Association Between Composite Dietary Antioxidant Index and the Risk of Endometriosis-Related Rheumatoid Arthritis in Women of Childbearing Age: A Cross-Sectional Study Based on the National Health and Nutrition Examination Survey Database
(Source: International Journal of Womens Health)
Source: International Journal of Womens Health - April 23, 2024 Category: OBGYN Tags: International Journal of Women's Health Source Type: research
Molecules, Vol. 29, Pages 1922: Correction: Sarwer et al. Green Synthesis and Characterization of Silver Nanoparticles Using Myrsine africana Leaf Extract for Their Antibacterial, Antioxidant and Phytotoxic Activities. Molecules 2022, 27, 7612
rez de la Lastra
The authors wish to make the following corrections to this paper [...] (Source: Molecules)
Source: Molecules - April 23, 2024 Category: Chemistry Authors: Qudsia Sarwer Muhammad Shoaib Amjad Ansar Mehmood Zakia Binish Ghazala Mustafa Atikah Farooq Mirza Faisal Qaseem Fozia Abasi Jos é Manuel Pérez de la Lastra Tags: Correction Source Type: research
Molecules, Vol. 29, Pages 1927: Unraveling the Nephroprotective Potential of Papaverine against Cisplatin Toxicity through Mitigating Oxidative Stress and Inflammation: Insights from In Silico, In Vitro, and In Vivo Investigations
This study investigated whether papaverine could mitigate cisplatin-induced kidney damage while preserving its chemotherapeutic efficacy. Integrative bioinformatics analysis predicted papaverine modulation of the mechanistic pathways related to cisplatin renal toxicity; notably, mitogen-activated protein kinase 1 (MAPK1) signaling. We validated protective effects in normal kidney cells without interfering with cisplatin cytotoxicity on a cancer cell line. Concurrent in vivo administration of papaverine alongside cisplatin in rats prevented elevations in nephrotoxicity markers, including serum creatinine, blood urea nitroge...
Source: Molecules - April 23, 2024 Category: Chemistry Authors: Shimaa A. Abass Abdullah A. Elgazar Sanad S. El-kholy Amal I. El-Refaiy Reem A. Nawaya Mashooq Ahmad Bhat Foad A. Farrag Abdelrahman Hamdi Marwa Balaha Mohammed A. El-Magd Tags: Article Source Type: research
Quercetin in Osteoporosis Treatment: A Comprehensive Review of Its Mechanisms and Therapeutic Potential
AbstractPurpose of ReviewThis review aims to provide a theoretical basis and insights for quercetin ’s clinical application in the prevention and treatment of osteoporosis (OP), analyzing its roles in bone formation promotion, bone resorption inhibition, anti-inflammation, antioxidant effects, and potential mechanisms.Recent FindingsOP, a prevalent bone disorder, is marked by reduced bone mineral density and impaired bone architecture, elevating the risk of fractures in patients. The primary approach to OP management is pharmacotherapy, with quercetin, a phytochemical compound, emerging as a focus of recent interest. Thi...
Source: Current Osteoporosis Reports - April 23, 2024 Category: Orthopaedics Source Type: research
Influence of the secondary ligand, phenanthroline, on the antioxidant and pro-oxidant and cytotoxic effects of the oxidovanadium(IV)/naringin complex
New J. Chem., 2024, Advance Article DOI: 10.1039/D4NJ00655K, PaperAndr és G. Restrepo, Angel L. Huamani, Alexandra Velásquez Bravo, Pablo J. González, Luciana G. Naso, Evelina G. Ferrer, Patricia A. M. Williams Replacement of phen in [VO(Narg)2] induces greater π electronic delocalization, thus improving antioxidant action. However, due to its lipophilic character, cellular uptake of V is increased, leading to enhanced pro-oxidant and anticancer effects. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC...
Source: RSC - New J. Chem. latest articles - April 22, 2024 Category: Chemistry Authors: Andr és G. Restrepo Source Type: research
Serum testosterone levels and oxidative stress in type 1 diabetes, type 2 diabetes, and obesity
CONCLUSIONS: Increased oxidative stress in diabetes may be an important factor that decreases serum testosterone levels.PMID:38646988 | DOI:10.5603/ep.98190 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Hamit Yasar Ellidag Rahime Aslanko ç Mehmet K ök G üzin Aykal Özgür Aydın Özlem Özmen Remzi Can Çakır U ğur Doğan Source Type: research
Alpha-lipoic Acid: An Antioxidant with Anti-Aging Properties for Disease Therapy
Curr Med Chem. 2024 Apr 19. doi: 10.2174/0109298673300496240416114827. Online ahead of print.ABSTRACTThe anti-aging effects of alpha-lipoic acid (αLA), a natural antioxidant synthesized in human tissues, have attracted a growing interest in recent years. αLA is a short- -chain sulfur-containing fatty acid occurring in the mitochondria of all kinds of eukaryotic cells. Both the oxidized disulfide of αLA and its reduced form (dihydrolipoic acid, DHLA) exhibit prominent antioxidant function. The amount of αLA inside the human body gradually decreases with age resulting in various health disorders. Its lack can be compensa...
Source: Atherosclerosis - April 22, 2024 Category: Cardiology Authors: Mariia Shanaida Roman Lysiuk Olha Mykhailenko Nataliia Hudz Abdullateef Abdulsalam Tetiana Gontova Oleksandra Oleshchuk Yana Ivankiv Volodymyr Shanaida Dmytro Lytkin Geir Bj ørklund Source Type: research
Mitochondrial Physiology of Cellular Redox Regulations
Physiol Res. 2024 Apr 22. Online ahead of print.ABSTRACTMitochondria (mt) represent the vital hub of the molecular physiology of the cell, being decision-makers in cell life/death and information signaling, including major redox regulations and redox signaling. Now we review recent advances in understanding mitochondrial redox homeostasis, including superoxide sources and H2O2 consumers, i.e., antioxidant mechanisms, as well as exemplar situations of physiological redox signaling, including the intramitochondrial one and mt-to-cytosol redox signals, which may be classified as acute and long-term signals. This review exempl...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: P Je žek A Dlaskov á H Engstov á J Špačková J Tauber P Pr ůchová E Kloppel O Mozheitova M Jab ůrek Source Type: research
Redox Status as a Key Driver of Healthy Pancreatic Beta-Cells
Physiol Res. 2024 Apr 22. Online ahead of print.ABSTRACTRedox status plays a multifaceted role in the intricate physiology and pathology of pancreatic beta-cells, the pivotal regulators of glucose homeostasis through insulin secretion. They are highly responsive to changes in metabolic cues where reactive oxygen species are part of it, all arising from nutritional intake. These molecules not only serve as crucial signaling intermediates for insulin secretion but also participate in the nuanced heterogeneity observed within the beta-cell population. A central aspect of beta-cell redox biology revolves around the localized p...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: B Holendov á Š Benáková M K řivonosková L Plecit á-Hlavatá Source Type: research
Comparative study of the anti-inflammatory activity of etoricoxib and Matcha green tea against acute kidney injury induced by gamma radiation in rats
CONCLUSIONS: These results contribute to the growing evidence supporting the use of MG in managing IR-induced renal complications. Future studies should focus on elucidating the molecular mechanisms and optimizing the application of MG in clinical settings.PMID:38647648 | DOI:10.1080/09553002.2024.2338515 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - April 22, 2024 Category: Radiology Authors: Sahar Khateeb Eman F S Taha Source Type: research
N-acetylcysteine Protects Against Myocardial Ischemia-Reperfusion Injury Through Anti-ferroptosis in Type 1 Diabetic Mice
Cardiovasc Toxicol. 2024 Apr 22. doi: 10.1007/s12012-024-09852-7. Online ahead of print.ABSTRACTThe hearts of subjects with diabetes are vulnerable to ischemia-reperfusion injury (IRI). In contrast, experimentally rodent hearts have been shown to be more resistant to IRI at the very early stages of diabetes induction than the heart of the non-diabetic control mice, and the mechanism is largely unclear. Ferroptosis has recently been shown to play an important role in myocardial IRI including that in diabetes, while the specific mechanisms are still unclear. Non-diabetic control (NC) and streptozotocin-induced diabetic (DM) ...
Source: Cardiovascular Toxicology - April 22, 2024 Category: Cardiology Authors: Dongcheng Zhou Yuhui Yang Jiajia Chen Jiaqi Zhou Jianfeng He Danyong Liu Anyuan Zhang Bixian Yuan Yuxin Jiang Weiyi Xia Ronghui Han Zhengyuan Xia Source Type: research
Effect of Elamipretide on the Vitrification of Mouse Ovarian Tissue by Freezing
In conclusion, SS-31 improved the cryopreservation of ovarian tissues, and 100 μmol/L SS-31 was found to be the most effective.PMID:38648553 | DOI:10.1089/bio.2023.0078 (Source: Biopreservation and Biobanking)
Source: Biopreservation and Biobanking - April 22, 2024 Category: Biomedical Science Authors: Xingfeng Yao Qingfang Lu Yuyin Wu Juan Liu Niang Liu Xiling Huang Changlong Xu Source Type: research
GSE131040 Maternal antioxidant treatment prevents behavioural and neurological changes in offspring exposed to prenatal social stress [RNA-seq]
Contributors : Hannah Scott ; Thomas J Phillips ; Ying Sze ; Alessio Alfieri ; Mark F Rogers ; Charles P Case ; Paula J BruntonSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusMaternal exposure to social stress during pregnancy is associated with an increased risk of psychiatric disorders in the offspring in later life. How the effects of maternal social stress are transmitted to the developing foetus is unclear. Using a rat model of maternal social stress during pregnancy, we explored the mechanisms by which maternal stress is conveyed to the foetus and the potential for targe...
Source: GEO: Gene Expression Omnibus - April 22, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus Source Type: research
Molecular insights of Eucalyptol (1,8-Cineole) as an anti-arthritic agent: in vivo and in silico analysis of IL-17, IL-10, NF- κB, 5-LOX and COX-2
AbstractThe monoterpene oxide, Eucalyptol (1,8-Cineole), a primary component of eucalyptus oil, has been evaluated pharmacologically for anti-inflammatory and analgesic activity. Current research aimed to evaluate Eucalyptol ’s anti-arthritic potential in a Complete Freund’s adjuvant induced arthritis that resembles human rheumatoid arthritis. Polyarthritis developed after 0.1 mL CFA injection into the left hind footpad in rats. Oral administration of Eucalyptol at various doses (100, 200 and 400 mg/kg) significan tly reduced paw edema, body weight loss, 5-LOX, PGE2 and Anti-CCP levels. Real‐time PCR investigation ...
Source: Inflammopharmacology - April 22, 2024 Category: Drugs & Pharmacology Source Type: research
Secondary metabolic profiling, antioxidant potential, enzyme inhibitory activities and in silico and ADME studies: a multifunctional approach to reveal medicinal and industrial potential of Tanacetum falconeri
Tanacetum falconeri is a significant flowering plant that possesses cytotoxic, insecticidal, antibacterial, and phytotoxic properties. Its chemodiversity and bioactivities, however, have not been thoroughly inves... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - April 22, 2024 Category: Complementary Medicine Authors: Muhammad Imran Tousif, Zaheer Abbas, Mamona Nazir, Muhammad Saleem, Saba Tauseef, Areeba Hassan, Sajid Ali, Maqsood Ahmed, Jallat Khan, Gokhan Zengin, Abeer Hashem, Khalid F. Almutairi, Graciela Dolores Avila-Quezada and Elsayed Fathi Abd-Allah Tags: Research Source Type: research
