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Probiotic plus low-calorie diet increase gene expression of Toll-like receptor 2 and FOXP3 in overweight and obese participants
Publication date: April 2018 Source:Journal of Functional Foods, Volume 43 Author(s): Bahareh Yazdani, Farzad Shidfar, Eisa Salehi, Fahimeh Baghbani-arani, Elham Razmpoosh, Zatollah Asemi, Elhameh Cheshmazar, Mitra Zarrati We evaluated the effects of probiotic supplementation with a low-calorie diet on the gene expression of mediators of the immune system among overweight and obese individuals; participants were randomly divided into three groups of 25 each: group 1 consumed conventional yogurt with a low-calorie diet (CLCD); group 2 consumed probiotic yogurt with a low-calorie diet (PLCD) and group 3 consumed probiotic y...
Source: Journal of Functional Foods - February 21, 2018 Category: Nutrition Source Type: research

Effect of Lactococcus lactis subsp. cremoris YRC3780 on birch pollinosis: a randomized, double-blind, placebo-controlled clinical trial
Publication date: April 2018 Source:Journal of Functional Foods, Volume 43 Author(s): Kenji Uchida, Hidemasa Motoshima, Naoya Katano, Satoshi Hachimura, Aiko Tanaka, Jun Nishihira In a randomized, double-blind, placebo-controlled trial, 114 patients with birch pollinosis received Lactococcus lactis subsp. cremoris YRC3780 (YRC3780) powder (n = 28, 29, 28, in each dose group) or a placebo (1 g starch powder, n = 29) daily for 12 weeks during the 2016 pollen season. Patients self-recorded their symptom and medication scores daily, and blood samples were evaluated every 4 weeks throughout the treatment observatio...
Source: Journal of Functional Foods - February 21, 2018 Category: Nutrition Source Type: research

Isoflavone-enriched soybean (Glycine max) leaves prevents ovariectomy-induced obesity by enhancing fatty acid oxidation
Publication date: April 2018 Source:Journal of Functional Foods, Volume 43 Author(s): Cheng-liang Xie, Sang Soo Kang, Kye Man Cho, Ki Hun Park, Dong Hoon Lee Dietary isoflavones have been gaining increased interest in the field of functional foods due to their ability to ameliorate several postmenopausal symptoms. Using ovariectomized (OVX) rats supplemented with isoflavone-enriched soybean leaves (IESLs), we investigated the effect of dietary isoflavones on menopausal-associated obesity. Oral administration of IESLs significantly reduced OVX-induced weight gain and visceral fat mass. Additionally, IESLs significantly ame...
Source: Journal of Functional Foods - February 21, 2018 Category: Nutrition Source Type: research

Chemical characterization and bioactive properties of decoctions and hydroethanolic extracts of Thymus carnosus Boiss.
Publication date: April 2018 Source:Journal of Functional Foods, Volume 43 Author(s): Carlos Martins-Gomes, Meriem Taghouti, Judith Schäfer, Mirko Bunzel, Amélia M. Silva, Fernando M. Nunes Thymus carnosus Boiss. is an endangered species endemic to Portugal. Studies on its phytochemical composition and bioactivity would increase its use and protection, as no data is available. LC-MS analysis of T. carnosus decoction and hydroethanolic extracts allowed the identification of a salvianolic A isomer, which has not been described in Thymus genus before, rosmarinic and salvianolic K acids as the main phenolics. Lute...
Source: Journal of Functional Foods - February 21, 2018 Category: Nutrition Source Type: research

Hepatoprotective effects of Lactobacillus plantarum C88 on LPS/D-GalN –induced acute liver injury in mice
This study aims to examine the protective effects of Lactobacillus plantarum C88 on LPS/D-GalN-induced ALF and elucidate its underlying molecular mechanisms in mice. The results showed that L. plantarum C88 pretreatment significantly reduced the levels of plasma ALT and AST in mice with LPS/D-GalN–induced liver injury. L. plantarum C88 pretreatment decreased the secretion of inflammatory cytokines. In addition, L. plantarum C88 remarkably increased the expression levels and nuclear translocations of Nrf2 mRNA in liver tissues, but inhibited NF-κB nuclear translocations and P65, P38 phosphorylation levels. Moreo...
Source: Journal of Functional Foods - February 17, 2018 Category: Nutrition Source Type: research

In vitro evaluation of the kinetics of the release of phenolic compounds from guava (Psidium guajava L.) fruit
Publication date: April 2018 Source:Journal of Functional Foods, Volume 43 Author(s): Francisco J. Blancas-Benitez, Jara Pérez-Jiménez, Efigenia Montalvo-González, Gustavo A. González-Aguilar, Sonia G. Sáyago-Ayerdi Psidium guajava L. is a source of phenolic compounds (PC). The aim of this study was to evaluate the bioaccessibility and kinetics of the release of PC from guava fruit by using an in vitro digestion model. Similar percentages of bioaccessibility were observed in whole guava (WG) (64.79%) and seedless guava (SG) (67.69%), and the release rates of PC were 10.55 and 8.70 mg/m...
Source: Journal of Functional Foods - February 16, 2018 Category: Nutrition Source Type: research

The effect of dietary pectins on object recognition memory, depression-like behaviour, and il-6 in mouse hippocampi
Publication date: April 2018 Source:Journal of Functional Foods, Volume 43 Author(s): Nikita M. Paderin, Sergey V. Popov People obtain pectins from plant foods. It has been shown that pectins change the concentration of cytokines. Numerous studies have demonstrated the influence of the immune system on the brain. Thus, we examined the effects of pectins on recognition memory, depression-like behaviour, spontaneous activity, the TNF-α, IL-1β, IL-6, and IFN-γ concentrations, and the NF-κB, STAT3 and pSTAT3 protein levels in mouse hippocampi. Mice treated with pectins showed better recognition memory a...
Source: Journal of Functional Foods - February 16, 2018 Category: Nutrition Source Type: research

Unsaturated fatty acids do not have a favourable metabolic response in overweight subjects: Results of a meta-analysis
Conclusion Scientific evidence did not sustain that unsaturated fats present favorable metabolic response in overweight subjects. Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - February 16, 2018 Category: Nutrition Source Type: research

Mechanisms of attenuation of clot formation and acute thromboembolism by syringic acid in mice
Publication date: April 2018 Source:Journal of Functional Foods, Volume 43 Author(s): Jun-Hui Choi, Seung Kim Several in vitro studies have proposed syringic acid as a benzoic acid derivative found in plant foods, which can reduces collagen-stimulated platelet aggregation. Nonetheless, to date, there are no reports elucidating the role of syringic acid in platelet activation and thrombosis. Syringic acid inhibited clot formation and procoagulant protease activity and induced blood clot degradation. Syringic acid decreased the expression of density-enhanced phosphatase-1 (DEP-1)/protein tyrosine phosphatase-1B (PTP1B)/&alp...
Source: Journal of Functional Foods - February 16, 2018 Category: Nutrition Source Type: research

Piperlongumine activates Sirtuin1 and improves cognitive function in a murine model of Alzheimer ’s disease
Publication date: April 2018 Source:Journal of Functional Foods, Volume 43 Author(s): Jun Go, Thi-Kim-Quy Ha, Ji Yeon Seo, Tae-Shin Park, Young-Kyoung Ryu, Hye-Yeon Park, Jung-Ran Noh, Yong-Hoon Kim, Jung Hwan Hwang, Dong-Hee Choi, Dae Youn Hwang, Sanghee Kim, Chul-Ho Lee, Won Keun Oh, Kyoung-Shim Kim Sirtuin1 (Sirt1) is an unusual target for aging and aging-associated diseases. During the screening for Sirt1 activators from natural compounds, piperlongumine (PL), one of the major constituents of Piper longum, potently activated the deacetylase ability of Sirt1 in vitro. Treatment with PL, which regulated the gene transcr...
Source: Journal of Functional Foods - February 10, 2018 Category: Nutrition Source Type: research

Beneficial effects of Apple Cider Vinegar on weight management, Visceral Adiposity Index and lipid profile in overweight or obese subjects receiving restricted calorie diet: A randomized clinical trial
Publication date: April 2018 Source:Journal of Functional Foods, Volume 43 Author(s): Solaleh Sadat Khezri, Atoosa Saidpour, Nima Hosseinzadeh, Zohreh Amiri A randomized, clinical trial was performed to examine whether Apple cider vinegar (ACV) can result in dietary modifications that provides beneficial effects on the management of body weight and serum metabolic profiles in overweight or obese individuals. The participants (n = 39) were randomly allocated into the ACV (subjected to a restricted calorie diet (RCD) with 250 kcal/day energy deficit and 30 mL/d of ACV)) or the control group (RCD only) for 12 weeks...
Source: Journal of Functional Foods - February 10, 2018 Category: Nutrition Source Type: research

Anti-obesity potential of natural methylxanthines
Publication date: April 2018 Source:Journal of Functional Foods, Volume 43 Author(s): David F. Carrageta, Tânia R. Dias, Marco G. Alves, Pedro F. Oliveira, Mariana P. Monteiro, Branca M. Silva Obesity is one of the most challenging health issue worldwide that has been steadily increasing in the last decades. Obesity arises from a positive energy balance in result of increased intake and decreased energy expenditure, usually due to inadequate dietary habits and a sedentary lifestyle, which results in the accumulation of excess body fat. There are few pharmacological tools to address obesity, thus calorie restriction ...
Source: Journal of Functional Foods - February 7, 2018 Category: Nutrition Source Type: research

Fructose exposure during gestation and lactation altered hepatic selenoprotein expression, oxidative balance and metabolic profile in female rat pups
Publication date: April 2018 Source:Journal of Functional Foods, Volume 43 Author(s): M. Luisa Ojeda, Olimpia Carreras, Paulina Muñoz del Valle, M. Luisa Murillo, Fátima Nogales Fructose-rich diets, an experimental model of induced metabolic syndrome (MS), affects pregnant and lactating rat dams, and moreover, it leads to an imbalance in their offspring’s metabolic profile. Selenium (Se) homeostasis and body distribution is also altered. Selenoproteins: Glutathione peroxidase (GPx) and selenoprotein P (SelP) appear to play a role in MS. To evaluate selenoproteins’ implication in the transmission ...
Source: Journal of Functional Foods - February 6, 2018 Category: Nutrition Source Type: research

Effect of sucrose on the functional composition and antioxidant capacity of buckwheat (Fagopyrum esculentum M.) sprouts
In this study, the effects of sucrose on nutritional and functional composition as well as antioxidant activities in buckwheat sprouts during germination were investigated. Treatment with 1%, 2%, or 3% sucrose resulted in an increase in the amount of vitamins, four C-glycosylflavones, and rutin. Tocopherols and β-carotene in sprouts treated with 1%, 2%, and 3% sucrose were increased in a dose-dependent manner. Similarly, the sum of individual flavonoid was 1.35, 1.29, and 1.60 times higher than that of control sprouts. Sucrose treatment increased tyrosine and phenylalanine ammonia-lyase activities resulting in an incr...
Source: Journal of Functional Foods - February 6, 2018 Category: Nutrition Source Type: research

Pomegranate peel polyphenols inhibits inflammation in LPS-induced RAW264.7 macrophages via the suppression of MAPKs activation
Publication date: April 2018 Source:Journal of Functional Foods, Volume 43 Author(s): Lin Du, Jianke Li, Xitong Zhang, Lifang Wang, Weimin Zhang Inflammatory response remains one of the most common and serious complications of disease in clinical studies. It has been established that some molecules found in pomegranate peel polyphenols (PPPs) are related to inflammatory processes; however, the mechanisms are unclear, leaving a significant unmet medical need. The goal of this study was to analyze the anti-inflammatory effects of PPPs in RAW264.7 macrophages and examine the relationship between certain special components su...
Source: Journal of Functional Foods - February 6, 2018 Category: Nutrition Source Type: research

A synergistic combination of Phyllanthus emblica and Alpinia galanga against H2O2-induced oxidative stress and lipid peroxidation in human ECV304 cells
Publication date: April 2018 Source:Journal of Functional Foods, Volume 43 Author(s): Chaisak Chansriniyom, Phichaporn Bunwatcharaphansakun, Waleewan Eaknai, Nonthaneth Nalinratana, Arkornnut Ratanawong, Mattaka Khongkow, Rataya Luechapudiporn A combination of ethanolic extract of Phyllanthus emblica fruits and ethanolic extract of Alpinia galanga rhizomes at a ratio of 7:3 (PE–AE (7:3)) exhibited synergistic antioxidant activities against DPPH , ABTS +, and superoxide anion (O2 −) radicals with Combination Indices (CIs) of 0.692 ± 0.048, 0.802 ± 0.033, and 0.840 ± 0.023, respe...
Source: Journal of Functional Foods - February 5, 2018 Category: Nutrition Source Type: research

Arthrospira maxima (Spirulina) and C-phycocyanin prevent the progression of chronic kidney disease and its cardiovascular complications
In conclusion, A. maxima or C-phycocyanin could be used to delay CKD because they prevent the progression of CKD and the associated cardiovascular complications. (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - February 5, 2018 Category: Nutrition Source Type: research

Silkworm (Bombyx mori) powder supplementation alleviates alcoholic fatty liver disease in rats
Publication date: April 2018 Source:Journal of Functional Foods, Volume 43 Author(s): Kyung-Sook Hong, Sun-Mi Yun, Jae-Min Cho, Da-Young Lee, Sang-Deok Ji, Jong-Gon Son, Eun-Hee Kim Chronic alcohol consumption causes hepatic injury including fatty liver and fibrosis. Global interests in edible insects as future food source have been increased. We have previously demonstrated a new technology to make hard mature silkworm, Bombyx mori, into edible form, steamed and freeze-dried mature silkworm larval powder (SMSP). Here, we assessed the protective effects of SMSP on ethanol-induced hepatic steatosis and lipid metabolism in ...
Source: Journal of Functional Foods - February 5, 2018 Category: Nutrition Source Type: research

Changes in conjugated linoleic acid and isoflavone contents from fermented soymilks using Lactobacillus plantarum P1201 and screening for their digestive enzyme inhibition and antioxidant properties
Publication date: April 2018 Source:Journal of Functional Foods, Volume 43 Author(s): Jin Hwan Lee, Baolo Kim, Chung Eun Hwang, Md. Azizul Haque, Su Cheol Kim, Chung Soo Lee, Sang Soo Kang, Kye Man Cho, Dong Hoon Lee This research was the first to investigate the variations of conjugated linoleic acid (CLA), isoflavone, digestive enzyme inhibition, and antioxidant properties in hydrolysate soybean milks under fermentation using Lactobacillus plantarum P1201. The average CLA contents increased significantly in the range of ND → 0.91–1.75 mg/g during fermentation, whereas the isoflavone glucosides were mark...
Source: Journal of Functional Foods - February 5, 2018 Category: Nutrition Source Type: research

Structural properties and protective effect of Sargassum fusiforme polysaccharides against ultraviolet B radiation in hairless Kun Ming mice
Publication date: April 2018 Source:Journal of Functional Foods, Volume 43 Author(s): Yuhui Ye, Desheng Ji, Lijun You, Lin Zhou, Zhengang Zhao, Charles Brennan Sargassum fusiforme polysaccharide (SFP) was extracted from Sargassum fusiforme by hot water boiling, concentration and ethanol precipitation. The composition was determined as 58.10 ± 2.12% carbohydrate, 1.01 ± 0.15% protein, 9.85 ± 0.96% sulfate group and 17.66 ± 0.54% glucuronic acid. The average molecular weight of SFP was 224 kDa. The monosaccharide composition of SFP was 43.2% L-fucose, 3.5% rhamnose, 18.4% galact...
Source: Journal of Functional Foods - February 5, 2018 Category: Nutrition Source Type: research

Tomato-antioxidants enhance viability of L. reuteri under gastrointestinal conditions while the probiotic negatively affects bioaccessibility of lycopene and phenols
Publication date: April 2018 Source:Journal of Functional Foods, Volume 43 Author(s): J. García-Hernández, M. Hernández-Pérez, I. Peinado, A. Andrés, A. Heredia Changes undergone by tomato-antioxidants during gastrointestinal digestion of raw and fried tomato, with or without presence of the probiotic Lactobacillus reuteri ATCC 55730, were studied. Frying process enhanced the extractability of antioxidant compounds, being their content higher in fried than in raw tomato. In vitro digestion led to a significant loss of antioxidant activity (65 and 75% losses for raw and fried tomato, resp...
Source: Journal of Functional Foods - February 5, 2018 Category: Nutrition Source Type: research

Data mining of nutrigenomics experiments: Identification of a cancer protective gene signature
Publication date: March 2018 Source:Journal of Functional Foods, Volume 42 Author(s): Roberto Martín-Hernández, Guillermo Reglero, Alberto Dávalos Regular consumption of certain foods has shown beneficial effects on cardiometabolic health. However, it is not clear by which molecular mechanisms they may exert their beneficial effects. Many genomic experiments available in public databases have generated gene expression data following the treatment of human cells with different food nutrients. Exploration of such data offers great possibilities for gaining insights into the molecular effects of nutrient...
Source: Journal of Functional Foods - February 4, 2018 Category: Nutrition Source Type: research

Effects of a vinegar-based multi-micronutrient supplement in rats: A multi-pronged assessment of dietary impact
We examined fecal metabolite and microbial profiles, and other physiological parameters. Body weights were less in rats that drank VMm water. Thirty fecal metabolites involved in amino acid and dipeptide metabolism were significantly altered in VMm-supplemented rats. Analysis of microbial 16S rRNA showed enrichment of bacteria in the family S24-7 in VMm-supplemented rats, and one in Ruminococcaceae in controls. Our data show that a VMm-containing beverage can alter growth, and gut metabolism and microbial community. Future work to correlate these parameters is warranted. (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - February 4, 2018 Category: Nutrition Source Type: research

Corn gluten hydrolysate regulates the expressions of antioxidant defense and ROS metabolism relevant genes in H2O2-induced HepG2 cells
This study aimed to investigate the effects of corn gluten hydrolysate (CGH) on the expressions of antioxidant defense and ROS metabolism relevant genes in HepG2 cells. Eighty-four genes involving in antioxidant defense and ROS metabolism were analyzed. The results showed that the genes such as GPX3, GPX5, SOD3, CYGB, SEPP1 and MT3 that down-regulated in oxidative damaged HepG2 cells were, however, up-regulated in CGH1 (molecular weights <1 kDa)-pretreated cells, suggesting that CGH1 could improve the expressions of several antioxidant genes that were initially suppressed by oxidative stress. In addition, pathway ...
Source: Journal of Functional Foods - February 4, 2018 Category: Nutrition Source Type: research

A 1.6  mg/kg dose of epicatechin in a supplemented cocoa mixture yielded the largest acute decrease in food intake in humans
Conclusions In our randomized trial two doses of epicatechin larger than1.6 mg/kg did not cause larger acute decreases in pizza intake. Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - February 4, 2018 Category: Nutrition Source Type: research

Extruded sorghum flour (Sorghum bicolor L.) modulate adiposity and inflammation in high fat diet-induced obese rats
Publication date: March 2018 Source:Journal of Functional Foods, Volume 42 Author(s): Priscila Marques Arbex, Maria Eliza de Castro Moreira, Renata Celi Lopes Toledo, Leandro de Morais Cardoso, Helena Maria Pinheiro-Sant'ana, Laércio dos Anjos Benjamin, Leandro Licursi, Carlos Wanderlei Piler Carvalho, Valeria Aparecida Vieira Queiroz, Hércia Stampini Duarte Martino The aim was to determine the effect of extruded sorghum flour (ESF) on the adiposity and inflammation modulation in obese Wistar rats. Four experimental groups: normal control (AIN-93), obese control (HFD) and two tested groups (replacing 50% of ...
Source: Journal of Functional Foods - February 4, 2018 Category: Nutrition Source Type: research

Modelling the effects of psyllium and water in gluten-free bread: An approach to improve the bread quality and glycemic response
Publication date: March 2018 Source:Journal of Functional Foods, Volume 42 Author(s): Camilly Fratelli, Denise G. Muniz, Fernanda G. Santos, Vanessa D. Capriles A 22 factorial design with three centre points was used to study psyllium (P) and water (W) addition level effects on gluten-free bread (GFB) physical properties and sensory acceptability. The P levels ranged from 2.86 to 17.14% and W levels from 82.14 to 117.86% on a flour basis. The results show that the P and W interactions improve the bread quality by yielding a better loaf volume, softer crumbs, and improved bread appearance and enhancing the sensory acceptab...
Source: Journal of Functional Foods - February 4, 2018 Category: Nutrition Source Type: research

Tamarind xyloglucan attenuates dextran sodium sulfate induced ulcerative colitis: Role of antioxidation
Publication date: March 2018 Source:Journal of Functional Foods, Volume 42 Author(s): Srinivasan Periasamy, Chia-Hui Lin, Balaji Nagarajan, Nehru Viji Sankaranarayanan, Umesh R. Desai, Ming-Yie Liu Ulcerative colitis (UC) is the leading chronic gastrointestinal disorder, if untreated can cause colon cancer. We characterized tamarind xyloglucan (TXG) as an edible nano-fiber and investigated its role in UC mice. TXG was an efficient free radical quencher and antioxidant in nature. TXG increased the cell viability in DSS-induced cytotoxicity of intestinal epithelial cells (IEC-6) and quenched intracellular reactive oxygen sp...
Source: Journal of Functional Foods - February 4, 2018 Category: Nutrition Source Type: research

The possible mechanism of hydroxytyrosol on reducing uric acid levels
In this study, the inhibitory effect of hydroxytyrosol against xanthine oxidase (XOD) by in vivo animal model and in vitro inhibition assay was analysed. The results showed that hydroxytyrosol could reduce uric acid in rat serum, inhibit XOD activity in rat liver, and adjust the mRNA transcription of the renal uric acid transporters URAT1, GLUT9, OAT1, UAT and ABCG2 towards normal in the transcription level. Hydroxytyrosol was observed as an inhibitor of XOD activity, which’s IC50 value of restraining XOD activity was 8.75 mM. Circular dichroism (CD) spectroscopy indicated that the secondary structures of XOD were ...
Source: Journal of Functional Foods - February 4, 2018 Category: Nutrition Source Type: research

Lycopene inhibits endothelial cells migration induced by vascular endothelial growth factor A increasing nitric oxide bioavailability
In conclusion, lycopene inhibits endothelial cells migration modulating VEGFA signalling system. Increased NO generation partly explains lycopene bioactivity. (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - February 4, 2018 Category: Nutrition Source Type: research

The probiotic supplementation reduced inflammation in polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial
This study observed that Lactobacillus supplementation modulates inflammation in PCOS patients. (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - February 4, 2018 Category: Nutrition Source Type: research

Changes in antioxidant activity of Alcalase-hydrolyzed soybean hydrolysate under simulated gastrointestinal digestion and transepithelial transport
In this study, the impact of simulated GI digestion and transepithelial transport on various antioxidant properties of SPH were investigated. SPH displayed DPPH radical scavenging (IC50 = 4.22 mg/mL), ABTS + radical scavenging (IC50 = 2.93 mg/mL), reducing power and metal ion-chelating activities (IC50 = 0.67 mg/mL). Furthermore, SPH significantly (P < .05) inhibited the generation of intracellular reactive oxygen species (ROS) in Caco-2 cells. After simulated GI digestion, the antioxidant properties of SPH were enhanced, except for a decrease in ABTS + radical scavenging activity. After transe...
Source: Journal of Functional Foods - February 4, 2018 Category: Nutrition Source Type: research

Antioxidant and angiotensin-I converting enzyme inhibitory activities of phenolic extracts and fractions derived from three phenolic-rich legume varieties
Publication date: March 2018 Source:Journal of Functional Foods, Volume 42 Author(s): Yan Zhang, Tibor Pechan, Sam K.C. Chang Lentil, black soybean and black turtle bean are commonly consumed legumes of different genera, containing high phenolic contents, which are effective antioxidants and angiotensin-I converting enzyme (ACE) inhibitors. However, these legumes’ phenolic compositions and ACE inhibition ability have not been compared. Crude water extract (CE) was semi-purified (SPE) and fractionated using column chromatography. Results showed that purification and fractionation could substantially increase phenolic...
Source: Journal of Functional Foods - February 4, 2018 Category: Nutrition Source Type: research

Neuroprotective effect of S-allyl cysteine on an experimental model of multiple sclerosis: Antioxidant effects
Publication date: March 2018 Source:Journal of Functional Foods, Volume 42 Author(s): B.M. Escribano, E. Agüera, M. Aguilar-Luque, E. Luque, M. Feijóo, M. LaTorre, A.I. Giraldo, A. Galván-Jurado, J. Caballero-Villarraso, F.I. Gacría-Maceira, A. Santamaría, I. Túnez S-allyl cysteine (SAC), has shown itself to performance important activity as a neuroprotective agent. This action is prompted by antioxidative activity. The aim of this study was to evaluate the neuroprotective effect of SAC, the principal organosulfur compound of garlic, on experimental autoimmune encephalomyelitis (EAE...
Source: Journal of Functional Foods - February 4, 2018 Category: Nutrition Source Type: research

Diabetic nephropathy is ameliorated with peppermint (Mentha piperita) infusions prepared from salicylic acid-elicited plants
Publication date: April 2018 Source:Journal of Functional Foods, Volume 43 Author(s): Marely G. Figueroa-Pérez, Iza F. Pérez-Ramírez, José A. Enciso-Moreno, Marco A. Gallegos-Corona, Luis M. Salgado, Rosalía Reynoso-Camacho Different alternatives are used to delay diabetic complications, and the functional foods have an important position due to their beneficial effects. For instance, herbal infusions are used widely to improve the health, and their favorable effects are enhanced by plant elicitation during cultivation. Peppermint (Mentha pipperita) infusions prepared from elicited plant...
Source: Journal of Functional Foods - February 2, 2018 Category: Nutrition Source Type: research

Bioactive compounds of tomato: Cancer chemopreventive effects and influence on the transcriptome in hepatocytes
Publication date: March 2018 Source:Journal of Functional Foods, Volume 42 Author(s): Inmaculada Navarro-González, Javier García-Alonso, María Jesús Periago The mechanisms of the effects of tomato extracts (containing lycopene and phenolic compounds) and these pure bioactive compounds on the viability, apoptosis, cell cycle, and the scavenging of ROS of HepG2 cells were investigated. Simultaneously, a transcriptomic analysis in human hepatocytes from obese patients, after the intake of tomato juice, was carried out using Human Gene Expression Array (Affymetrix). The viability of HepG2 decreased...
Source: Journal of Functional Foods - January 31, 2018 Category: Nutrition Source Type: research

Dried plum polyphenolic extract combined with vitamin K and potassium restores trabecular and cortical bone in osteopenic model of postmenopausal bone loss
This study investigated components of dried plum with potential osteoprotective activity utilizing aged, osteopenic Sprague Dawley rats fed diets supplemented with a crude polyphenol extract, potassium, vitamin K or their combination. Whole body and femoral bone mineral density were restored with the polyphenol and combination treatments to a similar extent as the dried fruit. The combination treatment reversed trabecular bone loss in the spine and cortical bone in the femur mid-diaphysis in a similar manner. Biomarkers of bone resorption were reduced by the polyphenol and combination treatments. The polyphenol extract acc...
Source: Journal of Functional Foods - January 31, 2018 Category: Nutrition Source Type: research

Nelumbo nucifera leaf extracts inhibit the formation of advanced glycation end-products and mechanism revealed by Nano LC-Orbitrap-MS/MS
Publication date: March 2018 Source:Journal of Functional Foods, Volume 42 Author(s): Lu Zhang, Chong-ju Zhang, Zong-cai Tu, Wen-hua Yang, Yi Zhao, Zheng-qi Xin, Hui Wang, Xiao-mei Sha, Juan Chen The inhibition of Nelumbo nucifera leaf (NNL) extract and its fractions on the formation of advanced glycation end-products (AGEs) was evaluated with different models. Changes in the conformational structure of bovine serum albumin (BSA) were analyzed by fluorescence spectrometry. Effect of ethyl acetate fraction (EAF) on the glycation sites and glycation degree of BSA was investigated by Nano LC-Orbitrap-MS/MS due to its stronge...
Source: Journal of Functional Foods - January 31, 2018 Category: Nutrition Source Type: research

Evaluation of randomized controlled trials of foods with functional claims request: The learning outcomes from studies in Japan
Publication date: March 2018 Source:Journal of Functional Foods, Volume 42 Author(s): Nanae Tanemura, Naobumi Hamadate, Hisashi Urushihara A new system for foods with functional claims (FFC) was implemented in April 2015. The efficacy of FFC must now be proven by systematic review or randomized clinical trials (RCTs). The aim of this study was to establish the scientific reporting quality of RCTs on the efficacy of FFC and to identify areas that require improvement. The reporting quality of 33 RCT papers on 31 FFC that were received between April 1, 2015 and December 31, 2016 were analyzed by two experts with regard to co...
Source: Journal of Functional Foods - January 31, 2018 Category: Nutrition Source Type: research

Extract of sesame cake and sesamol alleviate chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits
Publication date: March 2018 Source:Journal of Functional Foods, Volume 42 Author(s): Zhigang Liu, Xiaoning Liu, Shunyi Luo, Chuanqi Chu, Dandan Wu, Runhua Liu, Lei Wang, Jiamin Wang, Xuebo Liu Depression is a worldwide severe psychiatric disease associated with cognitive impairments. The aims of the present study are to investigate the preventive effects of alcoholic extract of sesame (Sesamum indicum L.) cake (SLE) and sesamol in a chronic unpredictable mild stress (CUMS)-induced mouse model. Oral administration of SLE (600 mg/kg/day) and sesamol (10 mg/kg/day) significantly restored CUMS-induced mice antidepressant...
Source: Journal of Functional Foods - January 31, 2018 Category: Nutrition Source Type: research

ROS-modulating anticancer effects of gastrointestinally digested Ribes nigrum L. fruit extract in human colon cancer cells
In this study, ROS-modulating anticancer effects were analysed in colon cancer HT-29 cells exposed to the blackcurrant (BC) extract digested in an artificial gastrointestinal tract. The obtained results indicate that the colon-available fraction of gastrointestinal-digested BC extract dose-dependently inhibited the growth of colon cancer cells by inducing a G0/G1 phase cell cycle arrest and targeting cells to a caspase 3-mediated apoptosis pathway. The extract significantly suppressed cell invasion by down-regulation of matrix metalloproteinase MMP-2 and MMP-9 expression. The anticancer effect of the BC extract was related...
Source: Journal of Functional Foods - January 31, 2018 Category: Nutrition Source Type: research

Benefits of the soluble and insoluble fractions of bitter gourd in mice fed a high-fat diet
Conclusion These results further support the position that bitter gourd has multiple active ingredients and that both fractions have beneficial effects on metabolic disorders. (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - January 13, 2018 Category: Nutrition Source Type: research

Cytoprotective effect and purification of novel antioxidant peptides from hazelnut (C. heterophylla Fisch) protein hydrolysates
Publication date: March 2018 Source:Journal of Functional Foods, Volume 42 Author(s): Chunlei Liu, Dayong Ren, Jingjing Li, Li Fang, Ji Wang, Jingsheng Liu, Weihong Min In the present study, antioxidant fraction (C2) has been obtained from a hazelnut processing by-product. The C2 exhibited strong antioxidant and cytoprotective effect against Ang II induced oxidant injury via up-regulation of SOD and heme oxygenase-1 (HO-1) levels and down-regulation of xanthine oxidase-1 (XO-1) level to inhibit the production of ROS synthesis in human umbilical vein endothelial cells (HUVECs). LC-ESI-MS/MS results revealed that C2 was fou...
Source: Journal of Functional Foods - January 12, 2018 Category: Nutrition Source Type: research

Lactobacillus gasseri SF1183 protects the intestinal epithelium and prevents colitis symptoms in vivo
We report that the oral administration of SF1183 cells had a protective effect in a murine model of DSS (Dextran-Sulfate-Sodium)-induced colitis. The analysis of the intestinal microbial composition indicated that several bacterial genera were differently represented in the intestine of DSS-treated animals. An overall similar alteration was observed in the microbiota of DSS-treated animals that received SF1183, suggesting that the beneficial role of the probiotic was not played through a reshuffling of the intestinal flora. Based on our in vivo data we propose the SF1183 strain of L. gasseri as a new anti-inflammatory prob...
Source: Journal of Functional Foods - January 12, 2018 Category: Nutrition Source Type: research

Liver-specific metabolomics characterizes the hepatoprotective effect of saponin-enriched Celosiae Semen extract on mice with nonalcoholic fatty liver disease
Publication date: March 2018 Source:Journal of Functional Foods, Volume 42 Author(s): Feng-Jie Liu, Dan Liang, Lan-Yun Miao, Ping Li, Hui-Jun Li Celosiae Semen, derived from the seeds of Celosia argentea L., has a long history of therapeutic uses for liver diseases in China and Japan. Phytochemical researches revealed a series of saponins from Celosiae Semen, which showed a variety of important pharmacological properties such as anti-hyperlipidemia and hepatoprotection. However, the exact protection mechanism is still looking forward to further elucidation. In present study, a liver-specific metabolomics approach based on...
Source: Journal of Functional Foods - January 12, 2018 Category: Nutrition Source Type: research

In vitro antitumor and hypotensive activity of peptides from olive seeds
Publication date: March 2018 Source:Journal of Functional Foods, Volume 42 Author(s): Romy Vásquez-Villanueva, Laura Muñoz-Moreno, M. José Carmena, M. Luisa Marina, M. Concepción García Peptides with molecular weights below 3 kDa from the hydrolysis of olive seed proteins with Thermolysin (OS-3 kDa) have demonstrated a high in vitro hypotensive effect. This fraction has been further fractionated by semipreparative RP-HPLC to obtain 8 fractions. ACE inhibitor capacity of fractions was evaluated observing the highest capacity in fraction F5. Peptides in fraction F5 were identified by R...
Source: Journal of Functional Foods - January 12, 2018 Category: Nutrition Source Type: research

Serum metabolomics analysis for biomarker of Lactobacillus plantarum NCU116 on hyperlipidaemic rat model feed by high fat diet
This study demonstrated that L. plantarum NCU116 improved hyperlipidaemic rats via metabolism pathways of amino acids, bile, fatty acids and glucose. (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - January 12, 2018 Category: Nutrition Source Type: research

A bioactive polysaccharide TLH-3 isolated from Tricholoma lobayense protects against oxidative stress-induced premature senescence in cells and mice
Publication date: March 2018 Source:Journal of Functional Foods, Volume 42 Author(s): Wen-Juan Pan, Qiu-Ying Ding, Ya Wang, Dan-Dan Wang, Yong-Ming Lu, Wei-Wei Yang, Zheng-Nan Cai, Xiao-Du Cheng, Wen-Na Zhang, Yan Chen To inform rational therapeutics to alleviate many senescence-related diseases in terms of the pathogenic pathways, we investigated the protective mechanisms of TLH-3 against premature senescence in tert-butyl hydroperoxide (t-BHP)-induced human embryonic lung fibroblast (HELF) cells model and d-galactose-induced premature aging mice model. We demonstrate that TLH-3 ameliorated t-BHP-induced premature senesc...
Source: Journal of Functional Foods - January 12, 2018 Category: Nutrition Source Type: research

Selective oncolytic effect in Epstein-Barr virus (EBV)-associated gastric carcinoma through efficient lytic induction by Euphorbia extracts
Publication date: March 2018 Source:Journal of Functional Foods, Volume 42 Author(s): Dong-eun Kim, Sunhee Jung, Hyung Won Ryu, Miri Choi, Mingu Kang, Hyunju Kang, Heung Joo Yuk, Hyejeong Jeong, Jiyeon Baek, Jae-Hyoung Song, Janghwan Kim, Hyojeung Kang, Sang-Bae Han, Sei-Ryang Oh, Sungchan Cho Lytic induction of latent Epstein-Barr virus (EBV) has been considered as a therapeutic approach for efficient treatment of EBV-associated malignancies. Here, we established a robust assay system quantitatively measuring EBV lytic induction and identified three Euphorbia extracts as strong inducers from a screen of Korean medicinal ...
Source: Journal of Functional Foods - January 12, 2018 Category: Nutrition Source Type: research

Fortified yogurt with vitamin D as a cost-effective food to prevent diabetes: A randomized double-blind clinical trial
This study was conducted on 90 subjects with pre-diabetes in three groups: those given fortified yogurt with vitamin D, those given plain yogurt and those given oral vitamin D supplements. The study variables were evaluated at the beginning and end of the intervention period. Results from the participants’ oral glucose tolerance tests (OGTT) decreased significantly in only the fortified-yogurt group. The mean fasting serum insulin and the insulin-resistance index (HOMA-IR) in the fortified-yogurt (p < .01) and oral-supplement (p < .03, p < .04) groups decreased significantly. Waist-to...
Source: Journal of Functional Foods - January 12, 2018 Category: Nutrition Source Type: research