Antidiarrheal and protein conservative activities of Psidium guajava in diarrheal rats
ConclusionP. guajava leaf extract elicited antidiarrheal and protein conservative effects. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - December 5, 2018 Category: Complementary Medicine Source Type: research

Telfairia occidentalis (Cucurbitaceae) pulp extract mitigates rifampicin-isoniazid-induced hepatotoxicity in an in vivo rat model of oxidative stress
Publication date: Available online 1 December 2018Source: Journal of Integrative MedicineAuthor(s): Lucky Legbosi Nwidu, Yibala Ibor ObomaAbstractObjectiveDrug-induced liver injury complicates antituberculosis drug treatment and is a leading cause of death worldwide. The aim of this study is to establish the ethnomedicinal claim of hepatoprotective effects of fruit pulp extract of Telfairia occidentalis against rifampicin (RIF) and isoniazid (INH)-induced oxidative stress in rats.MethodsT. occidentalis pulp extract (TOPE) (125–500 mg/kg) and silymarin (50 mg/kg) were evaluated in an induced hepatotoxicity model of ox...
Source: Journal of Integrative Medicine - December 1, 2018 Category: Complementary Medicine Source Type: research

Safe acupuncture and dry needling during pregnancy: New Zealand physiotherapists’ opinion and practice
ConclusionConflicting literature and a “fear of blame” influences NZ physiotherapists’ decisions to offer needling (both acupuncture and DN) during pregnancy. Further training in this field is recommended to ensure safe practice and adequate provision of acupuncture treatment options for pregnant women suffering musculoskeletal pain, such as LBP and PGP. Further research, particularly into DN, for women during pregnancy, is warranted. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - November 29, 2018 Category: Complementary Medicine Source Type: research

Acupuncture in living liver and kidney donors: a feasibility study
ConclusionPreliminary findings suggest it is feasible to integrate acupuncture into inpatient recovery for living organ donation. Tailoring interventions to the specific needs of patients is important to address ongoing concerns. Larger studies are needed to further ascertain benefits of peri-operative acupuncture. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - November 28, 2018 Category: Complementary Medicine Source Type: research

Integration of AYUSH and allopathy—pros and cons
Publication date: Available online 22 November 2018Source: Journal of Integrative MedicineAuthor(s): Preethi MohanAbstractAYUSH is an assembly of medical systems (Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homeopathy) that are practiced in India. There are various faulty notions about its practices. The author perceived one research article published in Journal of Integrative Medicine about the need to integrate AYUSH into the curriculum of allopathy. Integration is an approach open to alternate systems of medicine with other streams for their advancements through research and it explores new horizons of health prac...
Source: Journal of Integrative Medicine - November 23, 2018 Category: Complementary Medicine Source Type: research

Dietary supplementation with turmeric polyherbal formulation decreases facial redness: a randomized double-blind controlled pilot study
ConclusionPolyherbal combination tablet supplementation improved facial redness compared to the turmeric or placebo. Overall, our findings suggested further investigations into the effects of turmeric and polyherbal formulations in skin conditions associated with facial redness would be warranted.Trial registrationClinicalTrials.gov identifier: NCT03065504 (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - November 23, 2018 Category: Complementary Medicine Source Type: research

Effectiveness of hand self-shiatsu to improve sleep following sport-related concussion in young athletes: a proof-of-concept study
ConclusionThese findings support the hypothesis that HSS has the potential to improve sleep and reduce daytime fatigue in young postconcussion athletes. This pilot study provides guidance to refine research protocols and lays a foundation for further, large-sample, controlled studies. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - November 18, 2018 Category: Complementary Medicine Source Type: research

Internet survey on the provision of complementary and alternative medicine in Japanese private clinics: a cross-sectional study
ConclusionKampo medicines represent the most commonly used CAM in private clinics in Japan, and universal national health insurance coverage is considered to be the reason for the high rate of their use. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - November 18, 2018 Category: Complementary Medicine Source Type: research

Efficacy of equine-assisted psychotherapy in veterans with posttraumatic stress disorder
CONCLUSIONAs compared to the control group, a 6-week EAP program did not produce a statistically significant difference with respect to PCL-M and CD-RISC scores, or salivary cortisol. However, our results suggest that EAP may work as well as standard therapy with respect to these parameters. This study supports further inquiry into EAP as a potentially efficacious alternative for veterans suffering from PTSD. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - November 16, 2018 Category: Complementary Medicine Source Type: research

Effectiveness of two different acupuncture strategies in patients with vulvodynia: study protocol for a pilot pragmatic controlled trial
This study evaluates two different acupuncture strategies for the treatment of vulvodynia and aims to evaluate whether either of the acupuncture protocols reduce vulvar pain, pain duration or pain with intercourse. The study also examines how long the effect of acupuncture lasts in women with vulvodynia.Methods/designThe study is designed as a randomized controlled trial, focused on two acupuncture protocols. Fifty-one patients who have had vulvodynia for more than 3 months will be recruited. Among them, 34 patients will be randomized into Groups 1a and 1b; those who are unwilling to receive acupuncture will be recruited i...
Source: Journal of Integrative Medicine - October 10, 2018 Category: Complementary Medicine Source Type: research

Electro-acupuncture regulates the cholinergic anti-inflammatory pathway in a rat model of chronic obstructive pulmonary disease
In this study, we investigated whether electro-acupuncture (EA) affects the CAP in COPD.MethodsSprague-Dawley rats were induced into COPD through exposure to cigarette smoke combined with lipopolysaccharide. EA treatment was applied at Zusanli (ST36) and Feishu (BL13) points for 30 min/d for 7 d. Seventy-two rats were randomly divided into six study groups, including normal, normal + EA, normal + α-bungarotoxin (α-BGT) (the antagonist of the nicotinic acetylcholine receptor α7 subunit (α7nAChR)) + EA, COPD, COPD + EA, and COPD + α-BGT + EA. Lung function, pathology and vagus nerve discharge we...
Source: Journal of Integrative Medicine - October 6, 2018 Category: Complementary Medicine Source Type: research

An overview of the contribution of acupuncture to thyroid disorders
Publication date: Available online 6 October 2018Source: Journal of Integrative MedicineAuthor(s): Fung-Kei ChengAbstractThyroid dysfunction, affecting people of all ages, not only damages human growth and energy metabolism but is also comorbid with other illnesses such as cardiovascular disease, kidney disease and gastrointestinal disorders. With the increasing acceptance of alternative and complementary therapies, acupuncture, a traditional Chinese medical practice, has also been employed to address this problem. Analysing 29 clinical projects that were retrieved from 29 major digital databases and include 1757 patients ...
Source: Journal of Integrative Medicine - October 6, 2018 Category: Complementary Medicine Source Type: research

Anti-adipogenic effect of flavonoids from Chromolaena odorata leaves in 3T3-L1 adipocytes
ConclusionC. odorata leaves contained several flavonoids with anti-adipogenic effects against lipid accumulation in 3T3-L1 adipocytes. The plant, normally considered a useless weed, may actually provide an abundant source of biologically active flavonoids.Please cite this article as: Kumkarnjana S, Nimmannit U, Koobkokkruad T, Pattamadilok C, Suttisri R, Vardhanabhuti N. Anti-adipogenic effect of flavonoids from Chromolaena odorata leaves in 3T3-L1 adipocytes. J Integr Med. 2018; Epub ahead of print. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - October 5, 2018 Category: Complementary Medicine Source Type: research

Cytotoxic and antiproliferative activity of kanchnar guggulu, an Ayurvedic formulation
ConclusionKanchnar guggulu exhibited a cytotoxic effect by inhibiting cell division (antimitotic) and reducing cell proliferation. These results substantiate its potential for the treatment of cancer and support its traditional use in the treatment of cancer.Please cite this article as: Tomar P, Dey YN, Sharma D, Wanjari MM, Gaidhani S, Jadhav A. Cytotoxic and antiproliferative activity of kanchnar guggulu, an Ayurvedic formulation. J Integr Med. 2018; Epub ahead of print. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - October 4, 2018 Category: Complementary Medicine Source Type: research

The use of a standardized Chinese herbal formula in patients with advanced lung cancer: a feasibility study
ConclusionThis study provides preliminary evidence that short-term use of a carefully selected and prepared CH formula in patients with stage 4 NSCLC is acceptable and safe. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - September 22, 2018 Category: Complementary Medicine Source Type: research

In vitro antileishmanial effects of Physalis angulata root extract on Leishmania infantum
ConclusionAEPa presented antileishmanial activity against the promastigotes and amastigotes of L. infantum without macrophage cytotoxicity; these results show that natural products such as P. angulata have leishmanicidal potential and in the future may be an alternative treatment for leishmaniasis. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - August 25, 2018 Category: Complementary Medicine Source Type: research

Far infrared-emitting ceramics decrease Freund’s adjuvant-induced inflammatory hyperalgesia in mice through cytokine modulation and activation of peripheral inhibitory neuroreceptors
Publication date: Available online 11 August 2018Source: Journal of Integrative MedicineAuthor(s): Ralph Fernando Rosas, Aline Armiliato Emer, Ana Paula Batisti, Daniela Dero Ludtke, Bruna Turnes Lenfers, Franciane Bobinski, Francisco José Cidral-Filho, Daniel Fernandes MartinsAbstractObjectiveThe present study aimed to evaluate the analgesic and anti-inflammatory effects of far infrared-emitting ceramics (cFIRs) in a model of persistent inflammatory hyperalgesia and to elucidate the possible mechanisms of these effects.MethodsMice were injected with complete Freund’s adjuvant (CFA) and treated with cFIRs via ...
Source: Journal of Integrative Medicine - August 12, 2018 Category: Complementary Medicine Source Type: research

Synergistic effects of combined therapy of curcumin and Fructus Ligustri Lucidi for treatment of osteoporosis: cellular and molecular evidence of enhanced bone formation
ConclusionThe co-administration of CUR and FLL had superior promotion of elements of bone regeneration in cultured cells, thus could be a promising alternative herbal therapy for the management of bone erosive disorders such as osteoporosis.Please cite this article as: Bukhari SNA, Hussain F, Thu HE, Hussain Z. Synergistic efficacy of combined therapy of curcumin and Fructus Ligustri Lucidi for treatment of osteoporosis: cellular and molecular evidence of enhanced bone formation. J Integr Med. 2018; Epub ahead of print. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - August 11, 2018 Category: Complementary Medicine Source Type: research

Evaluation of in vitro antioxidant, antiglycation and antimicrobial potential of indigenous Myanmar medicinal plants
ConclusionThe results suggest that these plants are potential sources of antioxidants with free radicals-scavenging and antiglycation activities and could be useful for decreasing the oxidative stress and glycation end-products formation in glycation-related diseases.Please cite this article as: Moe TS, Win HH, Hlaing TT, Lwin WW, Htet ZM, Mya KM. Evaluation of in vitro antioxidant, antiglycation and antimicrobial potential of indigenous Myanmar medicinal plants. J Integr Med. 2018; Epub ahead of print. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - August 5, 2018 Category: Complementary Medicine Source Type: research

Protective roles of Vigna subterranea (Bambara nut) in rats with aspirin-induced gastric mucosal injury
Publication date: Available online 1 August 2018Source: Journal of Integrative MedicineAuthor(s): Morufu Eyitayo Balogun, Elizabeth Enohnyaket Besong, Jacinta Nkechi Obimma, Ogochukwu Sophia Mbamalu, Fankou Serges Athanase DjobissieAbstractObjectiveVigna subterranea is widely consumed as a traditional staple food in Nigeria and some West African countries. The ethanolic seed extract of V. subterranea (EEVS) was investigated for its gastroprotective effects on aspirin plus pylorus ligation-induced gastric ulcerated rats using an in vivo assay.MethodsGastric mucosal ulceration was induced experimentally in Groups 2 to 5 usin...
Source: Journal of Integrative Medicine - August 1, 2018 Category: Complementary Medicine Source Type: research

A brief illustration of the official national standards for the safe use of cupping therapy (Hijama) in Saudi Arabia
This article gives a brief illustration and highlights the important points of the first accredited Saudi Arabian standards for the safe use of cupping equipment and its applications. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - July 31, 2018 Category: Complementary Medicine Source Type: research

Antimicrobial activity of Cannabis sativa, Thuja orientalis and Psidium guajava leaf extracts against methicillin-resistant Staphylococcus aureus
CONCLUSIONThe leaf extracts of C. sativa, T. orientalis and P. guajava had potential for the control of both hospital- and community-acquired MRSA. Moreover, the inhibitory effect was enhanced when extracts were used in combination. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - July 29, 2018 Category: Complementary Medicine Source Type: research

Phytochemical characterization of polyphenolic compounds with HPLC–DAD–ESI–MS and evaluation of lipid-lowering capacity of aqueous extracts from Saharan plant Anabasis aretioides (Coss & Moq.) in normal and streptozotocin-induced diabetic rats
Publication date: May 2018Source: Journal of Integrative Medicine, Volume 16, Issue 3Author(s): Omar Farid, Farid Khallouki, Morad Akdad, Andrea Breuer, Robert Wyn Owen, Mohamed EddouksAbstractObjectiveAnabasis aretioides (Coss & Moq.), a Saharan plant belonging to Chenopodiaceae family, is widely distributed in semi-desert areas from the Tafilalet region of Morocco. This plant is extensively used by local population against diabetes and cardiovascular disorders. The purpose of the study was to investigate the effect of the aqueous A. aretioides extract on lipid metabolism in normal and streptozotocin (STZ)-induced dia...
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Home care with acupuncture increased the quality of life in a patient with advanced cancer with neuropathic pain induced by bone metastasis: a case report
Publication date: May 2018Source: Journal of Integrative Medicine, Volume 16, Issue 3Author(s): Ching-Feng SuAbstractA 66-year-old female patient was diagnosed with hepatocellular carcinoma accompanied by neuropathic pain induced by a metastatic tumor that compromised root and spinal canal. Although her pain was relieved following medical treatment, breakthrough pain occurring 1–2 times a day was still distressing. Neuropathic pain in her right lower limb caused discomfort and irritability and decreased her quality of life. We had limited options to adjust her prescription drug regime, due to the side effect of these...
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Noni (Morinda citrifolia L.) fruit juice delays immunosenescence in the lymphocytes in lymph nodes of old F344 rats
ConclusionThese results suggest that the immunostimulatory properties of NFJ are facilitated through intracellular signaling pathways involving ERK1/2, Akt and NF-κB. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Inhibitory potentials of phenolic-rich extracts from Bridelia ferruginea on two key carbohydrate-metabolizing enzymes and Fe2+-induced pancreatic oxidative stress
ConclusionThe phenolic-rich extracts of BF leaves showed antioxidant potentials and inhibited two key carbohydrate-metabolizing enzymes in vitro. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Double-blind evaluation of homeopathy on cocaine craving: a randomized controlled pilot study
This study investigates the effectiveness and tolerability of homeopathic Q-potencies of opium and E. coca in the integrative treatment of cocaine craving in a community-based psychosocial rehabilitation setting.Design, setting, participants, and interventionsA randomized, double-blind, placebo-controlled, parallel-group, eight-week pilot trial was performed at the Psychosocial Attention Center for Alcohol and Other Drugs (CAPS-AD), Sao Carlos/SP, Brazil. Eligible subjects included CAPS-AD patients between 18 and 65 years of age, with an International Classification of Diseases-10 diagnosis of cocaine dependence (F14.2)....
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Rhythmical massage improves autonomic nervous system function: a single-blind randomised controlled trial
ConclusionRMT causes specific and marked stimulation of the autonomic nervous system. Use of a medicinal aromatic oil had only a temporary effect on HRV, indicating that the RM causes the most relevant long-term effect. The effect is relatively specific, as the physiological effects seen in the group of subjects who received only SM were considerably less pronounced.Trial registrationRegistration trial DRKS00004164 on DRKS. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

A historical evaluation of Chinese tongue diagnosis in the treatment of septicemic plague in the pre-antibiotic era, and as a new direction for revolutionary clinical research applications
This article focuses on the historical development of what is the world’s earliest tongue diagnosis monograph, and discusses the directions that such knowledge may be used in future clinical research. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Casticin from Vitex species: a short review on its anticancer and anti-inflammatory properties
Publication date: May 2018Source: Journal of Integrative Medicine, Volume 16, Issue 3Author(s): Eric Wei Chiang Chan, Siu Kuin Wong, Hung Tuck ChanAbstractThis short review provides an update of the anticancer and anti-inflammatory properties of casticin from Vitex species. Casticin is a polymethylflavone with three rings, an orthocatechol moiety, a double bond, two hydroxyl groups and four methoxyl groups. Casticin has been isolated from various tissues of plants in the Vitex genus: fruits and leaves of V. trifolia, aerial parts and seeds of V. agnus-castus and leaves of V. negundo. Studies have reported the antiprolifera...
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Phytochemical profile and pharmacological activity of Aegle marmelos Linn.
Publication date: May 2018Source: Journal of Integrative Medicine, Volume 16, Issue 3Author(s): Bikash Manandhar, Keshav Raj Paudel, Biraj Sharma, Rajendra KarkiAbstractAegle marmelos Linn. (Rutaceae), commonly known as “bael” in Nepal and India, is a valuable medicinal plant and is considered sacred by the Hindus. It is used to cure several diseases in the Indian traditional medicine system of Ayurveda and has had similar uses among many ethnic communities residing in Indian subcontinent for over 5000 years. Its leaves, bark, stem, fruits and seeds have been used for various medicinal purposes. Bael fruits a...
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Patient blinding with blunt tip placebo acupuncture needles: comparison between 1 mm and 2 mm skin press
ConclusionPlacebo needles of 2 mm press made more subjects guess that the needles penetrated the skin than 1 mm press needles. The use of small diameter needles increased patient blinding. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf extract supplementation on insulin resistance in metabolic syndrome: a randomized, double-blind, placebo-controlled trial
This study examined the effects of ALE supplementation on metabolic parameters of the TCF7L2-rs7903146 polymorphism in patients with metabolic syndrome (MetS).Design, setting, participants and interventionsThis double-blind clinical trial was conducted on 80 patients with MetS in Sina Clinic, Khoy, Iran. The patients were randomized into ALE or placebo groups to receive either ALE (1800 mg/d as four tablets) or matching placebo for 12 weeks.Main outcome measuresAnthropometric indices, blood pressure, glucose and lipid profile levels were measured before and after the study. Moreover, patients were genotyped for TCF7L2 ...
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Effects of vitamin supplementation on inflammatory markers and psychological wellbeing among distressed women: a randomized controlled trial
ConclusionThe results suggest that administration of multivitamins was not effective in improving psychological state. However, some evidence supported the positive impact of multivitamin supplementation on pro-inflammatory cytokine profiles of women currently experiencing stress. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Acupuncture for migraine without aura: a systematic review and meta-analysis
Publication date: Available online 28 June 2018Source: Journal of Integrative MedicineAuthor(s): Jia Xu, Fu-qing Zhang, Jian Pei, Jun JiAbstractBackgroundMigraine without aura (MWoA), the most common type of migraine, has greatly impacts on quality of life for migraineurs. Acupuncture is used in the treatment and prevention of migraine for its analgesic effects.ObjectiveThe aim of this systematic review and meta-analysis is to systematically assess the therapeutic and preventive effect of acupuncture treatment and its safety for MWoA.Search strategyNine electronic databases (PubMed, MEDLINE, Cochrane Library, Lilacs, Embas...
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a review
Publication date: July 2018Source: Journal of Integrative Medicine, Volume 16, Issue 4Author(s): Bruno José Martins Da Silva, Amanda Anastácia Pinto Hage, Edilene Oliveira Silva, Ana Paula Drummond RodriguesAbstractLeishmaniasis, a neglected disease caused by Leishmania protozoans, primarily affects people in tropical and subtropical areas. Chemotherapy based on the use of pentavalent antimonials, amphotericin B, paromomycin, miltefosine and liposomal amphotericin B is currently the only effective treatment. However, adverse effects, long-term treatment and the emergence of parasite resistance have led to the...
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Hot aqueous leaf extract of Lasianthera africana (Icacinaceae) attenuates rifampicin-isoniazid-induced hepatotoxicity
Publication date: July 2018Source: Journal of Integrative Medicine, Volume 16, Issue 4Author(s): Lucky Legbosi Nwidu, Raphael Ellis TemeAbstractObjectivesThe aim of this study is to evaluate the hepatoprotective effect of Lasianthera africana (Icacinaceae) against isoniazid (INH) and rifampicin (RIF)-induced liver damage in rats.MethodsThe hepatoprotective effects of hot aqueous L. africana (HALA) leaf extract (0.1–1 g/kg) and silymarin (50 mg/kg) were assessed in a model of oxidative liver damage induced by RIF and INH (100 mg/kg each) in Wistar rats for 28 days. Biochemical markers of hepatic damage such as...
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Feiji Recipe inhibits the growth of lung cancer by modulating T-cell immunity through indoleamine-2,3-dioxygenase pathway in an orthotopic implantation model
Publication date: July 2018Source: Journal of Integrative Medicine, Volume 16, Issue 4Author(s): Bin Luo, Zu-jun Que, Zhi-yi Zhou, Qing Wang, Chang-sheng Dong, Yi Jiang, Bing Hu, Hui Shi, Yu Jin, Jian-wen Liu, He-gen Li, Lin Wang, Jian-hui TianAbstractObjectiveEscape from the body’s immune response is a basic characteristic of lung cancer, and indoleamine-2,3-dioxygenase (IDO) plays a key role in mediating immune escape of non-small-cell lung cancer, which leads to recurrence and metastasis. Feiji Recipe, a compound Chinese herbal medicine, has the effect of stabilizing lesions and prolonging survival in patients wit...
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Preliminary optimization of a Chinese herbal medicine formula based on the neuroprotective effects in a rat model of rotenone-induced Parkinson’s disease
ConclusionThe investigated formulations of Chinese herbs had neuroprotective effects against PD models, and the neuroprotective effects were weakly related to the proportion of key herbs. However the neuroprotective effects of the formula may not result from a single active constituent. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Evaluation of phenolic composition, antioxidant, anti-inflammatory and anticancer activities of Polygonatum verticillatum (L.)
ConclusionFrom the present study, it can be concluded that P. verticillatum possessed remarkable antioxidant, anti-inflammatory, and anticancer activities, which could be due to different secondary metabolites of the plant. Phenolic compounds are likely responsible for antioxidant and anti-inflammatory activities. However, flavonoids and other compounds might contribute to the anticancer potential of the plant. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Phytochemistry and biological activities of Heracleum persicum: a review
This article has provided comprehensive information on Iranian traditional uses, phytochemistry and pharmacological activities of H. persicum. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Clinical practice guidelines for the treatment of primary liver cancer with integrative traditional Chinese and Western medicine
Publication date: July 2018Source: Journal of Integrative Medicine, Volume 16, Issue 4Author(s): Chang-quan Ling, Jia Fan, Hong-sheng Lin, Feng Shen, Zhen-ye Xu, Li-zhu Lin, Shu-kui Qin, Wei-ping Zhou, Xiao-feng Zhai, Bai Li, Qing-hui Zhou, on behalf of the Chinese Integrative Therapy of Primary Liver Cancer Working GroupAbstractTraditional Chinese medicine (TCM) is an important part of the treatment of primary liver cancer (PLC) in China; however, the current instructions for the integrative use of traditional Chinese and Western medicine for PLC are mostly based on expert opinion. There is no evidence-based guideline for...
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Kaempferia parviflora ethanol extract improves self-assessed sexual health in men: a pilot study
ConclusionOur results suggest that KaempMax™ may improve erectile function in healthy middle-aged and older men. While the effects were not as pronounced as what might be seen with prescription medication, most participants found them satisfactory. Additional, longer and placebo-controlled clinical trials will be needed.Trial registrationClinicaltrials.gov identifier NCT03389867. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

In vitro antioxidant, antilipoxygenase and antimicrobial activities of extracts from seven climbing plants belonging to the Bignoniaceae
ConclusionMost of the extracts exhibited antioxidant activity as well as in vitro inhibition of lipoxygenase. The excellent antimicrobial activity of T. selloi and F. chica supports their use in traditional medicine as antiseptic agents. The extracts of F. caudigera and C. convoluta, both with notable biological activities in this study, could be used as herbal remedies for skin care. In addition, this study provides, for the first time, information about phenolic compounds present in C. convoluta. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers
Publication date: Available online 4 July 2018Source: Journal of Integrative MedicineAuthor(s): Rohitash JamwalAbstractCurcumin is a widely studied natural compound which has shown tremendous in vitro therapeutic potential. Despite that, the clinical efficacy of the native curcumin is weak due to its low bioavailability and high metabolism in the gastrointestinal tract. During the last decade, researchers have come up with different formulations with a focus on improving the bioavailability of curcumin. As a result, a significant number of bioavailable curcumin-based formulations were introduced with the varying range of e...
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Evaluation of acute and subacute toxicity of whole-plant aqueous extract of Vernonia mespilifolia Less. in Wistar rats
ConclusionThese results shown that AEVM at dosage levels up to 600 mg/kg is nontoxic and could also offer protection on some body tissues. AEVM could, therefore, be considered safe. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Ethnomedicinal, phytochemical and pharmacological updates on Hygrophila auriculata (Schum.) Hiene: an overview
This article explores the most recent evidence-based information on ethanomedicinal, phytochemical and pharmacological understanding of Hygrophila auriculata for the treatment of various diseases and health conditions. Various ethanomedicinal writings suggest the use of the plant or its parts for the treatment of jaundice, edema, gastrointestinal ailments, diarrhea, dysentery, urinogenital disorder, gall stones, urinary calculi, kidney stone, leucorrhoea, rheumatism, tuberculosis, anemia, body pain, constipation and skin disease, and as an aphrodisiac. The plant has been reported to contain flavonoids (apigenin, luteolin, ...
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Phytochemical characterization of polyphenolic compounds with HPLC–DAD–ESI–MS and evaluation of lipid-lowering capacity of aqueous extracts from Saharan plant Anabasis aretioides (Coss & Moq.) in normal and streptozotocin-induced diabetic rats
Publication date: May 2018Source: Journal of Integrative Medicine, Volume 16, Issue 3Author(s): Omar Farid, Farid Khallouki, Morad Akdad, Andrea Breuer, Robert Wyn Owen, Mohamed EddouksAbstractObjectiveAnabasis aretioides (Coss & Moq.), a Saharan plant belonging to Chenopodiaceae family, is widely distributed in semi-desert areas from the Tafilalet region of Morocco. This plant is extensively used by local population against diabetes and cardiovascular disorders. The purpose of the study was to investigate the effect of the aqueous A. aretioides extract on lipid metabolism in normal and streptozotocin (STZ)-induced dia...
Source: Journal of Integrative Medicine - July 5, 2018 Category: Complementary Medicine Source Type: research

Home care with acupuncture increased the quality of life in a patient with advanced cancer with neuropathic pain induced by bone metastasis: a case report
Publication date: May 2018Source: Journal of Integrative Medicine, Volume 16, Issue 3Author(s): Ching-Feng SuAbstractA 66-year-old female patient was diagnosed with hepatocellular carcinoma accompanied by neuropathic pain induced by a metastatic tumor that compromised root and spinal canal. Although her pain was relieved following medical treatment, breakthrough pain occurring 1–2 times a day was still distressing. Neuropathic pain in her right lower limb caused discomfort and irritability and decreased her quality of life. We had limited options to adjust her prescription drug regime, due to the side effect of these...
Source: Journal of Integrative Medicine - July 5, 2018 Category: Complementary Medicine Source Type: research

Noni (Morinda citrifolia L.) fruit juice delays immunosenescence in the lymphocytes in lymph nodes of old F344 rats
ConclusionThese results suggest that the immunostimulatory properties of NFJ are facilitated through intracellular signaling pathways involving ERK1/2, Akt and NF-κB. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - July 5, 2018 Category: Complementary Medicine Source Type: research