Comparison of the effect of lavender and bitter orange on anxiety in postmenopausal women: A triple-blind, randomized, controlled clinical trial.
CONCLUSION: The positive effect of bitter orange and lavender on anxiety in postmenopausal women suggests that they can be used to decrease anxiety in such women. PMID: 29705445 [PubMed - in process] (Source: Complementary Therapies in Clinical Practice)
Source: Complementary Therapies in Clinical Practice - May 1, 2018 Category: Complementary Medicine Authors: Farshbaf-Khalili A, Kamalifard M, Namadian M Tags: Complement Ther Clin Pract Source Type: research

Acute hematological and mood perception effects of bitter orange extract (p ‐synephrine) consumed alone and in combination with caffeine: A placebo‐controlled, double‐blind study
Phytotherapy Research, EarlyView. (Source: Phytotherapy Research)
Source: Phytotherapy Research - April 19, 2018 Category: Biochemistry Authors: Jill A.Bush , Nicholas A.Ratamess , Sidney J.Stohs , Nicole L.Ellis , Ira T.Vought , Elizabeth A.O'Grady , Jeremy D.Kuper , JieKang , Avery D.Faigenbaum Source Type: research

Antioxidant and hepato-preventive effect of Citrus aurantium extract against carbon tetrachloride-induced hepatotoxicity in rats and characterisation of its bioactive compounds by HPLC-MS
. (Source: Archives of Physiology and Biochemistry)
Source: Archives of Physiology and Biochemistry - April 17, 2018 Category: Physiology Authors: Anis Ben Hsouna Manel Gargouri Wissal Dhifi Walid Saibi Source Type: research

Food-drug interactions precipitated by fruit juices other than grapefruit juice: An update review
Publication date: Available online 15 February 2018 Source:Journal of Food and Drug Analysis Author(s): Meng Chen, Shu-yi Zhou, Erlinda Fabriaga, Pian-hong Zhang, Quan Zhou This review addressed drug interactions precipitated by fruit juices other than grapefruit juice based on randomized controlled trials (RCTs). Literature was identified by searching PubMed, Cochrane Library, Scopus and Web of Science till December 30 2017. Among 46 finally included RCTs, six RCTs simply addressed pharmacodynamic interactions and 33 RCTs studied pharmacokinetic interactions, whereas seven RCTs investigated both pharmacokinetic and...
Source: Journal of Food and Drug Analysis - February 15, 2018 Category: Food Science Source Type: research

Investigation of amyloid formation inhibition of chemically and biogenically from Citrus aurantium L. blossoms and Rose damascena oils of gold nanoparticles: Toxicity evaluation in rat pheochromocytoma PC12 cells.
Abstract Fibrillation inhibition effects of chemically and biogenically gold nanoparticles (GNPs) were investigated in vitro using human insulin as a model for fibrillation of protein. This inspection was followed using the Congo red assay, thioflavin T fluorescence measurements, transmission electron microscopy, and evaluation of cytotoxicity effects on rat pheochromocytoma PC12 cells. Biogenic GNPs were synthesized using oil extracts of Citrus aurantium L. blossoms and Rose damascena blossoms as reducing and concomitant agents. Congo red assay showed development of fibril formation of insulin at acidic m...
Source: International Journal of Biological Macromolecules - February 6, 2018 Category: Biochemistry Authors: Sattarahmady N, Firoozabadi V, Nazari-Vanani R, Azarpira N Tags: Int J Biol Macromol Source Type: research

The relationship between women's characteristics and herbal medicines use during pregnancy.
Abstract The use of herbal medicines (HM) has been increasing worldwide. This cross-sectional study investigated the prevalence of and characteristics related to use of HM among 320 pregnant women. Participants were admitted to Mazandaran-based hospitals' postnatal wards from March to June 2015. Data were collected via a self-report questionnaire, including herbs used during pregnancy and demographic, socioeconomic and pregnancy-related factors. Nearly half (48.4%) of the women reported taking one or more HM during pregnancy. The most frequently used herbs were Sour orange (30.97%), Peppermint (19.81%) and...
Source: Women and Health - January 16, 2018 Category: Primary Care Authors: Abdollahi F, Yazdani Cherati J Tags: Women Health Source Type: research

Induction of Regulatory CD4+ Cells and Prolongation of Fully Major Histocompatibility Complex Mismatched Murine Cardiac Allograft by Shigyakusan
Shigyakusan (also known as Tsumura Japan [TJ]-35) is composed of peony, bitter orange, licorice, and Bupleuri radix is used for cholecystitis and gastritis as an anti-inflammatory agent. We investigated the effect of TJ-35 on alloimmune response in a murine heart transplantation model. CBA mice that underwent transplantation of a C57BL/6 (B6) heart were assigned to four groups: no treatment, TJ-35 –exposed, each component–exposed, or each component missing–exposed. The four groups above each received oral administration of TJ-35, each component, or TJ-35 with each component missing from the day of transplantation unt...
Source: Transplantation Proceedings - January 1, 2018 Category: Transplant Surgery Authors: E. Yin, M. Uchiyama, M. Niimi Tags: Strides in Transplantation Source Type: research

Anxiolytic Effect of Citrus aurantium L. in Crack Users.
The objective of this study was to investigate the anxiolytic effects of the essential oil (EO) of Citrus aurantium L. in patients experiencing crack withdrawal. This was developed with internal users in therapeutic communities in Paraíba, Brazil. The test population consisted of 51 volunteers, subdivided into three groups. To elicit anxiety, the Simulated Public Speaking (SPS) method was used. Physiological measures were assessed at specific phases during the experiment using appropriate equipment. Psychological measures of anxiety were assessed using the Trait-State Anxiety Inventory (IDATE) and the Analog Smoke Scale (...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Analytical method for the evaluation of the outdoor air contamination by emerging pollutants using tree leaves as bioindicators.
Abstract In this work, an analytical method, based on sonication-assisted extraction, clean-up by dispersive solid-phase extraction and determination by liquid chromatography-tandem mass spectrometry, has been developed and validated for the simultaneous determination of 15 emerging pollutants in leaves from four ornamental tree species. Target compounds include perfluorinated organic compounds, plasticizers, surfactants, brominated flame retardant, and preservatives. The method was optimized using Box-Behnken statistical experimental design with response surface methodology and validated in terms of recov...
Source: Analytical and Bioanalytical Chemistry - December 6, 2017 Category: Chemistry Authors: Barroso PJ, Martín J, Santos JL, Aparicio I, Alonso E Tags: Anal Bioanal Chem Source Type: research

Actions of p ‐synephrine on hepatic enzyme activities linked to carbohydrate metabolism and ATP levels in vivo and in the perfused rat liver
p‐Synephrine is one of the main active components of the fruit of Citrus aurantium (bitter orange). Extracts of the bitter orange and other preparations containing p‐synephrine have been used worldwide to promote weight loss and for sports performance. The purpose of the study was to measure the action of p‐synephrine on hepatic enzyme activities linked to carbohydrate and energy metabolism and the levels of adenine mononucleotides. Enzymes and adenine mononucleotides were measured in the isolated perfused rat liver and in vivo after oral administration of the drug (50 and 300 mg/kg) by using standard techniques. p...
Source: Cell Biochemistry and Function - December 1, 2017 Category: Biochemistry Authors: Marcos Rodrigues Maldonado, L ívia Bracht, Anacharis Babeto Sá‐Nakanishi, Rúbia Carvalho Gomes Corrêa, Jurandir Fernando Comar, Rosane Marina Peralta, Adelar Bracht Tags: RESEARCH ARTICLE Source Type: research

Obtaining hesperetin 7-O-glucosyl  6′′-O-laurate, a high lipophilic flavonoid ester, from Citrus waste
Publication date: January 2018 Source:Biocatalysis and Agricultural Biotechnology, Volume 13 Author(s): Gustavo Céliz, Ramón Díaz, Mirta Daz A biotechnological process that combines the treatment of Citrus processing waste to extract a high-valuable biomolecule, neohesperidin (NEO), and its further modification by biocatalysis to enhance the lipophilicity of its flavonoic moiety is presented. NEO was extracted from immature fruits of Citrus aurantium and hydrolyzed by a commercial alpha-rhamnosidase to obtain hesperetin 7-glucoside (HG). NEO and HG were mono-acylated with vinyl laurate by using Novozym 435 in their...
Source: Biocatalysis and Agricultural Biotechnology - November 25, 2017 Category: Biotechnology Source Type: research

Citrus essential oils inhalation by mice: Behavioral testing, GCMS plasma analysis, corticosterone, and melatonin levels evaluation
The use of orange essential oils (EOs) as a complementary treatment is very common in Brazilian popular culture. The levels of melatonin (MEL) and corticosterone (CORT) hormones were investigated simultaneously, by the Luminex™ immunoassay system in mice plasma, after Citrus aurantium and Citrus sinensis EOs inhalation for 30 min. The plasma was analyzed by headspace through gas chromatography coupled to mass spectrometry for investigation of the EO components. Mice were submitted to behavioral testing to research anxiolytic‐like, sedative, and antidepressant‐like effects. The inhalation of atmosphere obtained from ...
Source: Phytotherapy Research - November 23, 2017 Category: Biochemistry Authors: Adriana Nunes Wolffenb üttel, Amanda Zamboni, Gabriela Becker, Maíra Kerpel Santos, Bruna Tassi Borille, Kristiane Cássia Mariotti, Ana Claudia Fagundes, Janaína Lucas Oliveira Salomón, Vanessa Rodrigues Coelho, Leire Virto Ruiz, Viviane Moura Linck, Tags: RESEARCH ARTICLE Source Type: research

Determination of trace elements in the seeds of fruits using instrumental neutron activation analysis (INAA) in Arak, I.R. Iran
In this study, four fruit ’s seed samples asPunica granatum L., Citrus medica var. limonum,Malus domestica L. and Citrus vulgaris Risso were prepared from Arak ’s markets. They were analyzed using instrumental neutron activation method (INAA). In this method, Tehran research reactor as a neutron source and relative INAA method has been used as the analysis method and to record gamma ray spectrum, the high purity germanium detector was used. Pomegranate s eeds had the highest number of essential elements. Apple seeds and sour orange seeds contain the highest levels of Mg and K, Respectively. (Source: Journal of Radioana...
Source: Journal of Radioanalytical and Nuclear Chemistry - November 15, 2017 Category: Nuclear Medicine Source Type: research