Exposure marker discovery of di-2(propylheptyl) phthalate using ultra-performance liquid chromatography-mass spectrometry and a rat model
Publication date: Available online 11 December 2018Source: Journal of Food and Drug AnalysisAuthor(s): Chia-Lung Shih, Jen-Yi Hsu, Chien-Ping Tien, Yi-Ning Chung, Victor G. Zgoda, Pao-Chi LiaoAbstractDi-(2-propylheptyl) phthalate (DPHP) is a plasticizer and has been suggested to be a subchronic toxicant in rats. DPHP has been approved to be used in food containers and handling by the U.S. Food and Drug Administration. The use of DPHP is still increasing, and the risk of human exposure to DPHP via food may be high. Exposure markers measured in human samples are commonly used to monitor human exposure levels. Ultra-performan...
Source: Journal of Food and Drug Analysis - December 12, 2018 Category: Food Science Source Type: research

Chemical isotope labeling liquid chromatography mass spectrometry for investigating acute dietary effects of cow milk consumption on human urine metabolome
Publication date: Available online 11 December 2018Source: Journal of Food and Drug AnalysisAuthor(s): Dorothea Mung, Liang LiAbstractBiomarker discovery has been increasingly important in the field of metabolomics for the detection and understanding of diseases. Of the many biofluids available for metabolomics, urine is a preferred option as it is non-invasive to collect and contains a wide range of metabolites reflective of the health status of the testing individual. However, urine also contains many exogenous metabolites which are introduced through various sources such as diet. This complicates the data interpretation...
Source: Journal of Food and Drug Analysis - December 12, 2018 Category: Food Science Source Type: research

Using ambient mass spectrometry and LC–MS/MS for the rapid detection and identification of multiple illicit street drugs
In this study the recently developed technique of thermal desorption electrospray ionization/mass spectrometry (TD–ESI/MS) was applied to the rapid analysis of multiple controlled substances. With the reallocation of mass spectral resources [from a standard ESI source coupled with liquid chromatography (LC) to an ambient TD–ESI source], this direct-analysis technique allows the identification of a wider range of illicit drugs through a dual-working mode (pretreatment-free qualitative screening/conventional quantitative confirmation). Through 60-MRM (multiple reaction monitoring) analysis—in which the MS/M...
Source: Journal of Food and Drug Analysis - December 5, 2018 Category: Food Science Source Type: research

Measuring serum total and free indoxyl sulfate and p-cresyl sulfate in chronic kidney disease using UPLC-MS/MS
Publication date: Available online 4 December 2018Source: Journal of Food and Drug AnalysisAuthor(s): Chia-Ni Lin, I-Wen Wu, Yun-Fen Huang, Shu-Yu Peng, Ya-Ching Huang, Hsiao-Chen NingAbstractChronic kidney disease (CKD) is a complex disorder that affects multiple organs and increases the risk of cardiovascular complications. CKD affects approximately 12% of the population in Taiwan. Loss of kidney function leads to accumulation of potentially toxic compounds such as indoxyl sulfate (IS) and p-cresyl sulfate (pCS), two protein-bound uremic solutes that can stimulate the progression of CKD. The aim of this study was to asse...
Source: Journal of Food and Drug Analysis - December 5, 2018 Category: Food Science Source Type: research

The regulation of drug-metabolizing enzymes and membrane transporters by inflammation: Evidences in inflammatory diseases and age-related disorders
Publication date: Available online 4 December 2018Source: Journal of Food and Drug AnalysisAuthor(s): Kuo-Chen Wu, Chun-Jung LinAbstractDrug-metabolizing enzymes (DMEs) and membrane transporters play important roles in the absorption, distribution, metabolism, and excretion processes that determine the pharmacokinetics of drugs. Inflammation has been shown to regulate the expression and function of these drug-processing proteins. Given that inflammation is a common feature of many diseases, in this review, the general mechanisms for inflammation-mediated regulation of DMEs and transporters are described. Also, evidences re...
Source: Journal of Food and Drug Analysis - December 5, 2018 Category: Food Science Source Type: research

Antcins, triterpenoids from Antrodia cinnamomea, as new agonists for peroxisome proliferator-activated receptor α
Publication date: Available online 4 December 2018Source: Journal of Food and Drug AnalysisAuthor(s): Yu-Jen Wang, Shih-Chin Lee, Chun-Hua Hsu, Yueh-Hsiung Kuo, Chien-Chih Yang, Fu-Jung LinAbstractPeroxisome proliferator-activated receptor α (PPARα) is a nuclear hormone receptor that transcriptionally regulates lipid metabolism and inflammation; therefore, PPARα agonists are promising agents to treat dyslipidemia and metabolic disorders. PPARα full agonists, such as fibrates, are effective anti-hypertriglyceride agents, but their use is limited by adverse side effects. Hence, the aim of this study w...
Source: Journal of Food and Drug Analysis - December 4, 2018 Category: Food Science Source Type: research

Shenmai-Yin decreased the clearance of nifedipine in rats: The involvement of time-dependent inhibition of nifedipine oxidation
Publication date: Available online 8 November 2018Source: Journal of Food and Drug AnalysisAuthor(s): Hong-Jaan Wang, Chung-Kuang Lu, Wei-Ching Chen, An-Chi Chen, Yune-Fang UengAbstractThe traditional Chinese herbal formula Shenmai-Yin (SY) and nifedipine have both been used to treat patients with cardiovascular disorders. Nifedipine is primarily oxidized by cytochrome P450 (CYP) 3A. The oxidation and pharmacokinetics of nifedipine were studied in rats in vitro and in vivo to illustrate the interaction of SY with nifedipine. Schisandrol A, schisandrin A and schisandrin B were identified as the main lignans in SY....
Source: Journal of Food and Drug Analysis - November 9, 2018 Category: Food Science Source Type: research

Comparative investigation for raw and processed Aconiti Lateralis Radix using chemical UPLC-MS profiling and multivariate classification techniques
Publication date: Available online 8 November 2018Source: Journal of Food and Drug AnalysisAuthor(s): Lili Sun, Guangjiao You, Xuexiao Cao, Meng Wang, Xiaoliang RenAbstractA strategy combining chemical UPLC-MS profiling and multivariate classification techniques has been used for the comparison of raw and processed Aconiti Lateralis Radix. UPLC-MS was used to identify 18 characteristic compounds, which were selected for discrimination of the raw and two processed products (Heishunpian and Baifupian). Chemometric analyses, including the combination of a heat map and hierarchical cluster analysis (HCA) and principal componen...
Source: Journal of Food and Drug Analysis - November 9, 2018 Category: Food Science Source Type: research

PON-1 carbamylation is enhanced in HDL of uremia patients
Publication date: Available online 28 October 2018Source: Journal of Food and Drug AnalysisAuthor(s): Chiz-Tzung Chang, Yun-Ping Lim, Chi-Wen Lee, Hsin-Yi Liao, Feng-Yu Chen, Chia-Ming Chang, Feng-Yao Tang, Chao-Yuh Yang, Chao-Jung ChenAbstractHigh-density lipoprotein (HDL) carbamylation has been known in uremia patients. Paraoxonase-1 (PON-1) is an important HDL protein responsible for HDL anti-oxidant, arylesterase and lactonase activities. PON-1 carbamylation in uremic HDL has never been explored. We isolated HDL from uremia patients and control healthy subjects for study. Sandwich ELISA was used to estimate carbamylate...
Source: Journal of Food and Drug Analysis - October 29, 2018 Category: Food Science Source Type: research

Method development of immunoglobulin G purification from micro-volumes of human serum for untargeted and targeted proteomics-based antibody repertoire studies
Publication date: Available online 27 October 2018Source: Journal of Food and Drug AnalysisAuthor(s): Yu-Ting Chang, Ming-Chu Chang, Yun-Jun Tsai, Christine Ferng, Hsi-Chang Shih, Ya-Po Kuo, Chung-Hsuan Chen, I-Lin TsaiAbstractImmunoglobulins (Igs) are major serum proteins which play important roles in immunity. Both untargeted and targeted proteomic workflows can be applied to investigate antigen-binding sites and the glycosylation profiles of Igs. For a more-comprehensive picture of IgG from human serum, we developed an IgG purification process and coupled the standardized method to untargeted and targeted proteomic work...
Source: Journal of Food and Drug Analysis - October 27, 2018 Category: Food Science Source Type: research

Analysis of heterocyclic amines in meat products by liquid chromatography – Tandem mass spectrometry
In this study, two sample preparation strategies, liquid–liquid extraction (LLE) with solid-phase extraction (SPE) and a rapid, easy, cheap, effective, rugged, and safe extraction (QuEChERS) method, were investigated for the determination of 11 types of HCAs in meat products by LC-MS/MS. The HCAs in the samples were first extracted with acetonitrile by LLE, and followed by SPE. In the case of QuEChERS extraction, acetonitrile is used as the LLME solvent, and PSA, C18EC and MgSO4 were used as the dSPE sorbent. Both methods showed good performance with respect to precision (RSD 0.993). The QuEChERS extraction stra...
Source: Journal of Food and Drug Analysis - October 27, 2018 Category: Food Science Source Type: research

Stability of glyoxal- and methylglyoxal-modified hemoglobin on dried blood spot cards as analyzed by nanoflow liquid chromatography tandem mass spectrometry
In this study, we examine the stability of these modifications of hemoglobin stored on DBS cards at room temperature or 4 °C in the ambient air. After hemoglobin was extracted from the DBS cards, it was digested by trypsin and analyzed by nanoflow liquid chromatography coupled with nanospray ionization tandem mass spectrometry. The results show that the extents of all these PTMs are stable within 14 and 21 days when stored on DBS at room temperature and at 4 °C, respectively. Extraction of globin from DBS cards is mostly advantageous for hemolytic blood samples. This assay is sensitive as only a quarter o...
Source: Journal of Food and Drug Analysis - October 27, 2018 Category: Food Science Source Type: research

Development of biomarkers of genitourinary cancer using mass spectrometry-based clinical proteomics
Publication date: Available online 27 October 2018Source: Journal of Food and Drug AnalysisAuthor(s): Yi-Ting Chen, Cheng-Han Tsai, Chien-Lun Chen, Jau-Song Yu, Ying-Hsu ChangAbstractProstate, bladder and kidney cancer are the three most common types of genitourinary cancer in the world. Of these, prostate and bladder cancers are within the top 10 most common cancers in men. Notably, kidney cancer causes no obvious symptoms in the early stages. To satisfy clinical-management requirements, researchers have developed numerous biomarkers by applying proteomic approaches using clinical serum, urine and tissue specimens, as wel...
Source: Journal of Food and Drug Analysis - October 27, 2018 Category: Food Science Source Type: research

Identification of bacteria in juice/lettuce using magnetic nanoparticles and selected reaction monitoring mass spectrometry
This study presents an accurate means for bacterial identification in food matrixes using MS. The analysis time is less than 90 min and the minimum concentration of E. coli detected was 5 × 103 CFU/mL. The interaction between bacteria and the magnetic nanoparticles was electrostatic and nonspecific, in contrast to immunoassays which require specific antibodies. The targeted peptide analysis focuses on the bacterial markers, thus significantly simplifying the analysis and leading to an accurate identification of bacteria.Graphical abstract (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - October 26, 2018 Category: Food Science Source Type: research

Simultaneous quantification combined with multivariate statistical analysis of multiple chemical markers of Wu Ji Bai Feng Pill by UHPLC–MS/MS
In conclusion, the established method offered speedy and sensitive determination for 20 compounds and is helpful for chemical standardization of commercial WJBFP products.Graphical abstract (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - October 25, 2018 Category: Food Science Source Type: research

CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-β, Wnt and STAT3 signaling pathways
Publication date: Available online 25 October 2018Source: Journal of Food and Drug AnalysisAuthor(s): In-Yu Lin, Yi-Shiou Chiou, Li-Ching Wu, Chen-Yu Tsai, Chiung-Tong Chen, Wu-Chang Chuang, Ming-Chung Lee, Ching-Che Lin, Ting-Ting Lin, Ssu-Ching Cheng, Min-Hsiung Pan, Nianhan MaAbstractCCM111 is an aqueous extract of Antrodia cinnamomea (AC) that has exhibited anti-liver fibrosis functions. However, the detailed mechanisms of AC action against liver fibrosis have not been elucidated yet. The present research showed that CCM111 significantly lowered the levels of the hepatic enzyme markers glutamate oxaloacetate transamina...
Source: Journal of Food and Drug Analysis - October 25, 2018 Category: Food Science Source Type: research

Applications of cyclic peptide nanotubes (cPNTs)
Publication date: Available online 28 September 2018Source: Journal of Food and Drug AnalysisAuthor(s): Wei-Hsien Hsieh, Jiahorng LiawAbstractSelf-assembled cyclic peptide nanotubes (cPNTs) have recently drawn particular attention as one of the most intriguing nanostructures in the field of nanotechnology. Given their unique features including high surface area, increased drug loading, environmental stability, enhanced permeation, and modifiable drug release, these hollow tubular structures can be constructed with cyclic di-, tri-, tetra-, hexa-, octa-, and decapeptides with various amino acid sequences, enantiomers, and f...
Source: Journal of Food and Drug Analysis - October 9, 2018 Category: Food Science Source Type: research

Novel technologies in detection, treatment and prevention of substance use disorders
Publication date: Available online 28 September 2018Source: Journal of Food and Drug AnalysisAuthor(s): Hichem Moulahoum, Figen Zihnioglu, Suna Timur, Hakan CoskunolAbstractSubstance use disorders are a widely recognized problem, which affects various levels of communities and influenced the world socioeconomically. Its source is deeply embedded in the global population. In order to fight against such an adversary, governments have spared no efforts in implementing substance abuse treatment centers and funding research to develop treatments and prevention procedures. In this review, we will discuss the use of immunological...
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research

Rapid screening of sulfonamides in dietary supplements based on extracted common ion chromatogram and neutral loss scan by LC-Q/TOF-mass spectrometry
In this study, a rapid screening method was developed for detection and confirmation of 35 sulfonamides in supplements by ultra-high performance liquid chromatography quadrupole/time of flight mass spectrometry. For effective extraction of sulfonamides from dietary supplements, four extraction protocols including HLB and WAX solid-phase extraction, Quick Easy Cheap Effective Rugged and Safe method, and pH-controlled liquid–liquid extraction were evaluated, and pH-controlled liquid–liquid extraction method was shown to be the most effective with high recovery efficiency and low matrix effect. Rapid separation of...
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research

In vivo pro-angiogenic effects of dracorhodin perchlorate in zebrafish embryos: A novel bioactivity evaluation platform for commercial dragon blood samples
In this study, we used zebrafish embryos as a platform to demonstrate the in vivo pro-angiogenic activity of dracorhodin perchlorate, the chemically synthesized analog of dracorhodin. By using this platform, three different commercial dragon blood samples were also examined. Our results clearly show that even though the commercial dragon blood samples had similar amounts of dracorhodin, they showed highly variable biological activity, such as pro-angiogenic effects and toxicity. In short, an in vivo activity assay platform for rapidly examining the biological activity of commercial dragon blood samples was succes...
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research

Determination of sulfamonomethoxine in tilapia (Oreochromis niloticus × Oreochromis mossambicus) by liquid chromatography-tandem mass spectrometry and its application pharmacokinetics study
This study investigated the pharmacokinetic properties and tissue distribution of SMM and its major metabolite N4-acetyl sulfamonomethoxine (AC-SMM) in tilapia after a single dose of 100 mg kg−1 body weight of orally administered SMM. Blood and tissues were collected between 0.5 and 192 h with 14 total sampling time points. SMM was rapidly absorbed, and extensively distributed in the bile and liver through systemic circulation. Enterohepatic circulation of SMM was observed in the tilapia body. Acetylation percentages were 45% (blood), 90% (liver), 62% (kidney), 98% (bile), and 52% (muscle). High concen...
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research

Applications of cyclic peptide nanotubes
Publication date: Available online 28 September 2018Source: Journal of Food and Drug AnalysisAuthor(s): Wei-Hsien Hsieh, Jiahorng LiawAbstractSelf-assembled cyclic peptide nanotubes (cPNTs) have recently drawn particular attention as one of the most intriguing nanostructures in the field of nanotechnology. Given their unique features including high surface area, increased drug loading, environmental stability, enhanced permeation, and modifiable drug release, these hollow tubular structures can be constructed with cyclic di-, tri-, tetra-, hexa-, octa-, and decapeptides with various amino acid sequences, enantiomers, and f...
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research

Instructions to Authors
Publication date: October 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 4Author(s): (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research

Novel inspection of sugar residue and origin in honey based on the 13C/12C isotopic ratio and protein content
Publication date: Available online 1 October 2018Source: Journal of Food and Drug AnalysisAuthor(s): Chun-Ting Chen, Bor-Yann Chen, Yu-Shin Nai, Yuan-Mou Chang, Kuan-Hua Chen, Yue-Wen ChenAbstractRegarding the honey industry, market prices are strongly affected by the origin and composition of products. In particular, the adulteration of honey can be divided into cases of honey being mixed with artificial syrup, the different origin of the adulteration and the presence of cane sugar residue. Unfortunately, recent studies mentioned that most honey is mixed with artificial syrups. Thus, determining such unnaturally present s...
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research

Rapid detection and quantitation of drugs-of-abuse by wooden-tip electrospray ionization mass spectrometry
In this study, wooden-tip electrospray ionization mass spectrometry (WT-ESI-MS), a simple and cost-effective technique, was developed for rapid detection and quantitation of common drugs-of-abuse, including methamphetamine, methylenedioxymethamphetamine (MDMA), cocaine, heroin and tetrahydrocannabinol (THC), in urine and oral fluid, following our previous successful demonstration for rapid and sensitive detection of ketamine and nor-ketamine in urine and oral fluid by this technique. It was found that the limit-of-detection for methamphetamine could fully fulfill the cut-off value requirements of the international standard...
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research

Keyword Index
Publication date: October 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 4Author(s): (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research

Authorship & Conflicts of Interest Statement
Publication date: October 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 4Author(s): (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research

Checklist
Publication date: October 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 4Author(s): (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research

Kinetics of lactose fermentation in milk with kombucha starter
Publication date: October 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 4Author(s): Katarina Gojko Kanurić, Spasenija Danilo Milanović, Bojana Branko Ikonić, Eva Stjepan Lončar, Mirela Dragoljub Iličić, Vladimir Radovan Vukić, Dajana Vukota VukićAbstractThe aim of this research was to investigate the effect of new, non-conventional starter culture on the kinetics of the lactose transformation during milk fermentation by kombucha, at pH 5.8; 5.4; 5.1; 4.8; and 4.6, at two different temperatures 37 °C and 42 °C. Milk fermentation at 42 °C lasted significantly shorter (abou...
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research

Effect of Phyllanthus emblica L. fruit on methionine and choline-deficiency diet-induced nonalcoholic steatohepatitis
In this study, the hepatoprotective effect of water extract of P. emblica (WEPE) on nonalcoholic steatohepatitis (NASH) was evaluated. C57BL/6 mice were fed methionine and choline-deficiency diet (MCD diet) for 4 or 8 weeks to induce NASH. Results showed that administration of WEPE could significantly reduce serum AST and ALT as compared to MCD diet-alone group. Administration of WEPE could significantly decrease lipid peroxidation and CYP2E1 mRNA expression, and elevate the antioxidant activities in mice livers. In addition, administration of WEPE after 8 weeks could significantly decrease the mRNA expressions of TNF-&alp...
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research

Title Index
Publication date: October 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 4Author(s): (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research

Acknowledgment of Reviewers
Publication date: October 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 4Author(s): (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research

Author Index
Publication date: October 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 4Author(s): (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research

Blotting paper as a disposable tool for sampling chemical residues from skin surface
Publication date: Available online 2 October 2018Source: Journal of Food and Drug AnalysisAuthor(s): Pei-Chi Wu, Ewelina P. Dutkiewicz, Pei-Han Liao, Hsien-Yi Chiu, Pawel L. UrbanGraphical abstract (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research

Analytical methods for cholesterol quantification
Publication date: Available online 4 October 2018Source: Journal of Food and Drug AnalysisAuthor(s): Li-Hua Li, Ewelina P. Dutkiewicz, Ying-Chen Huang, Hsin-Bai Zhou, Cheng-Chih HsuAbstractCholesterol is an important lipid molecule in cell membranes and lipoproteins. Cholesterol is also a precursors of steroid hormones, bile acids, and vitamin D. Abnormal levels of cholesterol or its precursors have been observed in various human diseases, such as heart diseases, stroke, type II diabetes, brain diseases and many others. Therefore, accurate quantification of cholesterol is important for individuals who are at increased risk...
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research

Antidepressant and anxiolytic effects of the proprietary Chinese medicine Shexiang Baoxin pill in mice with chronic unpredictable mild stress
This study explored whether SBP has antidepressant and anxiolytic effects in addition to hormonal and psychotropic mechanisms. Mice underwent 6 weeks of chronic unpredictable mild stress (CUMS) to induce depression- and anxiety-like behavior. During the 6-week experiment, mice received SBP at intragastric doses of 20.25 mg/kg or 40.5 mg/kg daily. Animals were then tested for depression in sucrose preference, forced-swimming, and tail suspension paradigms, and for anxiety in open-field and elevated plus-maze tests. Both SBP doses significantly reduced anhedonic behavior in the sucrose preference test; the high SBP...
Source: Journal of Food and Drug Analysis - August 25, 2018 Category: Food Science Source Type: research

The rapid and sensitive detection of edible bird's nest (Aerodramus fuciphagus) in processed food by a loop-mediated isothermal amplification (LAMP) assay
In conclusion, the LAMP assay established herein could be applicable for authenticating EBN and for identifying commercial EBN products in herbal markets.Graphical abstract (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - August 25, 2018 Category: Food Science Source Type: research

Ubiquitin-protein ligase E3a (UBE3A) as a new biomarker of cardiac hypertrophy in cell models
Publication date: Available online 24 August 2018Source: Journal of Food and Drug AnalysisAuthor(s): Kai-Chun Cheng, Yingxiao Li, Wei-Ting Chang, Zhih-Cherng Chen, Juei-Tang Cheng, Cheng-Chia TsaiAbstractCardiac hypertrophy is widely diagnosed in clinical cardiac disorders. The pathophysiology of hypertrophy is complex and multifactorial, a series of molecular and cellular changes are participated, such as activation of different signaling pathways, a switch of fetal gene program in the myocardium, and apoptosis. Some biomarkers have been applied to assess cardiac hypertrophy including atrial natriuretic peptides (ANP), br...
Source: Journal of Food and Drug Analysis - August 24, 2018 Category: Food Science Source Type: research

Encapsulation of babchi essential oil into microsponges: Physicochemical properties, cytotoxic evaluation and anti-microbial activity
Publication date: Available online 16 August 2018Source: Journal of Food and Drug AnalysisAuthor(s): Geetika Wadhwa, Sunil Kumar, Vineet Mittal, Rekha RaoAbstractBabchi essential oil (BEO) is a valuable essential oil reported to possess a variety of biological activities such as antitumor, anti inflammatory, immunomodulatory, antioxidant, antifungal and antibacterial properties. Due to its anti-microbial properties, this oil possesses an immense potential for the treatment of dermatological disorders. Further, it has minimal tendency to develop resistance, a common issue with most of the antibiotics. However, its highly vi...
Source: Journal of Food and Drug Analysis - August 16, 2018 Category: Food Science Source Type: research

A highly sensitive ultra-high performance liquid chromatography/tandem mass spectrometry method with in-source fragmentation for rapid quantification of raspberry ketone
Publication date: Available online 14 August 2018Source: Journal of Food and Drug AnalysisAuthor(s): Bo Yuan, Danyue Zhao, Ruoyuan Du, Dushyant Kshatriya, Nicholas T. Bello, James E. Simon, Qingli WuAbstractRaspberry ketone (RK) is the characteristic aromatic compound in raspberry (Rubus idaeus L.) with wide applications as food additive and anti-obesity agent. However, quantification of RK has presented difficulties in MS detection and reliable LC-MS method for RK analysis in literature is in limit to date. In order to facilitate quality control of raspberry derived products and RK metabolomics study, this study aimed to ...
Source: Journal of Food and Drug Analysis - August 14, 2018 Category: Food Science Source Type: research

Abelmoschus esculentus subfractions improved nephropathy with regulating dipeptidyl peptidase-4 and type 1 glucagon-like peptide receptor in type 2 diabetic rats
In conclusion, we have demonstrated AE has benefits to regulate DPP-4 and GLP-1R, to reduce oxidative stress and renal fibrosis, with resultant to improve renal function and prevent diabetic renal damage. Taken together, F2 could be more promising to be developed as adjuvant for diabetic nephropathy.Graphical abstract (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - August 14, 2018 Category: Food Science Source Type: research

A rapid LC-MS/MS method for simultaneous determination of quetiapine and duloxetine in rat plasma and its application to pharmacokinetic interaction study
This study could be readily applied in therapeutic drug monitoring of major depressive disorder patients receiving such drug combinations.Graphical abstract (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - August 14, 2018 Category: Food Science Source Type: research

Nanoparticle-based laser desorption/ionization mass spectrometric analysis of drugs and metabolites
Publication date: Available online 14 August 2018Source: Journal of Food and Drug AnalysisAuthor(s): Han-Wei Chu, Binesh Unnikrishnan, Anisha Anand, Ju-Yi Mao, Chih-Ching HuangAbstractNanoparticle-assisted laser desorption/ionization mass spectrometry (LDI-MS) is a powerful tool for the analysis of a wide range of molecules. Many of the drawbacks in the matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) can be avoided with the application of nanomaterials as matrices as well as substrates for the LDI-MS to achieve a low background noise in low m/z region and high reproducibility. Surface-assisted LDI ...
Source: Journal of Food and Drug Analysis - August 14, 2018 Category: Food Science Source Type: research

Rubiscolin-6 activates opioid receptors to enhance glucose uptake in skeletal muscle
In conclusion, rubiscolin-6 increases glucose uptake, potentially via an activation of AMPK to enhance GLUT4 translocation after binding to opioid receptors in skeletal muscle.Graphical abstract (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - August 14, 2018 Category: Food Science Source Type: research

Identification of baicalin from Bofutsushosan and Daisaikoto as a potent inducer of glucose uptake and modulator of insulin signaling-associated pathways
Publication date: Available online 14 August 2018Source: Journal of Food and Drug AnalysisAuthor(s): Yu-Ting Kuo, Chih-Chan Lin, Hsiao-Tzu Kuo, Jui-Hsiang Hung, Ching-Hsuan Liu, Alagie Jassey, Ming-Hong Yen, Shu-Jing Wu, Liang-Tzung LinAbstractType 2 diabetes mellitus (T2DM) is a chronic disease characterized by hyperglycemia that can lead to long-term complications including heart diseases, stroke, retinopathy, and renal failure. Treatment strategies include stimulating glucose uptake and controlling blood glucose level. Bofutsushosan (BOF) and Daisaikoto (DAI) are two herb-based kampo medicines that have been demonstrate...
Source: Journal of Food and Drug Analysis - August 14, 2018 Category: Food Science Source Type: research

The integration of multi-platform MS-based metabolomics and multivariate analysis for the geographical origin discrimination of Oryza sativa L.
In conclusion, the proposed approach successfully highlighted phospholipids as the better discrimination markers than sugars & sugar alcohols and fatty acids in differentiating white rice between Korea and China.Graphical abstract (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research

Mulberry Leaf Extracts prevent obesity-induced NAFLD with regulating adipocytokines, inflammation and oxidative stress
Publication date: April 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 2Author(s): Chiung-Huei Peng, Huei-Ting Lin, Dai-Jung Chung, Chien-Ning Huang, Chau-Jong WangAbstractMulberry (Morus alba) leaf has been used in Chinese medicine as the remedy for hyperlipidemia and metabolic disorders. Recent report indicated Mulberry leaf extract (MLE) attenuated dyslipidemia and lipid accumulation in high fat diet (HFD)-fed mice. Non-alcoholic fatty liver (NAFLD) is generally considered as the liver component of metabolic syndrome. The hepatic lipid infiltration induces oxidative stress, and is associated with interl...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research

Simultaneous quantification of eight organic acid components in Artemisia capillaris Thunb (Yinchen) extract using high-performance liquid chromatography coupled with diode array detection and high-resolution mass spectrometry
Publication date: April 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 2Author(s): Fangjun Yu, Hao Qian, Jiayu Zhang, Jie Sun, Zhiguo MaAbstractWe aim to determine the chemical constituents of Yinchen extract and Yinchen herbs using high-performance liquid chromatography coupled with diode array detection and high-resolution mass spectrometry. The method was developed to analyze of eight organic acid components of Yinchen extract (including neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, caffeic acid, 1,3-dicaffeoylquinic acid, 3,4-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid and 4,5-dic...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research

Effect of drying processes on prenylflavonoid content and antioxidant activity of Epimedium koreanum Nakai
Publication date: April 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 2Author(s): Yudan Zhao, Shifeng Chen, Yadan Wang, Chongning Lv, Jing Wang, Jincai LuAbstractEpimedium koreanum Nakai is a famous Chinese herbal medicine for the treatment of impotence, osteoporosis, immune suppression and cardiovascular diseases. Drying is the most common and fundamental procedure in post-harvest processing of E. koreanum, which contributes to the variations of flavonoid content, especially prenylflavonoids, the bioactive components. In present study, effect of drying processes on flavonoid content and antioxidant activ...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research

General survey of Fructus Psoraleae from the different origins and chemical identification of the roasted from raw Fructus Psoraleae
Publication date: April 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 2Author(s): Junjun Yang, Jing Yang, Jie Du, Yuxin Feng, Xin Chai, Mingming Xiao, Yuefei Wang, Xiumei GaoAbstractFructus Psoraleae, a traditional Chinese medicine, is widely used for preventing and treating various diseases such as vitiligo, osteoporosis and psoriasis. Coumarin, such as psoralenoside, isopsoralenoside, psoralen and isopsoralen, are important compounds in Fructus Psoraleae. In our study, ultra performance liquid chromatography coupled with diode array detector was employed for an excellent method validation for simultaneo...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research