Dietary phytochemical approaches to stem cell regulation
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Shuai Zhang, Kargo Kar Ho Lam, Jack Hei Wan, Chun Wang Yip, Harry Kwun-Hung Liu, Queenie Ming-Ngai Lau, Alice Hei-Yi Man, Chun-Hei Cheung, Lik Hang Wong, Hu Biao Chen, Jun Shi, George Par-Heng Leung, Calvin Kai-Fai Lee, Yi-Gang Shi, Sydney Chi-Wai Tang, Kalin Yan Bo ZhangAbstractControlling self-renewal and lineage differentiation of stem cells (SCs) is critical for SC therapy in regenerative medicine. Multiple signal pathways such as Wnt, TGF-β and BMP are involved in modulating proliferation or specific differentiation of different ...
Source: Journal of Functional Foods - February 15, 2020 Category: Nutrition Source Type: research

Egg white hydrolysate prevents reproductive impairments induced by cadmium in rats
Publication date: April 2020Source: Journal of Functional Foods, Volume 67Author(s): José Eudes Gomes Pinheiro, Caroline Silveira Martinez, Paola Zambelli Moraes, José Eduardo Stasiaki, Maria Elisa Trost, Dalton Valentim Vassallo, Fernando Barbosa, Franck Maciel Peçanha, Francielli Weber Santos Cibin, Marta Miguel, Giulia Alessandra WiggersAbstractHere, we investigated the ability of an egg white hydrolysate (EWH) to counteract the reproductive toxic effects induced by Cd in rats. 3-month-old male Wistar rats were treated for 14 days: (a) Untreated group (distilled water i.p.); (b) Cd group (CdCl2...
Source: Journal of Functional Foods - February 15, 2020 Category: Nutrition Source Type: research

Lectin rich horsegram protein and myricetin activates insulin signaling – A study targeting PTP1β
We examined the individual and combinational effect of Myr and horsegram protein (HP) on protein tyrosine phosphatase 1β (PTP1β), and its effect on insulin signaling in high-fat-diet (HFD) and a single dose of streptozotocin (STZ) induced diabetic rat model. Myr, HP, and their combination, Myr + HP, were orally administered to diabetic animals for four weeks. Myr, HP, and Myr + HP were effective in reducing elevated blood glucose, HbA1c, fasting insulin, insulin resistance, oxidative stress markers, and proinflammatory cytokines. Myr ameliorated dyslipidemia and significantly reduced PTP1&beta...
Source: Journal of Functional Foods - February 15, 2020 Category: Nutrition Source Type: research

S-layer protein modulates the stimulatory effects of Lactobacillus acidophilus CICC 6074 by triggering PKC signaling cascade in RAW 264.7 cells
This study provides important insights on the immunomodulatory properties of cell surface components in lactobacilli.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - February 15, 2020 Category: Nutrition Source Type: research

Chinese sweet tea (Rubus suavissimus) polyphefnols attenuate the allergic responses in a Balb/c mouse model of egg allergy
Publication date: April 2020Source: Journal of Functional Foods, Volume 67Author(s): Yoshinori Mine, Kaustav Majumder, Yan Jin, Yuhan ZengAbstractThe aim of this study was to evaluate the effects of Rubus suavissimus S. Lee extract against hen egg ovalbumin (OVA)-induced allergic response in mice. BALB/c mice were sensitized with OVA via intraperitoneal injection for four weeks and subsequently administered the different doses of Rubus suavissimus S. Lee extract (0.1 0.5 and 1.0% w/v) in drinking water. We demonstrated that Rubus suavissimus S. Lee extract can attenuate OVA allergic response in mice by inducing immune dese...
Source: Journal of Functional Foods - February 15, 2020 Category: Nutrition Source Type: research

Acute effect of juçara juice (Euterpe edulis Martius) on oxidative stress biomarkers and fatigue in a high-intensity interval training session: A single-blind cross-over randomized study
This study aimed to evaluate the effects of juçara juice on oxidative stress biomarkers and fatigue in a high-intensity interval training (HIIT) session. Fifteen physically active men were assigned to drink 250 mL of juçara juice or water (control) 1 h before exercise. Blood samples were collected 1 h prior to exercise, immediately post exercise, and 1 h post exercise. From the relative average changes, a decrease in oxidative stress index was observed immediately post exercise (P = 0.020) and an increase in reduced glutathione 1 h post exercise (P = 0.044) in the ...
Source: Journal of Functional Foods - February 15, 2020 Category: Nutrition Source Type: research

Polyphenol supplementation benefits human health via gut microbiota: A systematic review via meta-analysis
This study aimed to use meta-analytic methods to reveal the effects of polyphenol-rich foods on the abundance of human gut microbiota. Significant heterogeneity analysis showed the polyphenol intake dose and sources variedly affected on abundance of gut microbiota. Polyphenol supplementation stimulated the abundance of Lactobacillus and Bifidobacterium health promoting species, but inhibited the abundance of Clostridium pathogenic species in gut microbiota of human subjects. Notably, peak increase of abundance of Lactobacillus, Bifidobacterium, and Clostridum health promoting species was at polyphenol intake of 396 mg...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Rational use of prebiotics for gut microbiota alterations: Specific bacterial phylotypes and related mechanisms
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Shumin Wang, Yue Xiao, Fengwei Tian, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wei ChenAbstractPrebiotics play a widely recognized role in the regulation of intestinal microbiota, but most related studies have not been explored beyond the genus level. In recent years, some newly publicized findings have opened a window of opportunity regarding the dietary tuning of colonization by specific groups of gut bacteria. For example, seaweed polysaccharides were shown to enrich specific Bacteroides spp., while galacto-oligosaccharides (GOS) could spec...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Different source of commercial vegetable oils may regulate metabolic, inflammatory and redox status in healthy rats
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Sttefany Viana Gomes, Bruna Vidal Dias, Renata Rebeca Pereira, Karine de Pádua Lúcio, Débora Maria Soares de Souza, André Talvani, Geraldo Célio Brandão, Gustavo Pereira Cosenza, Karina Barbosa de Queiroz, Daniela Caldeira CostaAbstractOur goal was to carry out a comparative study to evaluate the metabolic and inflammatory effects and the redox status of commercial vegetable oils supplementation [linseed (LO), coconut (VCO), and sunflower (SO)] in metabolically healthy rats. The results found in th...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

A sulfated polysaccharide from the edible flesh of Cipangopaludina chinensis inhibits angiogenesis to enhance atherosclerotic plaque stability
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Qingping Xiong, Hailun Li, Li Zhou, Jian Liang, Ziyun Zhang, Yun Han, Yi Jing, Youdong Hu, Yingying Shi, Tingting Xu, Guoqing Qian, Jun YuanAbstractSulfated polysaccharide (CCPSs) of Cipangopaludina chinensis has shown significant antiangiogenic activity. In view of the closely relationship between angiogenesis and atherosclerotic plaque vulnerability, we speculated that CCPSs may stabilize atherosclerotic plaques by inhibiting angiogenesis. The purpose of this study was to demonstrate a correlation between the role of CCPSs in stabilizing...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Berberine and ginsenoside Rg3 act synergistically via the MAPK/ERK pathway in nasopharyngeal carcinoma cells
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Fangliang Zhou, Jing Hu, Na Dai, Lan Song, Ting Lin, Jie Liu, Kairui Li, Zhuang Peng, Yingchun He, Duan-fang LiaoAbstractHerein, we investigated the effects of combining berberine (Ber; the major active constituent of Rhizoma coptidis) with ginsenoside Rg3 (Rg3; an active ingredient of Panax ginseng) on the proliferation and apoptosis of nasopharyngeal carcinoma (NPC) cells, and explored the underlying mechanism. Combining Ber with Rg3 synergistically inhibited the proliferation of NPC CNE2 cells in vitro and in vivo. Additionally, Ber com...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism
This study investigates the possible mechanisms involved in the beneficial effect of chia seed on skeletal muscle lipotoxicity and insulin resistance in rats fed a sucrose-rich diet (SRD). Results showed that chia seed reduced the increased lipid content in the skeletal muscle of SRD-fed rats. This was accompanied by an increase of muscle-type carnitine palmitoyltransferase 1 enzyme activity, peroxisome proliferator-activated receptors (PPARα, PPARγ) and phosphorylated AMP activated protein kinase protein levels. Moreover, the precursor and mature forms of sterol regulatory element-binding protein-1 and lipogen...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

The effect of deacetylation degree of konjac glucomannan on microbial metabolites and gut microbiota in vitro fermentation
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Dongmei Ouyang, Jie Deng, Kai Zhou, Yuxuan Liang, Yongchun Chen, Da Wang, Jing Zhong, Yuanming Sun, Meiying LiAbstractDeacetylation was a phenomenon widely existed during konjac glucomannan (KGM) processing, which highly effected its functional properties. Herein, influence of deacetylation degree (DD) of KGM on microbial metabolites and gut microbiota was studied in vitro. The fermentability of KGM was relatively stable under the low (Da1) and medium (Da2) DD. But high DD (Da3) shown lower fermentability than that in KGM, which was charac...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

The effect of Metapanax delavayi leaf extract on testosterone‐induced benign prostatic hyperplasia in rats
In this study, we evaluated the effect of M. delavayi leaves aqueous extract (MD-T) and its fractions (MD-W and MD-E) on benign prostatic hyperplasia (BPH) in testosterone propionate (TP) induced rat model based on folk applications. The results showed that MD-T and MD-E could significantly reduce the prostate weight, prostate index, and serum level of prostate acid phosphatase (PAP) in BPH rats and improve the tissue morphology of the prostate. They mainly played roles in regulating the sex hormone level, reducing the levels of inflammatory factors and improving the antioxidant levels of prostate tissue. UPLC-Q-TOF-MS ana...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

EPA-enriched ethanolamine plasmalogen alleviates atherosclerosis via mediating bile acids metabolism
In conclusion, different with EPA in form of EE or PC, EPA-PlsEtn efficiently alleviated atherosclerosis via lowering cholesterol levels by suppressing FXR expression. These findings provided new evidence and thought to explain the unique bioactivity of EPA-PlsEtn and new sight to re-understand the structure-activities relationship of DHA/EPA.Graphical abstractThe possible underlying mechanism involved in the alleviation of dietary EPA-enriched ethanolamine plasmalogen (EPA-PlsEtn) on atherosclerosis. Administration with EPA-PlsEtn promoted excess cholesterol to synthesize bile acids via increasing CYP7A1 expression. Incre...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Selenium-rich yeast attenuates ochratoxin A-induced small intestinal injury in broiler chickens by activating the Nrf2 pathway and inhibiting NF-KB activation
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Cui Tong, Peng Li, Li-Hui Yu, Lin Li, Kang Li, Yueli Chen, Shu-Hua Yang, Miao LongAbstractThe aim was to investigate whether selenium-enriched yeast (SeY) can attenuate intestinal injury in broiler chickens induced by ochratoxin A (OTA). Here, the results showed that SeY addition increased the body weight, feed conversion ratio, villi height, villus/crypt ratio, and the numbers of goblet cells. Furthermore, the levels of oxidative stress by SeY addition (superoxide dismutase activity, total antioxidant capacity, and total glutathione conte...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Calabash (Lagenaria siceraria) potency to ameliorate hyperglycemia and oxidative stress in diabetes
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Lana Y.M. Juee, Alaadin M. NaqishbandiAbstractCalabash fruit is traditionally used as an antidiabetic remedy in the Kurdistan region. Different extracts (400 mg/kg) were investigated for antihyperglycemic potency on normal and alloxan-induced diabetic mice. The significant potency exhibited by the aqueous extract produced a decrease in fasting blood glucose level (52.685%, P ≤ 0.05) in diabetic mice with no apparent effect using extracts in the normoglycemic model. The antihyperglycemic extract was evaluated for in vitro ...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Modulation of equol production via different dietary regimens in an artificial model of the human colon
In conclusion, under the TIM-2 culture conditions established, the CH-ISO diet favoured the synthesis of equol.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Bioactive assessment of the antioxidative and antidiabetic activities of oleanane triterpenoid isolates of sprouted quinoa yoghurt beverages and their anti-angiogenic effects on HUVECS line
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Joy Ujiroghene Obaroakpo, Lu Liu, Shuwen Zhang, Lu Jing, Liu Liu, Xiaoyang Pang, Jiaping LvAbstractOleanolic acid (OA), a pentacyclic triterpene was isolated from sprouted quinoa yoghurt beverage (QYB). The influence of sprouting on the antioxidative, antidiabetic and anti-angiogenic activities of the OA extracts were assessed. The results showed that all samples exhibited significant (p  0.05) reduced after OA treatment at ranges of 52.39–65.81%, 31.47–80.46%, and 22.84–43.22% in QY100, QY124 and QY172 respecti...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Hericium erinaceus enhances neurotrophic factors and prevents cochlear cell apoptosis in senescence accelerated mice
In conclusions, HE could prevent hearing degeneration possibly by increasing neurotrophic expression, preventing OHCs loss, and reducing the caspase-independent apoptosis signalings.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Bioactive compounds from dietary whole grape seed meal improved colonic inflammation via inhibition of MAPKs and NF-kB signaling in pigs with DSS induced colitis
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Gina Cecilia Pistol, Daniela Eliza Marin, Mircea Catalin Rotar, Mariana Ropota, Ionelia TaranuAbstractThe management of Inflammatory Bowel Diseases symptoms is focused to find new alternative strategies which could have beneficial effects on intestinal inflammation including the nutritional interventions. Using an in vivo approach together with gene and protein analysis, we investigated the effect of a diet with 8% grape seed meal on inflammatory markers and signaling pathway molecules. DSS-challenged pigs were used as IBD animal model. Ou...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Anti-hyperuricemic effects of three theaflavins isolated from black tea in hyperuricemic mice
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Lingling Tai, Zenghui Liu, Minghui Sun, Qianjin Xie, Xiaqiang Cai, Ying Wang, Xu Dong, Yan XuAbstractTheaflavins are characteristic ingredients of black tea which are correlated with their qualities and functions. The study aimed to evaluate the effects and mechanism of major theaflavin monomers reducing serum uric acid (SUA) in hyperuricemic mice. Three theaflavin monomers of TF, TFDG and TF-3-G were isolated and purified from black tea. The results showed that they have obvious SUA-lowering effect on hyperuricemic mice. They suppressed t...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Isolation and identification of four antioxidants from Rhodiola crenulata and evaluation of their UV photoprotection capacity in vitro
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Yan-Shuo Wang, Si-Si Zhou, Chun-Yan Shen, Jian-Guo JiangAbstractRhodiola crenulata has recently been reported to be able to attenuate radiation induced oxidative injury and improve skin homeostasis. The purpose of this research is to identify and evaluate the active constituents responsible for its anti-photoaging effects. Four ingredients, Salidroside, Arbutin, Kaempferol and Rhodiolinin were purified form R. crenulata and their antioxidant effects were tested. Further, the protective effects of the four compounds against UVB irradiation ...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Polyphenolic extracts from Wushan tea leaves attenuate hepatic injury in CCl4-treated mice
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Jia Sha, Jiajia Song, Mingjia Yu, Xin Zhao, Hongwei Wang, Yu Zhang, Huayi SuoAbstractThe current study aimed to investigate the protective effects of polyphenolic extracts from Wushan tea leaves (WST-PE) on the liver of Kunming mice subjected to CCl4. Flavonoids, flavanones, and flavonols were major components of WST-PE that improved the elevation in serum AST and ALT and reduced the liver coefficient and pathological change in mice treated with CCl4. The CCl4-induced increase in MDA and decrease in antioxidases (SOD, CAT, and GSH-Px) were...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

The antitumor activity of Arthrospira platensis and/or cisplatin in a murine model of Ehrlich ascites carcinoma with hematinic and hepato-renal protective action
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Mohamed A. Hashem, Sara B.A. Shoeeb, Yasmina M. Abd-Elhakim, Wafaa A.M. MohamedAbstractHerein two experiments were conducted. The first experiment evaluated the antitumor activity of Arthrospira platensis (Spirulina platensis, SP) alone or in combination with cisplatin (CDDP) in Ehrlich ascites carcinoma (EAC) bearing mice. The second experiment assessed the outcomes of SP and/or CDDP administration on renal, hepatic, and bone marrow function in normal mice. The results showed that the EAC evoked a significant decrease in the mice survival...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Chokeberry (Aronia melanocarpa) fruit extract modulates immune response in vivo and in vitro
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Dragica Gajic, Tamara Saksida, Ivan Koprivica, Milica Vujicic, Sanja Despotovic, Katarina Savikin, Teodora Jankovic, Ivana StojanovicAbstractChokeberry (Aronia melanocarpa) is known for its anti-oxidant, anti-inflammatory and anti-diabetic properties. Since the effects of chokeberry extract on the immune response have been only sporadically assessed, our aim was to investigate chokeberry fruit water extract on the immune response in vivo and in vitro. When administered orally to healthy mice, the extract exerted immunomodulatory effects in...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

In vitro selenium bioaccessibility combined with in vivo bioavailability and bioactivity in Se-enriched microalga (Chlorella sorokiniana) to be used as functional food
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Verónica Gómez-Jacinto, Francisco Navarro-Roldán, Inés Garbayo-Nores, Carlos Vílchez-Lobato, Ana Arias Borrego, Tamara García-BarreraAbstractSpeciation of seleno-metabolites and selenoproteins in Se-enriched Chlorella sorokiniana microalgae, in vitro and in vivo extracts has been performed by HPLC-ICP-MS. Selenium bioaccesibility in Se-enriched Chlorela sorokiniana evaluated by in vitro gastrointestinal digestion of the selenized microalga was 81% (79% as SeMet). Mice supplemeted with Se-enriched C...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Eugenia uniflora (pitanga) leaf extract prevents the progression of experimental acute kidney injury
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Eduardo F. Meira, Nayara D. Oliveira, Noemia P. Mariani, Marcella L. Porto, Juliana A. Severi, Fabiana D.M. Siman, Silvana S. Meyrelles, Elisardo C. Vasquez, Agata L. GavaAbstractAcute kidney injury (AKI) is characterized by a rapid and potentially reversible decline in renal function. We hypothesized that Eugenia uniflora (pitanga) may present a protective effect in AKI due to its antioxidant properties. Extract from pitanga leaves (200 mg/kg, gavage) or vehicle was administered to Wistar rats (28 days) prior to AKI induction by...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Anti-hyperlipidemia effect of sea buckthorn fruit oil extract through the AMPK and Akt signaling pathway in hamsters
In this study, golden syrian hamsters were regarded as modeling objects, a series of sea buckthorn fruit oil (SBFO) extract, which is rich in palmitoleic acid (POA), was evaluated through in vivo experiments to explore its mechanism of action in anti-hyperlipidemia. The results revealed that SBFO extract could control body weight and adipose tissue mass, relieve fat accumulation, together with improving total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) level in dose-dependent manner. The extract could also alleviate oxidative str...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Polysaccharide from the seeds of Plantago asiatica L. alleviates nonylphenol induced reproductive system injury of male rats via PI3K/Akt/mTOR pathway
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Fenfen Li, Danfei Huang, Weiyu Yang, Xiaozhen Liu, Shaoping Nie, Mingyong XieAbstractThe preventive role of polysaccharide from the seeds of Plantago asiatica L. (PLCP) against reproductive system injury induced by nonylphenol (NP) was investigated. Male Sprague-Dawley rats were exposed orally to NP 1 h after PLCP intragastric administration continuously for 45 days. The results showed that NP induced significant decrease in relative weight of testes and epididymis, changed testicular histomorphology, and disrupted hormone secret...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Mouse skin fibroblasts with mesenchymal stem cell marker p75 neurotrophin receptor proliferate in response to prolyl-hydroxyproline
In this study, we focused on the mesenchymal stem cell marker p75 neurotrophin receptor (p75NTR), because p75NTR-positive cells are increased at wound healing sites. Most fibroblasts that had migrated from the dissected mouse skin for 1–4 days expressed p75NTR. After prolonged cultivation, however, the ratio of p75NTR-positive fibroblasts dropped. The p75NTR-positive fibroblasts specifically incorporated fluorescein isothiocyanate (FITC)-labeled Pro-Hyp and Pro-Hyp significantly increased the number of p75NTR-positive fibroblasts grown on collagen gel. These results suggest that Pro-Hyp could enhance wound heali...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cells
Publication date: April 2020Source: Journal of Functional Foods, Volume 67Author(s): Pablo S. Tate, Mariela C. Marazita, Melisa D. Marquioni-Ramella, Angela Maria SuburoAbstractAged-related macular degeneration (AMD), a prevalent chronic disease leading to blindness, is associated with oxidative damage of the retinal pigment epithelium (RPE). Ilex paraguariensis (yerba mate, YM), widely consumed in South America, is an excellent source of antioxidants and could prevent RPE cell impairment. Therefore, we evaluated the effects of YM extracts or caffeic (CAF) and chlorogenic (CHL) acids, two major Ilex polyphenols on cell dea...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Protective effects of polymethoxyflavone-rich cold-pressed orange peel oil against ultraviolet B-induced photoaging on mouse skin
Publication date: April 2020Source: Journal of Functional Foods, Volume 67Author(s): Guijie Li, Fang Tan, Qunlin Zhang, Anqun Tan, Yujiao Cheng, Qi Zhou, Manjiao Liu, Xiang Tan, Linhua Huang, Russell Rouseff, Houjiu Wu, Xin Zhao, Guolu Liang, Xiaochun ZhaoAbstractThe protective effects of the topical application of orange peel cold-pressed oil (CPO), a rich polymethoxyflavones (PMFs) source, on ultraviolet B (UVB)-induced skin injury were studied. Depilated KM mice were irradiated by UVB at one minimal erythemal dose every day and the treated groups were smeared with CPO before radiation. After two weeks we found that CPO ...
Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research

Evaluation of the bioavailability and intestinal effects of milk fermented by folate producing lactic acid bacteria in a depletion/repletion mice model
This study aimed to evaluate the bioavailability and effects on the intestinal mucosa of a bioenriched fermented milk (BFM) prepared with folate-producing lactic acid bacteria, using a depletion/repletion BALB/c mice model. Five Streptococcus thermophilus strains were combined with Lactobacillus plantarum 16cv and the combination that resulted in the best folate production was used for preparation of BFM. The folate content in BFM, prepared under controlled conditions (pH 6.0, 42 °C, 70 rpm, 24 h), was 321.1 ± 14.1 ng/mL. Results for mice fed with BFM were compared to those fed with...
Source: Journal of Functional Foods - January 31, 2020 Category: Nutrition Source Type: research

S-allylcysteine therapy reduces adverse cardiac remodelling after myocardial infarction in a rat model
This study investigated the impact of S-allylcysteine therapy on adverse cardiac remodelling after MI in a preclinical rat model. Wistar rats (n = 6–8/group) were subjected to MI via isoprenaline overdose and were then administered with S-allylcysteine (50 or 100 mg/kg) orally for 7 days. Compared to the sham controls, untreated MI rats showed enhanced cardiac hypertrophy and fibrosis 7 days after MI, accompanied by a significant reduction in left ventricle glutathione and glutathione reductase activities with concomitant increase in protein oxidation. S-allylcysteine therapy however, signifi...
Source: Journal of Functional Foods - January 31, 2020 Category: Nutrition Source Type: research

Ameliorative effect of anthocyanin on depression mice by increasing monoamine neurotransmitter and up-regulating BDNF expression
In this study, effects and relevant mechanisms of purified anthocyanin from purple cauliflower (PAPC) on chronic unpredictable mild stress (CUMS)-induced mice model of depression were investigated. After three weeks of CUMS induced, the mice were intragastric administration with PAPC for six weeks. The results showed that PAPC treatment significantly improved depression-like behaviors in mice following CUMS, increased monoamine neurotransmitter content and inhibited monoamine oxidases (MAO) in the brain. It also increased the expression of tyrosine receptor kinase B, brain-derive neurotrophic factor (BDNF), phosphorylation...
Source: Journal of Functional Foods - January 31, 2020 Category: Nutrition Source Type: research

Dairy-derived peptides for satiety
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Alina Kondrashina, André Brodkorb, Linda GiblinAbstractSatiety hormones produced in the gastrointestinal tract are key players in influencing appetite and food intake. Dairy proteins that target these gastric signals have the potential to make one feel ‘fuller for longer’. While effects of whey and casein on appetite and food intake are well documented, this review focuses on individual dairy peptides. The evidence of these peptide bioactives on satiety signaling in vitro using cellular models and in vivo via interventio...
Source: Journal of Functional Foods - January 30, 2020 Category: Nutrition Source Type: research

Protoilludane sesquiterpenoid aromatic esters from Armillaria mellea improve depressive-like behavior induced by chronic unpredictable mild stress in mice
This study mainly explored the antidepressant-like effects and mechanisms of protoilludane sesquiterpenoid aromatic esters from Armillaria mellea (PSAM) in depressive mice induced by chronic unpredictable mild stress (CUMS). The results demonstrated that PSAM exerted antidepressant-like effects in mice, as indicated by reversing CUMS-induced changes in body weight gain, sucrose preference, and behavior in the open field test, elevated plus maze test, tail suspension test and forced swimming test. Meanwhile, PSAM inhibited the release of hippocampus IL-6, IL-1β and TNF-α levels, and down-regulated hippocampus cas...
Source: Journal of Functional Foods - January 28, 2020 Category: Nutrition Source Type: research

Corrigendum to “A new procedure to measure cysteine equivalent methylglyoxal scavenging activity (CEMSA) of foods under simulated physiological conditions” [J. Funct. Foods 63 (2019) 103575]
Publication date: Available online 25 January 2020Source: Journal of Functional FoodsAuthor(s): Ezgi Doğan Cömert, Vural Gökmen (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - January 25, 2020 Category: Nutrition Source Type: research

Protein fraction from Artocarpus altilis pulp exhibits antioxidant properties and reverses anxiety behavior in adult zebrafish via the serotoninergic system
Publication date: Available online 25 January 2020Source: Journal of Functional FoodsAuthor(s): Nidyedja Goyanna Gomes Gonçalves, José Ismael Feitosa de Araújo, Francisco Ernani Alves Magalhães, Francisco Rogênio Silva Mendes, Marina Duarte Pinto Lobo, Ana Cristina de Oliveira Monteiro Moreira, Renato de Azevedo MoreiraAbstractBreadfruit (Artocarpus altilis) is a staple food in tropical regions and has several uses. The aim of this study was to establish the nutraceutical potential of an enriched protein fraction of breadfruit pulp (PFBp). PFBp was characterized by Fourier transform infrar...
Source: Journal of Functional Foods - January 25, 2020 Category: Nutrition Source Type: research

Wine pomace product ameliorates hypertensive and diabetic aorta vascular remodeling through antioxidant and anti-inflammatory actions
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Gisela Gerardi, Mónica Cavia-Saiz, Raquel del Pino-García, María D. Rivero-Pérez, María L. González-SanJosé, Pilar MuñizAbstractVascular remodeling in hypertension and diabetes is characterized by a low-grade inflammation of the arterial wall and enhanced oxidative stress. Wine pomace products attenuate hyperglycemia and hypertension through reduction of oxidative stress and inflammation by their polyphenol composition. The aim of the study was to assess the influence of the wine poma...
Source: Journal of Functional Foods - January 25, 2020 Category: Nutrition Source Type: research

Lactobacillus-fermented milk enhances postprandial muscle protein synthesis in Sprague-Dawley rats
This study aimed to investigate the effects of Lactobacillus-fermented milk on postprandial skeletal muscle protein synthesis (MPS) in rats. Within 4 h of administration, bulk and time-specific fractional MPS were measured using deuterium and the tracer D5-phenylalanine, respectively. Both bulk and fractional MPS were higher for the group given fermented milk compared to the groups given skim or acidified milk (Bulk P = 0.08 and 0.06 vs. skim and acidified milk, respectively; Fractional: P 
Source: Journal of Functional Foods - January 25, 2020 Category: Nutrition Source Type: research

Comparison of immunomodulatory effects of three polysaccharide fractions from Lentinula edodes water extracts
In this study, three polysaccharide fractions (F1, F2 and F3) were isolated from L. edodes water extracts. Their molecular weights distribution (F1 > F2 > F3) and their immunomodulatory properties were investigated. Thymus index, thickness of footpad, proliferation of splenocytes, immunoglobulin (Ig) content and cytotoxicity of natural killer (NK) cells were measured to evaluate the immunomodulatory effects of the polysaccharides. All three polysaccharide fractions protected host from immunosuppression. F1 had significant effects in enhancing cellular immunity only, while F2 and F3 improved cellul...
Source: Journal of Functional Foods - January 25, 2020 Category: Nutrition Source Type: research

Editorial Board
Publication date: February 2020Source: Journal of Functional Foods, Volume 65Author(s): (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - January 24, 2020 Category: Nutrition Source Type: research

Salidroside alleviates lipotoxicity-induced cell death through inhibition of TLR4/MAPKs pathway, and independently of AMPK and autophagy in AML-12 mouse hepatocytes
This study aimed at investigating Sal-inhibited lipotoxicity and clarify its potential mechanisms. Our study indicated that Sal significantly reversed palmitic acids-induced injury in dose-dependent manner in AML-12 mouse hepatocytes, accompanied with improvement of oxidative stress and mitochondrial damage. Mechanistic analysis revealed that Sal protected hepatic lipotoxicity via reversing TLR4/MAPKs (including JNK, p38, and ERk1/2) and p53 activation, independent from autophagy, AMPK, and Akt pathways. Moreover, TLR4 inhibition also contributed to salidroside-reduced lipids deposition. In sum, this research clearly demon...
Source: Journal of Functional Foods - January 24, 2020 Category: Nutrition Source Type: research

Lactoferrin improves cognitive function and attenuates brain senescence in aged mice
In this study, we evaluated the effects of LF (2000 mg/kg/day for 3 months) on the cognitive ability of 16-month-old C57/BL6J mice. Spatial cognition was improved in aged mice after LF administration, with more pyramidal cells detected in the hippocampi, and more regular distribution. LF also reduced iron deposition, malondialdehyde (MDA) and ROS levels in the hippocampus. Similarly, LF decreased the expression of two subunits of NAPDH oxidase: Gp91phox and P22phox, and reduced hippocampal and serum levels of IL-1β, IL-6 and TNF-α in aged mice. Metabolomic analysis revealed alterations in LysoPG, LysoP...
Source: Journal of Functional Foods - January 24, 2020 Category: Nutrition Source Type: research

Goat milk fermented by lactic acid bacteria modulates small intestinal microbiota and immune responses
Publication date: February 2020Source: Journal of Functional Foods, Volume 65Author(s): Xiaoxin Chen, Rui Zheng, Rong Liu, Linqianag LiAbstractThe impact of fermented cow milk on gut microbiota has been extensively studied, however, the role of fermented goat milk (FGM) has not been well evaluated. The present study using 16S rRNA gene sequencing technology investigated the effect of FGM intake on small intestinal microbiota in mice. It was found that FGM intake decreased microbial diversity and significantly altered microbiota composition, particularly the genera Lactobacillus and Streptococcus. Moreover, metabolism and d...
Source: Journal of Functional Foods - January 24, 2020 Category: Nutrition Source Type: research

Syzygium malaccense fruit supplementation protects mice brain against high-fat diet impairment and improves cognitive functions
In this study, we supplemented a high-fat diet (HF) with 5% powder of freeze-dried Syzygium malaccense fruit (HS) and investigated proofs of peripheral insulin resistance, hippocampal AKT–GSK3-β–tau activation, learning/memory performance, and brain frontal lobe oxidative stress. The intake of HS did not prevent weight gain but promoted peripheral insulin sensitivity, improved AKT signaling in the hippocampus, which prevented the activation of GSK3-β and lowered tau phosphorylation induced in HF. The results from the Morris water maze cognitive test were consistent with the lower tau-phosphorylation, ...
Source: Journal of Functional Foods - January 24, 2020 Category: Nutrition Source Type: research

Effect of dietary phytochemicals on the progression of breast cancer metastasis based on the in vivo detection of circulating tumor cells
In this study, the metastasis inhibition effects of eleven phytochemicals was evaluated by monitoring the number changes of circulating tumor cells (CTCs) in the overall procession of cancer metastasis using in vivo CTC capture method. Meanwhile, the anticancer effect on primary tumor growth and lung metastasis were also investigated on breast tumor BALB/c mouse model. At selected dose, the primary tumor growth were suppressed for all of the eleven food phytochemicals except β-carotene. The numbers of lung metastases were reduced and increased tendency of the number of captured CTCs in the blood circulation were delay...
Source: Journal of Functional Foods - January 24, 2020 Category: Nutrition Source Type: research

Beverage based on whey permeate with phenolic extract of jabuticaba peel: A pilot study on effects on muscle and oxidative stress in trained individuals
Publication date: February 2020Source: Journal of Functional Foods, Volume 65Author(s): Patricia Rodrigues Ferreira, João Carlos Bouzas Marins, Leandro Licursi de Oliveira, Daniel Silva Sena Bastos, Duílio Teixeira Soares Júnior, Cristiano Diniz da Silva, Edimar Aparecida Filomeno FontesAbstractA hydroelectrolytic beverage based on whey permeate plus phenolic extract of jabuticaba peel (HB) was tested by soccer athletes in order to evaluate effects on markers of muscle damage and oxidative stress. The athletes were randomized into three groups: intake of commercial isotonic without antioxidants (CB); w...
Source: Journal of Functional Foods - January 24, 2020 Category: Nutrition Source Type: research