Editorial Board
Publication date: April 2019Source: Journal of Food and Drug Analysis, Volume 27, Issue 2Author(s): (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - April 15, 2019 Category: Food Science Source Type: research

Detection of BPDE-DNA adducts in human umbilical cord blood by LC-MS/MS analysis
In this study, we employed our developed LC-MS/MS method to detect and quantity BPDE-dG adducts present in 42 normal human umbilical blood samples and 42 birth defect cases. We determined that there is no significant difference in the level of BPDE-dG formation between the normal and birth defect groups. This represents the first time to use an LC-MS/MS method to quantify BPDE-dG in human umbilical blood samples. The results indicated that under experimental conditions, BPDE-dG adducts were detected in all the human umbilical blood samples from the normal and birth defect groups.Graphical abstract (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - March 24, 2019 Category: Food Science Source Type: research

Determination of phenylenediamines in hair colors derivatizated with 5-(4, 6-dichlorotriazinyl)aminofluorescein via micellar electrokinetic chromatography
Publication date: Available online 21 March 2019Source: Journal of Food and Drug AnalysisAuthor(s): Hung-Yu Ko, Yi-Hui Lin, Chi-Jen Shih, Yen-Ling ChenAbstractPhenylenediamines (PDs), which are reported to cause allergic dermatitis and possess genotoxicity and carcinogenicity, are the ingredients used in permanent hair dyes. The fluorescent derivatization strategy coupled with micellar electrokinetic chromatography (MEKC) were established to analyze four PDs, including o-phenylenediamine (OPD), m-phenylenediamine (MPD), p-phenylenediamine (PPD) and toluene-2,5-diamine (PTD). Additionally, 5-(4, 6-dichlorotriazinyl) aminofl...
Source: Journal of Food and Drug Analysis - March 21, 2019 Category: Food Science Source Type: research

Comparative quality of the forms of decoction pieces evaluated by multidimensional chemical analysis and chemometrics: Poria cocos, a pilot study
Publication date: Available online 21 March 2019Source: Journal of Food and Drug AnalysisAuthor(s): Li-Xia Zhu, Jun Xu, Yun Wu, Li-Fei Su, Kelly Yin Ching Lam, Elizabeth R. Qi, Xiao-Ping Dong, Hu-Biao Chen, Yu-De Liu, Zhong-Zhen ZhaoAbstractMany Chinese medicinal materials (CMMs) are parts of plants or fungi that have been processed into different physical forms, termed decoction pieces, that are typically boiled in water for consumption. One CMM may have several decoction pieces forms, e.g., slices, small cubes (dice), or grains. The specifications that have different morphological parameters (shape, size and thickness) f...
Source: Journal of Food and Drug Analysis - March 21, 2019 Category: Food Science Source Type: research

Proanthocyanidins from the stem bark of Rhus tripartita ameliorate methylgloxal-induced endothelial cell apoptosis
Publication date: Available online 17 March 2019Source: Journal of Food and Drug AnalysisAuthor(s): Ali S. Alqahtani, Wael M. Abdel-mageed, Abdelaaty A. Shahat, Mohammad K. Parvez, Mohammed S. Al-Dosari, Ajamaluddin Malik, Maged S. Abdel-Kader, Mansour S. AlsaidAbstractIn traditional Arabian medicine, the Rhus tripartita plant (family Anacardiaceae) has been used to treat inflammatory conditions. Although Rhus extracts have been reported for their cardioprotective effects, information regarding their active principle compounds remains insufficient. The present investigation was aimed at determining the antioxidant chemical...
Source: Journal of Food and Drug Analysis - March 18, 2019 Category: Food Science Source Type: research

Multi-residue analysis using liquid chromatography tandem mass spectrometry for detection of 20 coccidiostats in poultry, livestock, and aquatic tissues
In this study, we developed a novel analysis method based on liquid chromatography/tandem mass spectrometry (LC–MS/MS) to allow the simultaneous identification of 20 coccidiostats in eight matrix categories, including the muscles of chicken, swine, cow, and fish as well as chicken eggs, bovine milk, and porcine viscera. In the pretreatment procedure, acetonitrile/methanol (95:5, v/v) containing 1% formic acid, 5 g of sodium acetate, and 6.0 g of anhydrous magnesium sulfate was used for extraction, followed by a clean-up procedure using n-hexane saturated with ACN to facilitate the elimination of analytes fr...
Source: Journal of Food and Drug Analysis - March 13, 2019 Category: Food Science Source Type: research

Potential prebiotics and their transmission mechanisms: Recent approaches
Publication date: Available online 4 March 2019Source: Journal of Food and Drug AnalysisAuthor(s): Ishu Khangwal, Pratyoosh ShuklaAbstractPrebiotics are non digestible carbohydrates which can be used as prime source of energy for gut microflora. These can be naturally occurring in fruit and vegetables or can be made synthetically by enzymatic digestions. New versatile sources of prebiotics had been found nowadays for economic commercialization. This review will decipher on highlighting the importance of prebiotics in immunomodulation and nutrient absorption abilities of gut, as it is important for anti-effective capacity o...
Source: Journal of Food and Drug Analysis - March 5, 2019 Category: Food Science Source Type: research

Determination of polycyclic aromatic hydrocarbons (PAHs) in cosmetic products by gas chromatography-tandem mass spectrometry
This study offers a sensitive and simple method to analyze 18 representative PAHs successfully and can be applied to cosmetic products and raw materials.Graphical abstract (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - February 22, 2019 Category: Food Science Source Type: research

An ultra-rapid drug screening method for acetaminophen in blood serum based on probe electrospray ionization-tandem mass spectrometry
Publication date: Available online 22 February 2019Source: Journal of Food and Drug AnalysisAuthor(s): Kiyotaka Usui, Haruka Kobayashi, Yuji Fujita, Eito Kubota, Tomoki Hanazawa, Tomohiro Yoshizawa, Yoshito Kamijo, Masato FunayamaAbstractPoisoning incidents caused by drugs, accidental ingestion of poisons, attempted suicide, homicide, and exposure to toxic compounds occur frequently every year across the globe. This raises the need to rapidly identify toxic agents in poisoned patients in a clinical emergency setting. In addition, determining drug/poison concentration is undoubtedly necessary to arrive at a toxicological tr...
Source: Journal of Food and Drug Analysis - February 22, 2019 Category: Food Science Source Type: research

Psychobiotics in mental health, neurodegenerative and neurodevelopmental disorders
Publication date: Available online 10 February 2019Source: Journal of Food and Drug AnalysisAuthor(s): Li-Hao Cheng, Yen-Wenn Liu, Chien-Chen Wu, Sabrina Wang, Ying-Chieh TsaiAbstractPsychobiotics are a group of probiotics that affect the central nervous system (CNS) related functions and behaviors mediated by the gut-brain-axis (GBA) via immune, humoral, neural, and metabolic pathways to improve not only the gastrointestinal (GI) function but also the antidepressant and anxiolytic capacity. As a novel class of probiotics, the application of psychobiotics has led researchers to focus on a new area in neuroscience. In the p...
Source: Journal of Food and Drug Analysis - February 11, 2019 Category: Food Science Source Type: research

Revisit gut microbiota and its impact on human health and disease
Publication date: Available online 1 February 2019Source: Journal of Food and Drug AnalysisAuthor(s): Rui-xue Ding, Wei-Rui Goh, Ri-na Wu, Xi-qing Yue, Xue Luo, Thwe Khine Wei Wei, Jun-rui Wu, Yuan-Kun LeeAbstractTrillions of microbes have evolved with and continue to live on human beings. With the rapid advances in tools and technology in recent years, new knowledge and insight in cross-talk between the microbes and their hosts have gained. It is the aim of this work to critically review and summarize recent literature reports on the role of microbiota and mechanisms involved in the progress and development of major human...
Source: Journal of Food and Drug Analysis - February 2, 2019 Category: Food Science Source Type: research

Next generation probiotics in disease amelioration
Publication date: Available online 2 February 2019Source: Journal of Food and Drug AnalysisAuthor(s): Chih-Jung Chang, Tzu-Lung Lin, Yu-Ling Tsai, Tsung-Ru Wu, Wei-Fan Lai, Chia-Chen Lu, Hsin-Chih LaiAbstractStudies on the role of gut commensal bacteria in health development have rapidly attracted much more attention beyond the classical pathogens over the last decade. Many important reports have highlighted the changes in the gut microbiota (dysbiosis) are closely related to development of intra- and extra-intestinal, chronic inflammation related diseases such as colitis, obesity/metabolic syndromes, diabetes mellitus, li...
Source: Journal of Food and Drug Analysis - February 2, 2019 Category: Food Science Source Type: research

Current status of MALDI-TOF mass spectrometry in clinical microbiology
Publication date: Available online 31 January 2019Source: Journal of Food and Drug AnalysisAuthor(s): Tsung-Yun Hou, Chuan Chiang-Ni, Shih-Hua TengAbstractMass spectrometry (MS) is a type of analysis used to determine what molecules make up a sample, based on the mass spectrum that are created by the ions. Mass spectrometers are able to perform traditional target analyte identification and quantitation; however, they may also be used within a clinical setting for the rapid identification of bacteria. The causative agent in sepsis is changed over time, and clinical decisions affecting the management of infections are often ...
Source: Journal of Food and Drug Analysis - January 31, 2019 Category: Food Science Source Type: research

Direct injection high performance liquid chromatography coupled to data independent acquisition mass spectrometry for the screening of antibiotics in honey
Publication date: Available online 29 January 2019Source: Journal of Food and Drug AnalysisAuthor(s): Annie von Eyken, Daniel Furlong, Samareh Arooni, Fred Butterworth, Jean-François Roy, Jerry Zweigenbaum, Stéphane BayenAbstractThe targeted analysis of veterinary drug residues in honey traditionally involves a series of extraction and purification steps prior to quantification with high performance liquid chromatography coupled to high resolution or tandem mass spectrometry. These steps, designed to separate the target analytes from interferences, are generally time-consuming and costly. In addition, traditi...
Source: Journal of Food and Drug Analysis - January 30, 2019 Category: Food Science Source Type: research

A nutraceutical extract from Inula viscosa leaves: UHPLC-HR-MS/MS based polyphenol profile, and antioxidant and cytotoxic activities
Publication date: Available online 14 January 2019Source: Journal of Food and Drug AnalysisAuthor(s): Nabila Brahmi-Chendouh, Simona Piccolella, Giuseppina Crescente, Francesca Pacifico, Lila Boulekbache, Sabrina Hamri-Zeghichi, Salah Akkal, Khodir Madani, Severina PacificoAbstractNowadays, advanced extraction techniques and highly sensitive metabolic profiling methods are effectively employed to get new information on plant chemical constituents. Among them wild medicinal plants or their parts, with large and ancient use in folk medicine, are investigated for their potential functional use and cultivation. In this context...
Source: Journal of Food and Drug Analysis - January 15, 2019 Category: Food Science Source Type: research

Corrigendum to “Investigation of borneols sold in Taiwan by chiral gas chromatography” [J Food Drug Anal 26 (2018) 348–352]
Publication date: January 2019Source: Journal of Food and Drug Analysis, Volume 27, Issue 1Author(s): Tsung-Jung Ho, Chien-Che Hung, Tzenge-Lien Shih, Lih-Ming Yiin, Hao-Ping Chen (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - January 13, 2019 Category: Food Science Source Type: research

Authorship & Conflicts of Interest Statement
Publication date: January 2019Source: Journal of Food and Drug Analysis, Volume 27, Issue 1Author(s): (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - January 13, 2019 Category: Food Science Source Type: research

Checklist
Publication date: January 2019Source: Journal of Food and Drug Analysis, Volume 27, Issue 1Author(s): (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - January 13, 2019 Category: Food Science Source Type: research

Editorial Board
Publication date: January 2019Source: Journal of Food and Drug Analysis, Volume 27, Issue 1Author(s): (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - January 13, 2019 Category: Food Science Source Type: research

Instructions to Authors
Publication date: January 2019Source: Journal of Food and Drug Analysis, Volume 27, Issue 1Author(s): (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - January 13, 2019 Category: Food Science Source Type: research

Reduction of aluminum ion neurotoxicity through a small peptide application – NAP treatment of Alzheimer's disease
The objective of this study was to identify protein biomarkers associated with aluminum ions toxicity (AD-like toxicity) in a human neuroblastoma cell model, SH-SY5Y and assess potential prevention by NAP (NAPVSIPQ). Complete proteomic techniques were implemented. Four proteins were identified as up-regulated with aluminum ion treatment, CBP80/20-dependent translation initiation factor (CTIF), Early endosome antigen 1 (EEA1), Leucine-rich repeat neuronal protein 4 (LRRN4) and Phosphatidylinositol 3-kinase regulatory subunit beta (PI3KR2). Of these four proteins, EEA1 and PI3KR2 were down-regulated after NAP-induced neuropr...
Source: Journal of Food and Drug Analysis - January 12, 2019 Category: Food Science Source Type: research

Direct and rapid characterization of illicit drugs in adulterated samples using thermal desorption electrospray ionization mass spectrometry
In this study, thermal desorption electrospray ionization mass spectrometry (TD-ESI/MS), an AMS technique, was utilized to efficiently characterize illicit drugs spiked in samples including drinks, powders, and jelly candies. To perform sensitive analysis, the mass analyzer was operated in multiple reaction monitoring mode to monitor the molecular and fragment ions of the target analytes. The time required to complete a typical TD-ESI/MS analysis was less than 30 s. The limits of detection (LODs) for illicit drugs were found to be 100 ppb in drinks, 100–1000 ppb in instant powders, and 1.3–6.5&nb...
Source: Journal of Food and Drug Analysis - January 9, 2019 Category: Food Science Source Type: research

Nelumbo nucifera leaves extract attenuate the pathological progression of diabetic nephropathy in high-fat diet-fed and streptozotocin-induced diabetic rats
Publication date: Available online 8 January 2019Source: Journal of Food and Drug AnalysisAuthor(s): Huan-Wei Chen, Mon-Yuan Yang, Tung-Wei Hung, Yun-Ching Chang, Chau-Jong WangAbstractDiabetic nephropathy is not only a common and severe microvascular complication of diabetes mellitus but also the leading cause of renal failure. Lotus (Nelumbo nucifera) possesses antioxidative and anticancer properties. The present study aimed to investigate the antidiabetic and renoprotective effects of N. nucifera leaf extract (NLE) in a rat model of type 2 diabetic mellitus. Male Sprague–Dawley rats with type 2 diabetes induced by...
Source: Journal of Food and Drug Analysis - January 9, 2019 Category: Food Science Source Type: research

Glycoproteomic identification of novel plasma biomarkers for oral cancer
In this study we aim to discover novel core-fucosylated glycoprotein biomarkers for oral cancer diagnosis with glycoproteomic approaches. First, forty plasma samples obtained from the Human Bioinformation Bank of NCKUH were subjected to AAL (Aleuria aurantia lectin) affinity chromatography. Core-fucosylated proteins were collected and applied for LC-MS/MS followed by electrophoresis. Fourteen proteins were identified, and expression levels of proteins in plasma were verified by western blot. Expression levels of some glycoproteins were elevated in the oral cancer group, including ceruloplasmin, haptoglobin, and leucin-rich...
Source: Journal of Food and Drug Analysis - January 9, 2019 Category: Food Science Source Type: research

Using gas chromatography and mass spectrometry to determine 25-hydroxyvitamin D levels for clinical assessment of vitamin D deficiency
In this study, gas chromatography coupled mass spectrometry with trimethylsilyl derivatization (TMS-GC-MS) is the most suitable protocol for quantitative analyses of 25(OH)D3. Performance of method was evaluated and compared with liquid chromatography and immunoassay. Method validation has been carried out with plasma specimens. The limit of quantitation of TMS-GC-MS method is 1.5 ppb with good linear correlation. Furthermore, the dietary intake and nutritional status of vegetarian and non-vegetarians in Taiwan were assessed by our validated method. As a result, this vitamin D nutrition survey demonstrates that most T...
Source: Journal of Food and Drug Analysis - January 9, 2019 Category: Food Science Source Type: research

Utilizing proteomic approach to identify nuclear translocation related serine kinase phosphorylation site of GNMT as downstream effector for benzo[a]pyrene
Publication date: Available online 8 January 2019Source: Journal of Food and Drug AnalysisAuthor(s): Ming-Hui Yang, Chia-Hung Yen, Chen-Chung Liao, Jung-Hsien Hung, Xiu-Ting Lai, Yi-Ming Arthur ChenAbstractGlycine N-methyltransferase (GNMT) protein is highly expressed in certain tissues, such as liver, pancreas, and prostate. GNMT serves multiple roles which include a methyl group transfer enzyme and a liver tumor suppressor. Benzo(a)pyrene (BaP), a family member of polycyclic aromatic hydrocarbon (PAH), is a known environmental carcinogen found in coal tar, tobacco smoke, barbecued food and incomplete combustion of auto f...
Source: Journal of Food and Drug Analysis - January 9, 2019 Category: Food Science Source Type: research

Targeting amine- and phenol-containing metabolites in urine by dansylation isotope labeling and liquid chromatography mass spectrometry for evaluation of bladder cancer biomarkers
This study confirmed discovery-phase features of the urine metabolome of bladder cancer patients and verified their importance for further study.Graphical abstract (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - January 8, 2019 Category: Food Science Source Type: research

Risk of adverse cardiovascular events with use of inhaled long-acting bronchodilators in management of chronic obstructive pulmonary disease
Publication date: Available online 7 January 2019Source: Journal of Food and Drug AnalysisAuthor(s): Meng-Ting Wang, Jyun-Heng Lai, Chen-Liang Tsai, Jun-Ting LiouAbstractInhaled long-acting bronchodilators, including long-acting β2 agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) are the mainstay therapy in the treatment of chronic obstructive pulmonary disease (COPD), a disease that poses a heavy burden on morbidity and mortality worldwide. Use of LABAs and LAMAs in patients with COPD, however, has been concerned about an increased risk of adverse cardiovascular events, despite inconsistent findings re...
Source: Journal of Food and Drug Analysis - January 8, 2019 Category: Food Science Source Type: research

Rapid identification of herbal toxins using electrospray laser desorption ionization mass spectrometry for emergency care
Publication date: Available online 3 January 2019Source: Journal of Food and Drug AnalysisAuthor(s): Hung Su, Kuan-Ting Liu, Bai-Hsiun Chen, Yen-Ping Lin, Yu-Min Jiang, Yi-Hong Tsai, Fang-Rong Chang, Jentaie Shiea, Chi-Wei LeeAbstractThe unintentional ingestion of toxic compounds in herbs is not uncommon in many parts of the world. To provide timely and life-saving care in the emergency department, it is essential to develop a point-of-care analytical method that can rapidly identify these toxins in herbs. Since electrospray laser desorption ionization mass spectrometry (ELDI/MS) has been successfully used to characterize ...
Source: Journal of Food and Drug Analysis - January 4, 2019 Category: Food Science Source Type: research

Complete mapping of disulfide linkages for etanercept products by multi-enzyme digestion coupled with LC-MS/MS using multi-fragmentations including CID and ETD
Publication date: Available online 2 January 2019Source: Journal of Food and Drug AnalysisAuthor(s): Li-Juan Huang, Chia-Wang Chiang, Shun-Li Chen, Shih-Yao Wei, Shu-Hui ChenAbstractThe disulfide linkages of two etanercept products, Enbrel® (innovator drug) and TuNEX®, were characterized and compared using a multi-fragmentation approach consisting of electron transfer dissociation (ETD) and collision induced dissociation (CID) in combination with multi-enzyme digestion protocols (from Lys-C, trypsin, Glu-C, and PNGase F). Multi-fragmentation approach allowed multi-disulfide linkages contained in a peptide to be un-...
Source: Journal of Food and Drug Analysis - January 3, 2019 Category: Food Science Source Type: research

Quantitation of serum 25(OH)D2 and 25(OH)D3 concentrations by liquid chromatography tandem mass spectrometry in patients with diabetes mellitus
Publication date: Available online 31 December 2018Source: Journal of Food and Drug AnalysisAuthor(s): Yi-Ching Lin, Hei-Hwa Lee, Shing-Cheng Tseng, Kun-Der Lin, Li-Ping Tseng, Jong-Feng Lee, Yung-Hung Lee, Bai-Hsiun ChenAbstractVitamin D has been considered to regulate calcium and phosphorus homeostasis and to preserve skeletal integrity. Serum 25-hydroxyvitamin D (25(OH)D) is the best indicator of vitamin D levels. The association of serum 25(OH)D deficiency with increased risk of type 1 diabetes (T1DM) and type 2 diabetes (T2DM) is controversial. We investigated serum 25(OH)D2 and 25(OH)D3 levels in diabetes patients by...
Source: Journal of Food and Drug Analysis - December 31, 2018 Category: Food Science Source Type: research

Simultaneous quantification of six indicator compounds in Wen-Qing-Yin by high-performance liquid chromatography-diode array detection
Publication date: Available online 28 December 2018Source: Journal of Food and Drug AnalysisAuthor(s): Chi-Chen Yeh, Shih-Shan Huang, Po-Yu Liu, Bo-Cheng Wang, Chia-Fen Tsai, Der-Yuan Wang, Hwei-Fang ChengAbstractA simple gradient high-performance liquid chromatography with diode array detection (HPLC-DAD) method was used to simultaneously to analyze characteristics of six indicator compounds in the traditional Chinese medicine (TCM) formulation Wen-Qing-Yin (WQY). Separate optimization was performed using a Cosmosil C18 column gradient method with 0.1% formic acid in both mobile phases of aqueous and acetonitrile (ACN), a...
Source: Journal of Food and Drug Analysis - December 29, 2018 Category: Food Science Source Type: research

The current application of nanotechnology in food and agriculture
Publication date: Available online 24 December 2018Source: Journal of Food and Drug AnalysisAuthor(s): Xiaojia He, Hua Deng, Huey-min HwangAbstractThe rapid development of nanotechnology has been facilitating the transformations of traditional food and agriculture sectors, particularly the invention of smart and active packaging, nanosensors, nanopesticides and nanofertilizers. Numerous novel nanomaterials have been developed for improving food quality and safety, crop growth, and monitoring environmental conditions. In this review the most recent trends in nanotechnology are discussed and the most challenging tasks and pr...
Source: Journal of Food and Drug Analysis - December 25, 2018 Category: Food Science Source Type: research

Exposure marker discovery of di-2(propylheptyl) phthalate using ultra-performance liquid chromatography-mass spectrometry and a rat model
Publication date: Available online 11 December 2018Source: Journal of Food and Drug AnalysisAuthor(s): Chia-Lung Shih, Jen-Yi Hsu, Chien-Ping Tien, Yi-Ning Chung, Victor G. Zgoda, Pao-Chi LiaoAbstractDi-(2-propylheptyl) phthalate (DPHP) is a plasticizer and has been suggested to be a subchronic toxicant in rats. DPHP has been approved to be used in food containers and handling by the U.S. Food and Drug Administration. The use of DPHP is still increasing, and the risk of human exposure to DPHP via food may be high. Exposure markers measured in human samples are commonly used to monitor human exposure levels. Ultra-performan...
Source: Journal of Food and Drug Analysis - December 12, 2018 Category: Food Science Source Type: research

Chemical isotope labeling liquid chromatography mass spectrometry for investigating acute dietary effects of cow milk consumption on human urine metabolome
Publication date: Available online 11 December 2018Source: Journal of Food and Drug AnalysisAuthor(s): Dorothea Mung, Liang LiAbstractBiomarker discovery has been increasingly important in the field of metabolomics for the detection and understanding of diseases. Of the many biofluids available for metabolomics, urine is a preferred option as it is non-invasive to collect and contains a wide range of metabolites reflective of the health status of the testing individual. However, urine also contains many exogenous metabolites which are introduced through various sources such as diet. This complicates the data interpretation...
Source: Journal of Food and Drug Analysis - December 12, 2018 Category: Food Science Source Type: research

Using ambient mass spectrometry and LC–MS/MS for the rapid detection and identification of multiple illicit street drugs
In this study the recently developed technique of thermal desorption electrospray ionization/mass spectrometry (TD–ESI/MS) was applied to the rapid analysis of multiple controlled substances. With the reallocation of mass spectral resources [from a standard ESI source coupled with liquid chromatography (LC) to an ambient TD–ESI source], this direct-analysis technique allows the identification of a wider range of illicit drugs through a dual-working mode (pretreatment-free qualitative screening/conventional quantitative confirmation). Through 60-MRM (multiple reaction monitoring) analysis—in which the MS/M...
Source: Journal of Food and Drug Analysis - December 5, 2018 Category: Food Science Source Type: research

Measuring serum total and free indoxyl sulfate and p-cresyl sulfate in chronic kidney disease using UPLC-MS/MS
Publication date: Available online 4 December 2018Source: Journal of Food and Drug AnalysisAuthor(s): Chia-Ni Lin, I-Wen Wu, Yun-Fen Huang, Shu-Yu Peng, Ya-Ching Huang, Hsiao-Chen NingAbstractChronic kidney disease (CKD) is a complex disorder that affects multiple organs and increases the risk of cardiovascular complications. CKD affects approximately 12% of the population in Taiwan. Loss of kidney function leads to accumulation of potentially toxic compounds such as indoxyl sulfate (IS) and p-cresyl sulfate (pCS), two protein-bound uremic solutes that can stimulate the progression of CKD. The aim of this study was to asse...
Source: Journal of Food and Drug Analysis - December 5, 2018 Category: Food Science Source Type: research

The regulation of drug-metabolizing enzymes and membrane transporters by inflammation: Evidences in inflammatory diseases and age-related disorders
Publication date: Available online 4 December 2018Source: Journal of Food and Drug AnalysisAuthor(s): Kuo-Chen Wu, Chun-Jung LinAbstractDrug-metabolizing enzymes (DMEs) and membrane transporters play important roles in the absorption, distribution, metabolism, and excretion processes that determine the pharmacokinetics of drugs. Inflammation has been shown to regulate the expression and function of these drug-processing proteins. Given that inflammation is a common feature of many diseases, in this review, the general mechanisms for inflammation-mediated regulation of DMEs and transporters are described. Also, evidences re...
Source: Journal of Food and Drug Analysis - December 5, 2018 Category: Food Science Source Type: research

Antcins, triterpenoids from Antrodia cinnamomea, as new agonists for peroxisome proliferator-activated receptor α
Publication date: Available online 4 December 2018Source: Journal of Food and Drug AnalysisAuthor(s): Yu-Jen Wang, Shih-Chin Lee, Chun-Hua Hsu, Yueh-Hsiung Kuo, Chien-Chih Yang, Fu-Jung LinAbstractPeroxisome proliferator-activated receptor α (PPARα) is a nuclear hormone receptor that transcriptionally regulates lipid metabolism and inflammation; therefore, PPARα agonists are promising agents to treat dyslipidemia and metabolic disorders. PPARα full agonists, such as fibrates, are effective anti-hypertriglyceride agents, but their use is limited by adverse side effects. Hence, the aim of this study w...
Source: Journal of Food and Drug Analysis - December 4, 2018 Category: Food Science Source Type: research

Shenmai-Yin decreased the clearance of nifedipine in rats: The involvement of time-dependent inhibition of nifedipine oxidation
Publication date: Available online 8 November 2018Source: Journal of Food and Drug AnalysisAuthor(s): Hong-Jaan Wang, Chung-Kuang Lu, Wei-Ching Chen, An-Chi Chen, Yune-Fang UengAbstractThe traditional Chinese herbal formula Shenmai-Yin (SY) and nifedipine have both been used to treat patients with cardiovascular disorders. Nifedipine is primarily oxidized by cytochrome P450 (CYP) 3A. The oxidation and pharmacokinetics of nifedipine were studied in rats in vitro and in vivo to illustrate the interaction of SY with nifedipine. Schisandrol A, schisandrin A and schisandrin B were identified as the main lignans in SY....
Source: Journal of Food and Drug Analysis - November 9, 2018 Category: Food Science Source Type: research

Comparative investigation for raw and processed Aconiti Lateralis Radix using chemical UPLC-MS profiling and multivariate classification techniques
Publication date: Available online 8 November 2018Source: Journal of Food and Drug AnalysisAuthor(s): Lili Sun, Guangjiao You, Xuexiao Cao, Meng Wang, Xiaoliang RenAbstractA strategy combining chemical UPLC-MS profiling and multivariate classification techniques has been used for the comparison of raw and processed Aconiti Lateralis Radix. UPLC-MS was used to identify 18 characteristic compounds, which were selected for discrimination of the raw and two processed products (Heishunpian and Baifupian). Chemometric analyses, including the combination of a heat map and hierarchical cluster analysis (HCA) and principal componen...
Source: Journal of Food and Drug Analysis - November 9, 2018 Category: Food Science Source Type: research

PON-1 carbamylation is enhanced in HDL of uremia patients
Publication date: Available online 28 October 2018Source: Journal of Food and Drug AnalysisAuthor(s): Chiz-Tzung Chang, Yun-Ping Lim, Chi-Wen Lee, Hsin-Yi Liao, Feng-Yu Chen, Chia-Ming Chang, Feng-Yao Tang, Chao-Yuh Yang, Chao-Jung ChenAbstractHigh-density lipoprotein (HDL) carbamylation has been known in uremia patients. Paraoxonase-1 (PON-1) is an important HDL protein responsible for HDL anti-oxidant, arylesterase and lactonase activities. PON-1 carbamylation in uremic HDL has never been explored. We isolated HDL from uremia patients and control healthy subjects for study. Sandwich ELISA was used to estimate carbamylate...
Source: Journal of Food and Drug Analysis - October 30, 2018 Category: Food Science Source Type: research

Method development of immunoglobulin G purification from micro-volumes of human serum for untargeted and targeted proteomics-based antibody repertoire studies
Publication date: Available online 27 October 2018Source: Journal of Food and Drug AnalysisAuthor(s): Yu-Ting Chang, Ming-Chu Chang, Yun-Jun Tsai, Christine Ferng, Hsi-Chang Shih, Ya-Po Kuo, Chung-Hsuan Chen, I-Lin TsaiAbstractImmunoglobulins (Igs) are major serum proteins which play important roles in immunity. Both untargeted and targeted proteomic workflows can be applied to investigate antigen-binding sites and the glycosylation profiles of Igs. For a more-comprehensive picture of IgG from human serum, we developed an IgG purification process and coupled the standardized method to untargeted and targeted proteomic work...
Source: Journal of Food and Drug Analysis - October 28, 2018 Category: Food Science Source Type: research

Analysis of heterocyclic amines in meat products by liquid chromatography – Tandem mass spectrometry
In this study, two sample preparation strategies, liquid–liquid extraction (LLE) with solid-phase extraction (SPE) and a rapid, easy, cheap, effective, rugged, and safe extraction (QuEChERS) method, were investigated for the determination of 11 types of HCAs in meat products by LC-MS/MS. The HCAs in the samples were first extracted with acetonitrile by LLE, and followed by SPE. In the case of QuEChERS extraction, acetonitrile is used as the LLME solvent, and PSA, C18EC and MgSO4 were used as the dSPE sorbent. Both methods showed good performance with respect to precision (RSD 0.993). The QuEChERS extraction stra...
Source: Journal of Food and Drug Analysis - October 28, 2018 Category: Food Science Source Type: research

Stability of glyoxal- and methylglyoxal-modified hemoglobin on dried blood spot cards as analyzed by nanoflow liquid chromatography tandem mass spectrometry
In this study, we examine the stability of these modifications of hemoglobin stored on DBS cards at room temperature or 4 °C in the ambient air. After hemoglobin was extracted from the DBS cards, it was digested by trypsin and analyzed by nanoflow liquid chromatography coupled with nanospray ionization tandem mass spectrometry. The results show that the extents of all these PTMs are stable within 14 and 21 days when stored on DBS at room temperature and at 4 °C, respectively. Extraction of globin from DBS cards is mostly advantageous for hemolytic blood samples. This assay is sensitive as only a quarter o...
Source: Journal of Food and Drug Analysis - October 28, 2018 Category: Food Science Source Type: research

Development of biomarkers of genitourinary cancer using mass spectrometry-based clinical proteomics
Publication date: Available online 27 October 2018Source: Journal of Food and Drug AnalysisAuthor(s): Yi-Ting Chen, Cheng-Han Tsai, Chien-Lun Chen, Jau-Song Yu, Ying-Hsu ChangAbstractProstate, bladder and kidney cancer are the three most common types of genitourinary cancer in the world. Of these, prostate and bladder cancers are within the top 10 most common cancers in men. Notably, kidney cancer causes no obvious symptoms in the early stages. To satisfy clinical-management requirements, researchers have developed numerous biomarkers by applying proteomic approaches using clinical serum, urine and tissue specimens, as wel...
Source: Journal of Food and Drug Analysis - October 28, 2018 Category: Food Science Source Type: research

Identification of bacteria in juice/lettuce using magnetic nanoparticles and selected reaction monitoring mass spectrometry
This study presents an accurate means for bacterial identification in food matrixes using MS. The analysis time is less than 90 min and the minimum concentration of E. coli detected was 5 × 103 CFU/mL. The interaction between bacteria and the magnetic nanoparticles was electrostatic and nonspecific, in contrast to immunoassays which require specific antibodies. The targeted peptide analysis focuses on the bacterial markers, thus significantly simplifying the analysis and leading to an accurate identification of bacteria.Graphical abstract (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - October 26, 2018 Category: Food Science Source Type: research

Simultaneous quantification combined with multivariate statistical analysis of multiple chemical markers of Wu Ji Bai Feng Pill by UHPLC–MS/MS
In conclusion, the established method offered speedy and sensitive determination for 20 compounds and is helpful for chemical standardization of commercial WJBFP products.Graphical abstract (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - October 26, 2018 Category: Food Science Source Type: research

CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-β, Wnt and STAT3 signaling pathways
Publication date: Available online 25 October 2018Source: Journal of Food and Drug AnalysisAuthor(s): In-Yu Lin, Yi-Shiou Chiou, Li-Ching Wu, Chen-Yu Tsai, Chiung-Tong Chen, Wu-Chang Chuang, Ming-Chung Lee, Ching-Che Lin, Ting-Ting Lin, Ssu-Ching Cheng, Min-Hsiung Pan, Nianhan MaAbstractCCM111 is an aqueous extract of Antrodia cinnamomea (AC) that has exhibited anti-liver fibrosis functions. However, the detailed mechanisms of AC action against liver fibrosis have not been elucidated yet. The present research showed that CCM111 significantly lowered the levels of the hepatic enzyme markers glutamate oxaloacetate transamina...
Source: Journal of Food and Drug Analysis - October 26, 2018 Category: Food Science Source Type: research

Applications of cyclic peptide nanotubes (cPNTs)
Publication date: Available online 28 September 2018Source: Journal of Food and Drug AnalysisAuthor(s): Wei-Hsien Hsieh, Jiahorng LiawAbstractSelf-assembled cyclic peptide nanotubes (cPNTs) have recently drawn particular attention as one of the most intriguing nanostructures in the field of nanotechnology. Given their unique features including high surface area, increased drug loading, environmental stability, enhanced permeation, and modifiable drug release, these hollow tubular structures can be constructed with cyclic di-, tri-, tetra-, hexa-, octa-, and decapeptides with various amino acid sequences, enantiomers, and f...
Source: Journal of Food and Drug Analysis - October 9, 2018 Category: Food Science Source Type: research