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The effects of modifiers on electrospray ionization for small-to-medium-sized molecules in comparison with solution-phase ionization
Rapid Commun Mass Spectrom. 2024 Jul 15;38(13):e9749. doi: 10.1002/rcm.9749.ABSTRACTModifiers are essential additives in electrospray ionization (ESI) mass spectrometric analysis to enhance the production of ionic species in the gas phase for the detection of small-to-medium-sized molecules in biological and aqueous samples. Therefore, an appropriate modifier, in conjunction with the right ionization polarity, is crucial for sensitive ESI mass spectrometric analysis. However, the charge carried by basic and acidic functional groups in solution is neither quantitatively nor qualitatively reflected in the MS spectrum. For ex...
Source: Rapid Communications in Mass Spectrometry : RCM - April 18, 2024 Category: Chemistry Authors: Pieter Venter Source Type: research

Installation protocol for charge transfer dissociation mass spectrometry on ion trapping mass spectrometers
CONCLUSIONS: Here, we provide a visual protocol to help others accomplish the instrument modification.PMID:38616287 | DOI:10.1002/rcm.9750 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - April 14, 2024 Category: Chemistry Authors: Zachary J Sasiene Glen P Jackson Source Type: research

Solvent-free sample preparation for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of polymer blends
CONCLUSIONS: The results clearly show that solvent-free sample preparation must be carefully considered when applied to synthetic polymer blends, as it may cause additional problems with regard to homogeneity and stability of the blends.PMID:38616296 | DOI:10.1002/rcm.9756 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - April 14, 2024 Category: Chemistry Authors: Mete Sungur Dalgic Steffen Weidner Source Type: research

Simulation study of digital waveform-driven quadrupole mass filter operated in higher stability regions for high-resolution inductively coupled plasma mass spectrometry
CONCLUSION: The results demonstrate that the use of a frequency-scanned, duty-cycle-modulated digital QMF as the mass analyzer for ICP-MS has the potential to produce high resolution while maintaining considerable transmission, thus overcoming most spectral interferences in elemental MS.PMID:38616299 | DOI:10.1002/rcm.9753 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - April 14, 2024 Category: Chemistry Authors: Rui Hu Alexander Gundlach-Graham Source Type: research

Development and validation of high-performance liquid chromatography-Orbitrap mass spectrometric method for quantification of NDMA in ranitidine drug products and evaluation of antioxidants as inhibitors of classical nitrosation reaction
CONCLUSIONS: This study compared the effectiveness of antioxidants as NDMA attenuators in ranitidine under storage conditions susceptible to NDMA generation. The study concluded that ascorbic acid and trolox are potent inhibitors of NDMA formation and nitrosation attenuators in ranitidine drug products.PMID:38600640 | DOI:10.1002/rcm.9747 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - April 11, 2024 Category: Chemistry Authors: Dande Aishwarya Pallaprolu Nikhil Subramanian Natesan Ravichandiran Velayutham Ramalingam Peraman Source Type: research

Imaging and quantification of neuropeptides in mouse pituitary tissue by atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry
CONCLUSION: Mouse pituitary neuropeptides have emerged as important signaling molecules due to their role in stress response. This work indicates the potential of modified AP-MALDI as a promising AP MSI method for in situ visualization and quantification of neuropeptides in complex biological tissues.PMID:38600731 | DOI:10.1002/rcm.9755 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - April 11, 2024 Category: Chemistry Authors: Qi Yang Chengyuan Liu Keke Qi Ying Xiong Yang Pan Changlin Tian Source Type: research

Characterization of the fragmentation mechanisms in electrospray ionization tandem mass spectrometry of chloroquinoline derivatives with larvicidal activity against Aedes aegypti
CONCLUSION: Our results provided a well-founded characterization of the fragmentation reactions of DCQ and its derivatives, which can be useful for complementary studies of the development of a larvicidal product against Ae. aegypti.PMID:38605205 | DOI:10.1002/rcm.9739 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - April 11, 2024 Category: Chemistry Authors: Rodrigo Moreira da Silva J éssica Guastalli Barbieri Valter Eduardo Murie Ma íra Rosato Silveira Silvério Rafael Augusto Soldi Lorena Carneiro Albernaz Laila Salmen Espindola Paulo C ézar Vieira Giuliano Cesar Clososki Ricardo Vessecchi Norberto Pepor Source Type: research

Simultaneous quantification of six proteins related to liver injury using nano liquid chromatography-tandem mass spectrometry
CONCLUSIONS: The proposed method provides a basis for establishing more specific diagnostic indicators of liver injury.PMID:38605420 | DOI:10.1002/rcm.9754 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - April 11, 2024 Category: Chemistry Authors: Siyu Cai Yuan Su Mengtian Shi Dandan Wang David Da Yong Chen Binjun Yan Source Type: research