Graft protective effect of HMG-CoA reductase inhibitor Pravastatin in murine cardiac allograft transplantation
The HMG-CoA reductase inhibitor (Statin), which reduces serum cholesterol has been demonstrated in the control of immune responses and may potential play an important role in the regulation of acute and chronic rejection in organ transplantations. We investigated the graft-protective effect of a kind of statin, Pravastatin, in the survival of fully MHC-mismatched murine cardiac allograft transplantation. Fully vascularized heterotopic hearts from C57BL/6 donors were transplanted into CBA recipients by using microsurgical techniques. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - June 5, 2018 Category: Transplant Surgery Authors: Enzhi Yin, Masanori Hara, Masateru Uchiyama, Masanori Niimi Source Type: research

An unusual case of Pulmonary Mucormycosis
Invasive fungal infections in solid organ transplant recipients are associated with significant morbidity and mortality. Of these fungal infections Mucormycosis presents as an aggressive, frequently fatal angioinvasive infection. Immunocompromised host and Diabetes are important risk factors. These infections are frequently difficult to diagnose. A high index of suspicion in appropriate setting and early, aggressive treatment with the newer antifungal agents have altered the previously grave prognosis. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - June 5, 2018 Category: Transplant Surgery Authors: Sajan Thomas, Basant Pawar, David Fernandes, Sajith Nayar, Pratish George, Sajiv Cherian Source Type: research

High-Dose Intravenous Immunoglobulin Treatment of Polyomavirus Nephropathy Developing After T Cell –Mediated Rejection Treatment: A Case Report
Reactivation of BK polyomavirus causes destructive virus allograft nephropathy; however, treatment options are limited. Herein, we report a case in which a patient with T cell –mediated rejection was treated with steroid therapy. The patient subsequently developed BK viremia and was successfully treated by using intravenous immunoglobulin (IVIG) after failing to respond to conventional treatment. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - June 2, 2018 Category: Transplant Surgery Authors: S.D. Hwang, J.H. Lee, S.W. Lee, J.K. Kim, M.-J. Kim, J.H. Song Source Type: research

Effect of Low-Dose Vs Standard-Dose Valganciclovir in the Prevention of Cytomegalovirus Disease in Kidney Transplantation Recipients: A Systemic Review and Meta-Analysis
Valganciclovir is widely used to prevent post-transplant cytomegalovirus (CMV) infection in kidney transplant patients. However, the currently used dose remains controversial because the continuous use of this drug decreases kidney function and can induce leukopenia. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - June 2, 2018 Category: Transplant Surgery Authors: S.D. Hwang, J.H. Lee, S.W. Lee, J.K. Kim, M.-J. Kim, J.H. Song Source Type: research

Impact of Volatile Anesthetic Agents on Early Clinical Outcomes in Liver Transplantation
This study compares inhaled anesthetics in early liver allograft IRI. LT recipient and organ donor data were extracted retrospectively for all LTs at a single center between 2001 and  2015. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - June 1, 2018 Category: Transplant Surgery Authors: R.S. Mangus, S.B. Kinsella, D.T. Farar, J.A. Fridell, L.T. Woolf, C.A. Kubal Tags: Milestones in Transplantation Source Type: research

High-Mobility Group Box 1 Protein Regulates Autophagy in LO2 Cells Following Anoxia-Reoxygenation Injury
This study aimed to assess the role of high-mobility group box 1 protein (HMGB1) in autophagy in LO2 cells following anoxia-reoxygenation injury. LO2 cells were pretreated with the HMGB1 inhibitor ammonium glycyrrhizinate (1000 μmol/L) or the HMGB1 agonist recombinant HMGB1 (rHMGB1, 10 ng/mL) at proper concentrations before induction of anoxia-reoxygenation injury. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and cell viability were evaluated. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - June 1, 2018 Category: Transplant Surgery Authors: M. Li, G. Peng, Q. Ye, Y. Wang, Y. Xiong, R. Wang, Z. Yang Tags: Milestones in Transplantation Source Type: research

Outcome of Kidney Transplantation From Donor After Cardiac Death: Reanalysis of the US Mycophenolic Renal Transplant Registry
Kidney transplantation is limited by the shortage of donor kidneys. Donation after cardiac death (DCD) has been explored to alleviate this problem. To better understand the outcome of DCD kidney transplantation, we reanalyzed the Mycophenolic Renal Transplant (MORE) Registry. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - June 1, 2018 Category: Transplant Surgery Authors: D. Zhu, K. McCague, W. Lin, R. Rong, M. Xu, L. Chan, T. Zhu Tags: Milestones in Transplantation Source Type: research

Outcomes of Liver Transplant Recipients With Model for End-Stage Liver Disease Exception: Single-Center Experience in the Northeast of Brazil
The objective of this study was to establish the profile of the patients submitted to liver transplantation with MELD exceptions based on symptoms in the University Hospital Walter Cant ídio, Ceara, Brazil, between the years of 2012 and 2015, analyzing donor and recipient data, with special attention to patients with refractory ascites and recurrent encephalopathy, including survival rates. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - June 1, 2018 Category: Transplant Surgery Authors: G.R. Coelho, A.M. Praciano, G.N.R. Viana, C.A. Lima, B.A. Feitosa Neto, J.H.P. Garcia Tags: Milestones in Transplantation Source Type: research

Racial and Ethnic Differences in Graft Loss Among Female Liver Transplant Recipients
Racial differences in post-liver transplantation (LT) outcomes are identified in predominantly male cohorts. Despite known sex differences in a spectrum of liver-related outcomes, it is not known how race influences graft outcomes in women. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - June 1, 2018 Category: Transplant Surgery Authors: S. Dave, J.L. Dodge, N.A. Terrault, M. Sarkar Tags: Milestones in Transplantation Source Type: research

Investigation of BK Virus by Real-Time Polymerase Chain Reaction in Patients With Allogeneic Bone Marrow Transplantation
In this study, we investigated BKV DNA in serum and plasma and urine specimens by real-time polymerase chain reaction (PCR) method in allogeneic hematopoietic stem cell transplantation patients. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - June 1, 2018 Category: Transplant Surgery Authors: F. Ek şi, T. Karslıgil, İ. Gündeş, M. Sağlam, M.P. Kırık, M.S. Büdeyri, H. Haydaroğlu Şahin, M. Pehlivan Tags: Milestones in Transplantation Source Type: research

Effect of Sirolimus on Native Total Kidney Volume After Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease: A Randomized Controlled Pilot Study
The mammalian target of rapamycin (mTOR) pathway has been shown to be central to cyst formation and growth in patients with autosomal dominant polycystic kidney disease (ADPKD). Drugs that suppress mTOR signaling are frequently used as antiproliferative agents for maintenance immunosuppression in patients who have undergone kidney transplantation. The aim of this study was to determine the effect of sirolimus, an mTOR inhibitor, on cyst volume regression in patients with ADPKD who have undergone renal transplantation. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - June 1, 2018 Category: Transplant Surgery Authors: S. Davis, J. Gralla, L. Chan, A. Wiseman, C.L. Edelstein Tags: Milestones in Transplantation Source Type: research

Comparison of Perioperative Renal Function Between Epidural and Intravenous Patient-Controlled Analgesia After Living-Donor Hepatectomy: A Retrospective Study
Sympathetic blockade associated with epidural analgesia was reported to be a risk factor for acute kidney injury (AKI) following liver resection. The purpose of this study was to compare the incidence of AKI after living-donor hepatectomies according to the type of patient-controlled analgesia (PCA). (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - June 1, 2018 Category: Transplant Surgery Authors: S.Y. Ham, E.J. Kim, T.H. Kim, B.-N. Koo Tags: Milestones in Transplantation Source Type: research

Safety of Direct-Acting Antiviral Therapy Regarding Renal Function in Post –Liver Transplant Patients Infected with Hepatitis C Virus and a 100% 12-Week Sustained Virologic Response—A Single-Center Study
Patients after liver transplantation (LT) with hepatitis C virus (HCV) infection often suffer from renal or hepatic impairment. Treating patients after LT with direct-acting antivirals (DAA) might result in decreasing renal function due to interaction of DAA and immunosuppressive therapy. In this single-center study we analyzed clinical parameters of 18 HCV-infected patients treated with DAA therapy after LT. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - June 1, 2018 Category: Transplant Surgery Authors: G. Peschel, L. Moleda, L. Baier, M. Selgrad, S. Schmid, M.N. Scherer, M. M üller, K. Weigand Tags: Milestones in Transplantation Source Type: research

Similar Microvascular Inflammation and Tubulointerstitial Injury in ABO-Incompatible and Matched ABO-Compatible Kidney Allografts
ABO-incompatible (ABOi) kidney transplantation represents a viable tool to increase the donor pool for kidney transplantation, however, increased alloimmune response has been debated. The early outcomes of 25 low-risk ABOi kidney transplant recipients were compared with thoroughly matched 50 ABO-compatible (ABOc) ones. The matching process was based on gender and age of recipients and immunologic parameters, such as panel reactive antibodies, number of human leukocyte antigen mismatches, and transplantation era. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - June 1, 2018 Category: Transplant Surgery Authors: K. Osickova, A. Parikova, J. Maluskova, J. Fronek, O. Viklicky Tags: Milestones in Transplantation Source Type: research

Renal Doppler Resistance Indices in Kidney Transplant Recipients With Proteinuria
The onset of proteinuria in renal transplant recipients may be associated with an increased risk of allograft failure. Little is known about the relationships between factors influencing proteinuria and the Doppler ultrasound (DU) intrarenal resistive index (RI) and pulsatility index (PI) among donor recipients with proteinuria   (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - June 1, 2018 Category: Transplant Surgery Authors: M. Boran, E. Boran, M. Boran, M. Tola Tags: Milestones in Transplantation Source Type: research