Phloridzin's Diabetic Wound Healing Potential through DPP-4 Enzyme Inhibition: A Review Article
This study offers new research directions for examining phloridzin's capacity to withstand oxidative stress, as well as for redefining its tactical function as a powerful DPP-4 inhibitor to regulate the process involved in the healing of diabetic wounds.PMID:38676506 | DOI:10.2174/0115733998291941240416053855 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - April 27, 2024 Category: Endocrinology Authors: Khushi Sharma Vadivelan Ramachandran Ashutosh Sharma Tharani Mohanasundaram Harshini Mageshkumar Source Type: research
Olmutinib Reverses Thioacetamide-Induced Cell Cycle Gene Alterations in Mice Liver and Kidney Tissues, While Wheat Germ Treatment Exhibits Limited Efficacy at Gene Level
Conclusions: It was predicted that the increased expression of the MKi67 gene by TAA leads to the increase in TP53, which negatively regulates the cell cycle via increased CDKN3 expression in kidneys and the restoration of TP53 levels in the liver. These findings contribute to our understanding of the effects of olmutinib and WGO on TAA-induced gene expression changes and highlight their contrasting effects based on cell cycle alterations.PMID:38674285 | PMC:PMC11052166 | DOI:10.3390/medicina60040639 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Seema Zargar Tanveer A Wani Salman Alamery Fatimah Yaseen Source Type: research
Ethnobotanical Significance, Phytopharmacology, and Toxicological Profile of Limonia acidissima L. (Rutaceae): A Review
Comb Chem High Throughput Screen. 2024 Apr 25. doi: 10.2174/0113862073285538240417051928. Online ahead of print.ABSTRACTMedicinal plants play a crucial role in traditional medicine, where they are extensively employed by traditional physicians for treating a wide array of ailments. Limonia acidissima (Linn), commonly known as the Wood apple and belonging to the Rutaceae family, is widely cultivated in countries, such as Pakistan, India, and Sri Lanka. The various parts of Limonia acidissima, including its roots, leaves, fruits, stem, and even the whole plant, have been traditionally used in the treatment of numerous condit...
Source: Combinatorial Chemistry and High Throughput Screening - April 27, 2024 Category: Chemistry Authors: Satyajit Mohanty Ashok Pattnaik Source Type: research
Uncovering the Role of Anmeidan against Atherosclerosis from Integrated Network Pharmacology and Pharmacological Experiments
CONCLUSIONS: This study confirmed that AMD could treat AS by regulating lipid metabolism and preliminarily explored the related mechanism. These findings provide new ideas for the treatment of AS with TCM.PMID:38676497 | DOI:10.2174/0113862073281925240417062009 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 27, 2024 Category: Chemistry Authors: Yuting Zheng Jianxiang Wang Chengcheng Pan Jihong Song Xingyue Li Wenjing Ta Wen Lu Source Type: research
Synthesis, Molecular Docking Studies and Biological Evaluation of Thiazolyl Hydrazone Derivatives of Chromone-3-carbaldehyde as Potent Anti-Oxidant and Anti-Inflammatory Agents
CONCLUSION: Thus, these compounds represent an attractive template for the evaluation of new antiinflammatory and antioxidant agents and might be useful for exploring new therapeutic tools.PMID:38676527 | DOI:10.2174/0115734064293848240408085039 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - April 27, 2024 Category: Chemistry Authors: Rakhi Gawali Raghunath Bhosale Rohit Bavi Shravan Jadhav Nargisbano Peerzade Source Type: research
