Antioxidant and Antimicrobial Potential of Peptide from Rabbit Meat Hydrolysate Prepared by Trypsin and Zingibain
Conclusion:</b> The combination zingibain enzyme and trypsin is feasible for hydrolyzing rabbit meat and the optimum hydrolysis time was 24 hrs with IC<sub>50</sub> 52.45 ppm, although accompanied by reduction in antibacterial activities.PMID:38686737 | DOI:10.3923/pjbs.2024.152.159 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - April 30, 2024 Category: Biomedical Science Authors: Eka Wulandari Wendry Setiyadi Putranto Andry Pratama Jajang Gumilar Rani Maharani Source Type: research
Antioxidant and Antibacterial Properties of 1,3-Dihydroxy-,2', 2'-Dimethylpyrano-(5,6)-Xanthone from < em > Streptomyces < /em > sp. SU84
Conclusion:</b> The findings suggested that compounds of <i>Streptomyces</i> sp. SU84 displayed antibacterial and antioxidant properties without cytotoxic activity. Extensive studies of compound <b>1</b> may be useful for the advancement of improved methods for avoidance, control and management of bacterial infections and metabolic-related free radical contribution.PMID:38686735 | DOI:10.3923/pjbs.2024.132.141 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - April 30, 2024 Category: Biomedical Science Authors: Thongchai Taechowisan Thanaporn Chuen-Im Waya S Phutdhawong Source Type: research
Evaluation of Melatonin and its Nanostructures Effects on Skin Disorders Focused on Wound Healing
Mini Rev Med Chem. 2024 Apr 29. doi: 10.2174/0113895575299255240422055203. Online ahead of print.ABSTRACTSkin is the largest organ of the human body functioning as a great primitive defensive barrier against different harmful environmental factors. However, it is damaged through varying injuries such as different wounds, burns, and skin cancers that cause disruption in internal organs and essential mechanisms of the body through inflammation, oxidation, coagulation problems, infection, etc. Melatonin is the major hormone of the pineal gland that is also effective in skin disorders due to strong antioxidant and anti-inflamm...
Source: Mini Reviews in Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Seyedeh Mohaddeseh Mousavi Leila Etemad Davood Yari Maryam Hashemi Zahra Salmasi Source Type: research
Fermentation-inspired macroporous and tough gelatin/sodium alginate hydrogel for accelerated infected wound healing
Int J Biol Macromol. 2024 Apr 28:131905. doi: 10.1016/j.ijbiomac.2024.131905. Online ahead of print.ABSTRACTGelatin and sodium alginate (SA) are two important biological macromolecules, exhibiting excellent biocompatibility and gel-forming ability. However, traditional SA and gelatin hydrogel displays limited mass transport, low porosity, instability, and poor mechanical properties extremely restricted their therapeutic effect and application scenarios. Herein, microbial fermentation and synergistic toughening strategies were used for preparing macroporous and tough hydrogel. The study investigated the fermentation and tou...
Source: International Journal of Biological Macromolecules - April 30, 2024 Category: Biochemistry Authors: Jing Cheng Rixuan Wang Yanyu Hu Mengxuan Li Lijun You Shaoyun Wang Source Type: research
Curdlan-polyphenol complexes prepared by pH-driven effectively enhanced their physicochemical stability, antioxidant and prebiotic activities
In conclusion, the curdlan-polyphenol complexes prepared by an alcohol-free pH-driven method could effectively enhance the gastrointestinal stability of polyphenols as well as increase the antioxidant and prebiotic activities of curdlan, which could be applied as a functional ingredient to improve gut health.PMID:38688789 | DOI:10.1016/j.ijbiomac.2024.131579 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 30, 2024 Category: Biochemistry Authors: Huan Li Saiqing Xu Ying Xie Qun Zhang Shenghua Ding Rongrong Wang Fuhua Fu Xiaobei Zhan Source Type: research
Effects of priming glycosyltransferase genes cps 2E and cps 4E on the exopolysaccharide biosynthesis by Lactiplantibacillus plantarum YM-4-3 strain
In conclusion, this study contributes to the efficient production and application of L. plantarum EPS and helps to understand the mechanism of EPS regulation in L. plantarum.PMID:38685537 | DOI:10.1016/j.ijbiomac.2024.131813 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 30, 2024 Category: Biochemistry Authors: Tian Wang Yong-Gang Xiong Tian-Zhao Si Jin-Ping Yan Xiao-Ran Li Chen-Jian Liu En Yang Source Type: research
Cyanidin-3-O-glucoside protects Zearalenone-induced in vitro maturation disorders of porcine oocytes by alleviating NOX4-dependent oxidative stress and endoplasmic reticulum stress in cumulus cells
In conclusion, C3G promoted in vitro maturation of porcine oocytes exposed to ZEN via mitigating NOX4-dependent oxidative stress and ERS in cumulus cells. These results contribute to our comprehension of the molecular mechanisms underlying the protective effects of C3G against ZEN toxicity in porcine oocytes, and they provide a novel theoretical foundation and strategy for future applications of C3G in the improvement of female reproduction.PMID:38688352 | DOI:10.1016/j.chemosphere.2024.142153 (Source: Chemosphere)
Source: Chemosphere - April 30, 2024 Category: Chemistry Authors: Xiuxiu Li Yu Tian Ning Zuo Jiatian Tang Shunfeng Cheng Lan Li Jinghe Tan Jianxin Zhang Wei Shen Source Type: research
Comprehensive physiology and proteomics analysis revealed the molecular toxicological mechanism of Se stress on indica and japonica rice
This study aimed to elucidate the physiological and proteomic molecular responses to Se stress in Oryza sativa. The results showed that under selenium stress, enzymatic activities of catalase, peroxidase, and superoxide dismutase in indica rice decreased by 61%, 28%, and 68%, respectively. The contents of non-enzymatic antioxidant substances ascorbic acid, glutathione, cysteine, proline, anthocyanidin, and flavonoids were decreased by 13%, 39%, 46%, 32%, 20%, and 5%, respectively, which significantly inhibited the antioxidant stress process of plants. At the same time, the results of proteomics analysis showed that rice se...
Source: Chemosphere - April 30, 2024 Category: Chemistry Authors: Sixi Zhu Suxia Sun Wei Zhao Xiuqin Yang Huan Mao Luying Sheng Source Type: research
Expression of Concern: Investigation of antibacterial, antifungal, antibiofilm, antioxidant and anticancer properties of methanol extracts of Salvia marashica İlçim, Celep & amp; Do ğan and Salvia caespitosa Montbret & amp; Aucher ex Benth plants with medicinal importance
Chemosphere. 2024 May;356:141989. doi: 10.1016/j.chemosphere.2024.141989. Epub 2024 Apr 11.NO ABSTRACTPMID:38685632 | DOI:10.1016/j.chemosphere.2024.141989 (Source: Chemosphere)
Source: Chemosphere - April 30, 2024 Category: Chemistry Source Type: research
Melatonin prevents pulmonary fibrosis caused by PM < sub > 2.5 < /sub > exposure by targeting epithelial-mesenchymal transition
Toxicol Appl Pharmacol. 2024 Apr 28:116949. doi: 10.1016/j.taap.2024.116949. Online ahead of print.ABSTRACTPulmonary fibrosis is a lung disorder characterized by the accumulation of abnormal extracellular matrix, scar tissue formation, and tissue stiffness. Type II alveolar epithelial cells (AEII) play a critical role in repairing lung tissue after injury, and repeated injury to these cells is a key factor in the development of pulmonary fibrosis. Chronic exposure to PM2.5, a type of air pollution, has been shown to increase the incidence and severity of pulmonary fibrosis by enhancing the activation of EMT in lung epithel...
Source: Toxicology and Applied Pharmacology - April 30, 2024 Category: Toxicology Authors: Po-Chun Chen Ming-Hong Yen Sheng-Yen Hsiao Wan-Chen Kao Mei-Ting Wang Pei-Chen Chiou Chia-Chia Chao Source Type: research
Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell
The objectives of this research were investigating the effects of these compounds on the pathogenesis and progress of Alzheimer's disease in cells modeled by formaldehyde. MTT, flow cytometry, and RT-PCR were used to investigate the toxicity, survival rate and apoptosis of the cells, and the expression level of PP2A, GSK3, NMDAR, BACE1, and APP genes, respectively. Also, the total antioxidant capacity of the modeled cells was measured. The results showed that the two compounds as well as the plants extract and essential oil were able to increase the percentage of cell survival; among them, Thymus vulgaris essential oil had...
Source: Brain Research - April 30, 2024 Category: Neurology Authors: Saba Foroughi Kahin Shahanipour Ramesh Monajemi Ali Mohammad Ahadi Source Type: research
Nrf2 expression, mitochondrial fission, and neuronal apoptosis in the prefrontal cortex of methamphetamine abusers and rats
Brain Res. 2024 Apr 27:148973. doi: 10.1016/j.brainres.2024.148973. Online ahead of print.ABSTRACTMethamphetamine (MA), a representative amphetamine-type stimulant, is one of the most abused drugs worldwide. Studies have shown that MA-induced neurotoxicity is strongly associated with oxidative stress and apoptosis. While nuclear factor E2-related factor 2 (Nrf2), an antioxidant transcription factor, is known to exert neuroprotective effects, its role in MA-induced dopaminergic neuronal apoptosis remains incompletely understood. In the present study, we explored the effects of MA on the expression levels of Nrf2, dynamin-re...
Source: Brain Research - April 30, 2024 Category: Neurology Authors: Qian-Yun Nie Gen-Meng Yang Peng Zhang Wen-Juan Dong Di Jing Zhen-Ping Hou Yan-Xia Peng Yang Yu Li-Hua Li Shi-Jun Hong Source Type: research
Anti-viral Effects of Pavetta indica Methanolic Extract and Acyclovir on Behavioral and Biochemical Parameters in Streptozotocin-induced Alzheimer's Disease in Rats
CONCLUSION: In a dose-dependent manner, acyclovir and Pavetta indica methanolic extract treatments abrogated the streptozotocin-induced behavioral and neurological abnormalities in rats. The potential therapeutic effects of PIME and acyclovir administration in intracerebroventricular-streptozotocin-treated rats may be attributed to its potential antiviral, antioxidant, and anti-inflammatory effects. The current study suggests that Pavetta indica methanolic extract and acyclovir are promising therapeutic targets against Alzheimer's disease.PMID:38685761 | DOI:10.2174/0118715303273145240110100341 (Source: Endocrine, Metaboli...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Endocrinology Authors: Deepak Kumar Govind Singh None Tarun Meenakshi Dhanawat Sumeet Gupta Mohamed A Morsy Anroop B Nair Asmaa I Matouk Source Type: research
Anti-viral Effects of Pavetta indica Methanolic Extract and Acyclovir on Behavioral and Biochemical Parameters in Streptozotocin-induced Alzheimer's Disease in Rats
CONCLUSION: In a dose-dependent manner, acyclovir and Pavetta indica methanolic extract treatments abrogated the streptozotocin-induced behavioral and neurological abnormalities in rats. The potential therapeutic effects of PIME and acyclovir administration in intracerebroventricular-streptozotocin-treated rats may be attributed to its potential antiviral, antioxidant, and anti-inflammatory effects. The current study suggests that Pavetta indica methanolic extract and acyclovir are promising therapeutic targets against Alzheimer's disease.PMID:38685761 | DOI:10.2174/0118715303273145240110100341 (Source: Herpes)
Source: Herpes - April 30, 2024 Category: Infectious Diseases Authors: Deepak Kumar Govind Singh None Tarun Meenakshi Dhanawat Sumeet Gupta Mohamed A Morsy Anroop B Nair Asmaa I Matouk Source Type: research
Protective effects of gallic acid against nickel-induced kidney injury: impact of antioxidants and transcription factor on the incidence of nephrotoxicity
This study investigated the mechanism by which gallic acid (GA) protects mice kidneys against renal damage induced by Nickel oxide nanoparticles (NiO-NPs). Forty male Swiss albino mice were randomly assigned into four groups, each consisting of ten mice (n = 10/group): Group I the control group, received no treatment; Group II, the GA group, was administrated GA at a dosage of 110 mg/kg/day body weight; Group III, the NiO-NPs group, received injection of NiO-NPs at a concentration of 20 mg/kg body weight for 10 consecutive days; Group IV, the GA + NiO-NPs group, underwent treatment with both GA and NiO-NPs. The results sho...
Source: Renal Failure - April 30, 2024 Category: Urology & Nephrology Authors: Areej I Alhazmi Mohamed F El-Refaei Eman A A Abdallah Source Type: research
