Investigation of sperm hsa-mir-145-5p and MLH1 expressions, seminal oxidative stress and sperm DNA fragmentation in varicocele
CONCLUSION: This is the first study investigating the expressions of sperm miR-145 and MLH1 in varicocele patients. Further studies are needed to clarify the potential effect of miR-145 on male fertility.PMID:38683237 | DOI:10.1007/s11033-024-09534-1 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Neslihan Hekim Sezgin Gunes Sercan Ergun Elzem Nisa Barhan Ramazan Asci Source Type: research
Assessing the possible association between MTHFR (rs1801133) and GPx-1 (rs1050450) polymorphisms with the risk of type 2 diabetes, diabetic neuropathy, and diabetic retinopathy
CONCLUSION: The MTHFR TT genotype increased the risk of neuropathy in diabetic patients significantly. The GPx-1 CT genotype is related to increased retinopathy risk among diabetic patients. Both MTHFR and Gpx-1 TT genotypes were associated with higher BMI levels.PMID:38683407 | DOI:10.1007/s11033-024-09519-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Soheila Asadi Zohreh Rahimi Maryam Kohsari Fatemeh Babajani Mohammad Amiri Nazanin Jalilian Rozita Naseri Lida Haghnazari Source Type: research
From swamp to field: how genes from mangroves and its associates can enhance crop salinity tolerance
Mol Biol Rep. 2024 Apr 29;51(1):598. doi: 10.1007/s11033-024-09539-w.ABSTRACTSalinity stress is a critical challenge in crop production and requires innovative strategies to enhance the salt tolerance of plants. Insights from mangrove species, which are renowned for their adaptability to high-salinity environments, provides valuable genetic targets and resources for improving crops. A significant hurdle in salinity stress is the excessive uptake of sodium ions (Na+) by plant roots, causing disruptions in cellular balance, nutrient deficiencies, and hampered growth. Specific ion transporters and channels play crucial roles ...
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Ganesan Govindan Prakash Harini Vinoth Alphonse Madasamy Parani Source Type: research
Silymarin inhibits dermal gelatinolytic activity and reduces cutaneous inflammation
Nat Prod Res. 2024 Apr 29:1-12. doi: 10.1080/14786419.2024.2347452. Online ahead of print.ABSTRACTMilk thistle (Silybum marianum) is well-known for its antioxidant activity due to the presence of silymarin. Albeit some studies show a potential for skin inflammation, its activity against dermal MMP-9 and MMP-2 remains to be studied. Silymarin isolated from an S. marianum herbal extract was tested for gelatinase inhibition in the presence of isolated MMP-9 and in dermal adenocarcinome HaCaT cells. Silymarin was then further tested in vivo, using a cutaneous inflammation mice model mediated by reactive oxygen species. Silymar...
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Joana Mota Catarina Faria-Silva Ana Resendes Maria Isabel Santos Manuela Colla Carvalheiro Ana Lima Sandra Sim ões Source Type: research
Isolation, purification, and biological activities of polysaccharides from < em > Amorpha fruticosa < /em > flowers
Nat Prod Res. 2024 Apr 29:1-8. doi: 10.1080/14786419.2024.2346272. Online ahead of print.ABSTRACTThe extraction, isolation, structural characterisation and biological activities of polysaccharides from Amorpha fruticosa flowers were investigated. First, the crude polysaccharide AFP was extracted, and two major purified polysaccharide fractions AFP-2 and AFP-3 were isolated. The molecular weight and monosaccharide compositions of AFP-2 and AFP-3 were determined. Then the antioxidant activities of AFP, AFP-2 and AFP-3 were assessed by DPPH radical, β-Carotene bleaching and hydroxyl radical assays. All three tested polysacch...
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Yixian Liu Ying Zhao Huiping Chen Weidong Wang Min Zou Source Type: research
Antioxidant and anti ‑inflammatory effects of esculin and esculetin (Review)
Exp Ther Med. 2024 Apr 12;27(6):248. doi: 10.3892/etm.2024.12536. eCollection 2024 Jun.ABSTRACTFraxinus chinensis Roxb is a deciduous tree, which is distributed worldwide and has important medicinal value. In Asia, the bark of Fraxinus chinensis Roxb is a commonly used traditional Chinese medicine called Qinpi. Esculetin is a coumarin compound derived from the bark of Fraxinus chinensis Roxb and its glycoside form is called esculin. The aim of the present study was to systematically review relevant literature on the antioxidant and anti-inflammatory effects of esculetin and esculin. Esculetin and esculin can promote the ex...
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Shaohua Ju Youli Tan Qiang Wang Ling Zhou Kun Wang Chenghong Wen Mingjian Wang Source Type: research
Extraction and antioxidant capacity of mycosporine-like amino acids from red algae in Japan
Biosci Biotechnol Biochem. 2024 Apr 29:zbae051. doi: 10.1093/bbb/zbae051. Online ahead of print.ABSTRACTMycosporine-like amino acids (MAAs) are the natural UV absorbing compounds with antioxidant activity found in microalgae and macroalgae. We collected red algae Asparagopsis taxiformis, Meristotheca japonica, and Polysiphonia senticulosa from Nagasaki, where UV radiation is more intense than in Hokkaido, and investigated the effect of UV radiation on MAAs content. It was suggested that A. taxiformis and M. japonica contained shinorine and palythine, while UV absorbing compound in P. senticulosa could not be identified. Th...
Source: Bioscience, Biotechnology, and Biochemistry - April 29, 2024 Category: Biochemistry Authors: Ryuya Yamamoto Shigeru Toriumi Chikara Kawagoe Wataru Saburi Hideki Kishimura Yuya Kumagai Source Type: research
Genomic prediction of blood biomarkers of metabolic disorders in Holstein cattle using parametric and nonparametric models
CONCLUSIONS: Our results indicate that the Stack approach was more accurate in predicting metabolic disturbances than GBLUP, BayesB, ENET, and GBM and seemed to be competitive for predicting complex phenotypes with various degrees of mode of inheritance, i.e. additive and non-additive effects. Selecting markers based on GBM improved accuracy of GBLUP.PMID:38684971 | PMC:PMC11057143 | DOI:10.1186/s12711-024-00903-9 (Source: Genet Sel Evol)
Source: Genet Sel Evol - April 29, 2024 Category: Genetics & Stem Cells Authors: Lucio F M Mota Diana Giannuzzi Sara Pegolo Enrico Sturaro Daniel Gianola Riccardo Negrini Erminio Trevisi Paolo Ajmone Marsan Alessio Cecchinato Source Type: research
From Antioxidant to Anticancer is Vitamin C Effective in Colorectal Cancer?
Asian Pac J Cancer Prev. 2024 Apr 1;25(4):1107-1108. doi: 10.31557/APJCP.2024.25.4.1107.NO ABSTRACTPMID:38679968 | DOI:10.31557/APJCP.2024.25.4.1107 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Kanza Farhan Muhammad Burhan Tariq Ahmed Saddiq Mansha Mansoor Aliza Ahmed Abdul-Samed Mohammed Source Type: research
Review of the evidence of radioprotective potential of creatine and arginine as dietary supplements
CONCLUSIONS: Creatine possesses significant radioprotective potential including: (1) radioprotective effect on the survival rate of rats subjected to acute whole-body X-ray irradiation in a LD70/30 dose of 6.5 Gy, (2) radioprotective effect on the population composition of peripheral blood cells, (3) radioprotective effect on the DNA damage of peripheral blood mononuclear cells, (4) radioprotective effect on the hepatocyte nucleus-nucleolar apparatus, and (5) radioprotective effect on the brain and liver Cr-Cr kinase systems of the respective animals. Taking into account these cytoprotective, gene-protective, hepatoprotect...
Source: International Journal of Radiation Biology - April 29, 2024 Category: Radiology Authors: Lyudmila Nersesova Mariam Petrosyan Gohar Tsakanova Source Type: research
Pharmacotherapeutic Potential of Bitter Gourd ( < em > Momordica charantia < /em > ) in Age-related Neurological Diseases
J Integr Neurosci. 2024 Apr 23;23(4):86. doi: 10.31083/j.jin2304086.ABSTRACTDue to the growth of the elderly population, age-related neurological disorders are an increasing problem. Aging begins very gradually and later leads to several neurological issues such as lower neurotransmitter levels, oxidative stress, neuronal inflammation, and continual neuronal loss. These changes might contribute to brain disorders such as Alzheimer's disease (AD), dementia or mild cognitive impairment, and epilepsy and glioma, and can also aggravate these disorders if they were previously present. Momordica charantia (bitter gourd), a membe...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Seyed Mohammad Hosein Hosseini Adarmanabadi Orod Jalali Khalil Abadi Amirhossein Amiri Rozhina Tamannaeifar Sahar Balanian Mehdi Rasekhjam Mohammad Sadra Samiazar Sara Hasanpour Samira Peiravi Dorsa Alijanzadeh Mohadeseh Poudineh Hamidreza Amiri Seyed Ami Source Type: research
Using multi-omics to explore the effect of Bacillus velezensis SAAS-63 on resisting nutrient stress in lettuce
This study explored the role of the plant growth-promoting rhizosphere bacteria (PGPR) strain Bacillus velezensis SAAS-63 in improving nutrient stress in lettuce. Compared with no inoculation, B. velezensis SAAS-63 inoculants exhibited significantly increased fresh weight, root length, and shoot height under nutrient deficiency, as well as improved antioxidant activities and proline contents. The exogenous addition of B. velezensis SAAS-63 also significantly increased the accumulation of macroelements and micronutrients in lettuce. To elucidate the resistance mechanisms induced by B. velezensis SAAS-63 under nutrient stres...
Source: Applied Microbiology and Biotechnology - April 29, 2024 Category: Microbiology Authors: Yinshuang Bai Ke Song Mengxiang Gao Juan Ma Yifan Zhou Hua Liu Haijuan Zeng Jinbin Wang Xianqing Zheng Source Type: research
The Potential Role of Phytochemicals of < em > Juniperus procera < /em > in the Treatment of Ovarian Cancer and the Inhibition of Human Topoisomerase II Alpha Activity
Bioinform Biol Insights. 2024 Apr 25;18:11779322241248904. doi: 10.1177/11779322241248904. eCollection 2024.ABSTRACTA variety of active chemicals found in medicinal plants can be used to develop new medications with few adverse effects. In vitro and in silico analyses were used to evaluate the anticancer properties of Juniperus procera fruit and leaf extracts. Here, we show that the methanolic extract from J procera fruit and leaf extracts inhibits 2 human ovarian cancer cell lines, A2780CP and SKOV-3. The leaf extract demonstrated strong cytotoxicity against A2780CP with an IC50 of 1.2 μg/mL, almost matching the IC50 of ...
Source: Bioinformatics and Biology Insights - April 29, 2024 Category: Bioinformatics Authors: Ateeq A Al-Zahrani Source Type: research
From swamp to field: how genes from mangroves and its associates can enhance crop salinity tolerance
Mol Biol Rep. 2024 Apr 29;51(1):598. doi: 10.1007/s11033-024-09539-w.ABSTRACTSalinity stress is a critical challenge in crop production and requires innovative strategies to enhance the salt tolerance of plants. Insights from mangrove species, which are renowned for their adaptability to high-salinity environments, provides valuable genetic targets and resources for improving crops. A significant hurdle in salinity stress is the excessive uptake of sodium ions (Na+) by plant roots, causing disruptions in cellular balance, nutrient deficiencies, and hampered growth. Specific ion transporters and channels play crucial roles ...
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Ganesan Govindan Prakash Harini Vinoth Alphonse Madasamy Parani Source Type: research
Assessing the possible association between MTHFR (rs1801133) and GPx-1 (rs1050450) polymorphisms with the risk of type 2 diabetes, diabetic neuropathy, and diabetic retinopathy
CONCLUSION: The MTHFR TT genotype increased the risk of neuropathy in diabetic patients significantly. The GPx-1 CT genotype is related to increased retinopathy risk among diabetic patients. Both MTHFR and Gpx-1 TT genotypes were associated with higher BMI levels.PMID:38683407 | DOI:10.1007/s11033-024-09519-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Soheila Asadi Zohreh Rahimi Maryam Kohsari Fatemeh Babajani Mohammad Amiri Nazanin Jalilian Rozita Naseri Lida Haghnazari Source Type: research
