Lu Yu, Uyory Choe, Jie Liu, Jianghao Sun, Pei Chen, Thomas T.Y. Wang, Liangli (Lucy) YuAbstractHot-water and ethanol extracts of Chrysanthemum morifolium cv. Fubaiju were investigated for their chemical compositions, effects on gut microbiota, anti-inflammatory, and free radical scavenging capacities. UPLC-IMS-QTOF-MS analysis detected tuberonic acid glucoside and tasumatrol B in the Fubaiju for the first time. The hot-water extract had greater anti-inflammation and free radical sc...
Source: Journal of Functional Foods - May 2, 2019 Category: Nutrition Source Type: research

Ameliorative effect of dieckol-enriched extraction from Laminaria japonica on hepatic steatosis induced by a high-fat diet via β-oxidation pathway in ICR mice
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Yixiang Liu, Di Zhang, Guang-Ming Liu, Qingchou Chen, Zhenhua LuAbstractAn increasing number of studies indicate that dietary polyphenols are beneficial to non-alcoholic fatty liver (NAFL) disease. However, the published reports about marine polyphenols are still limited. In this work, the ameliorative effect of polyphenols from Laminaria (L.) japonica on NAFL was investigated in vivo. According to the spectral analyses, dieckol was identified from L. japonica. After NAFL was induced by a high-fat diet, the ICR mice were administered diecko...
Source: Journal of Functional Foods - May 2, 2019 Category: Nutrition Source Type: research

Characterization of yeasts isolated from traditional kefir grains for potential probiotic properties
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Abraham Majak Gut, Todor Vasiljevic, Thomas Yeager, Osaana N. DonkorAbstractKefir is a mixed fermented product with numerous attributed health benefits due to presence of a complex culture composed of bacteria and yeasts in an exopolysaccharide matrix. This work aimed at isolating and identifying yeast species from two types of traditional kefir grains and establishing some potential probiotic properties including survival in the gastrointestinal tract, auto-aggregation, hydrophobicity and hydrolytic enzymes production. All the isolates sho...
Source: Journal of Functional Foods - May 2, 2019 Category: Nutrition Source Type: research

Satellite cells depletion in exercising human skeletal muscle is restored by ginseng component Rg1 supplementation
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Jinfu Wu, Suchada Saovieng, I-Shiung Cheng, Jørgen Jensen, Wei-Horng Jean, Ahmad Alkhatib, Chung-Lan Kao, Chih-Yang Huang, Chia-Hua KuoAbstractRg1 is a steroidal component in Panax ginseng, which increases high intensity exercise performance in humans. Here, we examined the effects of Rg1 supplementation on the dynamical changes of human muscle satellite cells following exercise. Twelve young men ingested Rg1 (5 mg) or Placebo (PLA) 1 h before exercise in a double-blind, placebo-controlled crossover design. Biopsy muscles were co...
Source: Journal of Functional Foods - April 30, 2019 Category: Nutrition Source Type: research

Resveratrol ameliorates long-term structural, functional and metabolic perturbations in a rat model of donor nephrectomy: Implication of SIRT1
In conclusion, resveratrol may be potentially beneficial as adjuvant therapy in human kidney donors.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - April 30, 2019 Category: Nutrition Source Type: research

Mechanism of fisetin suppressing superoxide anion and xanthine oxidase activity
Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Ni Zeng, Guowen Zhang, Xing Hu, Junhui Pan, Deming GongAbstractExcessive activity of xanthine oxidase (XO) will promote the formation of uric acid and superoxide anion (O2−), which may cause hyperuricemia and oxidative damage. Fisetin, a dietary flavonoid, was found to insert into flavin adenine dinucleotides (FAD) center of XO, which might hinder the diffusion of O2− out of the FAD site, leading to the significant decrease of uric acid formation. The promotion of reduced XO and the suppression of uric acid formation resulting f...
Source: Journal of Functional Foods - April 29, 2019 Category: Nutrition Source Type: research

Microalgae biomass intake positively modulates serum lipid profile and antioxidant status
This study investigated the biocompounds present in the Scenedesmus obliquus biomass and evaluated the effect of the supplementation in the serum lipid profile and tissues antioxidant status of mice. Male mice were divided into control and microalgae biomass treated groups (T1 = 400 and T2 = 800 mg·kg−1 bw·d−1) for four weeks. Serum and tissues (heart, liver, kidneys, and spleen) were analyzed. The microalgae biomass presented a valuable content of biocompounds. In serum, the T2 treatment promoted an increase in high-density lipoprotein but also triglycerides levels. The T1 increased g...
Source: Journal of Functional Foods - April 29, 2019 Category: Nutrition Source Type: research

Editorial Board
Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - April 26, 2019 Category: Nutrition Source Type: research

Daily intake of Lactobacillus gasseri CP2305 relieves fatigue and stress-related symptoms in male university Ekiden runners: A double-blind, randomized, and placebo-controlled clinical trial
In this study, we examined effects of CP2305 on top athletes experiencing physical and mental stresses. Forty-nine male university Ekiden (long distance relay race) runners daily took the CP2305-containing beverage for 12 weeks during training for and competing in All-Japan university championships. The CP2305 intake significantly facilitated recovery from fatigue and relieved anxiety and depressive mood, compared with placebo intake. The CP2305 intake significantly prevented the training-induced reduction of hemoglobin and facilitated exercise-induced increase in serum growth hormone levels. The CP2305 intake significan...
Source: Journal of Functional Foods - April 25, 2019 Category: Nutrition Source Type: research

Strawberry tree honey as a new potential functional food. Part 2: Strawberry tree honey increases ROS generation by suppressing Nrf2-ARE and NF-кB signaling pathways and decreases metabolic phenotypes and metastatic activity in colon cancer cells
Publication date: June 2019Source: Journal of Functional Foods, Volume 57Author(s): Sadia Afrin, Tamara Y. Forbes-Hernández, Danila Cianciosi, Francesca Pistollato, JiaoJiao Zhang, Mattia Pacetti, Adolfo Amici, Patricia Reboredo-Rodríguez, Jesus Simal-Gandara, Stefano Bompadre, Josè L. Quiles, Francesca Giampieri, Maurizio BattinoAbstractThe aim of the present study was to evaluate the effects of Strawberry tree honey (STH) on oxidative stress, metabolic phenotype, migration, invasion and epithelial-mesenchymal transition in adenocarcinoma (HCT-116) and metastatic (LoVo) colon cancer cells as well as i...
Source: Journal of Functional Foods - April 25, 2019 Category: Nutrition Source Type: research

Cholesterol-reducing effect of ergosterol is modulated via inhibition of cholesterol absorption and promotion of cholesterol excretion
This study investigated the cholesterol-reducing effect of ergosterol and its related potential mechanism in Sprague-Dawley rats. Thirty-two male rats were divided into four groups fed either a basic diet (NG) or one of three experimental diets, namely high-cholesterol diet (HC), and the two HC diets containing 0.5% ergosterol (EL) and 1.5% ergosterol (EH), respectively, for 8 weeks. Results demonstrated that feeding EL and EH diets decreased serum total cholesterol (TC) by 19.4–21.6%, low density lipoproptein cholesterol (LDL-C) by 42.0–42.6%, and TC/HDL-C ratio by 7.1–10.5%. This was accompanied by 46...
Source: Journal of Functional Foods - April 25, 2019 Category: Nutrition Source Type: research

Popular functional foods and herbs for the management of type-2-diabetes mellitus: A comprehensive review with special reference to clinical trials and its proposed mechanism
Publication date: June 2019Source: Journal of Functional Foods, Volume 57Author(s): Kamesh Venkatakrishnan, Hui-Fang Chiu, Chin-Kun WangAbstractDiabetes mellitus (DM) and its related complications are the serious public health concern globally. This is the first review highlight on major functional foods and herbs with anti-diabetic activity particularly focus on type 2 diabetes mellitus (T2DM) with special reference to clinical trials and their proposed anti-diabetic mechanisms. This contribution summarizes the current prevalence of DM, etiology and pathophysiology, complications related to DM, current conventional treatm...
Source: Journal of Functional Foods - April 24, 2019 Category: Nutrition Source Type: research