Prevalence of the Effects of Anxiety and Depression on People with Type 2 Diabetes Mellitus: An Analysis of Health Policy Studies in Improving the Quality of Life of Poor Families in the Urban Areas of West Lombok, Indonesia.
CONCLUSIONS: The lack of access to health for chronic patients with poor economic conditions who live far from the hospitals and the scarcity of medical staff to carry out socialization and treatment of chronic diseases such as diabetes for poor patients in urban areas certainly have an impact on the high number of patients of chronic diseases. Therefore, the government is expected to be able to provide easy health policies to remote rural communities in order to achieve optimal community welfare and health. PMID: 32744488 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - August 2, 2020 Category: Endocrinology Authors: Nasirin C, Lionardo A Tags: Curr Diabetes Rev Source Type: research

X-Ray Versus Magnetic Resonance Imaging in Diabetic Foot Osteomyelitis: A Clinical Comparison.
CONCLUSIONS: According to our clinical pathway, DFO episodes with positive MRI findings only did not differ epidemiologically and did not influence the choice of therapy nor remission rate. PMID: 32729421 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - July 29, 2020 Category: Endocrinology Authors: Gariani K, Lebowitz D, Kressmann B, Gariani J, Uçkay I Tags: Curr Diabetes Rev Source Type: research

Correlation of Waist to Calf Circumference Ratio and Carotid Intima Media Thickness in Diabetes Mellitus.
DISCUSSION: In our study with 150 population 25 patients had carotid atherosclerosis and 20 patients had CIMT>1.1. The waist circumference in patients with CA is in the range of 93.07 and 99.85 & the CC in patients with CA is in the range of 29.49 to 31.25. The WCR in patients with CA is in the range of 3.12 to 3.26. The difference was statistically significant with a p value of
Source: Current Diabetes Reviews - July 29, 2020 Category: Endocrinology Authors: Rao HA, Harischandra P, Yadav S Tags: Curr Diabetes Rev Source Type: research

High-dose Cholecalciferol Supplementation Reducing Morning Blood Pressure in Normotensive DM1 Patients.
DISCUSSION: We found an expressive reduction of systolic and diastolic morning blood pressures (117±14 vs 112±14, p
Source: Current Diabetes Reviews - July 29, 2020 Category: Endocrinology Authors: de Queiroz NNM, de Melo FTC, Resende FS, Janaú LC, de Souza Neto NJK, de Lemos MN, de Oliveira MCNI, de Alcântara AL, de Moraes LV, Mota Queiroz AD, de Souza ÍJA, Said NM, Dos Santos MC, D'Albuquerque Silva LS, Motta ARB, Dos Reis MSO, Lobato IJC, de F Tags: Curr Diabetes Rev Source Type: research

The Influence of Gender and Menopausal Status on Hba1c Variation in a Big Data Study of a Saudi Population.
This study aims to assess the impact of age and gender on HbA1c levels, and the influence of menopausal status on HbA1c variation in a large group of Saudis. METHOD: Age, gender, and HbA1c results of 168,614 Saudi adult individuals were obtained from their medical records. Patients' records were extracted irrespective of their status regarding presence of diabetes and status of glycaemic control. Linear regression models were used for predicting HbA1c from age and gender, and their interaction term. HbA1c levels were compared between genders in different age groups and different HbA1c categories. RESULTS AND DISC...
Source: Current Diabetes Reviews - July 29, 2020 Category: Endocrinology Authors: Alghamdi AS, Alqadi A, Jenkins RO, Haris PI Tags: Curr Diabetes Rev Source Type: research

Melatonin and its relationships with diabetes and obesity: a literature review.
ex AK Abstract SIGNIFICANCE: Obesity is a multifactorial disease with many risks to public health, affecting 39.6% of American adults and 18.5% of young people. Brazil ranks fifth in the world ranking, with about 18 million obese people. It is estimated that 415 million people live with diabetes in the world, which is roughly 1 in 11 of the world's adult population. This is expected to rise to 642 million people living with diabetes worldwide by 2040. In this scenario, Melatonin has evidenced an important function in the regulation of energy metabolism. OBJECTIVE: to carry out a broad narrative review of the ...
Source: Current Diabetes Reviews - July 26, 2020 Category: Endocrinology Authors: Ramirez AVG, Filho DR, de Sá LBPC, Arbex AK Tags: Curr Diabetes Rev Source Type: research

Health Information Technology and Diabetes Management: A Review of Motivational and Inhibitory Factors.
CONCLUSION: Identifying motivational and inhibitory factors can help to make better use of technology for diabetes management. This approach, in turn, can improve the acceptability of the technology and saves cost, reduces long-term complications of diabetes, and improves quality of life in diabetic patients. PMID: 32682380 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - July 18, 2020 Category: Endocrinology Authors: Dehnavi Z, Ayatollahi H, Hemmet M, Abbasi R Tags: Curr Diabetes Rev Source Type: research

A Comparative assessment of Metabolic Syndrome and its association with Vitamin D and other risk factors in Type 2 Diabetes Mellitus Patients.
CONCLUSION: the study revealed high prevalence rate of metabolic syndrome among type 2 diabetic patients, which was highest 87.3% according to IDF and lowest was observed in WHO criteria 48.1%. A significant variance in the prevalence of metabolic syndrome was reported between WHO, IDF and NCEP criteria. PMID: 32674733 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - July 16, 2020 Category: Endocrinology Authors: Jairoun AA, Shahwan MJ, Khattab MH Tags: Curr Diabetes Rev Source Type: research

Gender difference in the risk of adverse outcomes after diabetic foot disease: A mini review.
Abstract Diabetic foot disease (DFD) is a complication of diabetes mellitus, characterized by multiple pathogenetic factors and bearing a very high burden of disability as well as of direct and indirect costs for individuals or healthcare systems. A further characteristic of DFD is that it is associated with a marked risk of subsequent hospitalizations for incident cardiovascular events, chronic renal failure or of all-cause mortality. Additionally, DFD is strongly linked to the male sex, being much more prevalent among men. However, even if DFD mainly affects males, several past reports suggest that females are d...
Source: Current Diabetes Reviews - July 16, 2020 Category: Endocrinology Authors: Seghieri G, De Bellis A, Seghieri M, Gualdani E, Policardo L, Franconi F, Francesconi P Tags: Curr Diabetes Rev Source Type: research

Stem Cells: A Golden Therapy for Diabetic Wound.
Abstract Diabetes mellitus is the 7 th leading cause of death worldwide. Diabetes can affect the organ systems and lead to serious complication, majorly categorized as macrovascular complications, microvascular complications, and diabetic wound. Foot ulcer develops in 15-25% diabetic patient. In diabetic wound there is impairment in growth factor, neuropeptide, matrix metalloproteinases, angiogenesis, immune system. Many approaches are being experimented to manage this major complication of diabetic foot, but unfortunately with lesser success rate. Stem cell is an upcoming field which is being explored in the worl...
Source: Current Diabetes Reviews - July 16, 2020 Category: Endocrinology Authors: Buchade S, Desai S, Bhonde R, Kazi H, Sainani S, Rode K Tags: Curr Diabetes Rev Source Type: research

Mucoadhesive microspheres: An Emerging trends in therapy of diabetes mellitus.
CONCLUSION: In short, mucoadhsevie microspheres are a novel approach to overcome the disavadantages associated with the antidiabetic drugs. PMID: 32674736 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - July 16, 2020 Category: Endocrinology Authors: Singh D, Choudhary D Tags: Curr Diabetes Rev Source Type: research

Glycemic Variability, Oxidative Stress and Impact on Complications Related to Type 2 Diabetes Mellitus.
Abstract Chronic hyperglycemia is an established risk factor for the development of complications in both type 1 and type 2 diabetes, but glycemic variability has emerged as a possible independent risk factor for diabetes complications, possibly throughout oxidative stress. In this review we discuss methods to access glycemic variability and oxidative stress, as well as their correlations. We also debate non-pharmacological and pharmacological strategies to achieve a better glycemic control, not only by HbA1c target, but also with reduced glycemic fluctuations, possibly minimizing the risk of diabetes complication...
Source: Current Diabetes Reviews - July 16, 2020 Category: Endocrinology Authors: Valente T, Arbex AK Tags: Curr Diabetes Rev Source Type: research

Deranged fractional excretion of magnesium and serum magnesium levels in relation to retrograde glycaemic regulation in patients with type 2 diabetes mellitus.
CONCLUSION: In this study, hypomagnesemia was a parameter strongly associated with the diagnosis and progression of T2DM, while FEMg showed no significant association. PMID: 32664840 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - July 14, 2020 Category: Endocrinology Authors: Esmeralda CAC, Ibrahim SNA, David PE, Maldonado IC, David AS, Escorza MAQ, Dealmy DG Tags: Curr Diabetes Rev Source Type: research

GATA-3 as a potential therapeutic target for insulin resistance and type 2 diabetes mellitus.
CONCLUSION: This review discusses evidence supporting the inhibition of GATA-3 as a useful therapeutic strategy in obesity-associated insulin resistance and type 2 diabetes, through up-regulation adipogenesis and amelioration of the immune response. PMID: 32628587 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - July 5, 2020 Category: Endocrinology Authors: Al-Jaber H, Al-Mansoori L, Elrayess MA Tags: Curr Diabetes Rev Source Type: research

Prevalence and Factors Associated with Lower Limb Amputation in Patients Hospitalized for Diabetic Foot: a Cross-sectional Study.
CONCLUSION: Controlling these factors would allow better management of diabetes to avoid complications. PMID: 32628588 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - July 5, 2020 Category: Endocrinology Authors: Ndong A, Tendeng JN, Diao ML, Dia DG, Dia AD, Ba A, Diallo AC, Dia DA, Ngouamba BM, Ma Nyemb PM, Konaté I Tags: Curr Diabetes Rev Source Type: research

Effects of Antidiabetic Drugs on Muscle Mass in Type 2 Diabetes Mellitus.
CONCLUSION: Although semaglutide, dapaglifrozin, and canagliflozin have a large weight loss effect, it is important to pay attention to muscle loss because a decrease in FFM was observed. PMID: 32628589 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - July 5, 2020 Category: Endocrinology Authors: Ida S, Kaneko R, Imataka K, Okubo K, Shirakura Y, Azuma K, Fujiwara R, Murata K Tags: Curr Diabetes Rev Source Type: research

Design and Development of Key Chain Held Insulin injectable device.
CONCLUSIONS: A keychain held insulin administration device was successfully developed in this research. Patients could use this device to administer insulin everywhere to ensure timely dosage. Patients are able to carry it along and develop compliant behavior towards insulin usage. Its geometric as well as performance specifications were developed on the basis of syringes and typical insulin pens available in market. Final design fulfilled all the requirements provided by market held devices besides being half the geometric size of regular pens. It uses insulin tubes which can be discarded and device can be used again and ...
Source: Current Diabetes Reviews - July 3, 2020 Category: Endocrinology Authors: Manarvi IA, Matta NM Tags: Curr Diabetes Rev Source Type: research

Wound With Diabetes: Present Scenario And Future.
The objective of this review is to understand the potential of various management options which are available for diabetic wound, with a special focus on biological cells. PMID: 32619172 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - July 3, 2020 Category: Endocrinology Authors: Pawar KB, Desai S, Bhonde RR, Bhole RP, Deshmukh AA Tags: Curr Diabetes Rev Source Type: research

Quality Evaluation of English Mobile Applications for Gestational Diabetes: App Review using Mobile Application Rating Scale (MARS).
CONCLUSION: Findings revealed that apps designed for GDM are small in number and poor in quality based on MARS tools. Therefore, considering pregnant women's need for using the capabilities of these apps in pregnancy management and promoting community-based care, it seems essential to develop and design a series of high-quality apps in all four specified categories (only giving comments, obtaining data and giving comments, diagnosis of GDM, and diet calculator). PMID: 32619173 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - July 3, 2020 Category: Endocrinology Authors: Kalhori SRN, Hemmat M, Noori T, Heydarian S, Katigari MR Tags: Curr Diabetes Rev Source Type: research

Pathophysiological Mechanisms Underlying Excess Risk for Diabetes and Cardiovascular Disease in South Asians: The Perfect Storm.
CONCLUSION: In this comprehensive review, we have discussed risk factors that provide insights into the pathophysiology of excess risk of T2D and CVD in South Asians. PMID: 32619174 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - July 3, 2020 Category: Endocrinology Authors: Mehta A, Singh S, Saeed A, Mahtta D, Bittner VA, Sperling LS, Virani SS Tags: Curr Diabetes Rev Source Type: research

A systematic review and meta-analysis on efficacy of exercise on posture and balance in patients suffering from Diabetic Neuropathy.
Abstract BACKGROUND: Peripheral neuropathy is a major and chronic complication of diabetes mellitus affecting more than 50% of patients suffering from diabetes. There is involvement of both large and small diameter nerve fibres leading to altered somatosensory and motor sensations, thereby causing impaired balance and postural instability. OBJECTIVE: To assess the effects of exercises on posture and balance in patients suffering from diabetes mellitus. METHOD: Mean changes in Timed Up and Go test(TUGT), Berg Balance Scale and Postural Sway with eyes open and eyes closed on Balance System were primary out...
Source: Current Diabetes Reviews - July 3, 2020 Category: Endocrinology Authors: Thukral N, Kaur J, Malik M Tags: Curr Diabetes Rev Source Type: research

The Recent Advancement in the Field of Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) for Aiming Breast Cancer.
Abstract Increased frequency of cancer in recent years and its impact on different physical, mental, and social dimensions of human life have turned it to a major problem of this century. We can group cancer according to the type of cells they start from viz. skin cancer, colon cancer, bladder cancer, breast cancer, prostate cancer, kidney cancer oral cancer etc. Among this, breast cancer is one of the most prevalent type of malignant neoplasm within women with more than one million new cases per year. In the recent years, with the help of targeted drug delivery system, several attempts were made to restrict the d...
Source: Current Diabetes Reviews - June 27, 2020 Category: Endocrinology Authors: Maity D, Bhattacharya S, Baghel YS, Singh S, Rai S, Ritika S, Shrestha S, Singh N, Kumar A Tags: Curr Diabetes Rev Source Type: research

Lipid Nanoformulations in the Treatment of Neuropsychiatric Diseases: An Approach to Overcome the Blood Brain Barrier.
CONCLUSION: Thus, it can be concluded that the lipid nanoformulations bear immense potential in overcoming the challenges associated with the treatment of neuropsychiatric disorders. However, the area warrants conduction of clinical studies to ensure their commercialization which could revolutionize the treatment of neuropsychiatric diseases in the coming decades. PMID: 32593280 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - June 27, 2020 Category: Endocrinology Authors: Rehman S, Nabi B, Pottoo FH, Baboota S, Ali J Tags: Curr Diabetes Rev Source Type: research

Pharmacological effects of secondary bile acid microparticles in diabetic murine model.
CONCLUSION: Bile acids modulated the bile profile without affecting blood glucose levels. PMID: 32589561 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - June 26, 2020 Category: Endocrinology Authors: Mooranian A, Zamani N, Kovacevic B, Ionescu CM, Luna G, Mikov M, Goločorbin-Kon S, Stojanovic G, Kojic S, Al-Salami H Tags: Curr Diabetes Rev Source Type: research

Insulin Management for Type 1 Diabetic Patients During Social Alcohol Consumption: The SPRITZ Study.
CONCLUSION: Therefore, a personalized educational program on CHO + FPU counting together with insulin bolus management can improve glycemic control during social consumption of alcohol, with positive reflections on the psycho-affective dimension. Further studies are mandatory to confirm such preliminary results. PMID: 32552634 [PubMed - in process] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - June 20, 2020 Category: Endocrinology Authors: Cipponeri E, Blini C, Lamera C, De Mori V, Veronesi G, Bossi AC Tags: Curr Diabetes Rev Source Type: research

Proportion of type 2 diabetic patients achieving treatment goals and the survey of patient's attitude towards insulin initiation in patients with inadequate glycaemic control with oral anti-diabetic drugs.
Abstract BACKGROUND: Type 2 diabetic patients often require insulin therapy for better glycaemic control. However, many of these patients do not receive insulin or do not receive it in a timely manner. OBJECTIVE: The study was planned to assess the proportion of type 2 diabetic patients attaining treatment goals as per the ADA 2018 guidelines. In addition, patient's perception on insulin therapy assessed and compared between insulin naïve and insulin initiated type 2 diabetic patients. METHODS: The study was conducted in type 2 diabetic patients. Data on their demographics, medical history, duration...
Source: Current Diabetes Reviews - June 11, 2020 Category: Endocrinology Authors: Bhat S, Chowta M, Chowta N, Shastry R, Kamath P Tags: Curr Diabetes Rev Source Type: research

Anti-Insulin Receptor Antibodies in the Pathology and the Therapy of Diabetes Mellitus.
Abstract Diabetes mellitus (DM) is recognized as the most common and the world's fastestgrowing chronic disease with severe complications leading to increased mortality. Many strategies exist for the management of DM and its control including treatment with insulin and insulin analogs, oral hypoglycemic therapy such as insulin secretion stimulators and insulin sensitizers, and diet and physical training. Over the years, many types of drugs and molecules with an interesting pharmacological diversity have been developed and proposed for their anti-diabetic potential. Such molecules target diverse key receptors, enzy...
Source: Current Diabetes Reviews - June 4, 2020 Category: Endocrinology Authors: Ashraf A, Palakkott A, Ayoub MA Tags: Curr Diabetes Rev Source Type: research

Evaluation of the Prevalence of Sleep Disorder among Patients with Type 2 Diabetes Mellitus Referring to Ghaem Hospital from 2016 to 2017.
This study was aimed to identify the prevalence of sleep disorders as a modifiable lifestyle factor among diabetic patients. MATERIALS AND METHODS: This cross-sectional study was conducted on 190 patients with type 2 diabetes mellitus who referred to the Internal Medicine Clinic of the Ghaem Hospital, Mashhad, Iran from 2016 to 2017. A demographic questionnaire and the Pittsburgh Sleep Quality Assessment questionnaire (sleep disorder was defined as scores higher than 5) was filled for each subject. Blood tests including haemoglobin A1 C (Hb A1C), fasting blood sugar (FBS) and 2 hour post prandial glucose as well as th...
Source: Current Diabetes Reviews - May 27, 2020 Category: Endocrinology Authors: Khorasani ZM, Ravan VR, Hejazi S Tags: Curr Diabetes Rev Source Type: research

Cardiovascular Disease among Patients with Diabetes: The Current Scenario in Saudi Arabia.
Abstract One of the well-recognized conditions linked to diabetes mellitus (DM) is cardiovascular disease (CVD). Those affected by DM face greater risk for early onset of CVD. Although huge strides have been made in cardiovascular therapy and prevention, with striking results in decreasing diabetes-related coronary mortality in developed countries, the morbidity and mortality due to CVD continue to remain high among patients with diabetes. While there is an increasing incidence of cardiovascular event survivors with DM across the world, the number of DM patients with higher cardiovascular risk is predicted to soar...
Source: Current Diabetes Reviews - May 27, 2020 Category: Endocrinology Authors: Robert AA, Al Dawish MA Tags: Curr Diabetes Rev Source Type: research

Glucagon-Like Peptide-1 Receptor Agonists Cardio-protective effects: an umbrella review.
CONCLUSION: The RCT-s for GLP-1 RA should characterize cardiovascular risk in subjects with diabetes such that disparities between established cardiovascular risk (high, moderate and low), or medical history of cardiovascular disease been accounted for in subgroup analysis. PMID: 32442089 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - May 22, 2020 Category: Endocrinology Authors: Elnour AA, Al Hajri N, El Khidir IY, Al Amoodi A, Ahmed SA, Sadeq A Tags: Curr Diabetes Rev Source Type: research

Quality of life and Self-care behavior among people living with diabetes- A study from Coastal South India.
CONCLUSION: The Quality of Life was found to be good amongst majority of the study participants. Results of the study point that majority of the patients enjoy a good quality of life but also reinstate the importance of self-care activities for betterment of health. PMID: 32433007 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - May 19, 2020 Category: Endocrinology Authors: Joshi L, Bhagawan D, Holla R, Kulkarni V, Unnikrishnan B, Mohamed F, Kumar N, Thapar R, Mithra P, Kumar A Tags: Curr Diabetes Rev Source Type: research

High prevalence of vitamin D deficiency and correlation with cystatin-C and other cardiovascular and renal risk biomarkers in patients with type 2 diabetes mellitus complicated with hypertension.
Abstract BACKGROUND: Vitamin D is increasingly investigated as having a role in Type 2 Diabetes Mellitus (T2DM) and its cardiovascular and renal complications. OBJECTIVE: To investigate association between 25-hydroxyvitamin D (25-OHD) and biomarkers of cardiovascular and renal complications including cystatin-C. METHODS: This cross-sectional study involved 117 participants with T2DM that was not complicated with cardiovascular or renal diseases except hypertension. 25-OHD was measured by electrochemiluminescence immunoassay while cystatin-C was measured by enzyme-linkedimmunosorbent-assay. Other biomarke...
Source: Current Diabetes Reviews - May 16, 2020 Category: Endocrinology Authors: Alkhatatbeh MJ, Smadi SA, Abdul-Razzak KK, Saadeh NA Tags: Curr Diabetes Rev Source Type: research

The possible role of Saponin in Type-II Diabetes- A review.
CONCLUSION: Saponins having potential therapeutic benefits and are theorized as an alternative medication in decreasing serum blood glucose levels in the patient suffering from diabetes. PMID: 32416696 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - May 16, 2020 Category: Endocrinology Authors: Choudhary N, Khatik GL, Suttee A Tags: Curr Diabetes Rev Source Type: research

Type 1 Diabetes Mellitus - Risk Factor for Cardiovascular Disease Morbidity and Mortality.
Abstract Type 1 diabetes mellitus (T1DM) is a chronic disease which starts early in life and often leads to micro- and macrovascular complications. The incidence of the disease is lower than that of type 2 DM and varies in different countries and ethnical groups, and the etiological and pathogenetic factors are different from T2DM. The aim of this overview is to investigate the effect of T1DM on all-cause mortality and CVD morbidity and mortality. During the last decades the treatment of T1DM has improved the prognosis of the patients. Still, the mortality rates are higher than those of the age- and sex-matched ge...
Source: Current Diabetes Reviews - May 10, 2020 Category: Endocrinology Authors: Chalakova T, Yotov Y, Tzotchev K, Galcheva S, Balev B, Bocheva Y, Usheva N, Iotova V Tags: Curr Diabetes Rev Source Type: research

A Review of Statistical and Machine Learning Techniques for Microvascular Complications in Type 2 Diabetes.
CONCLUSION: The integration of AI based analytics techniques like machine learning and deep learning in clinical medicine will result in improved disease management through faster disease detection and cost reduction for disease treatment. PMID: 32389114 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - May 10, 2020 Category: Endocrinology Authors: Sambyal N, Saini P, Syal R Tags: Curr Diabetes Rev Source Type: research

Microrna 21 Emerging Role in Diabetic Complications: A Critical Update.
CONCLUSION: Considering the raised levels of miR-21 in various diabetic complications, it may prove to be a candidate biomarker for diabetic complications. Further, miR-21 antagonists have shown great potential in the treatment of diabetic cardiomyopathy, diabetic nephropathy, diabetic retinopathy, and diabetic neuropathy related complications in the future. The current review is the first of its kind encompassing the roles miR-21 plays in various diabetic complications, with a critical discussion of its future potential role as a biomarker and therapeutic target. PMID: 32359340 [PubMed - as supplied by publisher] (So...
Source: Current Diabetes Reviews - May 2, 2020 Category: Endocrinology Authors: Roy D, Modi A, Khokar M, Sankanagoudar S, Yadav D, Sharma S, Purohit P, Sharma P Tags: Curr Diabetes Rev Source Type: research

Inter-Tissue and Intra-Tissue Co-Expression Networks in Human Metabolism: Morphological Evaluation of the Link Between Transcription Factors ER β and NFAT in Morbid Obesity.
CONCLUSIONS: We believe that our findings will shed light on the complex underlying mechanisms and that the investigated biomarkers could represent future targets for the prevention and therapy of obesity and its comorbidities. PMID: 32351187 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - April 30, 2020 Category: Endocrinology Authors: Chasapi A, Balampanis K, Kourea E, Kalfaretzos F, Lambadiari V, Lambrou GI, Melachrinou M, Sotiropoulou-Bonikou G Tags: Curr Diabetes Rev Source Type: research

Stem Cell Therapies for the Treatment of Diabetic Neuropathies: Future Perspectives.
CONCLUSION: In the present review, we attempt to discuss the potential of most studied types of stem cells, their application for the treatment of experimental diabetic neuropathies and associated clinical manifestations including future perspectives around these themes. PMID: 32303173 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - April 17, 2020 Category: Endocrinology Authors: de Figueiredo CS, Dos Reis LC Tags: Curr Diabetes Rev Source Type: research

A Review on natural products and herbs used in the management of diabetes.
CONCLUSION: The significance of natural products and herbs in the anticipation of diabetes and allied complications are being described herein. We observed that a huge work is being done to explore the natural products and herbs to manage the diabetes and this review gives the highlights of them. PMID: 32268866 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - April 7, 2020 Category: Endocrinology Authors: Patle D, Vyas M, Khatik GL Tags: Curr Diabetes Rev Source Type: research

Insulin U-500, the practical solution for treatment of patients with high insulin requirements.
CONCLUSIONS: Overall, insulin U-500 is an effective and safe treatment for patients with type 2 diabetes and insulin resistance. Randomized trials are needed to compare longterm efficacy and safety of insulin U-500 with other forms of insulin regimens. PMID: 32268867 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - April 7, 2020 Category: Endocrinology Authors: Mikhail N Tags: Curr Diabetes Rev Source Type: research

Vaccines For Type 1 Diabetes: Prevention Or Reversal?
Abstract Type 1 diabetes mellitus (T1DM) is an autoimmune disease which leads to destruction of pancreatic β-cells, thereby causing insufficient insulin production. Globally, around 98, 200 children and adolescents below 15 years of age and almost 128,900 subjects below 20 years of age develop T1DM annually, along with severe complications deteriorating their quality of life. In India alone, around 15,900 incident cases below 15 years have reported annually. Hence, its prevention and reversal are significant. Unlike other chronic diseases, T1DM involves the presence of various autoantigens which can be target...
Source: Current Diabetes Reviews - March 30, 2020 Category: Endocrinology Authors: Desai S, Buchade S, Chitlange S, Sharma H, Bhombe D, Shewale S, Pujari P Tags: Curr Diabetes Rev Source Type: research

Prediabetic dysglycemia: Call for action.
Å Abstract Different dysglycemic states precede overt type 2 diabetes. Prediabetic dysglycemia also carries an increased cardiovascular risk per se. Prediabetic dysglycemia may be divided into impaired fasting glycemia, impaired glucose tolerance and intermediate hyperglycemia. Mixed forms of these are very common. Dysglycemia develops insidiously for many years and usually produces no symptoms until very late. It is possible to prevent prediabetic dysglycemia from progressing to manifest type 2 diabetes and it can also be made to return to normoglycemia. The importance of lifestyle interventions, pharmacol...
Source: Current Diabetes Reviews - March 27, 2020 Category: Endocrinology Authors: Sjöholm Å Tags: Curr Diabetes Rev Source Type: research

Diabetes Mellitus and Osteoporosis Correlation: Challenges and Hopes.
Abstract Diabetes and osteoporosis are two common diseases with different complications. Despite different therapeutic strategies, managing these diseases and reducing their burden has not been satisfactory, especially when they appear one after the other. In this review, we aimed to clarify the similarity, common etiology and possible common adjunctive therapies of these two major diseases and designate the known molecular pattern observed in them. Based on different experimental findings, we want to illuminate that interestingly there are similar pathways lead to diabetes and osteoporosis. Meanwhile, there are a...
Source: Current Diabetes Reviews - March 24, 2020 Category: Endocrinology Authors: Ala M, Jafari RM, Dehpour AR Tags: Curr Diabetes Rev Source Type: research

A Case Report: Euglycemic Diabetic Ketoacidosis Presenting as Chest Pain in a Patient on a Low Carbohydrate Diet.
CONCLUSION: We present a case of euDKA triggered by a ketogenic diet while on SGLT2 inhibitor therapy presenting as chest pain. The recognition of euDKA is important in the context of increased SGLT2 use for management of cardiovascular risk for patients with diabetes. PMID: 32178617 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - March 16, 2020 Category: Endocrinology Authors: Dorcely B, Nitis J, Schwartzbard A, Newman J, Goldberg I, Sum M Tags: Curr Diabetes Rev Source Type: research

The role of diabetes mellitus in diseases of the gallbladder and biliary tract.
DISCUSSION: Overall, there are many problems for the GI system in general with diabetes, including gastroparesis and other diseases that have a wide range of morbidity and mortality rates and treatment options. Through this review, a focus will be taken on the diabetic complications that arise on the gallbladder and associations to it. PMID: 32133965 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - March 4, 2020 Category: Endocrinology Authors: Rahmani B, Gandhi J, Joshi G, Smith N, Reid I, Khan S Tags: Curr Diabetes Rev Source Type: research

Susceptibility Factors for Early Reamputation in Diabetic Great Toe Gangrene.
CONCLUSION: While limited ankle dorsiflexion and sepsis condition need to be addressed comprehensively, from the surgical options point of view we suggest ray amputation to be preferred over metatarsophalangeal joint disarticulation to prevent early reamputation. PMID: 32091343 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - February 23, 2020 Category: Endocrinology Authors: Primadhi RA Tags: Curr Diabetes Rev Source Type: research

Potential Biomarkers in Diabetic Retinopathy.
CONCLUSION: Above mentioned biomarkers play a key role in the pathogenesis of diabetic retinopathy hence they can also be considered as potential targets for new drug development. PMID: 32065092 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - February 16, 2020 Category: Endocrinology Authors: Adki KM, Kulkarni YA Tags: Curr Diabetes Rev Source Type: research

Reducing the burden of diabetes treatment: A review of low-cost oral hypoglycemic medications.
Abstract BACKGROUND: The vast majority of individuals diagnosed with diabetes are low/middle income and may have access to only three of the 11 oral hypoglycemic medications (OHMs) due to cost: metformin intermediate release (IR) or extended release (ER), sulfonylureas (glimepiride, glipizide, glyburide), and pioglitazone. Sulfonylureas and pioglitazone have had significant controversy related to potential adverse events, but it remains unclear whether these negative outcomes are class-, drug-, or dose-related. OBJECTIVE: We conducted a narrative review of low-cost OHMs. METHODS: We evaluated the maximum...
Source: Current Diabetes Reviews - February 5, 2020 Category: Endocrinology Authors: Vaughan EM, Rueda JJ, Samson SL, Hyman DJ Tags: Curr Diabetes Rev Source Type: research

Burden Of Thyroid Dysfunction Among Type 2 Diabetes Mellitus Patients With Emphasis On Its Prevalence And Pattern Of Presentation: A Case Controlled Study.
This study is a descriptive cross-sectional study involving patients with type 2 diabetes mellitus attending the Diabetes Clinic, or receiving treatment in the Medical Wards. Subjects were recruited using systematic sampling. The first patient was selected by simple random sampling, and subsequently, every consecutive subject was selected. Blood samples were tested for HbA1c, fT3, fT4 and thyrotropin, thyroid stimulating hormone. Socio-demographic information was retrieved from patient medical records. We used the student t-test for statistical comparison of quantitative variables such as weight, height, blood pressure, se...
Source: Current Diabetes Reviews - February 5, 2020 Category: Endocrinology Authors: Ezeani Iu, Ogbonna Su Tags: Curr Diabetes Rev Source Type: research

Redefining Cardiovascular (CV) Death as a primary end point component in Cardiovascular Outcome Trials.
Abstract Sodium Glucose cotransporter-2 inhibitors (SGLT-2i) and Glucagon like peptide 1 receptor agonists (GLP1-RA) have revolutionised the approach for modern management of type 2 diabetes in view of their outcome altering abilities. An objective component of the primary endpoints used in the Cardiovascular Outcome Trials (CVOT) is cardiovascular (CV) death. However, the reason behind the decrease in CV deaths (compared to the placebo arm) appear to arise from divergent underlying processes. Recent meta-analysis of SGLT-2i and GLP1-RA indicated that the reduction in CV death associated with the former is predomi...
Source: Current Diabetes Reviews - February 5, 2020 Category: Endocrinology Authors: Ghosal S, Sinha B Tags: Curr Diabetes Rev Source Type: research