Toward a standardised protocol for the stable isotope analysis of scleractinian corals.
CONCLUSIONS: For going toward a standardised protocol in coral research, we recommend using an available drying method (as they are equally acceptable) for the stable isotope analysis of scleractinian corals, examining the need for lipid extraction on a case-by-case basis, performing a direct acidification of Symbiodiniaceae and animal tissues, and avoiding washing animal tissue with distilled water. PMID: 31802564 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - December 5, 2019 Category: Chemistry Authors: Sturaro N, Hsieh YE, Chen Q, Wang PL, Denis V Tags: Rapid Commun Mass Spectrom Source Type: research

Thermal Desorption and Pyrolysis Direct Analysis in Real Time Mass Spectrometry for Qualitative Characterization of Polymers and Polymer Additives.
CONCLUSIONS: In comparison with direct analysis by positioning sample directly in the heated DART gas stream, thermal desorption and pyrolysis DART (TDPy DART) provides a more versatile sampling method and provides thermal separation and profiling of polymer additives, intact short polymer chains and pyrolysis fragments. PMID: 31797453 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - December 4, 2019 Category: Chemistry Authors: Cody RB, Fouquet TNJ, Takei C Tags: Rapid Commun Mass Spectrom Source Type: research

Ultra-high Performance Supercritical Fluid Chromatography Combined with Quadrupole Time-of-Flight Mass Spectrometry for the Characterization of Pentaerythritol Fatty Acid Esters.
CONCLUSIONS: A UHPSFC/QTof-MS method was successfully employed for the separation of pentaerythritol fatty acid esters. Exact masses and product ion information were given by high resolution mass spectrometry. The composition of the fatty acids was effectively deduced by characteristic ions and their relative abundances. This method is an effective means for the quality control and process optimization of this type of product, serving as a positive reference for further study on pentaerythritol fatty acid esters. PMID: 31800119 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - December 4, 2019 Category: Chemistry Authors: Tang Y, Pan J, Sun T, Hu Y, Du Z Tags: Rapid Commun Mass Spectrom Source Type: research

The measurement of KRAS G12 mutants using multiplexed SRM and Ion Mobility Mass Spectrometry.
This study advocates that LC/SRM and IM-MS could both be used to identify single amino acid substitutions in KRAS as an alternative to commonly used methods such as circulating tumour DNA (ctDNA) analysis. PMID: 31800120 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - December 4, 2019 Category: Chemistry Authors: Norman RL, Singh R, Langridge JI, Ng L, Jones DJL Tags: Rapid Commun Mass Spectrom Source Type: research

Differential adsorption of analyte and deuterated analogue onto the rotor seal of the injector in high-performance liquid chromatography/electrospray ionisation mass spectrometry.
CONCLUSIONS: This study has demonstrated the problem of differential adsorption onto HPLC Vespel rotor seals, and that the use of a stable isotope analogue as internal standard does not guarantee the constancy of the analyte/internal response ratio in quantitative methods. The partial solution was to work at much higher concentration where adsorption, whilst still apparent, was relatively insignificant. PMID: 31800127 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - December 4, 2019 Category: Chemistry Authors: Lord GA Tags: Rapid Commun Mass Spectrom Source Type: research

Optimization of ion trajectories in a dynamically harmonized Fourier-Transform Ion Cyclotron Resonance cell using a Design of Experiments strategy.
CONCLUSIONS: This computational procedure based on an experimental design can be applied for any other mass spectrometric parameter optimization problem. This strategy will lead more transparent and data-driven method development. PMID: 31800128 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - December 4, 2019 Category: Chemistry Authors: Maillard J, Ferey J, Rüger CP, Schmitz-Afonso I, Bekri S, Gautier T, Carrasco N, Afonso C, Tebani A Tags: Rapid Commun Mass Spectrom Source Type: research

Simple and sensitive method for analysis of 14 anti-tuberculosis drugs using LC/MS/MS in human plasma.
CONCLUSIONS: The method applied the sensitive and reproducible determination of 14 frequently-used anti-TB drugs, which already showed benefit for some TB patients. PMID: 31800129 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - December 4, 2019 Category: Chemistry Authors: Lei Q, Zhao Y, Wang H, Zhou J, Lv X, Dang L, Zhu C Tags: Rapid Commun Mass Spectrom Source Type: research

Demonstration of a memory calibration method in water isotope measurement by laser spectroscopy.
CONCLUSIONS: By measuring the memory coefficients and establishing the calibration equations, a highly effective method was developed for determining the δ18 O and δ2 H values of water, which could significantly improve sample throughput for liquid water dual isotope measurement without sacrificing the precision. PMID: 31802558 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - December 4, 2019 Category: Chemistry Authors: Qu D, Tian L, Zhao H, Yao P, Xu B, Cui J Tags: Rapid Commun Mass Spectrom Source Type: research

Effect of Reducing Sample Volume on the Detection of Drugs in Urine by Transmission Mode Direct Analysis in Real Time - Mass Spectrometry.
CONCLUSIONS: Reducing the sample volume to sub-microliter levels improved the detection of drugs-of-abuse present as either individual or multiple components of the untreated urine. The improved signal demonstrates the potential for using sub-microliter volumes for screening drugs in urine without the need for chromatography or sample pre-treatment. PMID: 31794630 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - December 3, 2019 Category: Chemistry Authors: Liang P, Li F, Laramee B, Musselman B Tags: Rapid Commun Mass Spectrom Source Type: research

In vitro metabolism of sunscreen compounds by liquid chromatography-high resolution tandem mass spectrometry.
CONCLUSIONS: The results of this study will help better understand the metabolism and detoxification pathways of these xenobiotics. PMID: 31782973 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 29, 2019 Category: Chemistry Authors: Guesmi A, Ohlund L, Sleno L Tags: Rapid Commun Mass Spectrom Source Type: research

Molecular networking-based dereplication of strictosidine-derived monoterpene indole alkaloids from the curare ingredient Strychnos peckii.
CONCLUSIONS: The use of MN combined with the analysis of the fragmentation patterns showed to be a useful strategy for the dereplication of strictosidine-derived MIAs from S. peckii, highlighting known and unprecedented structures, as well as useful diagnostic product ions. Therefore, this workflow is an effective approach for the characterization of strictosidine-type alkaloids in future dereplication works. PMID: 31783430 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 29, 2019 Category: Chemistry Authors: Santos CLG, Angolini CFF, Neves KOG, Costa EV, de Souza ADL, Pinheiro MLB, Koolen HHF, da Silva FMA Tags: Rapid Commun Mass Spectrom Source Type: research

Decomposition of Electron Ionization Mass Spectra for Space Application using a Monte-Carlo approach.
CONCLUSIONS: By removing the solution degeneracy in the decomposition of mass spectra, the method described herein could significantly increase the scientific retrieval from archived space flight mass spectrometry data, where calibration of the ionization source is no longer an option. PMID: 31783433 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 29, 2019 Category: Chemistry Authors: Gautier T, Serigano J, Bourgalais J, Hörst SM, Trainer MG Tags: Rapid Commun Mass Spectrom Source Type: research

Interlaboratory Test for Stable Carbon Isotope Analysis of Dissolved Inorganic Carbon (DIC) in Geothermal Fluids.
CONCLUSIONS: The δ13 C values of solid Na2 CO3 and its solution and lake water (i.e. DIC concentration samples>100 mg/L carbon) are consistent among all the participating laboratories. The dispersion in the δ13 C values of solid CaCO3 is associated with its lower chemical affinity than that of Na2 CO3 . The poor reproducibility in the δ13 C values of geothermal fluids, collected at three points of a geothermal well, despite overall consistent trends regarding their collection points suggests inadequate sample handling (atmospheric CO2 exchange) and/or inappropriate analytical approaches (incomplete H3 ...
Source: Rapid Communications in Mass Spectrometry : RCM - November 29, 2019 Category: Chemistry Authors: Verma MP, van Geldern R, Carvalho MC, Grassa F, Delgado-Huertas A, Monvoisin G, Carrizo D Tags: Rapid Commun Mass Spectrom Source Type: research

An Ideal Solution? Optimising Pretreatment Methods for Artificially Mummified Ancient Egyptian Tissues.
CONCLUSIONS: The choice of tissue and the preparation methods used can have a significant effect on the accuracy of stable isotope data obtained from mummified tissue, particularly when embalming materials are also present. A mixture of solvents appears to be a more effective cleaning agent than a single solvent. Demineralisation with HCl is preferable for well-preserved bone as used in this study, but whether this is the case for more fragile, less well-preserved bone requires further study. Skin samples produce more consistent data than muscle, but visually distinguishing between these tissues is not simple on ancient mu...
Source: Rapid Communications in Mass Spectrometry : RCM - November 29, 2019 Category: Chemistry Authors: Cockitt J, Lamb A, Metcalfe R Tags: Rapid Commun Mass Spectrom Source Type: research

Identification and distinction of acrolein-deoxyguanosine adduct isomers by HPLC-DTIMS-QTOF MS combined with in-source CID.
PMID: 31778227 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 28, 2019 Category: Chemistry Authors: Wu C, Zhang F, Guo Y Tags: Rapid Commun Mass Spectrom Source Type: research

Towards a generic method for ion chromatography-mass spectrometry of low molecular weight amines in pharmaceutical drug discovery and development.
CONCLUSIONS: This study demonstrates the value of IC-MS for analysing low molecular weight amines. Good chromatographic separation of mixtures was possible without derivatisation. Ionisation efficiency was greatest using a make-up flow of 0.05 % acetic acid in ethanol, and optimisation of ESI source conditions promoted protonated molecule generation for easy determination of molecular weight. PMID: 31778589 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 28, 2019 Category: Chemistry Authors: Lewis Z, Jackson BA, Crampton A, Ray AD, Holman SW Tags: Rapid Commun Mass Spectrom Source Type: research

Feasibility of microwave-induced combustion combined with inductively coupled plasma mass spectrometry for bromine and iodine determination in human nail.
CONCLUSIONS: The proposed analytical method presents important characteristics for routine analysis. It allows ultra-trace determination even using low sample masses because of the low blank values, reduced reagents volume, and powerful detectability using ICP-MS. PMID: 31770460 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 26, 2019 Category: Chemistry Authors: La Rosa Novo D, Schneider Henn A, Flores EMM, Mesko MF Tags: Rapid Commun Mass Spectrom Source Type: research

Evaluation of the combination of different atmospheric pressure ionization sources for the analysis of extremely complex mixtures.
CONCLUSIONS: Combining different ionization methods can be used as an alternative in order to gain more information about compounds present in a complex mixture although a combination of different ion sources could enhance suppression effects. PMID: 31773793 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 26, 2019 Category: Chemistry Authors: Kondyli A, Schrader W Tags: Rapid Commun Mass Spectrom Source Type: research

Stable isotope relationships between apatite phosphate ( δ18 O), structural carbonate (δ18 O, δ13 C) and collagen (δ2 H, δ13 C, δ15 N, δ34 S) in modern human dentine.
CONCLUSION: The direct stable isotope relationships between oxygen in the apatite phosphate or carbonate and the hydrogen in the collagen fraction are explained by the fact that they were formed from ingested water with similar oxygen or hydrogen isotope signals. The highly significant correlation of δ18 Ophos , δ18 Ocarb and δ2 Hcoll values in the modern human dentine implies that measurement of δ2 H values in collagen or δ18 O values in bioapatite will provide reliable information about the climate at the person's whereabouts. PMID: 31769096 [PubMed - as supplied by publisher] (Source: ...
Source: Rapid Communications in Mass Spectrometry : RCM - November 25, 2019 Category: Chemistry Authors: Lehn C, Rossmann A, Mayr C Tags: Rapid Commun Mass Spectrom Source Type: research

MALDI ionization behavior of neat linear and cyclic poly(L-lactide)s and their blends.
CONCLUSIONS: An overestimation of cyclic species in MALDI TOF mass spectra of poly(L-lactide)s must be considered, but the commonly assumed peak suppression of linear polymers in mixtures of both architectures can be excluded. PMID: 31760663 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 23, 2019 Category: Chemistry Authors: Weidner SM, Kricheldorf HR Tags: Rapid Commun Mass Spectrom Source Type: research

Monitoring recombinant protein expression in bacteria by rapid evaporative ionisation mass spectrometry.
CONCLUSION: REIMS has considerable potential as a near-instantaneous monitoring tool for protein production in a biotechnology environment. PMID: 31760669 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 23, 2019 Category: Chemistry Authors: Sarsby J, McLean L, Harman VM, Beynon RJ Tags: Rapid Commun Mass Spectrom Source Type: research

Improved three filaments TIMS ion source for isotope ratios determination of two samples.
CONCLUSION: The small change of the ionizer filament configuration significantly improves the functionality of the ion source. The proposed modification enables us to perform alternating isotope analyses under the same working conditions of two different samples (e.g. studied sample and standard). PMID: 31760670 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 23, 2019 Category: Chemistry Authors: Pacek A, Pieńkos T, Czarnacki M, Hałas S, Pelc A Tags: Rapid Commun Mass Spectrom Source Type: research

Laser spectroscopy steered 13 C-labelling of plant material in a walk-in growth chamber.
CONCLUSIONS: Laser spectroscopy controlled 13 C labelling of plants in a walk-in growth chamber successfully kept the isotopic ratio of the CO2 in the chamber air constant. Therefore, large quantities of material were labelled homogeneously at the inter- and intra-plant level, thus establishing a method to provide high quality input for quantitative isotopic tracer studies. PMID: 31758611 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 23, 2019 Category: Chemistry Authors: Slaets JIF, Resch C, Mayr L, Weltin G, Heiling M, Gruber R, Dercon G Tags: Rapid Commun Mass Spectrom Source Type: research

Analytical effects on clumped isotope thermometry: Comparison of a common sample set analyzed using multiple instruments, types of standards, and standardization windows.
CONCLUSIONS: Our results show that background effects are the largest factor potentially affecting Δ47 results, and there may be an improvement in interlaboratory precision by using carbonate standards. Critically, all techniques utilized for standardizing Δ47 results converge on a common slope as long as background effects are properly corrected. The use of carbonate standards is recommended as a component of standardization procedures. PMID: 31756007 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 22, 2019 Category: Chemistry Authors: Defliese WF, Tripati A Tags: Rapid Commun Mass Spectrom Source Type: research

Increasing Clinical LC-MS/MS Assay Throughput Using a Full Calibration Curve Generated by One Injection from a Single-Tube Calibrator.
CONCLUSION: The results show that LC-MS/MS throughput can be increased by using a single-tube calibrator because it reduces assay calibration time while delivering equivalent results to those generated using traditional, multiple-tube calibrators. The single-tube calibrator may also offer cost savings to laboratories through reductions in consumable consumption, technician labor time, and inventory management, as well as to manufacturers because fewer vials would need to be manufactured, tested, stored, and shipped. PMID: 31756771 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 22, 2019 Category: Chemistry Authors: Cournoyer JJ, Dey S Tags: Rapid Commun Mass Spectrom Source Type: research

Analysing Sr isotopes in low Sr samples such as single insects with ICP-MS/MS using N2 O as a reaction gas for in-line Rb separation.
CONCLUSIONS: A minimum of 5 mg of insect tissue is required for Sr isotope analysis. This new ICP-MS/MS method enables Sr isotope analysis in single insects, allowing population-scale studies to be feasible and applications with time-critical uses such as biosecurity possible. PMID: 31756774 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 22, 2019 Category: Chemistry Authors: Murphy DT, Allen CM, Ghidan O, Dickson A, Hu WP, Briggs E, Holder PW, Armstrong KF Tags: Rapid Commun Mass Spectrom Source Type: research

A new method of UPLC-MS/MS for determination of chlorogenic acid in human plasma and urine.
CONCLUSIONS: These results showed that the novel UPLC method was robust and sensitive, and fulfilled the requirements for a clinical pharmacokinetic study of CA in patients with advanced cancer. PMID: 31756778 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 22, 2019 Category: Chemistry Authors: Han X, Li N, Liu S, Yang S, Song Y, Shi Y Tags: Rapid Commun Mass Spectrom Source Type: research

Volatile compounds released by Nalophan; implications to SIFT-MS and other chemical ionisation mass spectrometry analytical methods.
CONCLUSIONS: Using H3 O+ reagent ions for SIFT-MS and SESI-MS analyses, the following analyte ions (m/z values) are affected by the Nalophan impurities: 45, 63, 81, 89, 99, which can compromise analyses of acetaldehyde, ethylene glycol, monoterpenes, acetoin, butyric acid, hexanal and heptane. PMID: 31756780 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 22, 2019 Category: Chemistry Authors: Brůhová Michalčíková R, Dryahina K, Smith D, Španěl P Tags: Rapid Commun Mass Spectrom Source Type: research

Validation and Extension of the Gas-Phase Superacidity Scale.
CONCLUSIONS: The introduced methodological innovations were found to be adequate and strong evidence is presented in support of the current GA values of the strong acids. PMID: 31756781 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 22, 2019 Category: Chemistry Authors: Leesment A, Kaljurand I, Trummal A, Kütt A, Netscher T, Bonrath W, Leito I Tags: Rapid Commun Mass Spectrom Source Type: research

Study on properties of wooden capillary electrospray ionization mass spectrometry.
CONCLUSIONS: The signal intensity produced by WC-ESI-MS is significantly higher than that of MC-ESI-MS, and the polymerization and electrolysis are reduced, thus the spectra become simpler. In addition, it is also tolerant to high flow rates and high aqueous phase samples. PMID: 31756782 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 22, 2019 Category: Chemistry Authors: Lin J, Yan J, Xu Q, Wang X Tags: Rapid Commun Mass Spectrom Source Type: research

Analyzing the solid soot particulates formed in a fuel-rich flame by solvent-free MALDI FT ICR mass spectrometry.
Abstract RATIONALE: The compositional and structural information of the soot particles is essential for a better understanding of the chemistry and mechanism during the combustion. The aim of the present study was to develop a method to analyze such soot particulate samples with high complexity and poor solubility. METHODS: The solvent-free sample preparation MALDI technique was combined with the ultrahigh resolution FT ICR mass spectrometry for the characterization of solid soot particulates. Moreover, a modified iso-abundance plot (Carbon Number vs. Hydrogen Number vs. Abundance) was introduced to visualize...
Source: Rapid Communications in Mass Spectrometry : RCM - November 22, 2019 Category: Chemistry Authors: Zhang W, Shao C, Sarathy SM Tags: Rapid Commun Mass Spectrom Source Type: research

Precise Determination of the Molybdenum Isotopic Composition of Urine by MC-ICP-MS.
CONCLUSIONS: The employed methodology is suitable for rapid, low-blank and high-throughput Mo isotope analysis of urine samples. Although resolvable δ98/95 Mo variability is seen in this preliminary dataset, the mechanism driving this variability is unknown. High-precision Mo isotopic analysis might be added to the urinalysis tool-kit, with the potential to provide valuable clinical information in the future. PMID: 31733129 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 16, 2019 Category: Chemistry Authors: Zhang J, Li J, Zhang L, Wang ZB, Sun SL, Luo ZY Tags: Rapid Commun Mass Spectrom Source Type: research

Charge migration fragmentation in the negative ion mode of cyclopentenone and cyclopentanone intermediates in the biosynthesis of jasmonates.
CONCLUSIONS: CID of 12-OPDA and 12-OPEA generates cyclopentanone enolate anions at m/z 165 by charge-driven hydride transfer as a common mechanism and by bond cleavage between C-7 and C-8 of the carboxyl side chains with either gain or loss of a hydrogen atom. PMID: 31734961 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 16, 2019 Category: Chemistry Authors: Oliw EH, Hamberg M Tags: Rapid Commun Mass Spectrom Source Type: research

Limitations of Ion Mobility Spectrometry-Mass Spectrometry for the relative quantification of architectural isomeric polymers: a case study.
CONCLUSIONS: These results are explained by an ionization efficiency issue. This work underlines some intrinsic limitations when using IMS in the context of the relative quantification of isomers having different ionization efficiency. Nevertheless, the linear-to-cyclic ratio can be roughly estimated by this method. PMID: 31732989 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 15, 2019 Category: Chemistry Authors: Lienard R, Duez Q, Grayson SM, Gerbaux P, Coulembier O, De Winter J Tags: Rapid Commun Mass Spectrom Source Type: research

Identification of the metabolites of erianin in rat and human by liquid chromatography electrospray ionization tandem mass spectrometry.
Conclusions The present study provides an overview pertaining to the in vitro and in vivo metabolic profiles of erianin, which is indispensable for us to understand the efficacy and safety of erianin, as well as the herb medicine D. chrysotoxum. PMID: 31732995 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 15, 2019 Category: Chemistry Authors: Liu N, Wang X, Liu H, Zhang C Tags: Rapid Commun Mass Spectrom Source Type: research

Mass Spectrometry and Ion Mobility Study of Poly (ethylene glycol)-based Polyurethane Oligomers.
Conclusion Mono-disperse PEG-PUR oligomers were synthesized and analyzed. Although the polymeric oligomers analyzed in this study are quite small and structurally simple, this work serves as a model system for the synthesis and structural characterization of larger, more complex block copolymers. PMID: 31731326 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 15, 2019 Category: Chemistry Authors: Harris RA, Picache JA, Tomlinson ID, Zlibut E, Ellis BM, May JC, McLean JA, Hercules DM Tags: Rapid Commun Mass Spectrom Source Type: research

Direct analysis bromine and iodine of dried serum spots by laser ablation-Inductively coupled plasma mass spectrometry.
CONCLUSIONS: A novel and simple approach for high-throughput screening of bromine and iodine in DSS screening analysis has been established by LA-ICP-MS. Calibration could achieved using aqueous standard solution instead of matrix matching solution. The method allowed analysis of low-volume biological samples without decomposition preparation and decreased the risk of contamination or loss. PMID: 31729085 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 14, 2019 Category: Chemistry Authors: He J, Li AF, Han HY, Su S, Zhang P, Zhang EP Tags: Rapid Commun Mass Spectrom Source Type: research

Effect of Berberine on In Vitro Metabolism of Sulfonylureas: A herb-drug interactions study.
CONCLUSIONS: The metabolism of sulfonylureas and berberine was affected when these compounds were co-incubated with each other. This may be attributable to competitive binding of the herb and drug to the catalytic sites of same isozymes. PMID: 31721320 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 12, 2019 Category: Chemistry Authors: Singh A, Zhao K, Bell C, Shah AJ Tags: Rapid Commun Mass Spectrom Source Type: research

Automatic Peak Assignment and Visualisation of Copolymer Mass Spectrometry Data Using the "Genetic Algorithm".
Automatic Peak Assignment and Visualisation of Copolymer Mass Spectrometry Data Using the "Genetic Algorithm". Rapid Commun Mass Spectrom. 2019 Nov 12;: Authors: Town JS, Gao Y, Hancox E, Liarou E, Shegiwal A, Atkins CJ, Haddleton D Abstract Copolymer analysis is vitally important as the materials have a wide variety of applications due to their tunable properties. Mass spectrometry data for copolymer samples can be very complex due to the increase in the number of species when the polymer chains are formed by 2 or more monomeric units. In this paper, we describe the use of the genetic algor...
Source: Rapid Communications in Mass Spectrometry : RCM - November 12, 2019 Category: Chemistry Authors: Town JS, Gao Y, Hancox E, Liarou E, Shegiwal A, Atkins CJ, Haddleton D Tags: Rapid Commun Mass Spectrom Source Type: research

A mass spectrometry imaging method for visualizing synthetic polymers by using average molecular weight and dispersity as indices.
CONCLUSIONS: The visualization of Mn , Mw and Đ will help provide an overview of the spatial distribution of polymer series combined with ion intensity distribution made by conventional methods. It can be also applied to other mass spectrometric imaging method such as DESI or TOF-SIMS. PMID: 31721332 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 12, 2019 Category: Chemistry Authors: Satoh T, Nakamura S, Fouquet T, Sato H, Ueda Y Tags: Rapid Commun Mass Spectrom Source Type: research

Metabolomics of soybean green stem and foliar retention (GSFR) disease using Mass Spectrometry and Molecular Networking.
CONCLUSIONS: Liquid chromatography, mass spectrometry and Molecular Networking approaches proved to be a powerful tool for the metabolomic study of GSFR. This study showed metabolomics differences of protective substances in the roots, evidencing a quick response of the plant to the attack of A. besseyi. PMID: 31721333 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 12, 2019 Category: Chemistry Authors: Zanzarin DM, Hernandes CP, Leme LM, Silva E, Porto C, Martin do Prado R, Meyer MC, Favoreto L, Nunes EO, Pilau EJ Tags: Rapid Commun Mass Spectrom Source Type: research

Interactions of Indole Alkaloids with Myoglobin: A Mass Spectrometry-based Spectrometric and Computational Method.
CONCLUSIONS: A new mass spectrometry-based integrated analysis method has been developed to successfully study the interactions of Mb and IAs extracted from Ophiorrhiza japonica. The experimental and calculation results have good consistency, revealing all of the four IA molecules could bind to Mb to form 1:1, 1:2 and 1:3 Mb-IA complexes, respectively. The order of binding ability of these IAs to Mb was Ophiorrhine B> Compound C> Ophiorrhine A> Compound D. CD and HDX-MS results indicated that binding with IAs destabilizes resulted of Mb. HDX-MS analysis suggests that Mb becomes more accessible to HDX, indicating t...
Source: Rapid Communications in Mass Spectrometry : RCM - November 12, 2019 Category: Chemistry Authors: Li YW, Chi Q, Feng T, Xiao H, Li L, Wang X Tags: Rapid Commun Mass Spectrom Source Type: research

Z0 ion from saikosaponins with 16 α-OH and Y0 -H2 O from saikosaponins with 16 β-OH may underlie their different dissociation patterns of [aglycone-H2 O+H].
Z0 ion from saikosaponins with 16 α-OH and Y0 -H2 O from saikosaponins with 16 β-OH may underlie their different dissociation patterns of [aglycone-H2 O+H]. Rapid Commun Mass Spectrom. 2019 Nov 12;: Authors: Liu G, Zhang Z, Lv X, Zhan S, Ding B, Yang X, Zhu Q PMID: 31722115 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 12, 2019 Category: Chemistry Authors: Liu G, Zhang Z, Lv X, Zhan S, Ding B, Yang X, Zhu Q Tags: Rapid Commun Mass Spectrom Source Type: research

A novel caged Cookson-type reagent toward a practical vitamin D derivatization method for mass spectrometric analyses.
CONCLUSION: DAP-PA was stable enough for mid to long term storage in solution. This advantage shall contribute to the VD detection and quantification in clinical laboratories, and as such to the broader use of clinical mass spectrometry. PMID: 31715032 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 12, 2019 Category: Chemistry Authors: Seki M, Sato M, Takiwaki M, Takahashi K, Kikutani Y, Satoh M, Nomura F, Kuroda Y, Fukuzawa S Tags: Rapid Commun Mass Spectrom Source Type: research

MSPolyCalc: a web-based App for polymer mass spectrometry data interpretation. The case study of a pharmaceutical excipient.
CONCLUSIONS: MSPolyCalc offers assisted data interpretation to target the needs of polymer chemists. It facilitates structure characterization, ionization adducts identification, and end-group determination together with visual result reporting. PMID: 31715638 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 12, 2019 Category: Chemistry Authors: Desport JS, Frache G, Patiny L Tags: Rapid Commun Mass Spectrom Source Type: research

Elevated urinary cobalt concentrations identified in routine doping controls can originate from vitamin B12.
s M PMID: 31715649 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 12, 2019 Category: Chemistry Authors: Knoop A, Görgens C, Geyer H, Thevis M Tags: Rapid Commun Mass Spectrom Source Type: research

Retention Time Shift Analysis and Correction in Chemical Isotope Labeling LC/MS for Metabolome Analysis.
CONCLUSIONS: A RT-check method and program tailored to CIL LC/MS metabolome analysis have been developed for quick detection and correction of RT shifts during the course of running many metabolome samples. PMID: 31705568 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 8, 2019 Category: Chemistry Authors: Li Y, Li L Tags: Rapid Commun Mass Spectrom Source Type: research

Quantitative determination of human IgA subclasses and their Fc-glycosylation patterns in plasma by using peptide analogue internal standard and ultra-high-performance liquid chromatography-triple quadrupole mass spectrometry.
In this study, we developed and validated a method for absolute quantification of IgA subclasses and relative quantification of IgA-Fc glycopeptides by using affinity purification and UHPLC-MS/MS. Only micro-volumes of plasma were required from each sample and we also applied the method to discover IgA and IgA-glycopeptides profiles in patients with chronic kidney diseases and IgA nephropathy. METHODS: Peptide M affinity bead was used to purify IgA, and a cost effective peptide analog was added as internal standard. With an efficient on-bead digestion process, purified samples were analyzed by UHPLC-MS/MS with multipl...
Source: Rapid Communications in Mass Spectrometry : RCM - November 8, 2019 Category: Chemistry Authors: Chen HF, Shiao CY, Wu MY, Lin YC, Chen HH, Chang WC, Wu MS, Kao CC, Tsai IL Tags: Rapid Commun Mass Spectrom Source Type: research

Identification of two novel trace impurities in mobile phase prepared with commercial formic acid.
CONCLUSIONS: To the best of our knowledge, this is the first time that trihexylamine and N-methyldihexylamine have been reported in such systems. We hypothesize that these are derived from the formic acid manufacturing process and recommend that users monitor supplies pf formic acid for the presence of impurities. PMID: 31705588 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 8, 2019 Category: Chemistry Authors: Bakota EL, Levine RA Tags: Rapid Commun Mass Spectrom Source Type: research

Comparison of data-acquisition modes with Orbitrap high resolution mass spectrometry (HRMS) for targeted and non-targeted residue screening in aquacultured eel.
CONCLUSION: For residue screening, AIF has fast MS1 scan speed with adequate detection of product ions, but may lead to false positive findings. DIA methods are better suited to monitor for both targeted and non-targeted compounds because they generate more characteristic MS2 spectra for retrospective library searching. For follow-up targeted analysis, PRM is prefered over DDMS2 when searching for a limited set of compounds. PMID: 31702084 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 8, 2019 Category: Chemistry Authors: Wu IL, Turnipseed SB, Storey JM, Andersen WC, Madson M Tags: Rapid Commun Mass Spectrom Source Type: research