Unlocking renal Restoration: Mesaconine from Aconitum plants restore mitochondrial function to halt cell apoptosis in acute kidney injury
This study explored mesaconine, derived from processed Fuzi, as a promising low-toxicity alternative for AKI treatment. In this study, we assessed the protective effects of mesaconine in gentamicin (GM)-induced NRK-52E cells and AKI rat models in vitro and in vivo, respectively. Mesaconine promotes the proliferation of damaged NRK-52E cells and down-regulates intracellular transforming growth factor β1 (TGF-β1) and kidney injury molecule 1 (KIM-1) to promote renal cell repair. Concurrently, mesaconine restored mitochondrial morphology and permeability transition pores, reversed the decrease in mitochondrial membrane pote...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Yixin Rui Xiumeng Zhang Xinran Min Hongxiao Xie Xiuying Ma Funeng Geng Rong Liu Source Type: research
Short-term dietary teprenone improved thermal tolerance and mitigated liver damage caused by heat stress in juvenile largemouth bass (Micropterus salmoides)
This study offers theoretical support for applying teprenone in aquaculture to reduce financial losses caused by abiotic factors.PMID:38692348 | DOI:10.1016/j.cbpb.2024.110984 (Source: Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology.)
Source: Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology. - May 1, 2024 Category: Biochemistry Authors: Hongyun Li Feifei Chen Mu Qin Chenlei Liao Yaqi Shi Sihan Wu Keming Rong Xuezhen Zhang Source Type: research
Liensinine alleviates sepsis-induced acute liver injury by inhibiting the NF- κB and MAPK pathways in an Nrf2-dependent manner
Chem Biol Interact. 2024 Apr 29:111030. doi: 10.1016/j.cbi.2024.111030. Online ahead of print.ABSTRACTSepsis remains a serious public health issue that needs to be addressed globally. Severe liver injury caused by sepsis increases the risk of death in patients with sepsis. Liensinine (Lie) is one of the primary active components in Plumula nelumbinis and has anti-inflammatory and antioxidant effects. Nevertheless, the effects of Lie on septic liver injury are unclear. This research investigated the protective effect of Lie (10, 20 and 40 mg/kg) on liver damage via intraperitoneal administration of LPS (10 mg/kg) to C57BL/6...
Source: Chemico-Biological Interactions - May 1, 2024 Category: Molecular Biology Authors: Xiao Zhang Silong Yuan Hui Fan Wei Zhang Honggang Zhang Source Type: research
Comparative transcriptomics combined with physiological and functional analysis reveals the regulatory mechanism of rainbow trout (Oncorhynchus mykiss) under acute hypoxia stress
This study highlights the differences in the regulatory mechanism of rainbow trout under different concentrations of hypoxia stress and provides valuable data for further research on the molecular mechanisms of fish adaptation to hypoxic environments.PMID:38691881 | DOI:10.1016/j.ecoenv.2024.116347 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - May 1, 2024 Category: Environmental Health Authors: Shenji Wu Jinqiang Huang Yongjuan Li Lu Zhao Source Type: research
Preparation and characterization of vitamin E microcapsules stabilized by Zein with different polysaccharides
In this study, we used alcohol ether glycoside as an emulsifier to prepare VE microcapsules using the biological macromolecule Zein and various polysaccharides. The resulting nano microcapsules exhibited a spherical structure, stable morphology, uniform size, and a >90% encapsulation efficiency. They also had good thermal stability and slow-release properties. Of these, xanthan gum/Zein-VE microcapsules were superior, with antioxidant properties up to 3.05-fold higher than untreated VE. We successfully developed VE nano microcapsules that meet eco-friendly and sustainable requirements, which may have applications in the...
Source: International Journal of Biological Macromolecules - May 1, 2024 Category: Biochemistry Authors: Yunqin Qi Zhihui Zhang Yukai Wang Zhiyu Wu Ziyu Qin Yuan Zhou Xiuquan Yang Source Type: research
Exogenous of different elicitors: proline and ornithine on Sansevieria trifasciata under particulate matter (PM) and volatile organic compounds (VOC)
This study aims to investigate different elicitors to maintain plant health and improve the use of plants in phytoremediation for PM and VOC pollution. This experiment used Sansevieria trifasciata hort. ex Prain under PM and VOC stress. Exogenous elicitors, such as proline, ornithine, and a commercial product, were applied to the leaf parts before exposure to PM and VOC stress. The initial concentrations of PM1, PM2.5, and PM10 were 300-350, 350-450, and 400-500 µg m-3, respectively, while the VOC concentration was 2.5-3.0 mg m-3. The plant was stressed for 7 days. The result indicated that ornithine 10 mM is vital in imp...
Source: Environmental Science and Pollution Research International - May 1, 2024 Category: Environmental Health Authors: Bayu Hadi Permana Paitip Thiravetyan Chairat Treesubsuntorn Source Type: research
Therapeutic administration of Luteolin protects against Escherichia coli-derived Lipopolysaccharide-triggered Inflammatory Response and Oxidative Injury
Acta Trop. 2024 Apr 29:107236. doi: 10.1016/j.actatropica.2024.107236. Online ahead of print.ABSTRACTEndometritis reduces reproductive effectiveness and leads to significant financial losses in the dairy sector. Luteolin is a natural phyto-flavonoid compound with many biological activities. However, the therapeutic effect of Luteolin against lipopolysaccharides (LPS)-induced endometritis has not yet been explored. A total of eighty female Kunming mice were randomly assigned into four treatment groups (n = 20). Following a successful initiation of the endometritis model by LPS, Luteolin was intraperitoneally administered th...
Source: Acta Tropica - May 1, 2024 Category: Infectious Diseases Authors: Aftab Shaukat Shahid Ali Rajput Mehboob Ali Rizwan Shukat Sana Hanif Mubashar Hassan Dalia Fouad Farid S Ataya Irfan Shaukat Arfan Yousaf Shadab Shaukat Renwei Su Source Type: research
Britanin - a beacon of hope against gastrointestinal tumors?
World J Clin Oncol. 2024 Apr 24;15(4):523-530. doi: 10.5306/wjco.v15.i4.523.ABSTRACTBritanin is a bioactive sesquiterpene lactone known for its potent anti-inflammatory and anti-oxidant properties. It also exhibits significant anti-tumor activity, suppressing tumor growth in vitro and in vivo. The current body of research on Britanin includes thirty papers predominantly related to neoplasms, the majority of which are gastrointestinal tumors that have not been summarized before. To drive academic debate, the present paper reviews the available research on Britanin in gastrointestinal tumors. It also outlines novel research ...
Source: Clinical Colorectal Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Agnieszka Kajdanek Damian Ko łat Lin-Yong Zhao Mateusz Kciuk Zbigniew Pasieka Żaneta Kałuzińska-Kołat Source Type: research
Role of antioxidants in the neurobiology of drug addiction: An update
Biomed Pharmacother. 2024 Apr 30;175:116604. doi: 10.1016/j.biopha.2024.116604. Online ahead of print.ABSTRACTRelationships between protective enzymatic and non-enzymatic pro-antioxidant mechanisms and addictive substances use disorders (SUDs) are analyzed here, based on the results of previous research, as well as on the basis of our current own studies. This review introduces new aspects of comparative analysis of associations of pro-antixidant and neurobiological effects in patients taking psychoactive substances and complements very limited knowledge about relationships with SUDs from different regions, mainly Europe. ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Piotr Kami ński Ma łgorzata Lorek J ędrzej Baszyński Tadeusz Tadrowski Edward Jacek Gorzela ńczyk Julia Feit Halina Tkaczenko Jakub Owoc Alina Wo źniak Natalia Kurhaluk Source Type: research
FGF10 protects against particulate matter-induced lung injury by inhibiting ferroptosis via Nrf2-dependent signaling
Int Immunopharmacol. 2024 Apr 30;134:112165. doi: 10.1016/j.intimp.2024.112165. Online ahead of print.ABSTRACTParticulate matter (PM) is considered the fundamental component of atmospheric pollutants and is associated with the pathogenesis of many respiratory diseases. Fibroblast growth factor 10 (FGF10) mediates mesenchymal-epithelial signaling and has been linked with the repair process of PM-induced lung injury (PMLI). However, the pathogenic mechanism of PMLI and the specific FGF10 protective mechanism against this injury are still undetermined. PM was administered in vivo into murine airways or in vitro to human bronc...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Yao Qian Qiangqiang Shi Wanting Zhou Baiqi He Haibo Xu Bin Liu Wanqi Miao Saverio Bellusci Chengshui Chen Nian Dong Source Type: research
Unlocking renal Restoration: Mesaconine from Aconitum plants restore mitochondrial function to halt cell apoptosis in acute kidney injury
This study explored mesaconine, derived from processed Fuzi, as a promising low-toxicity alternative for AKI treatment. In this study, we assessed the protective effects of mesaconine in gentamicin (GM)-induced NRK-52E cells and AKI rat models in vitro and in vivo, respectively. Mesaconine promotes the proliferation of damaged NRK-52E cells and down-regulates intracellular transforming growth factor β1 (TGF-β1) and kidney injury molecule 1 (KIM-1) to promote renal cell repair. Concurrently, mesaconine restored mitochondrial morphology and permeability transition pores, reversed the decrease in mitochondrial membrane pote...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Yixin Rui Xiumeng Zhang Xinran Min Hongxiao Xie Xiuying Ma Funeng Geng Rong Liu Source Type: research
Mitochondrial antioxidant elamipretide improves learning and memory impairment induced by chronic sleep deprivation in mice
ConclusionTaken together, these results suggest that SS-31 could improve CSD-induced mitochondrial biogenesis dysfunction, inflammatory response, synaptic dysfunction, and cognitive impairment by increasing SIRT1 expression levels. (Source: Brain and Behavior)
Source: Brain and Behavior - May 1, 2024 Category: Neurology Authors: Yue ‐Ming Zhang,
Ya‐Tao Wang,
Ru‐Meng Wei,
Xue‐Yan Li,
Bao‐Ling Luo,
Jing‐Ya Zhang,
Kai‐Xuan Zhang,
Shi‐Kun Fang,
Xue‐Chun Liu,
Gui‐Hai Chen Tags: ORIGINAL ARTICLE Source Type: research
Dietary chamomile flowers extract improved performance and mitigated aflatoxin B1 toxicity in rabbits
In conclusion, dietary Cha could mitigate the oxidative stress of AFB1-induced liver deterioration. (Source: Journal of Animal Physiology and Animal Nutrition)
Source: Journal of Animal Physiology and Animal Nutrition - May 1, 2024 Category: Zoology Authors: Mahmoud Gamal Rashad,
Mahmoud Mohamed Arafa,
Abd Elfattah Ibrahim El ‐Zanaty,
Mohamed El‐Saeed,
Saeed Abdelalim El‐Ashram,
Ebtesam Mohamed Al‑Olayan,
Mostafa Mahmoud Hegazy,
Mohammed Hamdy Farouk Tags: ORIGINAL ARTICLE Source Type: research
Molecules, Vol. 29, Pages 2093: Ultrasonic-Assisted Extraction of Xanthorrhizol from Curcuma xanthorrhiza Roxb. Rhizomes by Natural Deep Eutectic Solvents: Optimization, Antioxidant Activity, and Toxicity Profiles
This study indicates the protective effect of GluLA and GluLA extracts against oxidation-induced DNA damage, which was comparable with those obtained for ethanol extract. In addition, the stability of the xanthorrhizol extract over 90 days was revealed when stored at −20 and 4 °C. The FTIR and NMR spectra confirmed the hydrogen bond formation in GluLA. Our study reported, for the first time, the feasibility of using glucose/lactic acid (1:3, 30% water v/v) for the sustainable extraction of xanthorrhizol. (Source: Molecules)
Source: Molecules - May 1, 2024 Category: Chemistry Authors: Adelina Simamora Kris Herawan Timotius Heri Setiawan Febrina Amelia Saputri Chinthia Rahadi Putri Dewi Aryani Ratih Asmana Ningrum Abdul Mun ’im Tags: Article Source Type: research
Molecules, Vol. 29, Pages 2097: Hemp Seeds (Cannabis sativa L.) as a Valuable Source of Natural Ingredients for Functional Foods & mdash;A Review
Molecules, Vol. 29, Pages 2097: Hemp Seeds (Cannabis sativa L.) as a Valuable Source of Natural Ingredients for Functional Foods—A Review
Molecules doi: 10.3390/molecules29092097
Authors:
Virginia Tănase Apetroaei
Eugenia Mihaela Pricop
Daniela Ionela Istrati
Camelia Vizireanu
Hemp (Cannabis sativa L.) has experienced a significant resurgence in popularity, and global interest in diversifying its use in various industries, including the food industry, is growing. Therefore, due to their exceptional nutritional value, hemp seeds have recently gained increasing interest as a valuable ingredient for o...
Source: Molecules - May 1, 2024 Category: Chemistry Authors: Virginia T ănase Apetroaei Eugenia Mihaela Pricop Daniela Ionela Istrati Camelia Vizireanu Tags: Review Source Type: research
