Evaluation of anticancer effects of a pharmaceutically viable extract of a traditional polyherbal mixture against non-small-cell lung cancer cells
Publication date: Available online 20 February 2020Source: Journal of Integrative MedicineAuthor(s): Varuni Colamba Pathiranage, Ira Thabrew, Sameera R. Samarakoon, Kamani H. Tennekoon, Umapriyatharshini Rajagopalan, Meran K. EdiriweeraAbstractObjectiveThe present work tested organic solvents to prepare an extract with anticancer properties from a polyherbal mixture containing Nigella sativa (seeds), Hemidesmus indicus (roots) and Smilax glabra (rhizomes). We evaluate anticancer effects in non-small-cell lung cancer cells (NCI-H292), and discuss optimization for pharmaceutical use in the context of efficacy, yield and toxi...
Source: Journal of Integrative Medicine - February 21, 2020 Category: Complementary Medicine Source Type: research

Phenolic constituents and anticancer properties of Morus alba (white mulberry) leaves
Publication date: Available online 20 February 2020Source: Journal of Integrative MedicineAuthor(s): Eric Wei Chiang Chan, Siu Kuin Wong, Joseph Tangah, Tomomi Inoue, Hung Tuck ChanAbstractFlavonoids are by far the most dominant class of phenolic compounds isolated from Morus alba leaves (MAL). Other classes of compounds are benzofurans, phenolic acids, alkaloids, coumarins, chalcones and stilbenes. Major flavonoids are kuwanons, moracinflavans, moragrols and morkotins. Other major compounds include moracins (benzofurans), caffeoylquinic acids (phenolic acids) and morachalcones (chalcones). Research on the anticancer prope...
Source: Journal of Integrative Medicine - February 21, 2020 Category: Complementary Medicine Source Type: research

Traditional chinese medicine is a resource for drug discovery against 2019 novel coronavirus (SARS-CoV-2)
Publication date: Available online 19 February 2020Source: Journal of Integrative MedicineAuthor(s): Chang-quan Ling (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - February 21, 2020 Category: Complementary Medicine Source Type: research

In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus
ConclusionChinese herbal treatments classically used for treating viral respiratory infection might contain direct anti-2019-nCoV compounds. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - February 21, 2020 Category: Complementary Medicine Source Type: research

Analgesic and anti-inflammatory properties of hydroalcoholic extracts of Malva sylvestris, Carum carvi or Medicago sativa, and their combination in a rat model
Publication date: Available online 7 February 2020Source: Journal of Integrative MedicineAuthor(s): Masoud Seddighfar, Sayid Mahdi Mirghazanfari, Masoumeh DadpayAbstractObjectiveThe aim of this study was to evaluate the analgesic and anti-inflammatory effects of the hydroalcoholic extracts of Malva sylvestris flowers or Carum carvi and Medicago sativa seeds, alone and in combination, which have been used in traditional Iranian medicine.MethodsMale Wistar rats were divided into 6 treatment groups: distilled water, sodium salicylate (SS), M. sylvestris extract (600 mg/kg), C. carvi extract (600 mg/kg), M. sativa extract (300...
Source: Journal of Integrative Medicine - February 7, 2020 Category: Complementary Medicine Source Type: research

Caulerpa okamurae extract attenuates inflammatory interaction, regulates glucose metabolism and increases insulin sensitivity in 3T3-L1 adipocytes and RAW 264.7 macrophages
ConclusionTogether, these findings suggest that COE has potential to treat or prevent obesity-induced metabolic disorders. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - February 7, 2020 Category: Complementary Medicine Source Type: research

Traditional chinese medicine targeting cancer stem cells as an alternative treatment for hepatocellular carcinoma
Publication date: Available online 7 February 2020Source: Journal of Integrative MedicineAuthor(s): Kai-yue Tang, Shi-lin Du, Qian-lei Wang, Yi-fan Zhang, Hai-yan SongAbstractHepatocellular carcinoma (HCC) is a prevalent and highly malignant cancer throughout the world. Effective treatment of this disease is impeded by the high rate of metastasis, recurrence, and chemoresistance. Recent studies have revealed the close relationship between the malignant phenotype of HCC and cancer stem cells (CSCs). Therefore, CSC-targeted therapy is considered a promising strategy to eradicate HCC. Traditional Chinese medicine (TCM) can be...
Source: Journal of Integrative Medicine - February 7, 2020 Category: Complementary Medicine Source Type: research

Aamar-e-Advia (Shelf-lives) of drugs in Unani system of medicine: A conceptual review
Publication date: Available online 13 January 2020Source: Journal of Integrative MedicineAuthor(s): Ameena Yasmeen, Ghulamuddin Sofi, Kaleemullah KhanAbstractIn an era of globalization and increased global demand for herbal medicines, it is essential to ensure the quality and consistency of drugs. Changes in the quality of an herbal product over time should be detectable. The assessments of chemical quality and therapeutic efficacy of herbal drugs are necessary to establish their shelf-lives. Thus, stability testing is needed to establish standards for herbal products. Unani medicine has its own conceptual framework for st...
Source: Journal of Integrative Medicine - January 24, 2020 Category: Complementary Medicine Source Type: research

Acceptability of an adjunct equine-assisted activities and therapies program for veterans with posttraumatic stress disorder and/or traumatic brain injury
ConclusionThese data offer preliminary evidence that an adjunct EAAT program is acceptable for veterans with PTSD and/or TBI participating in an IOP. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - January 22, 2020 Category: Complementary Medicine Source Type: research

Controversial conclusions from two randomized controlled trials for acupuncture’s effects on polycystic ovary syndrome or in vitro fertilization support
Publication date: Available online 21 January 2020Source: Journal of Integrative MedicineAuthor(s): Sherman Gu, Arthur Yin FanAbstractTwo reports of trials investigating the potential effect of acupuncture in increasing live birth rate (LBR) in women with polycystic ovary syndrome (PCOS) or those undergoing in vitro fertilization (IVF) were published by Journal of American Medical Association in 2017 and 2018 respectively. The trial investigators did not recommend acupuncture for the women with PCOS or IVF based on their findings. This paper raises the concern that the findings that acupuncture did not increase LBR for wom...
Source: Journal of Integrative Medicine - January 22, 2020 Category: Complementary Medicine Source Type: research

Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats
ConclusionTaken together, our data suggest that acute cerebral ischemia induces neuronal ferroptosis and the effects of treating MCAO rats with NTE involved inhibition of ferroptosis through the TFR1/DMT1 and SCL7A11/GPX4 pathways. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - January 22, 2020 Category: Complementary Medicine Source Type: research

Women’s preconception health patterns in traditional Chinese medicine as a predictor of fertility outcomes
ConclusionThree unhealthy TCM patterns during the preconception period might be risk factors for low fecundity or poor pregnancy outcomes. The TCM preconception pattern identification may provide a convenient and effective way to screen for potential pregnancy risks beyond the NFPC. Further, appropriate interventions based on the TCM preconception health patterns are needed to improve quality in women’s fecundability and birth outcomes. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - January 22, 2020 Category: Complementary Medicine Source Type: research

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review
ConclusionBerberine could impede the development of dementia via multiple mechanisms: preventing brain damages and enhancing cognition directly in the brain, and indirectly through alleviating risk factors such as metabolic dysfunction, and cardiovascular, kidney and liver diseases. This study provided evidence to support the value of berberine in the prevention of dementia associated with MetS. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - January 18, 2020 Category: Complementary Medicine Source Type: research

Shelf-lives of drugs in Unani system of medicine: a conceptual review
Publication date: Available online 13 January 2020Source: Journal of Integrative MedicineAuthor(s): Ameena Yasmeen, Ghulamuddin Sofi, Kaleemullah KhanAbstractIn an era of globalization and increased global demand for herbal medicines, it is essential to ensure the quality and consistency of drugs. Changes in the quality of an herbal product over time should be detectable. The assessments of chemical quality and therapeutic efficacy of herbal drugs are necessary to establish their shelf-lives. Thus, stability testing is needed to establish standards for herbal products. Unani medicine has its own conceptual framework for st...
Source: Journal of Integrative Medicine - January 15, 2020 Category: Complementary Medicine Source Type: research

Editorial Board
Publication date: January 2020Source: Journal of Integrative Medicine, Volume 18, Issue 1Author(s): (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - January 9, 2020 Category: Complementary Medicine Source Type: research

Effects of plant-derived analgesic compounds sinomenine and salvinorin A in infant rats
ConclusionThe increased modest effectiveness of sinomenine in older animals and the minimum salvinorin A drug effect suggest that the compounds act on sites that develop during the preweaning period (sinomenine) or after weaning (salvinorin A). (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - January 9, 2020 Category: Complementary Medicine Source Type: research

Nigerian antimalarial plants and their anticancer potential: a review
Publication date: Available online 3 January 2020Source: Journal of Integrative MedicineAuthor(s): Kayode Ezekiel AdewoleAbstractCancer is a leading cause of death globally, while malaria is the leading cause of death from parasitic diseases in Nigeria. Historically, plant remedies have been used to manage both cancer and malaria. Interestingly, the possibility of treating cancer with antimalarial remedies has long been reported, even though the two diseases appear to have little in common. However, a body of research has indicated the potential anticancer activity of both synthetic and nature-derived antimalarials. In Nig...
Source: Journal of Integrative Medicine - January 4, 2020 Category: Complementary Medicine Source Type: research

Traditional chinese medicine in the treatment of idiopathic pulmonary fibrosis based on syndrome differentiation: study protocol of an exploratory trial
This study evaluates the efficacy and safety of TCM in the treatment of IPF.Methods and designA multicenter, exploratory, randomized, double-blind and placebo-controlled trial is planned. A total of 80 patients will be enrolled in the study, which will include 26 weeks of treatment. Participants will be randomly assigned into TCM group or control group in a 1:1 ratio. The TCM group will be given TCM granules based on syndrome differentiation. Formulae include Bu-Fei Yi-Qi granule for lung qi deficiency, Bu-Fei Yi-Shen granule for lung-kidney qi deficiency and Yang-Yin Qing-Re granule for yin deficiency and inner heat. The ...
Source: Journal of Integrative Medicine - December 28, 2019 Category: Complementary Medicine Source Type: research

Current state of cancer patient care incorporating Thai traditional medicine in Thailand: A qualitative study
ConclusionTTM is an alternative treatment modality for patients with cancer and is supported by a national policy in Thailand. To increase accountability to patients and other practitioners, TTM treatments should be refined to rely on scientific principles and practitioners of TTM should receive academic training. Practical treatment guidelines need to be established and thoroughly disseminated to TTM practitioners.Please cite this article as: Nootim P, Kapol N, Bunchuailua W, Poompruek P, Tungsukruthai P. Current state of cancer patient care incorporating Thai traditional medicine in Thailand: A qualitative study. J Integ...
Source: Journal of Integrative Medicine - December 15, 2019 Category: Complementary Medicine Source Type: research

Mechanisms underlying the vascular relaxation activities of Zingiber officinale var. rubrum in thoracic aorta of spontaneously hypertensive rats
ConclusionThis study demonstrates that ZOP may exert an antihypertensive effect in the SHR model. Its possible vascular relaxation mechanisms involve nitric oxide and prostacyclin release, activation of cGMP-KATP channels, stimulation of muscarinic receptors, and transmembrane calcium channel or Ca2+ release from intracellular stores. Possible active compounds that contribute to the vasorelaxant effects are 6-gingerol, 8-gingerol and 6-shogaol. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - December 15, 2019 Category: Complementary Medicine Source Type: research

A case-based approach to integrative medicine for cardiovascular disease prevention
Publication date: Available online 14 December 2019Source: Journal of Integrative MedicineAuthor(s): Brody Slostad, Tejinder Khalsa, Kathleen Young, Hildalicia Guerra, Anjali BhagraAbstractCardiovascular disease is commonly encountered in the adult population and has large impacts on morbidity and mortality. The ever-expanding evidence base for the use of integrative medicine in cardiology necessitates providers caring for patients with cardiovascular disease to be familiar with these therapies. However, providers may find it difficult to adequately discuss these therapies in an average office visit. Through a case-based, ...
Source: Journal of Integrative Medicine - December 15, 2019 Category: Complementary Medicine Source Type: research

Effects of Citrullus colocynthis L. in a rat model of diabetic neuropathy
ConclusionThe present study showed that C. colocynthis fruit, through its antioxidant and hypoglycemic activities, has a positive effect in the treatment of diabetic neuropathy. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - December 6, 2019 Category: Complementary Medicine Source Type: research

Effects of the use of bioceramic wraps in patients with lower limb venous ulcers: a randomized double-blind placebo-controlled trial
ConclusioncFIR clinically improved ulcer healing in patients with lower limb venous ulcers. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - November 29, 2019 Category: Complementary Medicine Source Type: research

Editorial Board
Publication date: November 2019Source: Journal of Integrative Medicine, Volume 17, Issue 6Author(s): (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - November 23, 2019 Category: Complementary Medicine Source Type: research

Gastroprotective herbs for headache management in Persian medicine: a comprehensive review
Publication date: Available online 23 November 2019Source: Journal of Integrative MedicineAuthor(s): Maryam Naeimi, Narjes Gorji, Zahra Memariani, Reihaneh Moeini, Mohammad Kamalinejad, Fatemeh KolangiAbstractThe gut-brain axis is a bidirectional communication system that exists between the brain and gut. Several studies claimed that some types of headaches are associated with various gastrointestinal (GI) disorders. In Persian medicine (PM), physicians believed gastric disturbances could stimulate headache and introduced some herbs for boosting gastric function as a therapeutic remedy for headache. Here we review the curr...
Source: Journal of Integrative Medicine - November 23, 2019 Category: Complementary Medicine Source Type: research

Antioxidant status following postprandial challenge of two different doses of tocopherols and tocotrienols
Publication date: Available online 23 November 2019Source: Journal of Integrative MedicineAuthor(s): Syed Fairus, Hwee Ming Cheng, Kalyana SundramAbstractObjectiveTocotrienols (T3s) have been hypothesized to have greater antioxidant capacity than tocopherols (Ts) due to differences in biokinetics that affect their absorption and function. The present trial compares the antioxidant effectiveness following postprandial challenge of two different doses of α-T or palm T3-rich fraction (TRF) treatments and evaluates their dose-response effects on antioxidant status.MethodsTen healthy volunteers were given four different d...
Source: Journal of Integrative Medicine - November 23, 2019 Category: Complementary Medicine Source Type: research

Mechanisms of action of Sri Lankan herbal medicines used in the treatment of diabetes: A review
Publication date: Available online 14 November 2019Source: Journal of Integrative MedicineAuthor(s): Dona Nirmani Ann Wijewickrama Samarakoon, Deepthi Inoka Uluwaduge, Malith Aravinda SiriwardheneAbstractNatural plant-based remedies for diabetes mellitus have been proven to be safe and effective alternatives to Western medications, and details about more than 400 plants are available in the literature. Sri Lanka is a tropical country which is blessed with many natural plant products that can be utilized for the treatment of diabetes. But the knowledge of these plant-derived remedies, especially their doses, mechanism of ac...
Source: Journal of Integrative Medicine - November 14, 2019 Category: Complementary Medicine Source Type: research

Evaluation of antiplasmodial properties in 15 selected traditional medicinal plants from India
The objective of this study was to evaluate the in vitro antiplasmodial properties against malaria parasite in 15 plants mentioned in Indian traditional medicine texts.MethodsIn vitro antiplasmodial activity of methanolic extracts obtained from Indian traditional medicinal plants was evaluated on Plasmodium falciparum of FCK2 and INDO strains using schizont maturation inhibition assay and parasite lactate dehydrogenase inhibition assay.ResultsMethanolic extracts of Adhatoda zeylanica, Embelia ribes, Piper nigrum and Plumbago zeylanica exhibited more than 50% inhibition in both the stains in schizont maturation inhibition a...
Source: Journal of Integrative Medicine - November 12, 2019 Category: Complementary Medicine Source Type: research

Galen’s place in Avicenna’s The Canon of Medicine: respect, confirmation and criticism
Publication date: Available online 11 November 2019Source: Journal of Integrative MedicineAuthor(s): Sajjad Sadeghi, Farzaneh Ghaffari, Ghazaleh Heydarirad, Mehdi AlizadehAbstractGalen (129–199 A.D.), an ancient Greek scholar, is one of the most influential and recognized physicians and surgeons in the history of medicine. He is one of the most influential Greek scholar in Persian medicine, which has been repeatedly cited by Iranian scholars. The purpose of this article is to describe the exact position of Galen in Avicenna’s The Canon of Medicine, the most important work of Persian medicine. In The Canon of Me...
Source: Journal of Integrative Medicine - November 12, 2019 Category: Complementary Medicine Source Type: research

Study of the safety of oral Triphala aqueous extract on healthy volunteers
ConclusionsWe conclude that aqueous extract of Triphala is safe for healthy volunteers and that it elevates HDL-C levels and lowers blood sugar. Further clinical study should investigate its effects on HDL-C and blood sugar levels among the dyslipidemic and prediabetic groups.Trial registration:This trial was registered in the Thai Clinical Trial Registry with the identifier TCTR20180423002. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - October 17, 2019 Category: Complementary Medicine Source Type: research

Opening of liver mitochondrial permeability transition pore in streptozotocin-induced diabetic rats and its inhibition by methanol fraction of Ficus mucoso (Welw) root bark
Publication date: Available online 16 October 2019Source: Journal of Integrative MedicineAuthor(s): Olubukola Titilope Oyebode, Foluso Olayemi Ogunbiyi, Olufunso Olabode OlorunsogoAbstractObjectiveSeveral pathologies arise from the inappropriate opening of the mitochondrial permeability transition (mPT) pore. In this regard, inhibition of mPT pore represents a cytoprotective approach to preserve mitochondrial function for treatment of diseases characterized by excessive tissue wastage such as diabetes mellitus. The aim of this study, therefore, was to study the effects of fractions of Ficus mucoso, a medicinal plant used i...
Source: Journal of Integrative Medicine - October 17, 2019 Category: Complementary Medicine Source Type: research

Antioxidant activity of dichloromethane fraction of Dichrocephala integrifolia in Salmonella typhi-infected rats
Publication date: Available online 30 September 2019Source: Journal of Integrative MedicineAuthor(s): Gaëtan Olivier Fankem, Michel Archange Fokam Tagne, Paul Aimé Noubissi, Angèle Foyet Fondjo, Idrice Kamtchouing, Adela Ngwewondo, Henri Wambe, Joseph Ngakou Mukam, René KamgangAbstractObjectiveInfectious diseases such as typhoid fever leads to the formation of free radicals which can damage the body. Many medicinal plants have antioxidant molecules that neutralize free radicals. The present work evaluated the antioxidant activity and histopathological effects of the dichloromethane fraction of Dic...
Source: Journal of Integrative Medicine - October 1, 2019 Category: Complementary Medicine Source Type: research

Induction of sub-G0 arrest and apoptosis by seed extract of Moringa peregrina (Forssk.) Fiori in cervical and prostate cancer cell lines
ConclusionSeed extract of M. peregrina displayed a significant antitumor effect through apoptosis induction in HELA and PC-3 cells. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - October 1, 2019 Category: Complementary Medicine Source Type: research

Use of complementary and alternative medicine in pregnant women: a cross-sectional survey in the south of Iran
ConclusionUnderstanding TM/CAM use and the associated factors in different ethnic groups of pregnant women will benefit the evaluation of the proper health policies and mother-infant health programs. This study contributes to the growing literature on TM/CAM, ethnic diversity and pregnant women. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - September 12, 2019 Category: Complementary Medicine Source Type: research

Factors influencing communication of traditional Chinese medicine use between patients and doctors: a multisite cross-sectional study
Publication date: Available online 9 September 2019Source: Journal of Integrative MedicineAuthor(s): Wen Qiang Lee, Jeremy Teoh, Pei Zheng Kenneth Lee, Zhi Xiong Gerard Low, Xueling Sim, Foong Fong Mary Chong, Norbert Ludwig WagnerAbstractObjectiveIn Singapore, the use of traditional Chinese medicine (TCM) alongside Western medicine (WM) is common. There are risks of adverse herb-drug interactions when taken concurrently. Current literature suggests that TCM use is not regularly reported to WM doctors in Singapore, but the underlying reasons are not understood.MethodsA cross-sectional study was conducted across Singapore b...
Source: Journal of Integrative Medicine - September 11, 2019 Category: Complementary Medicine Source Type: research

Tiaoxin Recipe, a Chinese herbal formula, inhibits microRNA-34a expression in the APPswe/PS1ΔE9 mouse model of Alzheimer’s disease
Publication date: Available online 9 September 2019Source: Journal of Integrative MedicineAuthor(s): Yi Ran Hu, San Li Xing, Chuan Chen, Ding Zhu Shen, Jiu Lin ChenAbstractObjectiveTo investigate the effect and underlying mechanisms of Tiaoxin Recipe (a Chinese herbal formula) treatment on Alzheimer’s disease (AD).MethodsTwelve-week-old APPswe/PS1ΔE9 (APP/PS1) double transgenic mice were used as a model of AD-afflicted mice. One group of mice was treated with Tiaoxin Recipe by gastrogavage for 12 weeks, while two other groups were given intraperitoneal injections of nicotinamide adenine dinucleotide or FK866 fo...
Source: Journal of Integrative Medicine - September 11, 2019 Category: Complementary Medicine Source Type: research

Editorial Board
Publication date: September 2019Source: Journal of Integrative Medicine, Volume 17, Issue 5Author(s): (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - September 6, 2019 Category: Complementary Medicine Source Type: research

Therapeutic potential of ethyl acetate fraction of Tephrosia purpurea Linn. leaves in a rat model of gout
ConclusionEATP lowered the serum uric acid level and increased the urine uric acid level through excretion, which is useful in the treatment of gout. Hence the EATP was found to be helpful in the treatment of gout. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - August 22, 2019 Category: Complementary Medicine Source Type: research

Chemical compounds as well as antioxidant and litholytic activities of Arbutus unedo L. leaves against calcium oxalate stones
Publication date: Available online 13 August 2019Source: Journal of Integrative MedicineAuthor(s): Rabie Kachkoul, Tarik Squalli Housseini, Mohamed Mohim, Radouane El Habbani, Youssef Miyah, Anissa LahrichiAbstractObjectiveThe present study aimed to quantify and identify the bioactive compounds of the Arbutus unedo L. leaves in order to evaluate both their antioxidant properties and litholytic activities against calcium oxalate stones.MethodsThis survey was carried out using hydroalcoholic extract (E.FA) and infusion (I.FA) of A. unedo leaves. The quantification of phenolic compounds, flavonoids, flavonols and anthocyanins...
Source: Journal of Integrative Medicine - August 14, 2019 Category: Complementary Medicine Source Type: research

E-noise: An increasingly relevant health risk
In conclusion, e-noise is a potential danger in our world, and further studies are needed of its effects on mechanisms of aging, disease, and human health. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - July 20, 2019 Category: Complementary Medicine Source Type: research

Cyclophosphamide-induced reproductive toxicity: beneficial effects of Helichrysum odoratissimum (Asteraceae) in male Wistar rats
Publication date: Available online 17 July 2019Source: Journal of Integrative MedicineAuthor(s): Pierre Watcho, Ismaelle Rosine Mpeck, Patrick Brice Defo Deeh, Modeste W.eu-Nya, Esther Ngadjui, Georges Romeo Fozin Bonsou, Pierre Kamtchouing, Albert KamanyiAbstractObjectiveCyclophosphamide (CP) is commonly used to treat some cancers, but its clinical efficacy is also linked with testicular toxicity. We investigated the effects of aqueous extract (AE) and methanolic extract (ME) of Helichrysum odoratissimum for reducing CP-induced reproductive toxicity in male rats.MethodsIn addition to a normal control (group 1), drugs or v...
Source: Journal of Integrative Medicine - July 18, 2019 Category: Complementary Medicine Source Type: research

Benfotiamine supplementation prevents oxidative stress in anterior tibialis muscle and heart
ConclusionThe results show that benfotiamine is an efficient antioxidant for the anterior tibialis muscle and heart; however, swimming training did not alter redox status. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - July 17, 2019 Category: Complementary Medicine Source Type: research

Acupuncture price in forty-one metropolitan regions in the United States: an out-of-pocket cost analysis based on OkCopay.com
We examined descriptive statistics (range, median and 20% intervals) for the cost of acupuncture “first-time visits” and “follow-up visits” in 41 metropolitan regions in the U.S. The acupuncture prices of 723 clinics throughout 39 metropolitan regions were included, except for Birmingham, Alabama and Detroit, Michigan as there was no online data available at the time of the study for these two regions. The cost range for a first-time acupuncture visit was $15–400; the highest median was $150 in Charleston, South Carolina, while the lowest was $45 in St. Louis, Missouri. The top 10 cities for t...
Source: Journal of Integrative Medicine - June 29, 2019 Category: Complementary Medicine Source Type: research

Editorial Board
Publication date: July 2019Source: Journal of Integrative Medicine, Volume 17, Issue 4Author(s): (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - June 20, 2019 Category: Complementary Medicine Source Type: research

Effects of a novel isoflavonoid from the stem bark of Alstonia scholaris against fructose-induced experimental cataract
ConclusionResults revealed that administration of ASII played a crucial role in the reduction of cataract formation in diabetic and hypertensive models.Please cite this article as: Soni P, Choudhary R, Bodakhe SH. Effects of a novel isoflavonoid from the stem bark of Alstonia scholaris against fructose-induced experimental cataract. J Integr Med. 2019; Epub ahead of print. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - June 10, 2019 Category: Complementary Medicine Source Type: research

Health care in light of different theories of health—a proposed framework for integrating a social humanistic perspective into health care
The objective of this paper is to provide an overview of the biomedical, the biopsychosocial, and the social humanistic theories of health and to propose a framework for integrating the latter into health care. In summary, the definitions of health, illness and disease are essential to the practice of health care and play fundamental roles in how patients’ experiences of being ill are valued and assessed within health care systems. Principally, the biomedical perspective proceeds from pathoanatomical deficiencies defining disease and malfunction; the addition of psychosocial components forms a biopsychosocial perspec...
Source: Journal of Integrative Medicine - June 7, 2019 Category: Complementary Medicine Source Type: research

The efficacy of a Persian herbal formulation on functional bloating: a double-blind randomized controlled trial
This study investigated the efficacy and compliance of a formulation called KAASER comprised of Trachyspermum ammi (L.) Sprague seed, Zingiber officinale Roscoe. rhizome and Piper nigrum L. berry in the treatment of functional bloating.Design, setting, participants and interventionA total of 106 patients with functional bloating, between 20 and 50 years of age, participated in this double-blind randomized controlled trial. Patients were divided into 3 parallel groups that received 500 mg of placebo, dimethicone or KAASER, three times a day for 2 weeks.Main outcome measuresThe frequency and severity of bloating were primary...
Source: Journal of Integrative Medicine - May 26, 2019 Category: Complementary Medicine Source Type: research

Beneficial effects of hirudotherapy in a chronic case of complex regional pain syndrome
We report about hirudotherapy in a patient with chronic complex regional pain syndrome (CRPS) in the right hand. CRPS is a multifactorial disease associated with disabling pain as well as sensory and motor deficits. The optimal therapeutic management is based on personalized multimodal treatment approaches; however, hirudotherapy has not been described in the available literature. To date, we have completed five medicinal leech treatments. Altogether, hirudotherapy led to rapid and substantial relief of symptoms, especially with respect to pain intensity ratings and skin temperature asymmetries. In Addition, the patient&rs...
Source: Journal of Integrative Medicine - May 24, 2019 Category: Complementary Medicine Source Type: research

Understanding hypothyroidism in Unani Medicine
Publication date: Available online 23 May 2019Source: Journal of Integrative MedicineAuthor(s): Md. Anzar Alam, Mohd Aleemuddin Quamri, Ghulamuddin Sofi, Barkati Md.TariqueAbstractHypothyroidism (Qillat-e-Ifraz-e-Darqiyya) is a condition where the thyroid gland is underactive and unable to produce enough thyroid hormone. The description of hypothyroidism as a disease is not directly found in Unani texts. However, the signs and symptom of hypothyroidism resemble the clinical manifestation associated with Su-e-Mizaj Barid Maddi (derangement in cold temperament), such as plethora (Imtila), excessive salivation (Kasrat-e-Luabe...
Source: Journal of Integrative Medicine - May 24, 2019 Category: Complementary Medicine Source Type: research

Corrigendum to “Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers” [J. Integr. Med. 16(6) (2018) 367–374]
Publication date: Available online 6 May 2019Source: Journal of Integrative MedicineAuthor(s): Rohitash Jamwal (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - May 22, 2019 Category: Complementary Medicine Source Type: research