Comparative bio-accessibility, bioavailability and bioequivalence of quercetin, apigenin, glucoraphanin and carotenoids from freeze-dried vegetables incorporated into a baked snack versus minimally processed vegetables: Evidence from in vitro models and a human bioavailability study
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Natalia Perez-Moral, Shikha Saha, Mark Philo, Dave J. Hart, Mark S. Winterbone, Wendy J. Hollands, Mike Spurr, John Bows, Vera van der Velpen, Paul A. Kroon, Peter J. CurtisAbstractThe aim was to incorporate vegetables containing the phytochemicals quercetin, apigenin, glucoraphanin and carotenoids into a processed potato-based snack and assess their bioaccessibility and bioavailability. Three different processing routes were tested for incorporation and retention of phytochemicals in snacks using individually quick frozen or freeze-dr...
Source: Journal of Functional Foods - July 22, 2018 Category: Nutrition Source Type: research

Inulin as microencapsulating agent improves physicochemical properties of spray-dried aspalathin-rich green rooibos (Aspalathus linearis) extract with α-glucosidase inhibitory activity
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Neil Miller, Dalene De Beer, Marique Aucamp, Christiaan J. Malherbe, Elizabeth JoubertAbstractLimiting aspalathin degradation during spray-drying of green rooibos extract (GRE) is crucial to produce a functional food ingredient with antidiabetic properties. Retention of aspalathin in a GRE-inulin mixture (1:1, m/m) was not affected by process conditions (inlet air temperature, feed concentration and feed flow rate) tested according to a central composite design. Powder yield could subsequently be optimised by applying response surface ...
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Influence of probiotics, prebiotics, synbiotics and bioactive phytochemicals on the formulation of functional yogurt
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Nurul Farhana Fazilah, Arbakariya B. Ariff, Mohd Ezuan Khayat, Leonardo Rios-Solis, Murni HalimAbstractThe new concept of functional foods has led to the varieties in the production of foods that deliver not only basic nutrition, but can also warrant good health and longevity. Yogurt has become one of the prevalent choices and considered as a healthy food since it provides excellent sources of essential nutrients. As the popularity of yogurt continues to grow, manufacturers and scientists continuously investigate the value adding ingre...
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

A polyphenol-rich prebiotic in combination with a novel probiotic formulation alleviates markers of obesity and diabetes in Drosophila
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Susan Westfall, Nikita Lomis, Satya PrakashAbstractImbalances in the gut microbiota are directly associated with the pathogenesis of diabetes and obesity. The current study investigates how the combination of three probiotics Lactobacillus plantarum NCIMB 8826, L. fermentum NCIMB 5221 and Bifidobacteria longum subsp. infantis NCIMB 702255 with a novel polyphenol-rich prebiotic Triphala has combinatorial benefits on the symptoms and underlying mechanisms of diet-induced diabetes and obesity. Drosophila melanogaster fed either a high-fat...
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Preparation, characterization of polysaccharides fractions from Inonotus obliquus and their effects on α-amylase, α-glucosidase activity and H2O2-induced oxidative damage in hepatic L02 cells
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Cong Wang, Ramesh Kumar Santhanam, Xudong Gao, Zhongqin Chen, Yue Chen, Chunli Wang, Leilei Xu, Haixia ChenAbstractIn the present study, three homogeneous protein bounded acidic polysaccharides fractions (IOPS-1, IOPS-2 and IOPS-5) were isolated from I. obliquus using DEAE-52 cellulose chromatography. The relationship between their physicochemical properties and bioactivities was comparatively investigated. Results showed that IOPS-1, IOPS-2 and IOPS-5 were composed of rhamnose, arabinose, xylose, mannose, glucose and galactose with th...
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Whole fractions from probiotic bacteria induce in vitro Th17 responses in human peripheral blood mononuclear cells
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Claudio Hidalgo-Cantabrana, María Rosa Lucena-Prieto, Marco Antonio Moro-García, Rebeca Alonso-Arias, Borja SánchezAbstractProbiotics are used to improve human health due to their capability to induce beneficial effects in gastrointestinal diseases and modulate the immune response. However, scarce information is known about the bacterial active compounds and the metabolic pathways of interaction with immune cells. In the present study, we analyzed the immune response elicited by surface-associated proteins, the who...
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Exploring inhibitory mechanism of gallocatechin gallate on a-amylase and a-glucosidase relevant to postprandial hyperglycemia
This study may provide theoretical basis for designing novel functional foods of GCG for the prevention and treatment of diabetes.Graphical abstractGallocatechin gallate can inhibit the activity of α-amylase and α-glucosidase relevant to postprandial hyperglycemia. (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Prenylflavonoids sanggenon C and kuwanon G from mulberry (Morus alba L.) as potent broad-spectrum bacterial β-glucuronidase inhibitors: Biological evaluation and molecular docking studies
In this study, two prenylflavonoids sanggenon C (SGC) and kuwanon G (KWG) exhibited strong inhibition on p-nitrophenyl-β-D-glucuronide-hydrolyzing activity in pooled human gut microbiota and eight bacterial isolates, while amoxapine, a previously reported Escherichia coli β-glucuronidase (EcoGUS) inhibitor, only showed poor inhibition on the pooled samples and relatively selective inhibition on individual strains with incomplete inhibition on Staphylococcus.pasteuri 3I10. Both prenylflavonoids exhibited mixed-type inhibition against the recombinant enzymes EcoGUS and S. pasteuri 3I10 β-glucuronidase (SpasGUS...
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Fucoidan alleviates dyslipidemia and modulates gut microbiota in high-fat diet-induced mice
This study aims to determine the effects of fucoidan from Undaria pinnatifida on gut microbiota and dyslipidemia in BALB/c mice. In vitro, fucoidan could support the growth of three lactic acid bacteria strains. The test groups with high fat diet (HFD) were gavaged with fucoidan at a dose of 50 mg/kg/day or 100 mg/kg/day for 8 weeks. Fucoidan decreased total serum cholesterol (P 
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Lactobacillus rhamnosus and Lactobacillus delbrueckii ameliorate the expression of miR-155 and miR-181a in SLE patients
ConclusionsL. rhamnosus and L. delbrueckii modulate the expression of miR-181a and miR-155 in SLE patients and might be beneficial in the management of SLE patients.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Potential health advantages of Periploca laevigata: Preliminary phytochemical analysis and evaluation of in vitro antioxidant capacity and assessment of hepatoprotective, anti-inflammatory and analgesic effects
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Nizar Tlili, Meriam Tir, Anouar Feriani, Yassine Yahia, Mohamed Salah Allagui, Ezzeddine Saadaoui, Mhammed El Cafsi, Nizar NasriAbstractThe goal of the present work was a phytochemical screening together with the study of a possible hepatoprotective, anti-inflammatory and analgesic effects of Periploca laevigata seeds extract. Soxhlet extraction revealed that the oil content was ca. 5.5% DW and Kjeldhal method revealed that the protein level was ca. 22% DW. Phenolic compounds, flavonoids and condensed tannin contents were 21.2 mg GAE...
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Polyphenolic derivatives from mango (Mangifera Indica L.) modulate fecal microbiome, short-chain fatty acids production and the HDAC1/AMPK/LC3 axis in rats with DSS-induced colitis
This study elucidated how polyphenols from mango (Mangifera Indica L.) affect gut microbiota composition and SCFAs production in rats with DSS-induced colitis. Rats were administered either control or mango beverage for nine weeks, exposed to three cycles of 3% DSS with a 2-week recovery period. Mango intake caused a significant increase in tannase-producing bacteria Lactobacillus plantarum and Lactococcus lactis (p = 0.0494 and 0.0312, respectively), and butyrate-producing bacteria Clostridium butyrium (p = 0.0494). The concentrations of butyrate and valerate were increased by 150% and 119% in mango group. Mango b...
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Beneficial changes of gut microbiota and metabolism in weaned rats with Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 supplementation
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Mengxia Wang, Yongxiong Chen, Yuanyuan Wang, Yuan Li, Xiaojun Zhang, Haihui Zheng, Fangli Ma, ChungWah Ma, Biyu Lu, Zhiyong Xie, Qiongfeng LiaoAbstractTo investigate the effect of Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 (1:1) on microbiota composition and function, metabolism as well as microbiota-metabolite relationships of weaned rats, four groups of male Sprague-Dawley rats were orally supplemented with either probiotics (2.5 × 1010 cfu/kg, 5.0 × 1010 cfu/kg, 1.0 × 1011 cfu...
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Jaboticaba berry peel intake increases short chain fatty acids production and prevent hepatic steatosis in mice fed high-fat diet
In conclusion, MJP intake induces higher production of the gut SCFA, compounds known to counteract obesity markers, as shown by the lowering of adipose tissue inflammation, weight gain, dyslipidemia and hepatic steatosis.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Gastroprotective property of Pseudocydonia sinensis fruit jelly on the ethanol-induced gastric lesions in rats
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Yasunori Hamauzu, Hiyo Kishida, Nozomi YamazakiAbstractThe gastroprotective activity of Chinese quince (Pseudocydonia sinensis) jellies made from boiling water extracts of the fruit were investigated. Pre-administration of the jellies to rats protected gastric tissues against HCl/ethanol-induced gastric injury, demonstrated by a reduction in the gastric lesion index and TNF-α levels. The effect was stronger in the jellies made from extracts obtained by longer periods of boiling and having high contents of pectin and polyphenols. ...
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Extracts of Cerbera manghas L. effectively inhibit the viability of glioblastoma cell lines and their cancer stemloids in vitro and in mouse xenograft model
In this study, neriifolin effectively inhibited the growth and colony formation of CD133+ GBM tumorspheres. Both C. manghas extracts and neriifolin inhibited Akt activation and caused cell cycle G1 arrest. They also reduced the expression of the stem cell marker Sox2. Treatment with their higher doses induced the apoptosis of GBM tumorspheres. Furthermore, neriifolin inhibited the growth of CD133+ GBM tumorsphere-derived tumors in vivo. In summary, neriifolin obtained from extracts of C. manghas may serve as a drug lead compound for GBM therapies.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Does gamma-aminobutyric acid have a potential role on the antihypertensive effect of fermented milk with Lactococcus lactis NRRL B-50571?
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Lilia María Beltrán-Barrientos, Carmen Estrada-Montoya, Ricardo Reyes-Díaz, Adrián Hernández-Mendoza, Aarón Fernando González-Córdova, Belinda Vallejo-CórdobaAbstractGamma-aminobutyric acid (GABA) may be generated during milk fermentation, and this metabolite may have antihypertensive effect in spontaneously hypertensive rats (SHR). We determined the potential role of GABA on the antihypertensive effect of the water-soluble extract obtained from fermented milk with Lactococ...
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

A soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese mice
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Juliana de Carvalho Marchesin, Larissa Sbaglia Celiberto, Allan Botinhon Orlando, Alexandra Ivo de Medeiros, Roseli Aparecida Pinto, José Antônio Sampaio Zuanon, Luis Carlos Spolidorio, Andrey dos Santos, Maria Pía Taranto, Daniela Cardoso Umbelino CavalliniAbstractThis work investigates the effect of a soy-based probiotic drink (Enterococcus faecium CRL 183 and Bifidobacterium longum ATCC 15707) on the fecal microbiota composition, body weight and inflammatory parameters in diet-induced obese mice. The probiotic gr...
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Enhancement of cognitive functions by rice bran extract in a neuroinflammatory mouse model via regulation of PPARγ
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): A.O. Mostafa, R.M. Abdel-Kader, O.A. HeikalAbstractActivation of the peroxisome proliferator-activated receptor gamma (PPARγ), has been recently demonstrated to attenuate inflammatory response and improve cognitive dysfunction in neurodegenerative diseases. RBE is rich in polyunsaturated fatty acids, which were recently considered as new PPARγ modulators. Accordingly, the effect of RBE on memory and cognition in a neuroinflammatory mouse model was examined to investigate whether RBE improves cognition through modulating PPA...
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Influence of zinc deficiency and supplementation on NK cell cytotoxicity
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Benjamin Rolles, Martina Maywald, Lothar RinkAbstractKnowledge about the role of zinc on natural killer (NK) cell activity and function is limited and needs further instigation. Hence, in this study, the influence of interleukin (IL)-1, IL-2, zinc, and the zinc-chelator N,N,N′,N′-tetrakis(2-pyridylmethyl)ethane-1,2-diamine (TPEN) on the human NK cell line (YTS cell line) and primary NK cells were examined. We mainly focused on NK cell killing activity by using the K562 cell line as target cells. We uncovered a significantly...
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Olive oil combined with Lycium barbarum polysaccharides attenuates liver apoptosis and inflammation induced by carbon tetrachloride in rats
This study investigated anti-apoptotic, anti-inflammatory and anti-fibrotic effects of olive oil and/or Lycium barbarum polysaccharides (LBP) on CCl4-induced liver fibrosis in rats. The results showed that CCl4 caused liver fatty change, cell death, inflammation and collagen accumulation. The olive oil-treated groups reduced hepatic transforming growth factor (TGF)-β1 and tissue inhibitors of metalloproteinase (TIMP)-1 levels. The LBP-treated groups inhibited hepatic caspase-9 and caspase-3 activities, decreased hepatic tumor necrosis factor (TNF)-α levels, increased hepatic interleukin (IL)-10 levels and IL-10/...
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Hepatoprotective effect of flavonoid-enriched fraction from Cyclocarya paliurus leaves on LPS/D-GalN-induced acute liver failure
This study aimed to investigate the chemical composition and hepatoprotective effect of flavonoid fraction from Cyclocarya paliurus leaves (CPF) on the lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced acute liver failure (ALF). UPLC-MS analysis revealed that CPF mainly contained quercetin-3-O-glycoside, quercetin-3-O-rhamnoside, kaempferol-3-O-rhamnoside, quercetin and kaempferol. CPF treatment (100, 200, and 400 mg/kg) effectively prevented LPS/D-GalN-induced ALF by lessening the mortality; improving hepatic morphological structures and oxidative stress; decreasing the ALT and AST levels and inflammatory cytokine...
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Preventive effects of Eucommia ulmoides leaf extract and its components on UVB-induced immunosuppression in mice
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Keiichi Hiramoto, Yurika Yamate, Tetsuya Hirata, Takahiko FujikawaAbstractUltraviolet (UV) irradiation is a well known photo-immunosuppressant. To determine the effect of Eucommia ulmoides leaf extract (ELE) components (chlorogenic acid, geniposidic acid, and asperuloside) on UVB induced immunosuppression, we examined mice that were contact hypersensitized. Systemic immunosuppression was induced in the C57BL/6j mice that were sensitized with 0.5% oxazolone through the skin by a single exposure to UVB. Consecutive oral administration of...
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Ormosanine from Akebia quinata suppresses ethanol-induced inflammation and apoptosis and activates antioxidants via the mitogen activated protein kinase signaling pathway
In this study, we evaluated whether ormosanine from AQ exhibited antioxidant, anti-inflammatory, or anti-apoptotic effects in a rat model of ethanol-induced liver injury. The protective activities of ormosanine against ethanol toxicity in the liver include the suppression of acetaldehyde through activation of ALDH2 and suppression of CYP2E1. Our study shows that ormosanine protects against ethanol-induced liver injury by reducing the expression of inflammatory regulators (COX-2, TNF-α, and IL-6), and apoptosis-associated protein (p53, Bax, cytochrome C, procaspase-3, PARP-1) via activating the p-AKT and MAPK (p-ERK, ...
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Components of heat-treated Helianthus annuus L. pectin inhibit tumor growth and promote immunity in a mouse CT26 tumor model
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Yuan Guan, Zhongyu Zhang, Xiyao Yu, Jingmin Yan, Yifa Zhou, Hairong Cheng, Guihua TaiAbstractHeat-treated pectin is known to have anti-tumor activity. The present study was designed to identify its active components and mechanism of action. Here, we investigated the anti-tumor effect of heat-treated Helianthus annuus L. pectin (HT-HAP), alkali-inactivated HT-HAP representing the pectin fragment fraction (HT-HAP-P), and heat-treated galacturonic acid representing the small molecule fraction (HT-HAP-S). Our results demonstrate that HT-HA...
Source: Journal of Functional Foods - July 21, 2018 Category: Nutrition Source Type: research

Melatonin increases magnesium concentrations in white adipose tissue and pancreas of diabetic obese rats
This study reveals for the first time that melatonin intake increases Mg concentrations in subcutaneous lumbar, visceral, omentum, and gonadal adipose tissue and in the pancreas. These findings may be related to an improvement in the homeostatic regulation of adipocytokines produced by white adipose tissues, and to a reduction in plasmatic oxidative stress, which would lead to a decrease in insulin resistance and improvement in glucose homeostasis. These results open up the beneficial use of melatonin for the development of functional foods to ameliorate glucose homeostasis in obesity-associated diabetes.Graphical abstract...
Source: Journal of Functional Foods - July 12, 2018 Category: Nutrition Source Type: research

Isomaltulose: Recent evidence for health benefits
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Sangeetha Shyam, Amutha Ramadas, Sui Kiat ChangAbstractIsomaltulose (IM) is a naturally occurring disaccharide composed of alpha-1,6-linked glucose and fructose monomers. IM is gaining interest as an alternative sweetener to sucrose primarily because of its low glycaemic index (GI) properties. Low GI has been implicated in the prevention and management of chronic diseases such as cardio-metabolic diseases and cancers. The low glycaemic potential of IM has fuelled the many recent in-vitro, animal and human studies including randomised-c...
Source: Journal of Functional Foods - July 12, 2018 Category: Nutrition Source Type: research

Antibacterial activity and mechanism of Chuzhou chrysanthemum essential oil
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Haiying Cui, Mei Bai, Yanhui Sun, Mohamed Abdel-Shafi Abdel-Samie, Lin LinAbstractChuzhou chrysanthemum is well-known in China and has been used to make tea over centuries. However, neither integrated background about the antibacterial activity nor the antibacterial mechanism of Chuzhou chrysanthemum oil (CCO) is available. SDS-PAGE analysis, oxidative respiratory metabolism measurement and the DNA topoisomerase activity were employed to investigate the antibacterial mechanism of CCO. CCO could lead to the leakage of proteins of E. col...
Source: Journal of Functional Foods - July 11, 2018 Category: Nutrition Source Type: research

Supplementation with the probiotic strain Weissella cibaria JW15 enhances natural killer cell activity in nondiabetic subjects
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Young Ju Lee, Ayoung Lee, Hye Jin Yoo, Minkyung Kim, Geon Min Noh, Jong Ho LeeAbstractThe aim of this study was to investigate the impact of consuming Weissella cibaria (W. cibaria) JW15 on natural killer (NK) cell activity, cytokines and immunoglobulins (Igs). This randomized, double-blinded, placebo-controlled study enrolled 100 nondiabetic participants. For eight weeks, the probiotic group consumed capsules containing 1 × 1010 colony forming units (cfu) of W. cibaria JW15 daily, whereas the placebo group consumed the same ...
Source: Journal of Functional Foods - July 11, 2018 Category: Nutrition Source Type: research

Effects of prebiotic inulin addition to low- or high-fat diet on maternal metabolic status and neonatal traits of offspring in a pregnant sow model
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Pan Zhou, Yongsheng Wang, Shuang Li, Yang Zhao, Kai Deng, Dandan Chao, Chao Jin, Yong Zhuo, Lianqiang Che, Jian Li, Yan Lin, Shengyu Xu, Bin Feng, Zhengfeng Fang, De WuAbstractThe effects of adding inulin to low- or high-fat diet on the metabolic status and nutrient digestibility in gestating sows and the neonatal traits of their offspring were examined. Sixty sows were allocated to a 2 × 2 factorial treatment design with levels of inulin (0% or 1.5%) and fat (0% or 5%) addition as the fixed factors during gestation. Inulin s...
Source: Journal of Functional Foods - July 11, 2018 Category: Nutrition Source Type: research

Synergistic effect of B-type oligomeric procyanidins from lotus seedpod in combination with water-soluble Poria cocos polysaccharides against E. coli and mechanism
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Jingyi Wang, Wanjun Zhang, Cuie Tang, Juan Xiao, Bijun Xie, Zhida SunAbstractThe synergistic antibacterial effects of lotus seedpod oligomeric procyanidins (LSPC) and water-soluble Poria cocos polysaccharides (WPCP) against two Escherichia coli (E. coli) strains were evaluated. The mixture showed an obviously synergistic inhibitory effect against E. coli, improving the adverse effects by which LSPC at low concentration (≤0.8 mg/mL) proliferated E. coli. The minimal inhibitory concentration (MIC) of the mixture was significantly lo...
Source: Journal of Functional Foods - July 11, 2018 Category: Nutrition Source Type: research

Donkey milk lysozyme ameliorates dextran sulfate sodium-induced colitis by improving intestinal barrier function and gut microbiota composition
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Lun Jiang, Jiayi Lv, Jingwen Liu, Xianghui Hao, Fazheng Ren, Huiyuan GuoAbstractDonkey milk lysozyme (DML) is a potential therapeutic agent for inflammatory bowel disease (IBD), while the mechanism remains obscure. Here, we reported that DML ameliorated weight loss, colon damage and mucosal inflammation in colitis mice. Additionally, DML increased the expression of occluding and zonula occludens-1, and reduced that of claudin-2, thus improving mechanical barrier function. It also inhibited the expression of tumour necrosis factor-&alph...
Source: Journal of Functional Foods - July 11, 2018 Category: Nutrition Source Type: research

Preface
Publication date: Available online 27 June 2018Source: Journal of Functional FoodsAuthor(s): Paola Lavermicocca, Lucio Capurso, Vincenzo Fogliano (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - July 10, 2018 Category: Nutrition Source Type: research

Editorial Board
Publication date: August 2018Source: Journal of Functional Foods, Volume 47Author(s): (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - July 10, 2018 Category: Nutrition Source Type: research

A functional and genetic overview of exopolysaccharides produced by Lactobacillus plantarum
Publication date: August 2018Source: Journal of Functional Foods, Volume 47Author(s): Yunyun Jiang, Zhennai YangAbstractLactobacillus plantarum strains have been widely used in food processing and preservation, and capability of their production of exopolysaccharides (EPSs) contributes significantly to the improvement of food quality and function. During the last decade, rapid development and accumulation of data in the research field of EPSs produced by L. plantarum have been observed. Availability of complete genome sequences from forty-three L. plantarum strains to date has provided good basis for deep analysis and unde...
Source: Journal of Functional Foods - July 10, 2018 Category: Nutrition Source Type: research

Health and technological aspects of methylxanthines and polyphenols from guarana: A review
Publication date: August 2018Source: Journal of Functional Foods, Volume 47Author(s): Ádina L. Santana, Gabriela A. MacedoAbstractBrazil is the major producer of guarana, a stimulant largely consumed worldwide. Interest in health benefits of its consumption has increased the inclusion of guarana extracts in industry applications, providing dietary supplements, medicines, cosmetics, and functional foods. Major bioactive constituents of guarana popularly known are methylxanthines and catechins. Methylxanthines, particularly caffeine, are associated with improvement in cognitive function and energy-expenditure increasi...
Source: Journal of Functional Foods - July 10, 2018 Category: Nutrition Source Type: research

Bioactive flavonoids in Moringa oleifera and their health-promoting properties
Publication date: August 2018Source: Journal of Functional Foods, Volume 47Author(s): Mengfei Lin, Junjie Zhang, Xiaoyang ChenAbstractMoringa oleifera is widely cultivated as an important vegetable for human consumption. Moringa contains numerous dietary phytonutrients, including flavonoids, which are secondary plant metabolites with health-promoting effects, such as prevention of damage to normal cell DNA and promotion of cancer cell apoptosis, thereby reducing the burden of non-communicable diseases (NCDs). Therefore, flavonoids in M. oleifera have attracted great interest as chemotherapeutic modality due to its edible, ...
Source: Journal of Functional Foods - July 10, 2018 Category: Nutrition Source Type: research

Nutraceuticals for better management of osteoporosis: An overview
Publication date: August 2018Source: Journal of Functional Foods, Volume 47Author(s): Richa Rajput, Sarika Wairkar, Ram GaudAbstractOsteoporosis is a common bone disorder observed particularly in aging population and post-menopausal women. It results from an imbalance in the natural process of bone remodeling, a continuous cycle for bone formation and bone resorption. Though various drugs acting on different therapeutic targets of osteoporosis are available, focus is now shifting towards the natural alternatives to avoid side effects associated with the drug therapy. This review encompasses the spectrum of nutraceuticals s...
Source: Journal of Functional Foods - July 10, 2018 Category: Nutrition Source Type: research

Mucoadhesive role of tamarind xyloglucan on inflammation attenuates ulcerative colitis
Publication date: August 2018Source: Journal of Functional Foods, Volume 47Author(s): Srinivasan Periasamy, Chia-Hui Lin, Balaji Nagarajan, Nehru Viji Sankaranarayanan, Umesh R. Desai, Ming-Yie LiuAbstractTamarind xyloglucan (TXG) is edible, bioavailable and mucoadhesive polysaccharide. The aim of this study was (i) to investigate molecular docking studies on the interaction of TXG to MUC1 and cytokine receptors and (ii) to assess the mucoadhesive role of TXG in UC. In vivo study: C57Bl6 mice were administered with DSS 3% (w/v) in drinking water; TXG 100 or 300 mg/kg/day was given orally for 7 days simultaneously. TXG ...
Source: Journal of Functional Foods - July 10, 2018 Category: Nutrition Source Type: research

Anti-aging effect of sea cucumber (Cucumaria frondosa) hydrolysate on fruit flies and d-galactose-induced aging mice
Publication date: August 2018Source: Journal of Functional Foods, Volume 47Author(s): Lianzhu Lin, Kun Yang, Lin Zheng, Mouming Zhao, Weizheng Sun, Qiyuan Zhu, Sijun LiuAbstractThe search for treatment of aging and age-related diseases is a public health issue. Sea cucumber (Cucumaria frondosa) hydrolysate (CFH) prepared by enzymatic hydrolysis and purified by ultrafiltration was examined for its peptide profile and ability to prevent and/or delay aging in fruit flies and age-related neurodegenerative disorders in d-galactose-induced aging mice. CFH contained peptides with low molecular weights (mainly 
Source: Journal of Functional Foods - July 10, 2018 Category: Nutrition Source Type: research

In vitro anti-inflammatory activity among probiotic Lactobacillus species isolated from fermented foods
Publication date: August 2018Source: Journal of Functional Foods, Volume 47Author(s): Sundru Manjulata Devi, Nawneet K. Kurrey, Prakash M. HalamiAbstractProbiotic bacteria have the ability to alter immune response conferring treatment to inflammatory diseases. In the current study, probiotic Lactobacillus strains were subjected to adhesion to epithelial Caco-2 cells. Subsequently, gene expression of pro-and anti-inflammatory genes were studied under three stimulation conditions (which includes LPS-challenge, stress induction and pathogens invasion). Herein, immunomodulatory activity of native Lactobacillus strains (n =...
Source: Journal of Functional Foods - July 10, 2018 Category: Nutrition Source Type: research

PMFs-rich Citrus extract prevents the development of non-alcoholic fatty liver disease in C57BL/6J mice induced by a high-fat diet
In this study, the effect of PMFs-enriched extract of Daoxianyeju (Citrus daoxianensis S.W. He) (EDX) on NAFLD were examined using high fat diet-induced obesity (DIO) C57BL/6 mice. Daily supplementation of 0.2% and 0.5% EDX with high fat diet (w/w) over ten weeks markedly improved glucose tolerance and insulin resistance as well as lipid profiles, alleviated hepatic steatosis, inflammatory and oxidative stress. The benefit of EDX on improving pathology of NAFLD induced by high fat diet may associate with the activation of nuclear factor erythroid-2 related factor 2 (Nrf2) pathways in liver tissues. Our study showed that ci...
Source: Journal of Functional Foods - July 10, 2018 Category: Nutrition Source Type: research

Consumption of the edible sea urchin Mesocentrotus nudus attenuates body weight gain and hepatic lipid accumulation in mice
In conclusion, consumption of sea urchin might provide a protective effect against the development of obesity and/or nonalcoholic fatty liver disease.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - July 10, 2018 Category: Nutrition Source Type: research

Combinatorial effect of magnolia bark extract and ethyl lauroyl arginate against multi-species oral biofilms: Food additives with the potential to prevent biofilm-related oral diseases
In conclusion, MBE and LAE exhibited anti-biofilm and antimicrobial effects. The combination of MBE and LAE improved their individual effect.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - July 10, 2018 Category: Nutrition Source Type: research

Milk fat globule membrane supplementation modulates the gut microbiota and attenuates metabolic endotoxemia in high-fat diet-fed mice
Publication date: August 2018Source: Journal of Functional Foods, Volume 47Author(s): Tiange Li, Jing Gao, Min Du, Xueying MaoAbstractGut microbiota plays an important role in the development of obesity and related metabolic endotoxemia. The aim of this study was to evaluate whether milk fat globule membrane (MFGM) could alter the composition of gut microbiota and exert a beneficial impact on combating high-fat diet-induced metabolic endotoxemia. Results showed that MFGM improved the gut microbiota dysbiosis induced by high-fat diet in C57BL/6J mice, including increasing the Bacteroidetes/Firmicutes ratios and the relative...
Source: Journal of Functional Foods - July 10, 2018 Category: Nutrition Source Type: research

Effect of pectin of tansy, Tanacetum vulgare L., on feeding behaviour and food intake in mice
Publication date: August 2018Source: Journal of Functional Foods, Volume 47Author(s): Nikita M. Paderin, Fedor V. Vityazev, Nikita Yu. Saveliev, Pavel A. Markov, Vasily I. Mikhaylov, Olga A. Patova, Sergey V. PopovAbstractRheological properties of pectins with a different chemical characteristic in a simulated gastrointestinal fluid, as well as behavioural satiety sequence and food intake in mice, were investigated. Mice treated with pectin isolated from floscules of tansy Tanacetum vulgare L. (TVF) spent less time feeding and ate less food. Apple pectin (AU701) failed to alter food intake and feeding time. Whole-gut trans...
Source: Journal of Functional Foods - July 10, 2018 Category: Nutrition Source Type: research

The combination of Puerariae Lobatae Radix and Chuanxiong Rhizoma enhanced the absorption and pharmacokinetics of puerarin by modulating the intestinal barrier and influenced gut microbiota
In conclusion, combining PLR with CXR enhanced the absorption and pharmacokinetics of puerarin by modulating the intestinal barrier and influenced gut microbiota. The gut microbiota is likely to be a potential target for the combination of PLR and CXR.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - July 10, 2018 Category: Nutrition Source Type: research

Transport of gallocatechin gallate and catechin gallate in high-temperature-processed green tea extract from gastrointestinal tract to brain by an in vitro bio-mimic model system coupled with sequential cell cultures
Publication date: August 2018Source: Journal of Functional Foods, Volume 47Author(s): Kang-Hyun Jeong, Si-Young Cho, Yong-Deog Hong, Jin-Oh Chung, Kwang-Sik Kim, Soon-Mi ShimAbstractThe aim of this study was to evaluate the transport of gallocatechin gallate (GCG), catechin gallate (CG) and their metabolites in high-temperature-processed green tea extract (HTP_GTE) from the gastrointestinal tract to blood-brain barrier (BBB) with an in vitro bio-mimic model system with sequential cell cultures including Caco-2, HepG2 and HBMECs. Transports from the GI to BBB, the final concentrations of GCC and CG were 18.95 ± 3...
Source: Journal of Functional Foods - July 10, 2018 Category: Nutrition Source Type: research

Prevention of necrotizing enterocolitis through surface layer protein of Lactobacillus acidophilus CICC6074 reducing intestinal epithelial apoptosis
Publication date: August 2018Source: Journal of Functional Foods, Volume 47Author(s): Yuxing Guo, Xiaoxiao Jiang, Yao Yang, Jinye Zhang, Xiaoqun Zeng, Zhen Wu, Yangying Sun, Daodong PanAbstractNeonatal necrotizing enterocolitis (NEC) is a serious inflammatory gastrointestinal disease in premature infants. Lactobacillus acidophilus is a probiotic, which exhibits many beneficial effects on the digestive and immune systems. In a rat model of NEC, administration of L. acidophilus CICC6074 reduced NEC symptoms, intestinal apoptosis and the levels of inflammatory cytokines TNF-α and IL-6. LiCl-treated L. acidophilus CICC60...
Source: Journal of Functional Foods - July 10, 2018 Category: Nutrition Source Type: research

Soluble dietary fiber from Qing Ke (highland barley) brewers spent grain could alter the intestinal cholesterol efflux in Caco-2 cells
Publication date: August 2018Source: Journal of Functional Foods, Volume 47Author(s): Huijuan Zhang, XinRan Cao, Meng Yin, Jing WangAbstractThe present study investigated the antioxidant activities and hypocholesterolemic properties of soluble dietary fiber (SDF) obtained from Qing Ke brewer’s spent grain using Caco-2 cells. SDF simultaneously increased the activities and mRNA expression levels of the phase II detoxifying/antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidise (GPx). The expression levels of the intestinal genes for cholesterol efflux, ABCA1, ABCG5, and LXRα,...
Source: Journal of Functional Foods - July 10, 2018 Category: Nutrition Source Type: research