Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell
The objectives of this research were investigating the effects of these compounds on the pathogenesis and progress of Alzheimer's disease in cells modeled by formaldehyde. MTT, flow cytometry, and RT-PCR were used to investigate the toxicity, survival rate and apoptosis of the cells, and the expression level of PP2A, GSK3, NMDAR, BACE1, and APP genes, respectively. Also, the total antioxidant capacity of the modeled cells was measured. The results showed that the two compounds as well as the plants extract and essential oil were able to increase the percentage of cell survival; among them, Thymus vulgaris essential oil had...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Saba Foroughi Kahin Shahanipour Ramesh Monajemi Ali Mohammad Ahadi Source Type: research
Albiflorin Inhibits Advanced Glycation End Products-Induced ROS and MMP-1 Expression in Gingival Fibroblasts
CONCLUSION: Albiflorin exhibited protective effects against AGEs-induced oxidative stress and inflammation in gingival fibroblasts, highlighting its potential as a therapeutic agent for periodontitis in diabetic patients. The modulation of the NF-κB and Nrf2 pathways by albiflorin provides insight into its mechanism of action.PMID:38685787 | DOI:10.2174/011574888X302174240420165019 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - April 30, 2024 Category: Stem Cells Authors: Linlin Gao Wenqi Fu Yanyan Liu Lili Fan Shiwei Liu Nan Zhang Source Type: research
Oxidative medicine and cellular longevity the role and mechanism of NCOA4 in ferroptosis induced by intestinal ischemia reperfusion
CONCLUSION: This thesis explored the role of NCOA4 in II/R injury in mice and the mechanism of action. The research results suggest that NCOA4 can mediate ferritinophagy to induce ferroptosis during II/R injury. This experiment reveals the pathological mechanism of II/R injury and provides some scientific basis for the development of drugs for the treatment of II/R injury based on the purpose of alleviating ferroptosis.PMID:38688134 | DOI:10.1016/j.intimp.2024.112155 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 30, 2024 Category: Allergy & Immunology Authors: Kun Li Annan Wang Yunpeng Diao Shuyuan Fan Source Type: research
Phoenix dactylifera L.: An Overview of Phytochemical Constituents and Impact on Women's Health
Chem Biodivers. 2024 Apr 30:e202400456. doi: 10.1002/cbdv.202400456. Online ahead of print.ABSTRACTGenus Phoenix is one of the most common genera in the palm family (Arecaceae) with 17 species distributed around the world. Phoenix spp. have been used for centuries as food and medicine by different cultures. Phoenix dactylifera L. (date palm) is the utmost significant, particularly in the Middle East and Arab World. This review displays the main phytochemical constituents of P. dactylifera and describes its impact on women's health from menarche to menopause, effects on fertility and during certain health conditions. Studie...
Source: Chemistry and Biodiversity - April 30, 2024 Category: Biochemistry Authors: Enaam AbouZeid Ahmed Hassan Afifi Rehab Ali Hussein Abeer Salama Fadia Salah Youssef Sherweit ElAhmady Nagwa Mohamed Ammar Source Type: research
Glutathione peroxidase 4 restrains temporomandibular joint osteoarthritis progression by inhibiting ferroptosis
In conclusion, GPX4 and ferroptosis regulated the progression of TMJOA. Targeting ferroptosis might be an effective therapeutic strategy for TMJOA patients in the clinic.PMID:38686488 | PMC:PMC11058612 | DOI:10.1111/jcmm.18377 (Source: J Cell Mol Med)
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Chunyan Pang Hongmei Zhang Yi Liu Na Tang Kun Tian Yandong Mu Xue Li Li Xiao Source Type: research
Expression of human dCTP pyrophosphatase 1 (DCTPP1) and its association with cisplatin resistance characteristics in ovarian cancer
In this study, we aimed to understand the role of DCTPP1 in cancer progression and cisplatin response. Using publicly available databases, we analysed the expression and clinical significance of DCTPP1 in ovarian cancer. Our bioinformatics analysis confirmed that DCTPP1 is significantly overexpressed in ovarian cancer and is closely associated with tumour progression and poor prognosis after cisplatin treatment. We also found that DCTPP1 located in oxidoreductase complex and may be involved in various biological processes related to cisplatin resistance, including pyrimidine nucleotide metabolism, the P53 signalling pathwa...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Yu Wang Xiangyun Chen Qiduan Chen Tiancai Liu Yingsong Wu Liping Huang Yao Chen Source Type: research
Anti-viral Effects of Pavetta indica Methanolic Extract and Acyclovir on Behavioral and Biochemical Parameters in Streptozotocin-induced Alzheimer's Disease in Rats
CONCLUSION: In a dose-dependent manner, acyclovir and Pavetta indica methanolic extract treatments abrogated the streptozotocin-induced behavioral and neurological abnormalities in rats. The potential therapeutic effects of PIME and acyclovir administration in intracerebroventricular-streptozotocin-treated rats may be attributed to its potential antiviral, antioxidant, and anti-inflammatory effects. The current study suggests that Pavetta indica methanolic extract and acyclovir are promising therapeutic targets against Alzheimer's disease.PMID:38685761 | DOI:10.2174/0118715303273145240110100341 (Source: Endocrine, Metaboli...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Drugs & Pharmacology Authors: Deepak Kumar Govind Singh None Tarun Meenakshi Dhanawat Sumeet Gupta Mohamed A Morsy Anroop B Nair Asmaa I Matouk Source Type: research
Concurrent improvement of rice grain yield and abiotic stress tolerance by overexpression of cytokinin activating enzyme LONELY GUY (OsLOG)
Plant Physiol Biochem. 2024 Apr 16;211:108635. doi: 10.1016/j.plaphy.2024.108635. Online ahead of print.ABSTRACTMeristem activity is important for normal plant growth as well as adaptive plastic development under abiotic stresses. Cytokinin has been recognized to have a major role in regulating meristem function which is controlled by cytokinin activating enzymes by fine-tuning the concentrations and spatial distribution of its bioactive forms. It was previously reported that LONELY GUY (LOG) acts in the direct activation pathway of cytokinin in rice shoot meristems. LOG has a cytokinin specific phosphoribohydrolase activi...
Source: Physiological Research - April 30, 2024 Category: Physiology Authors: Ray Singh Rathore Manjari Mishra Ashwani Pareek Sneh Lata Singla-Pareek Source Type: research
Resveratrol alleviates inorganic arsenic-induced ferroptosis in chicken brain via activation of the Nrf2 signaling pathway
Pestic Biochem Physiol. 2024 May;201:105885. doi: 10.1016/j.pestbp.2024.105885. Epub 2024 Mar 26.ABSTRACTInorganic arsenic (iAs) is a well-recognized environmental pollutant that induces severe brain injury in humans and animals. The antioxidant, anti-inflammatory, and anti-ferroptotic effects of resveratrol (Res) were demonstrated in multiple animal experiments. In order to investigate the protective effect of Res on iAs-induced chicken brain injury, the 40 chickens (19-d-old, female) brain injury model was established by oral administration of iAs (30 mg/L NaAsO2) for 6 weeks. All chickens had free access to both food an...
Source: Physiological Research - April 30, 2024 Category: Physiology Authors: Shan Pang Biqi Han Pengfei Wu Xu Yang Yunfeng Liu Jiayi Li Zhanjun Lv Zhigang Zhang Source Type: research
Pharmacological and Therapeutic Potential of Berbamine: A Potent Alkaloid from Genus Berberis
Curr Top Med Chem. 2024 Apr 29. doi: 10.2174/0115680266289292240420062705. Online ahead of print.ABSTRACTBerbamine (Ber) is an active medicinal bisbenzylisoquinoline alkaloid, which is usually obtained from different plants of the genus Berberis (family Berberidaceae) and is used to cure various disorders in traditional Chinese and Ayurvedic systems of medicine. Numerous in-vitro and in-vivo studies revealed the apoptotic and cytotoxic potential of Ber against different cell lines (SMMC-7721, A549, MDA-MB-231, and K562) by upregulating pro-apoptotic (Bax, p53) and downregulating anti-apoptotic (Bcl-2, survivin) proteins. O...
Source: Current Topics in Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Gulzar Muhammad Muhammad Ajaz Hussain Zahid Shafiq Adnan Ashraf Umer Shafique Ajmal Khan Asaad Khalid Javid Hussain Ahmed Al-Harrasi Source Type: research
Expression of human dCTP pyrophosphatase 1 (DCTPP1) and its association with cisplatin resistance characteristics in ovarian cancer
In this study, we aimed to understand the role of DCTPP1 in cancer progression and cisplatin response. Using publicly available databases, we analysed the expression and clinical significance of DCTPP1 in ovarian cancer. Our bioinformatics analysis confirmed that DCTPP1 is significantly overexpressed in ovarian cancer and is closely associated with tumour progression and poor prognosis after cisplatin treatment. We also found that DCTPP1 located in oxidoreductase complex and may be involved in various biological processes related to cisplatin resistance, including pyrimidine nucleotide metabolism, the P53 signalling pathwa...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Yu Wang Xiangyun Chen Qiduan Chen Tiancai Liu Yingsong Wu Liping Huang Yao Chen Source Type: research
Glutathione peroxidase 4 restrains temporomandibular joint osteoarthritis progression by inhibiting ferroptosis
In conclusion, GPX4 and ferroptosis regulated the progression of TMJOA. Targeting ferroptosis might be an effective therapeutic strategy for TMJOA patients in the clinic.PMID:38686488 | PMC:PMC11058612 | DOI:10.1111/jcmm.18377 (Source: Molecular Medicine)
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Chunyan Pang Hongmei Zhang Yi Liu Na Tang Kun Tian Yandong Mu Xue Li Li Xiao Source Type: research
Cyanidin-3-O-glucoside protects Zearalenone-induced in vitro maturation disorders of porcine oocytes by alleviating NOX4-dependent oxidative stress and endoplasmic reticulum stress in cumulus cells
In conclusion, C3G promoted in vitro maturation of porcine oocytes exposed to ZEN via mitigating NOX4-dependent oxidative stress and ERS in cumulus cells. These results contribute to our comprehension of the molecular mechanisms underlying the protective effects of C3G against ZEN toxicity in porcine oocytes, and they provide a novel theoretical foundation and strategy for future applications of C3G in the improvement of female reproduction.PMID:38688352 | DOI:10.1016/j.chemosphere.2024.142153 (Source: Chemosphere)
Source: Chemosphere - April 30, 2024 Category: Chemistry Authors: Xiuxiu Li Yu Tian Ning Zuo Jiatian Tang Shunfeng Cheng Lan Li Jinghe Tan Jianxin Zhang Wei Shen Source Type: research
Expression of Concern: Investigation of antibacterial, antifungal, antibiofilm, antioxidant and anticancer properties of methanol extracts of Salvia marashica İlçim, Celep & amp; Do ğan and Salvia caespitosa Montbret & amp; Aucher ex Benth plants with medicinal importance
Chemosphere. 2024 May;356:141989. doi: 10.1016/j.chemosphere.2024.141989. Epub 2024 Apr 11.NO ABSTRACTPMID:38685632 | DOI:10.1016/j.chemosphere.2024.141989 (Source: Chemosphere)
Source: Chemosphere - April 30, 2024 Category: Chemistry Source Type: research
Comprehensive physiology and proteomics analysis revealed the molecular toxicological mechanism of Se stress on indica and japonica rice
This study aimed to elucidate the physiological and proteomic molecular responses to Se stress in Oryza sativa. The results showed that under selenium stress, enzymatic activities of catalase, peroxidase, and superoxide dismutase in indica rice decreased by 61%, 28%, and 68%, respectively. The contents of non-enzymatic antioxidant substances ascorbic acid, glutathione, cysteine, proline, anthocyanidin, and flavonoids were decreased by 13%, 39%, 46%, 32%, 20%, and 5%, respectively, which significantly inhibited the antioxidant stress process of plants. At the same time, the results of proteomics analysis showed that rice se...
Source: Chemosphere - April 30, 2024 Category: Chemistry Authors: Sixi Zhu Suxia Sun Wei Zhao Xiuqin Yang Huan Mao Luying Sheng Source Type: research
