Poncirin ameliorates cardiac ischemia-reperfusion injury by activating PI3K/AKT/PGC-1 α signaling
In conclusion, both in vitro and in vivo studies suggested that poncirin alleviates cardiac ischemia-reperfusion injury by mitigating oxidative stress, which is dependent on activation of the PI3K/AKT/PGC-1α signaling pathway.PMID:35032487 | DOI:10.1016/j.ejphar.2022.174759 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - January 15, 2022 Category: Drugs & Pharmacology Authors: Bingda Li Tianpeng Chen Wenfeng Hu Zhenhua Wang Ji Wu Qing Zhou Ping Li Source Type: research

Poncirin ameliorates cardiac ischemia-reperfusion injury by activating PI3K/AKT/PGC-1 α signaling
In conclusion, both in vitro and in vivo studies suggested that poncirin alleviates cardiac ischemia-reperfusion injury by mitigating oxidative stress, which is dependent on activation of the PI3K/AKT/PGC-1α signaling pathway.PMID:35032487 | DOI:10.1016/j.ejphar.2022.174759 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - January 15, 2022 Category: Drugs & Pharmacology Authors: Bingda Li Tianpeng Chen Wenfeng Hu Zhenhua Wang Ji Wu Qing Zhou Ping Li Source Type: research

p-Synephrine, the main protoalkaloid of Citrus aurantium, raises fat oxidation during exercise in elite cyclists
(Source: European Journal of Sport Science)
Source: European Journal of Sport Science - December 10, 2021 Category: Sports Medicine Authors: Guti érrez-Hellín, Jorge Baltazar-Martins, Gabriel Rodr íguez, Iván Lara, Beatriz Ruiz-Moreno, Carlos Aguilar-Navarro, Mill án Del Coso, Juan Source Type: research

Ultrasound-assisted aqueous two-phase extraction of synephrine, naringin, and neohesperidin from Citrus aurantium L. fruitlets
(Source: Preparative Biochemistry)
Source: Preparative Biochemistry - December 3, 2021 Category: Biochemistry Authors: Yan, Yang Zhou, Hui Wu, Chuanhai Feng, Xiaoye Han, Chenggang Chen, Hao Liu, Yan Li, Yanfang Source Type: research

The Effects of Caffeine and Citrus Aurantium on Performance During Repeated Maximal Anaerobic Exercise Bouts in Habitual Caffeine Users
McLester, CN, Bailey, P, Bechke, EE, Williamson, CM, McLester, JR, and Kliszczewicz, B. The effects of caffeine and Citrus aurantium on performance during repeated maximal anaerobic exercise bouts in habitual caffeine users. J Strength Cond Res 35(12): 3394–3399, 2021—The combination of caffeine (CAF) and Citrus aurantium (CA) have demonstrated the potential to improve various types of performance. To date, few studies have explored this relationship in purely anaerobic-based exercise. Therefore, the purpose of this study was to examine the influence of an acute dose of CAF + CA on peak anaerobic performance an...
Source: Journal of Strength and Conditioning Research - November 29, 2021 Category: Sports Medicine Tags: Original Research Source Type: research

Electrospun nanofiber based on Ethyl cellulose/Soy protein isolated integrated with bitter orange peel extract for antimicrobial and antioxidant active food packaging
Int J Biol Macromol. 2021 Oct 30:S0141-8130(21)02332-1. doi: 10.1016/j.ijbiomac.2021.10.182. Online ahead of print.ABSTRACTThe present work was aimed to produce a novel bioactive nanofiber (NFs) based on Ethyl cellulose (EC), Soy protein isolated (SPI), and containing Bitter orange peel extract (BOPE) by electrospinning technology. The EC/SPI NFs were formulated with different weight ratios of 1:1, 2:1, and 1:2 denoted as ES11, ES21, and ES12, respectively, and investigated by several analyses. Based on the obtained results, the maximum hydrogen interactions between these two polymers, ES11 NFs offered a uniform morphology...
Source: International Journal of Biological Macromolecules - November 3, 2021 Category: Biochemistry Authors: Mohsen Rashidi Sepidar Seyyedi Mansour Parisa Mostashari Soghra Ramezani Maryam Mohammadi Marjan Ghorbani Source Type: research

Long-Term Mootral Application Impacts Methane Production and the Microbial Community in the Rumen Simulation Technique System
In conclusion, Mootral has the transient ability to reduce methane production significantly due to a selective effect on archaea numbers and archaeal community composition with little effect on the bacterial community. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - October 8, 2021 Category: Microbiology Source Type: research

Molecules, Vol. 26, Pages 5832: Citrus aurantium L. Active Constituents, Biological Effects and Extraction Methods. An Updated Review
érance Debs Citrus genus is a prominent staple crop globally. Long-term breeding and much hybridization engendered a myriad of species, each characterized by a specific metabolism generating different secondary metabolites. Citrus aurantium L., commonly recognized as sour or bitter orange, can exceptionally be distinguished from other Citrus species by unique characteristics. It is a fruit with distinctive flavor, rich in nutrients and phytochemicals which possess different health benefits. This paper presents an overview of the most recent studies done on the matter. It intends to provide an in-depth understand...
Source: Molecules - September 26, 2021 Category: Chemistry Authors: Sawssan Maksoud Roula M. Abdel-Massih Hiba N. Rajha Nicolas Louka Farid Chemat Francisco J. Barba Esp érance Debs Tags: Review Source Type: research

Molecules, Vol. 26, Pages 5452: Simultaneous Hydrodistillation-Steam Distillation of Rosmarinus officinalis, Lavandula angustifolia and Citrus aurantium from Morocco, Major Terpenes: Impact on Biological Activities
raça Miguel Interest in the use of essential oils (EOs) in the biomedical and food industries have seen growing over the last decades due to their richness in bioactive compounds. The challenges in developing an EO extraction process that assure an efficient levels of monoterpenes with impact on biological activities have driven the present study, in which the EO extraction process of rosemary, lavender and citrus was performed by simultaneous hydrodistillation–steam distillation, and the influence of EO composition on biological activities, namely antioxidant, anti-inflammatory, antidiabetic, anti-acetylc...
Source: Molecules - September 7, 2021 Category: Chemistry Authors: Sara El Kharraf Maria Leonor Faleiro Farah Abdellah Souka ïna El-Guendouz El Mestafa El Hadrami Maria Gra ça Miguel Tags: Article Source Type: research

The Effects of Lavender and Citrus aurantium on Anxiety and Agitation of the Conscious Patients in Intensive Care Units: A Parallel Randomized Placebo-Controlled Trial
Biomed Res Int. 2021 Jun 15;2021:5565956. doi: 10.1155/2021/5565956. eCollection 2021.ABSTRACTBACKGROUND: Conscious patients admitted to intensive care units (ICU) suffer from anxiety and agitation for various reasons, which can affect their recovery processes.AIMS: To compare the effects of lavender and Citrus aurantium essential oils on anxiety and agitation of conscious patients admitted to ICUs.DESIGN: A randomized parallel placebo-controlled trial.METHODS: One hundred and fifty conscious patients admitted to ICUs were selected by convenience sampling and were randomly divided into three groups, groups of lavender arom...
Source: Biomed Res - July 5, 2021 Category: Research Authors: Zahra Karimzadeh Mansooreh Azizzadeh Forouzi Elham Rahiminezhad Mehdi Ahmadinejad Mahlagha Dehghan Source Type: research

The Effects of Lavender and Citrus aurantium on Anxiety and Agitation of the Conscious Patients in Intensive Care Units: A Parallel Randomized Placebo-Controlled Trial
Biomed Res Int. 2021 Jun 15;2021:5565956. doi: 10.1155/2021/5565956. eCollection 2021.ABSTRACTBACKGROUND: Conscious patients admitted to intensive care units (ICU) suffer from anxiety and agitation for various reasons, which can affect their recovery processes.AIMS: To compare the effects of lavender and Citrus aurantium essential oils on anxiety and agitation of conscious patients admitted to ICUs.DESIGN: A randomized parallel placebo-controlled trial.METHODS: One hundred and fifty conscious patients admitted to ICUs were selected by convenience sampling and were randomly divided into three groups, groups of lavender arom...
Source: Biomed Res - July 5, 2021 Category: Research Authors: Zahra Karimzadeh Mansooreh Azizzadeh Forouzi Elham Rahiminezhad Mehdi Ahmadinejad Mahlagha Dehghan Source Type: research

A Review of Auraptene as an Anticancer Agent
Auraptene is a bioactive monoterpene coumarin isolated from Citrus aurantium and Aegle marmelos that belong to the Rutaceae family. Auraptene can modulate intracellular signaling pathways that control cell growth, inflammation and apoptosis and can exert pharmacological properties such as anti-bacterial, anti-fungal, antileishmania and anti-oxidant activity. Auraptene had inhibitory and chemo-preventive effects on the proliferation, tumorigenesis and growth of several cancer cell lines through increase in the activity of glutathione S-transferase, formation of DNA adducts and reduction of the number of aberrant crypt foci....
Source: Frontiers in Pharmacology - June 22, 2021 Category: Drugs & Pharmacology Source Type: research

Inhibitory effect of chloroform extracts from Citrus aurantium L. var. amara Engl. on fat accumulation
Publication date: Available online 19 June 2021Source: PhytomedicineAuthor(s): Xiao-Yi Li, Yun-Fang Hao, Zhan-Xi Hao, Jian-Guo Jiang, Qiang Liu, Qun Shen, Li Liu, Yan-Kui Yi, Chun-Yan Shen (Source: Phytomedicine)
Source: Phytomedicine - June 21, 2021 Category: Drugs & Pharmacology Source Type: research

Phenolics in Citrus aurantium fruit identified by UHPLC-MS/MS and their bioactivities
Publication date: July 2021Source: LWT, Volume 147Author(s): Lingrong Wen, Mingyang He, Chunxiao Yin, Yueming Jiang, Donghui Luo, Bao Yang (Source: LWT Food Science and Technology)
Source: LWT Food Science and Technology - May 12, 2021 Category: Food Science Source Type: research

Racemic synephrine found in Citrus aurantium ‐listing pre‐workout supplements suggests a non‐plant‐based origin
The first implementation ofCitrus aurantium standardised reference material (SRM) to compare the ratios of synephrine enantiomers found in plant material with those commercially available pre ‐workout supplements. Out of 12 products, five containedR‐(−)‐synephrine that were suggested to be from a natural plant source. For the remaining supplements, four had racemic synephrine and one had only 5S‐(+)‐synephrine, which questions the origin of the synephrine to a synthetic rather than a plant source. AbstractMulti ‐ingredient pre‐workout supplements (MIPS) containCitrus aurantium as a source of bioactive a...
Source: Drug Testing and Analysis - April 16, 2021 Category: Drugs & Pharmacology Authors: Andy Hsien Wei Koh, Russ Chess ‐Williams, Anna Elizabeth Lohning Tags: SHORT COMMUNICATION Source Type: research

Evaluation of antioxidant and inhibitory properties of Citrus aurantium L. on the acetylcholinesterase activity and the production of amyloid nano-bio fibrils
Int J Biol Macromol. 2021 Apr 10:S0141-8130(21)00798-4. doi: 10.1016/j.ijbiomac.2021.04.043. Online ahead of print.ABSTRACTThe blossoms of Citrus aurantium are considered for the treatment of Alzheimer's disease because of their fragrant essential oils. The aim of this study was to investigate the antioxidant and inhibitory effects of Citrus aurantium extract on the acetylcholinesterase and production of amyloid nanobiofibrils from bovine serum albumin (BSA). The Citrus aurantium petals were harvested from Rasht city in northern IRAN. Chemical composition was investigated by GC-MS. The anti-Alzheimer's effects were evaluat...
Source: International Journal of Biological Macromolecules - April 13, 2021 Category: Biochemistry Authors: Shayan Pasandideh Amir Arasteh Source Type: research

Evaluation of antioxidant and inhibitory properties of Citrus aurantium L. on the acetylcholinesterase activity and the production of amyloid nano-bio fibrils
Int J Biol Macromol. 2021 Apr 10:S0141-8130(21)00798-4. doi: 10.1016/j.ijbiomac.2021.04.043. Online ahead of print.ABSTRACTThe blossoms of Citrus aurantium are considered for the treatment of Alzheimer's disease because of their fragrant essential oils. The aim of this study was to investigate the antioxidant and inhibitory effects of Citrus aurantium extract on the acetylcholinesterase and production of amyloid nanobiofibrils from bovine serum albumin (BSA). The Citrus aurantium petals were harvested from Rasht city in northern IRAN. Chemical composition was investigated by GC-MS. The anti-Alzheimer's effects were evaluat...
Source: International Journal of Biological Macromolecules - April 13, 2021 Category: Biochemistry Authors: Shayan Pasandideh Amir Arasteh Source Type: research

Evaluation of antioxidant and inhibitory properties of Citrus aurantium L. on the acetylcholinesterase activity and the production of amyloid nano-bio fibrils
Int J Biol Macromol. 2021 Apr 10:S0141-8130(21)00798-4. doi: 10.1016/j.ijbiomac.2021.04.043. Online ahead of print.ABSTRACTThe blossoms of Citrus aurantium are considered for the treatment of Alzheimer's disease because of their fragrant essential oils. The aim of this study was to investigate the antioxidant and inhibitory effects of Citrus aurantium extract on the acetylcholinesterase and production of amyloid nanobiofibrils from bovine serum albumin (BSA). The Citrus aurantium petals were harvested from Rasht city in northern IRAN. Chemical composition was investigated by GC-MS. The anti-Alzheimer's effects were evaluat...
Source: International Journal of Biological Macromolecules - April 13, 2021 Category: Biochemistry Authors: Shayan Pasandideh Amir Arasteh Source Type: research

A strategy combining solid-phase extraction, multiple mass defect filtering and molecular networking for rapid structural classification and annotation of natural products: characterization of chemical diversity in Citrus aurantium as a case study
Anal Bioanal Chem. 2021 Apr 6. doi: 10.1007/s00216-021-03201-1. Online ahead of print.ABSTRACTMedicinal plants are complex chemical systems containing thousands of secondary metabolites. The rapid classification and characterization of the components in medicinal plants using mass spectrometry (MS) remains an immense challenge. Herein, a novel strategy is presented for MS through the combination of solid-phase extraction (SPE), multiple mass defect filtering (MMDF) and molecular networking (MN). This strategy enables efficient classification and annotation of natural products. When combined with SPE and MMDF, the improved ...
Source: Analytical and Bioanalytical Chemistry - April 6, 2021 Category: Chemistry Authors: Yi-Kun Wang Xue-Rong Xiao Zi-Meng Zhou Yao Xiao Wei-Feng Zhu Hong-Ning Liu Fei Li Source Type: research

A strategy combining solid-phase extraction, multiple mass defect filtering and molecular networking for rapid structural classification and annotation of natural products: characterization of chemical diversity in Citrus aurantium as a case study
Anal Bioanal Chem. 2021 Apr 6. doi: 10.1007/s00216-021-03201-1. Online ahead of print.ABSTRACTMedicinal plants are complex chemical systems containing thousands of secondary metabolites. The rapid classification and characterization of the components in medicinal plants using mass spectrometry (MS) remains an immense challenge. Herein, a novel strategy is presented for MS through the combination of solid-phase extraction (SPE), multiple mass defect filtering (MMDF) and molecular networking (MN). This strategy enables efficient classification and annotation of natural products. When combined with SPE and MMDF, the improved ...
Source: Analytical and Bioanalytical Chemistry - April 6, 2021 Category: Chemistry Authors: Yi-Kun Wang Xue-Rong Xiao Zi-Meng Zhou Yao Xiao Wei-Feng Zhu Hong-Ning Liu Fei Li Source Type: research

Anti-anxiety properties of selected medicinal plants.
The objective of this review is to provide information about the healing outcomes of anxiety treatment with natural products. Valeriana officinalis, Citrus aurantium, Commelina benghalensis, Achyranthes aspera, Mimosa pudica, Achillea millefolium, Nymphaea alba, Leonurus cardiac, Camellia sinensis, Turnera aphrodisiaca, Crataegus oxyacantha and Piper methysticum showed promising effects on anxiety in animal models. In clinical studies, passion flower, kava, valerian, St John's wort, and ashwagandha showed the most positive results. More studies are needed for the exploration of the anti-anxiety of medicinal plants. In drug...
Source: Current Pharmaceutical Biotechnology - January 22, 2021 Category: Biotechnology Authors: Khan A, Akram M, Thiruvengadam M, Daniyal M, Zakki SA, Munir N, Zainab R, Heydari M, Mosavat SH, Rebezov M, Shariati MA Tags: Curr Pharm Biotechnol Source Type: research

Effects of lavender and Citrus aurantium on pain of conscious intensive care unit patients: A parallel randomized placebo-controlled trial
Publication date: Available online 14 January 2021Source: Journal of Integrative MedicineAuthor(s): Zahra Karimzadeh, Mansooreh Azizzadeh Forouzi, Haleh Tajadini, Mehdi Ahmadinejad, Callista Roy, Mahlagha Dehghan (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - January 14, 2021 Category: Complementary Medicine Source Type: research

Growth sites and their impacts on sour orange ʽCitrus aurantium (Tournef.)ʼ essential oil
Publication date: Available online 9 January 2021Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Khalid A. Khalid (Source: Biocatalysis and Agricultural Biotechnology)
Source: Biocatalysis and Agricultural Biotechnology - January 9, 2021 Category: Biotechnology Source Type: research

Botanical illustration of Citrus vulgaris, 1880
Traditionally, the leaves and fruit of bitter orange were used to alleviate nausea and aid digestion. (Source: The Pharmaceutical Journal)
Source: The Pharmaceutical Journal - December 3, 2020 Category: Drugs & Pharmacology Source Type: research

A Combined Phytochemistry and Network Pharmacology Approach to Reveal the Effective Substances and Mechanisms of Wei-Fu-Chun Tablet in the Treatment of Precancerous Lesions of Gastric Cancer
This study offers an applicable approach to identify chemical components, absorbed compounds, and metabolic compounds in WFC, and provides a method to explore bioactive ingredients and action mechanisms of WFC. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 18, 2020 Category: Drugs & Pharmacology Source Type: research

HPLC-UV-QDa analysis of Citrus aurantium-labelled pre-workout supplements suggest only a minority contain the plant extract
Publication date: Available online 5 November 2020Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Andy Hsien Wei Koh, Russ Chess-Williams, Anna Elizabeth Lohning (Source: Journal of Pharmaceutical and Biomedical Analysis)
Source: Journal of Pharmaceutical and Biomedical Analysis - November 6, 2020 Category: Drugs & Pharmacology Source Type: research

Effects of Citrus aurantium L. on Gastrointestinal Motility and Gastric Cancer Cell Proliferation
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Source: Cancer Biotherapy and Radiopharmaceuticals - October 28, 2020 Category: Cancer & Oncology Authors: Meng Gao Wuliang Yang Source Type: research

The Effect of Aromatherapy Massage with Lavender and Citrus Aurantium Essential Oil on Quality of Life of Patients on Chronic Hemodialysis: A Parallel Randomized Clinical Trial Study
Poor quality of life are major problems in hemodialysis patients. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - August 30, 2020 Category: Palliative Care Authors: Reza Mohammadpourhodki, Hosein Sadeghnezhad, Hossein Ebrahimi, Mohammad Hasan Basirinezhad, Maryam Maleki, Maurizio Bossola Source Type: research

Molecules, Vol. 25, Pages 3956: Biological Activity and Antibiofilm Molecular Profile of Citrus aurantium Essential Oil and Its Application in a Food Model
á Soňa Felšöciová Eva Tvrdá Jana Žiarovská Renáta Benda Prokeinová Nenad Vukovic The main aim of the study was to investigate the chemical composition, antioxidant, antimicrobial, and antibiofilm activity of Citrus aurantium essential oil (CAEO). The biofilm profile of Stenotrophonomonas maltophilia and Bacillus subtilis were assessed using the mass spectrometry MALDI-TOF MS Biotyper and the antibiofilm activity of Citrus aurantium (CAEO) was studied on wood and glass surfaces. A semi-quantitative composition using a modified version was applied for the ...
Source: Molecules - August 29, 2020 Category: Chemistry Authors: Miroslava Ka čániová Margarita Terentjeva Lucia Galovi čová Eva Ivani šová Jana Štefániková Veronika Valkov á Petra Borotov á Przemys ław Łukasz Kowalczewski Simona Kunov á So ňa Felšöciová Eva Tvrd á Jana Žiarovská Ren áta Benda Pr Tags: Article Source Type: research

Synergistic potential of Citrus aurantium L. essential oil with antibiotics against Candida albicans
Publication date: 15 November 2020Source: Journal of Ethnopharmacology, Volume 262Author(s): Prakriti Nidhi, Rajan Rolta, Vikas Kumar, Kamal Dev, Anuradha Sourirajan (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 20, 2020 Category: Drugs & Pharmacology Source Type: research

Facile green and one-pot synthesis of seville orange derived carbon dots as a fluorescent sensor for Fe3+ ions
Publication date: December 2020Source: Microchemical Journal, Volume 159Author(s): Ayse Merve Senol, Ebru Bozkurt (Source: Microchemical Journal)
Source: Microchemical Journal - August 13, 2020 Category: Chemistry Source Type: research

Analysis of bitter orange dietary supplements for natural and synthetic phenethylamines by LC –MS/MS
In this study, an LC –MS/MS method was established to quantify five natural amines (synephrine, octopamine, tyramine,N‐methyltyramine, and hordenine) and four synthetic phenethylamines (phenylephrine, methylsynephrine, etilefrine, and isopropyloctopamine) in dietary supplements sold in the US. The method was validated and found to have acceptable performance to accurately measure analytes in complex botanical pro ducts. The average recoveries from a blank matrix were 88–125% with an RSD of 0.5–7.0%. Fifty‐nine products labeled to contain bitter orange peel, extract, or its amines were purchased and th...
Source: Drug Testing and Analysis - June 27, 2020 Category: Drugs & Pharmacology Authors: Rahul S. Pawar, Satyanarayanaraju Sagi, Dmitry Leontyev Tags: RESEARCH ARTICLE Source Type: research

Essential Oil from Citrus aurantium Alleviates Anxiety of Patients Undergoing Coronary Angiography: A Single-Blind, Randomized Controlled Trial
ConclusionInhalation of the essential oil fromCitrus aurantium was effective in reducing anxiety and stress levels in patients undergoing coronary angiography. Trial registration: IRCT2016040816797N2 (retrospectively registered on 21 April 2016,https://en.irct.ir/trial/15600) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - June 21, 2020 Category: Internal Medicine Source Type: research

Exploiting Citrus aurantium seeds and their secondary metabolites in the management of Alzheimer disease
Publication date: Available online 5 June 2020Source: Toxicology ReportsAuthor(s): Doha H. Abou Baker, Bassant M.M. Ibrahim, Nabila S. Hassan, A.F Yousuf, Souad El Gengaihi (Source: Toxicology Reports)
Source: Toxicology Reports - June 5, 2020 Category: Toxicology Source Type: research

Analysis of bitter orange dietary supplements for natural and synthetic phenethylamines by LC ‐MS/MS
In this study, an LC ‐MS/MS method was established to quantify five natural amines (synephrine, octopamine, hordenine, tyramine andN‐methyltyramine) and four synthetic amines (phenylephrine, methylsynephrine, etilefrine and isopropyloctopamine) in dietary supplements sold in the US. The method was validated and found to have acceptable performance to accurately measure analytes in complex botanical products. The average recove ries from a blank matrix were between 88 – 125% with an RSD of 0.5 – 7.0%. Fifty‐nine products labeled to contain bitter orange peel, extract, or its amines were purchased and their...
Source: Drug Testing and Analysis - June 3, 2020 Category: Drugs & Pharmacology Authors: R.S. Pawar, S. Sagi, D. Leontyev Tags: RESEARCH ARTICLE Source Type: research

Rapid identification of chemical composition and metabolites of Pingxiao Capsule in vivo using molecular networking and untargeted data-dependent tandem mass spectrometry.
In this study, a ultra-high performance liquid chromatography (UHPLC) system equipped with high resolution Q-Orbitrap mass spectrometry (MS), and comparative global natural product social (GNPS) molecular networking together with the Compound Discoverer (CD) software were used to identify metabolites of PXC in vitro and in vivo. Based on untargeted data-dependent MS2 and data-mining techniques, 89 peaks of alkaloids, flavonoids, organic acid, and phenolic compounds were identified in the PXC 70% methanol extract. Furthermore, 15 absorbed prototype compounds and their metabolites were rapidly confirmed in rat blood. Glucuro...
Source: Biomedical Chromatography : BMC - May 11, 2020 Category: Biomedical Science Authors: Wang D, Fu Z, Xing Y, Tan Y, Han L, Yu H, Wang T Tags: Biomed Chromatogr Source Type: research

The Effects of Low-Dose and High-Dose Decoctions of Fructus aurantii in a Rat Model of Functional Dyspepsia.
CONCLUSIONS In the rat model of FD, low-dose Fructus aurantii with stir-fried wheat bran increased gastrointestinal motility and gastrointestinal hormone levels. PMID: 32248203 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Molecules, Vol. 25, Pages 1485: Protein Extraction, Enrichment and MALDI MS and MS/MS Analysis from Bitter Orange Leaves (Citrus aurantium)
Anna Napoli Citrus aurantium is a widespread tree in the Mediterranean area, and it is mainly used as rootstock for other citrus. In the present study, a vacuum infiltration centrifugation procedure, followed by solid phase extraction matrix-assisted laser desorption ionization tandem mass spectrometry (SPE MALDI MS/MS) analysis, was adopted to isolate proteins from leaves. The results of mass spectrometry (MS) profiling, combined with the top-down proteomics approach, allowed the identification of 78 proteins. The bioinformatic databases TargetP, SignalP, ChloroP, WallProtDB, and mGOASVM-Loc were used to predict the s...
Source: Molecules - March 24, 2020 Category: Chemistry Authors: Donatella Aiello Carlo Siciliano Fabio Mazzotti Leonardo Di Donna Roberta Risoluti Anna Napoli Tags: Article Source Type: research

Chemical profile and antioxidant potency of Citrus aurantium L. flower extracts with antibacterial effect against foodborne pathogens in rice pudding
Publication date: Available online 16 March 2020Source: LWTAuthor(s): Huseyin Degirmenci, Hatice Erkurt (Source: LWT Food Science and Technology)
Source: LWT Food Science and Technology - March 17, 2020 Category: Food Science Source Type: research

Citrus aurantium L. polymethoxyflavones promote thermogenesis of brown and white adipose tissue in high-fat diet induced C57BL/6J mice
This study demonstrated that citrus PMFs could prevent obesity by activating thermogenesis of BAT and iWAT. PMFs may use as a novel dietary supplemental approach for obesity.Graphical abstract (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - February 24, 2020 Category: Nutrition Source Type: research

Inducing mutations in Citrus spp.: Sensitivity of different sources of plant material to gamma radiation.
In this study in vitro and ex vitro mutagenesis was induced by gamma radiation in several citrus species ('Alemow' and sour orange as citrus rootstocks, lemon cv. 'Fino 49' and 'Verna 51', mandarin cv. 'Nova' and lime cv. 'Bearss'). Three different sources of materials - seeds, budwoods and nodal segments - from in vitro explants, were tested. Seeds and budwoods were germinated or induced to sprout, and de novo regeneration was obtained from in vitro nodal segments from which preexisting buds were previously removed. Budwoods were tested in summer and winter in order to assess their capacity for mutation and further sprout...
Source: Applied Radiation and Isotopes - February 19, 2020 Category: Radiology Authors: Pérez-Jiménez M, Tallón CI, Pérez-Tornero O Tags: Appl Radiat Isot Source Type: research

Selective pressurized extraction as single-step extraction and clean-up for the determination of organophosphate ester flame retardant in Citrus aurantium leaves by gas chromatography-tandem mass spectrometry.
nso E Abstract In this work, an analytical method has been developed and validated for the determination of organophosphate esters (OPEs) in urban ornamental tree leaves. OPEs are flame retardants and plasticizers which are classified as health and environmental hazards substances. Their presence in urban air has been previously described. The method proposed in this work would allow the use of urban tree leaves as simple, cheap, and widely distributed in urban areas alternative to the existing active and passive sampler for sample collection. The method was based on sample treatment by selective pressurized liqui...
Source: Analytical and Bioanalytical Chemistry - February 17, 2020 Category: Chemistry Authors: Santos JL, Malvar JL, Abril C, Martín J, Aparicio I, Alonso E Tags: Anal Bioanal Chem Source Type: research

Citrus aurantium L.: Cultivar impact on sensory profile
Publication date: Available online 11 February 2020Source: International Journal of Gastronomy and Food ScienceAuthor(s): Diana De Santis, Maria Teresa FrangipaneAbstractThe purpose of this study was to identify the sensory attributes for the evaluation of bitter orange (Citrus aurantium L.) sensory profile, in three different cultivars (Canaliculata, C1; Crispifolia, C2; Salicifolia C3), so that it was possible to highlight their sensory characteristics, through the application of the official procedure. Our results revealed that the odor of C1 was mainly characterized by the citrus flavor, while the aroma of C3 was gover...
Source: International Journal of Gastronomy and Food Science - February 12, 2020 Category: Food Science Source Type: research

Naturally Occurring TPE-CA Maintains Gut Microbiota and Bile Acids Homeostasis via FXR Signaling Modulation of the Liver –Gut Axis
Antibiotics-induced changes in intestinal flora (dysbiosis) may have various effects on the host. Dysbiosis is associated with numerous metabolites including bile acids, which are produced in the liver from cholesterol and metabolized in the gut by intestinal microbiota. Total phenolic extracts of Citrus aurantium L. (TPE-CA) are rich in dietary flavanones and their glycosyl derivatives, including flavones, flavonols, polymethoxyflavones and coumarins, which exert positive health effects on the microbiota. The aim of this study is to elucidate the interplays between the intestinal microbiota and bile acids metabolism attri...
Source: Frontiers in Pharmacology - February 5, 2020 Category: Drugs & Pharmacology Source Type: research

Identification and quantification of limonoid aglycones content of Citrus seeds
ABSTRACT Citrus fruits are recognized as an important source of bioactive molecules such as limonin and nomilin. However, these molecules exhibit low bioavailability, therefore, obtaining these molecules using biotechnological techniques may be an alternative to harvesting them directly from fruits. The aim of this study was to quantify and identify limonoids in the dichloromethane extracts of Citrus seeds of Criolla orange, Oneco tangerine, Tangerine-lemon, Sour orange and Valencia orange from department of Antioquia-Colombia by high performance liquid chromatography with diode array detection, and high-resolution mass sp...
Source: Revista Brasileira de Farmacognosia - February 3, 2020 Category: Drugs & Pharmacology Source Type: research

Metabolites from the citrus extracts inhibit the activity of selected proteins in Indian Cobra (Naja naja) venom
ConclusionThe present study provides new molecular insight and scientific evidence on the utility of the methanolic extracts of citrus peels to neutralize the venom toxins of Naja naja.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - January 15, 2020 Category: Drugs & Pharmacology Source Type: research

Molecules, Vol. 25, Pages 357: Systematic Detection and Identification of Bioactive Ingredients from Citrus aurantium L. var. amara Using HPLC-Q-TOF-MS Combined with a Screening Method
Qing Zeng Bitter orange, Citrus aurantium L. var. amara (CAVA), is an important crop and its flowers and fruits are widely used in China as a food spice, as well as in traditional Chinese medicine, due to its health-promoting properties. The secondary metabolites that are present in plant-derived foods or medicines are, in part, responsible for the health benefits and desirable flavor profiles. Nevertheless, detailed information about the bioactive ingredients in CAVA is scarce. Therefore, this study was aimed at exploring the phytochemicals of CAVA by high performance liquid chromatography/quadrupole time-of-flig...
Source: Molecules - January 14, 2020 Category: Chemistry Authors: Yu Chen Liu Huang He Qing Zeng Tags: Article Source Type: research

The effects of Citrus aurantium aroma on anxiety and fatigue in patients with Acute Myocardial Infarction: A Two-center, randomized, controlled trial
Publication date: Available online 23 December 2019Source: Journal of Herbal MedicineAuthor(s): Razieh Shirzadegan, Mohammad Gholami, Shirin Hasanvand, Afsaneh BeiranvandAbstractObjectivesAnxiety and fatigue affect the clinical course and quality of life in patients with Acute Myocardial Infarction (AMI). Complementary therapies are recommended for managing these symptoms. The present study was conducted to evaluate the effects of Citrus aurantium aroma on anxiety and fatigue in patients with AMI admitted to coronary care units.DesignIn this triple-blind, randomized, controlled, clinical trial, 80 patients with AMI were al...
Source: Journal of Herbal Medicine - December 25, 2019 Category: Complementary Medicine Source Type: research

Molecules, Vol. 24, Pages 4254: The Effects of Different Varieties of Aurantii Fructus Immaturus on the Potential Toxicity of Zhi-Zi-Hou-Po Decoction Based on Spectrum-Toxicity Correlation Analysis
This study provides a reference for the clinical, safe use of ZZHPD, and also provides a new perspective for the study of the potential toxic substances of traditional Chinese medicine compound preparations. (Source: Molecules)
Source: Molecules - November 21, 2019 Category: Chemistry Authors: Qianqian Zhang Fang Feng Tags: Article Source Type: research