Integrated Nutritional Supports for Diabetic Patients during COVID-19 Infection: A Comprehensive Review
CONCLUSION: There is an urgent need for healthy diet and integrated nutritional supports with home-based physical activities for diabetic patients during the self-isolation period of COVID-19 Infection.PMID:33645486 | DOI:10.2174/1573399817666210301103233 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - March 1, 2021 Category: Endocrinology Authors: A K Obidul Huq Abu Naim Mohammad Bazlur Rahim S M Golam Moktadir Ielias Uddin Mohammad Zahidul Manir Muhammad Abu Bakr Siddique Khaleda Islam Md Sirajul Islam Source Type: research

Integrated Nutritional Supports for Diabetic Patients during COVID-19 Infection: A Comprehensive Review
CONCLUSION: There is an urgent need for healthy diet and integrated nutritional supports with home-based physical activities for diabetic patients during the self-isolation period of COVID-19 Infection.PMID:33645486 | DOI:10.2174/1573399817666210301103233 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - March 1, 2021 Category: Endocrinology Authors: A K Obidul Huq Abu Naim Mohammad Bazlur Rahim S M Golam Moktadir Ielias Uddin Mohammad Zahidul Manir Muhammad Abu Bakr Siddique Khaleda Islam Md Sirajul Islam Source Type: research

Are our diabetic patients' adherent to the treatment?
CONCLUSION: Adherence was more among the males as compared to the females. Most patients in the study had been adherent towards their medications prescribed to them. Most of them were on oral drugs only. The majority of the patients who had diabetes mellitus were found to have inadequate self-care management for diabetes mellitus.PMID:33622226 | DOI:10.2174/1573399817666210223114010 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - February 24, 2021 Category: Endocrinology Authors: Avinash Kumar Dhruv Indiresh Hejmady None Unnikrishnan B Rekha Thapar Nithin Kumar Ramesh Holla None Darshan Bb Vishnu J Shetty I S Divya Charitha Rakshith Hegde K Source Type: research

Are our diabetic patients' adherent to the treatment?
CONCLUSION: Adherence was more among the males as compared to the females. Most patients in the study had been adherent towards their medications prescribed to them. Most of them were on oral drugs only. The majority of the patients who had diabetes mellitus were found to have inadequate self-care management for diabetes mellitus.PMID:33622226 | DOI:10.2174/1573399817666210223114010 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - February 24, 2021 Category: Endocrinology Authors: Avinash Kumar Dhruv Indiresh Hejmady None Unnikrishnan B Rekha Thapar Nithin Kumar Ramesh Holla None Darshan Bb Vishnu J Shetty I S Divya Charitha Rakshith Hegde K Source Type: research

Are our diabetic patients' adherent to the treatment?
CONCLUSION: Adherence was more among the males as compared to the females. Most patients in the study had been adherent towards their medications prescribed to them. Most of them were on oral drugs only. The majority of the patients who had diabetes mellitus were found to have inadequate self-care management for diabetes mellitus.PMID:33622226 | DOI:10.2174/1573399817666210223114010 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - February 24, 2021 Category: Endocrinology Authors: Avinash Kumar Dhruv Indiresh Hejmady None Unnikrishnan B Rekha Thapar Nithin Kumar Ramesh Holla None Darshan Bb Vishnu J Shetty I S Divya Charitha Rakshith Hegde K Source Type: research

Are our diabetic patients' adherent to the treatment?
CONCLUSION: Adherence was more among the males as compared to the females. Most patients in the study had been adherent towards their medications prescribed to them. Most of them were on oral drugs only. The majority of the patients who had diabetes mellitus were found to have inadequate self-care management for diabetes mellitus.PMID:33622226 | DOI:10.2174/1573399817666210223114010 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - February 24, 2021 Category: Endocrinology Authors: Avinash Kumar Dhruv Indiresh Hejmady None Unnikrishnan B Rekha Thapar Nithin Kumar Ramesh Holla None Darshan Bb Vishnu J Shetty I S Divya Charitha Rakshith Hegde K Source Type: research

GST T1, M1, and IRS-1 G972R Genetic Variants Association to Gestational Diabetes Mellitus (GDM) in Egyptian women: Linkage to Maternal Hyperglycemia
Curr Diabetes Rev. 2021 Feb 19. doi: 10.2174/1573399817666210219124628. Online ahead of print.ABSTRACTBACKGROUND: Gestational diabetes mellitus (GDM) shares in part pathogenic mechanisms of multiple genetic interactions. Some ofT2D susceptibility genes are encountered in association with GDM.OBJECTIVE: We aimed to investigate for GST T1, M1 and G972R IRS-I gene polymorphisms with the risk of developing GDM.PATIENTS AND METHODS: In this randomized case-control study, pregnant women with GDM were genotyped for by PCR analysis for glutathione s-transferase-T1, M1 variant polymorphisms. RFLP was done for the G972R IRS 1 gene. ...
Source: Current Diabetes Reviews - February 19, 2021 Category: Endocrinology Authors: Naglaa Fathy Barseem Essam Khattab Ragab Dawood Sally Mohamed Source Type: research

GST T1, M1, and IRS-1 G972R Genetic Variants Association to Gestational Diabetes Mellitus (GDM) in Egyptian women: Linkage to Maternal Hyperglycemia
Curr Diabetes Rev. 2021 Feb 19. doi: 10.2174/1573399817666210219124628. Online ahead of print.ABSTRACTBACKGROUND: Gestational diabetes mellitus (GDM) shares in part pathogenic mechanisms of multiple genetic interactions. Some ofT2D susceptibility genes are encountered in association with GDM.OBJECTIVE: We aimed to investigate for GST T1, M1 and G972R IRS-I gene polymorphisms with the risk of developing GDM.PATIENTS AND METHODS: In this randomized case-control study, pregnant women with GDM were genotyped for by PCR analysis for glutathione s-transferase-T1, M1 variant polymorphisms. RFLP was done for the G972R IRS 1 gene. ...
Source: Current Diabetes Reviews - February 19, 2021 Category: Endocrinology Authors: Naglaa Fathy Barseem Essam Khattab Ragab Dawood Sally Mohamed Source Type: research

GST T1, M1, and IRS-1 G972R Genetic Variants Association to Gestational Diabetes Mellitus (GDM) in Egyptian women: Linkage to Maternal Hyperglycemia.
Abstract BACKGROUND: Gestational diabetes mellitus (GDM) shares in part pathogenic mechanisms of multiple genetic interactions. Some ofT2D susceptibility genes are encountered in association with GDM. OBJECTIVE: We aimed to investigate for GST T1, M1 and G972R IRS-I gene polymorphisms with the risk of developing GDM. PATIENTS AND METHODS: In this randomized case-control study, pregnant women with GDM were genotyped for by PCR analysis for glutathione s-transferase-T1, M1 variant polymorphisms. RFLP was done for the G972R IRS 1 gene. Their newborns were additionally assayed for whole of the clinical, labo...
Source: Current Diabetes Reviews - February 19, 2021 Category: Endocrinology Authors: Barseem NF, Khattab E, Dawood R, Mohamed S Tags: Curr Diabetes Rev Source Type: research

Risk Mortality, prevalence, and possible therapeutics to treat diabetic patients infected with nCOVID-19.
Abstract The whole world is facing the current potential life-threatening virus nCOVID-19, the most severe health crisis in the modern era. The World Health Organization (WHO) has announced the nCOVID-19 as a pandemic in global concern. People with diabetes are not more likely to get nCOVID-19 than the general population. However, nCOVID-19 can cause more severe symptoms and complications in some people living with Diabetes. Older individuals and individuals with previous ailments, (such as diabetes, coronary illness, and asthma) have all the earmarks of being more susceptible to nCOVID-19 infection. People having...
Source: Current Diabetes Reviews - February 15, 2021 Category: Endocrinology Authors: Ashique S, Sandhu NK Tags: Curr Diabetes Rev Source Type: research

MicroRNAs and Diabetes Mellitus Type 1.
Abstract Type 1 diabetes mellitus is a multifactorial, progressive, autoimmune disease with a strong genetic feature that can affect multiple organs, including kidney, eyes, and nerves. Early detection of type 1 diabetes can help critically to avoid serious damages to these organs. MicroRNAs are small RNA molecules that act in post-transcriptional gene regulation by attaching to the complementary sequence in the 3'-untranslated region of their target genes. Alterations in the expression of microRNA coding genes are extensively reported in several diseases such as type 1 diabetes. Presenting non-invasive biomarkers...
Source: Current Diabetes Reviews - February 14, 2021 Category: Endocrinology Authors: Bahreini F, Rayzan E, Rezaei N Tags: Curr Diabetes Rev Source Type: research

Physicians' perception about use of vitamin B12 in treatment or prevention of diabetic neuropathy: A cross-sectional survey in Saudi Arabia.
CONCLUSION: The findings of this study indicate a tendency of unnecessarily prescribing vitamin B12 supplementation for the prevention or treatment of diabetic neuropathy as well as a lack of knowledge on the matter among doctors in primary care hospitals in Saudi Arabia. The study has also shown that it is patients who often request this prescription, adding pressure on their physicians to comply. Future studies should investigate hospitals in a greater number of Saudi cities and include less experienced residents and medical students. PMID: 33573558 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - February 10, 2021 Category: Endocrinology Authors: Aldossari KK, Al-Ghamdi S, Alzahrani J, Al Turki MS, Almuhareb M, Alanazi ZG, Alshahrani ZM, Wong J Tags: Curr Diabetes Rev Source Type: research

Prospect for type 2 diabetes mellitus in the combination of exercise and synbiotic: a perspective.
Abstract Change in gut microbiome diversity (the so-called dysbiosis) is correlated with insulin resistance conditions. Exercise is typically one of the first management for people with type 2 diabetes mellitus (T2DM), which is generally well-known for improved glucose regulation. The new design of prebiotic and probiotic, like synbiotic form, to target specific diseases is needed for additional studies. While the effectiveness of exercise and the combination of exercise and synbiotic prescription seems promising, this review discusses the possibility of these agents to increase the diversity of gut microbiota and...
Source: Current Diabetes Reviews - January 28, 2021 Category: Endocrinology Authors: Dewi L, Rosidi A, Noer ER, Ayuningtyas A Tags: Curr Diabetes Rev Source Type: research

Specificities of the diabetic population in French Guiana: The health barometer survey.
CONCLUSIONS: The prevalence rate of diabetes and obesity in French Guiana was one of the highest among the French territories, with specific vulnerabilities requiring to be addressed by local health policies. PMID: 33511949 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - January 28, 2021 Category: Endocrinology Authors: Sabbah N, Massicard M, Mathieu N Tags: Curr Diabetes Rev Source Type: research

Nonglycemic Adverse Effects of Insulin.
Abstract Insulin is primarily thought of for its glycemic effects in patients with diabetes. There are, however, non-glycemic adverse effects of insulin that may significantly impact patient health and can interfere with glycemic control. Insulinogenic edema primarily occurs with rapid improvement in glycemic control either in patients with newly discovered diabetes or in patients with poorly-controlled diabetes. Insulin-induced sympathetic activation, vasodilation, changes in vascular permeability and most importantly sodium retention play significant etiologic roles in the development of edema. Clinically, it is...
Source: Current Diabetes Reviews - January 28, 2021 Category: Endocrinology Authors: Guarneri AM, Hoffman RP Tags: Curr Diabetes Rev Source Type: research

The impact of type 2 diabetes on women's health and well-being during their reproductive years: A mixed-methods systematic review.
CONCLUSION: This review highlighted specific health issues affecting women of reproductive age with T2DM and which represent an important focus for health services research and health care delivery. Future research needs to address identified health domains to improve women's health and well-being living with T2DM. Prospero Registration number: CRD42019146535. PMID: 33461469 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - January 18, 2021 Category: Endocrinology Authors: Celik A, Forde R, Racaru S, Forbes A, Sturt J Tags: Curr Diabetes Rev Source Type: research

The role of alpha-lipoic acid supplementation in the prevention of diabetes complications: A comprehensive review of clinical trials.
Abstract Alpha-lipoic acid (ALA) is a substantial antioxidant in the prevention of diabetes and diabetes complications. It can regenerate other antioxidants like vitamin E, vitamin C, Coenzyme Q10 and glutathione and is often known as a universal antioxidant. Antioxidants play a role in diabetes treatment due to hyperglycemia-induced stimulation of the polyol pathway and formation of advanced glycation end products (AGE) and reactive oxygen species (ROS). Clinical trials examining alpha-lipoic acid supplementation on diabetic neuropathy, nephropathy, cardiomyopathy and erectile dysfunction display positive results...
Source: Current Diabetes Reviews - January 18, 2021 Category: Endocrinology Authors: Jeffrey S, Samraj PI, Raj BS Tags: Curr Diabetes Rev Source Type: research

Genetic and Non-genetic Determinants of Cardiovascular Disease in South Asians.
Abstract South Asians (SAs), people from the Indian subcontinent (e.g. India, Pakistan, Bangladesh, Sri Lanka, and Nepal) have a higher prevalence of cardiovascular disease (CVD) and suffer from a greater risk of CVD-associated mortality compared to other global populations. These problems are compounded by the alterations in lifestyles due to urbanization and changing cultural, social, economic, and political environment. Current methods of CV risk prediction are based on white populations that under-estimate the CVD risk in SAs. Prospective studies are required to obtain actual CVD morbidity/mortality rates so t...
Source: Current Diabetes Reviews - January 17, 2021 Category: Endocrinology Authors: Goyal S, Sanghera DK Tags: Curr Diabetes Rev Source Type: research

Antidiabetics with Herbs : A compressive Review on Interactions.
Abstract Diabetes mellitus is chronic illness with variety of causes and pathophysiology. For the management of diabetes various synthetic antidiabetic drug available but people also preferred complementary and alternative therapies as well as traditional herbal home remediesbecause they are perceived to be free of side effects and generally recognized as safe due to their natural origin. Worldwide majority of population is consuming herbs and/or herbal product in their daily routine. It has been observed that diabetic individuals also consume herbs/herbal products either with or without medical supervision. This ...
Source: Current Diabetes Reviews - January 12, 2021 Category: Endocrinology Authors: Jirapure K, Undale V Tags: Curr Diabetes Rev Source Type: research

Dyslipidemia and Cardiovascular Disease Prevention in South Asians: A Review and Discussion of Causes, Challenges and Management Strategies.
CONCLUSIONS: While combined efforts to study the expatriate South Asians in western countries have been able to identify South Asian specific dyslipidemias, causal associations and optimal management remains relatively less explored. Larger scale studies are needed to better quantify the relationship of each lipid parameter with ASCVD risk among South Asians as well as optimal lipid targets and management strategies to reduce morbidity and mortality in this high-risk group. PMID: 33438542 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - January 12, 2021 Category: Endocrinology Authors: Saeed A, Virani SS, Mulukutla S, Chow CK Tags: Curr Diabetes Rev Source Type: research

Outcomes of Clinical Treatments Among Patients with Diabetes Mellitus in Selangor, Malaysia: A Retrospective Study.
CONCLUSION: Controlled readings were found only in the readings of fasting blood glucose during the first and second visits, followed by family history, types of medication received and compliance with the treatment. This study has recommended that Type 2 patients with diabetes without a family history of Diabetes Mellitus need to exercise more control over the readings of HbA1c. PMID: 33438543 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - January 12, 2021 Category: Endocrinology Authors: Mahmud Z, Abrahhim SA, Sulong S Tags: Curr Diabetes Rev Source Type: research

Diabetes Mellitus and Renal Function: Current Medical Research and Opinion.
Abstract Diabetes mellitus (DM) which is defined as high blood glucose level is a major public health worldwide. While discussing DM, the knowledge in this field is unlimited hence a syndrome that populations are living with for more than a decade is always an important matter to keep searching for updates on it. Challenges are always present in different means as comorbidities, poorly controlled DM especially type 2 Diabetes mellitus(T2DM) is considered as a risk factor for a lot of different diseases including but not limited to chronic kidney Disease (CKD). Complications might appear through time, as the aging ...
Source: Current Diabetes Reviews - January 11, 2021 Category: Endocrinology Authors: Shahwan M, Hassan N, Shaheen RA, Gaili A, Jairoun A, Shahwan M, Najjar O, Jamshed S Tags: Curr Diabetes Rev Source Type: research

Retinal Protein O-GlcNAcylation and the Ocular Renin Angiotensin System: Signaling Cross-Roads in Diabetic Retinopathy.
Abstract It is well established that diabetes and its associated hyperglycemia negatively impacts retinal function, yet we know little about the role played by augmented flux through the hexosamine biosynthetic pathway (HBP). This offshoot of the glycolytic pathway produces UDP-N-acetyl-glucosamine which serves as the substrate for post-translational Olinked modification of proteins in a process referred to as O-GlcNAcylation. HBP flux and subsequent protein OGlcNAcylation serve as a nutrient sensor, enabling cells to integrate metabolic information to appropriately modulate fundamental cellular processes includin...
Source: Current Diabetes Reviews - January 11, 2021 Category: Endocrinology Authors: Dennis MD, Dierschke SK Tags: Curr Diabetes Rev Source Type: research

High-dose Vitamin D Supplementation on type 1 Diabetes Mellitus Patients: is there an Improvement in Glycemic Control?
This study aims to analyze the effects of high-dose VD supplementation on T1DM patients' glycemic levels, maintaining stable doses of insulin. METHODS: Prospective, 12-week clinical trial including 67 T1DM patients, who were supplemented with high doses of cholecalciferol according to participants' VD value. Patients with VD levels below 30 ng/mL received 10,000 IU/day; those with levels between 30-60 ng/mL received 4,000 IU/day. Patients who had not achieved 25(OH)D levels> 30 ng/ml or presented insulin dose variation during the study were not analyzed. RESULTS: Only 46 out of 67 patients accomplished the cri...
Source: Current Diabetes Reviews - January 5, 2021 Category: Endocrinology Authors: de Melo FTC, Felício KM, de Queiroz NNM, de Rider Brito HA, Neto JFA, Janaú LC, de Souza Neto NJK, Silva ALA, de Lemos MN, de Oliveira MCNI, de Alcântara AL, de Moraes LV, de Souza ÍJA, Said NM, da Silva WM, de Lemos GN, Dos Santos MC, De Souza D Albu Tags: Curr Diabetes Rev Source Type: research

Impact of Knowledge, Attitude and Practice in the Management of Type 2 Diabetes Mellitus in Developing Countries: A Review.
CONCLUSION: The review concludes the importance of patient counselling to modify their KAP towards the disease will be highly effective in countries like India, where the count of diabetes mellitus patients is increasing aggressively. Investment in patient counselling to improve their KAP score will significantly help in palliating the effect of this disease. PMID: 33413065 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - January 5, 2021 Category: Endocrinology Authors: Gautam SK, Gupta V Tags: Curr Diabetes Rev Source Type: research

Growth Differentiation Factor-15 as a Biomarker of Obese Pre-diabetes and Type 2 Diabetes Mellitus in Indian Subjects: A Case-control Study.
Abstract BACKGROUND: Type 2 diabetes mellitus (T2DM) is an ever-growing epidemic in India, and poses significant morbidity, mortality, and socioeconomic burden. INTRODUCTION: Growth differentiation factor-15 (GDF15) is a stress-responsive cytokine, increased in T2DM patients compared to control subjects without the disease. We aimed to assess whether serum GDF15 and adipose tissue GDF15 expression can differentiate between obese pre-diabetes and T2DM and control populations. METHODOLOGY: We recruited 156 individuals including 73 type 2 diabetes, 30 pre-diabetes, and 53 healthy controls. Clinical history,...
Source: Current Diabetes Reviews - January 3, 2021 Category: Endocrinology Authors: Roy D, Purohit P, Modi A, Khokhar M, Shukla RKG, Chaudhary R, Sankanagoudar S, Sharma P Tags: Curr Diabetes Rev Source Type: research

Genomics, Proteomics and Metabolomics Approaches for Predicting Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients.
CONCLUSION: The combination of genomics, proteomics, and metabolomics assays as suitable biological systems that can provide new and deeper insights into the pathogenesis of diabetes, as well as to discover prospects for developing suitable and targeted interventions. PMID: 33393899 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - December 31, 2020 Category: Endocrinology Authors: Darmayanti S, Lesmana R, Meiliana A, Abdulah R Tags: Curr Diabetes Rev Source Type: research

Diabetes mellitus and SARS-CoV-2 infection: pathophysiologic mechanisms and implications in management.
CONCLUSION: This review summarizes the pathophysiologic mechanisms underlying the co-existence of both pandemics as well as the current recommendations and future perspectives regarding optimal treatment of inpatients and outpatients with DM in the era of SARS-CoV-2 infection. Notably, the current recommended drugs for the treatment of severe COVID-19, dexamethasone and remdesivir, may cause hyperglycemia, an adverse effect that physicians should bear in mind, when caring for patients with DM and COVID-19. PMID: 33388022 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - December 31, 2020 Category: Endocrinology Authors: Vallianou NG, Evangelopoulos A, Kounatidis D, Stratigou T, Christodoulatos GS, Karampela I, Dalamaga M Tags: Curr Diabetes Rev Source Type: research

Methylation profile of miR-9-1 and miR-9-1/-9-3 as potential biomarkers of Diabetic Retinopathy.
CONCLUSION: Our results suggest that both methylation of miR-9-1 and e miRs-9-1 / 9-3 favors DR in patients with diabetes in the period of 5 to 10 years of diagnosis. PMID: 33388023 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - December 31, 2020 Category: Endocrinology Authors: de Assis CS, Silva AS, Dos Santos Nunes MK, Filho JM, do Nascimento RAF, Gomes CNAP, de Queiroga Evangelista IW, de Oliveira NFP, Persuhn DC Tags: Curr Diabetes Rev Source Type: research

An Efficacy and Safety Study of Remogliflozin in Obese Indian Type 2 Diabetes Mellitus Patients Who Were Inadequately Controlled on Insulin glargine plus other oral hypoglycemic agents.
The objective of this retrospective study was to investigate the efficacy of adding remogliflozin to current insulin glargine plus two oral drug i.e. metformin and teneligliptin therapy in poorly controlled Indian type 2 diabetes. MATERIAL AND METHODS: 173 study participants were initially selected from patient database who continued on their insulin glargine or received an increased dose of insulin glargine along with other OHA based therapy (Group A) and 187 were selected who had received remogliflozin (100 mg BD) (Group B) in addition to insulin glargine along with other OHA based therapy. Glycated haemoglobin (HbA...
Source: Current Diabetes Reviews - December 21, 2020 Category: Endocrinology Authors: Shankar A Tags: Curr Diabetes Rev Source Type: research

Human Postnatal Mesenchymalstem Cell Derived Islets as a Model for Diabetes Research.
Abstract BACKGROUND: The scarcity of human cadaver islets for transplantation in patients with Diabetes Mellitus (DM) has necessitated the search for alternative islet sources. With advancing islet biology research, islet-like clusters (ILCs) derived from stem cells have demonstrated potential for treating DM and in novel drug discovery programs for drug and cytotoxicity testing. In vitro differentiation of ILCs from stem cells also provides an opportunity to mimic the in vivo islet developmental pathways. In vitro derived ILCs are often considered immature,as they do not respond to glucose challenge efficiently. ...
Source: Current Diabetes Reviews - December 14, 2020 Category: Endocrinology Authors: Kharat A, Chadravanshi B, Sanap A, Kheur S, Bhonde R Tags: Curr Diabetes Rev Source Type: research

Impact of metabolic surgery on type-2 diabetes remission.
ex AK Abstract Diabetes Mellitus is characterized by numerous metabolic disorders, which have in common the serum elevation of glucose, caused for a pancreatic malfunction in insulin secretion and / or its action. It is a non-communicable disease, considered major public health problems and generalized growth worldwide, being a chronic disease, which can generate a high treatment cost. Metabolic surgery is a safe treatment, regulated by the Federal Council of Medicine and useful in treating people with BMI over 30 years of age, who are unable to control pathologies associated with obesity, especially type 2 diabet...
Source: Current Diabetes Reviews - December 14, 2020 Category: Endocrinology Authors: Baiocchi CAF, Rocha de Sá DA, Arbex AK Tags: Curr Diabetes Rev Source Type: research

Nanoemulsions- A better Approach for Anti Diabeticdrugs Delivering.
Abstract Conventional delivery of antidiabetic drugs faces many problems like poor absorption, low bioavailability, and drug degradation. Nanoemulsion is a unique drug technology which is very suitable for the delivery of antidiabetic drugs. In recent years the flaws of delivering anti-hypoglycaemic drugs have been overcome by choosing nanoemulsion drug technology. They are thermodynamically stable and also deliver the therapeutic agent for a longer duration. Generally, Nanoemulsions are made up of either oil-in-water or water-in-oil and size of the droplets is from fifty to thousand nanometer. Surfactants are cri...
Source: Current Diabetes Reviews - December 8, 2020 Category: Endocrinology Authors: Manimaran V, Sivakumar PM, Narayanan J, Parthasarathi S, Prabhakar PK Tags: Curr Diabetes Rev Source Type: research

Flavonoids in the Treatment of Diabetes Clinical Outcomes and Mechanism to ameliorate Blood Glucose levels.
Conclusion: Articles that we reviewed showed the positive role of flavonoids, which at a certain way reduce diabetes, but its side effects are still missing, this review focus on the different type of dietary flavonoids along with their mechanism in reducing blood glucose and enhance insulin sensitivity as well as some side effects. PMID: 33290200 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - December 7, 2020 Category: Endocrinology Authors: Al-Duhaidahawi D, Hasan SA, Al-Zubaidy HFS Tags: Curr Diabetes Rev Source Type: research

Metabolic and appetite effects of fructose and glucose in subjects with type 1 diabetes: a randomized crossover clinical trial.
CONCLUSIONS: Fructose induced smaller increase in postprandial blood glucose than glucose, without changes in triglycerides and glucagon. In addition, leptin levels and appetite sensations were similar to glucose. Other studies are needed in order to confirm these findings, especially in the long term, so that their use becomes really reliable. PMID: 33261542 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - November 30, 2020 Category: Endocrinology Authors: Dos Santos Lima É, Souto DL, Rodacki M, Pereira JRD, Zajdenverg L, Rosado EL Tags: Curr Diabetes Rev Source Type: research

The patient-centered medical home as an intervention strategy for diabetes mellitus: A systematic review of the literature.
CONCLUSION: The quality and strength of the outcomes were largely inconclusive about the overall effectiveness of the PCMH. Defining and comparing concepts across studies was difficult as universal definitions specific to the PCMH were not often applied. More research is needed to unpack the care model of the PCMH to further understand how the individual key components, such as care bundles, contribute to improved outcomes. Further evaluations are needed for team-based care, communication, and care coordination with comparisons to patient, clinical, health, and financial outcomes. PMID: 33231158 [PubMed - as supplied ...
Source: Current Diabetes Reviews - November 22, 2020 Category: Endocrinology Authors: McManus LS, Dominguez-Cancino KA, Stanek MK, LeyvaMoral JM, Bravo-Tare CE, Rivera-Lozada O, Palmieri PA Tags: Curr Diabetes Rev Source Type: research

Current evidence regarding Low-carb diets for the metabolic control of type-2 diabetes.
Abstract The management of diabetes requires a medical nutritional therapy as an essential part of this treatment. There should be no 'one-size-fits-all' eating pattern for different patient´s profiles with diabetes. It´s clinically complex to suggest an ideal percentage of calories from carbohydrates, protein and lipids recommended for all patients with diabetes. Among the eating patterns that have shown beneficial effects on metabolic control of patients with type 2 diabetes is the Low-Carb diet, since the carbohydrate ingestion is viewed as the most important determinant of postprandial glucose and ...
Source: Current Diabetes Reviews - November 22, 2020 Category: Endocrinology Authors: Sousa AA, Renke G, Leal A, Rassi MMB, Feuser CS, Cunha H, Silva FM, Arbex A Tags: Curr Diabetes Rev Source Type: research

Dipeptidyl Peptidase IV Inhibitors for Nonalcoholic Fatty Liver Disease - Systematic Review and Metanalysis.
CONCLUSION: Because of the poor overall quality of the studies and heterogeneity of the population analyzed, i DPP-IV did not show efficacy on inflammatory markers or fibrosis in patients with NAFLD. PMID: 33176658 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - November 10, 2020 Category: Endocrinology Authors: Dos Santos LR, Duarte ML, Peccin MS, Gagliardi ART, Melnik T Tags: Curr Diabetes Rev Source Type: research

Perceived Barriers, Benefits, Facilitators, and Attitudes of Health Professionals towards Multidisciplinary Team Care in Type 2 Diabetes Management: a Systematic Review.
CONCLUSIONS: There is a huge gap in shared roles among health professionals in T2DM therapy. Hence, there is need for allied health professionals such as physiotherapists, dieticians, and psychologists with expertise in diabetes to explore primary healthcare. Barriers and facilitators for successful integration of multidisciplinary team, seamlessly cut across three hierarchal levels namely, health management; health professionals; and diabetic patients. PMID: 33176659 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - November 10, 2020 Category: Endocrinology Authors: Dankoly US, Vissers D, El Farkouch Z, Kolasa E, Ziyyat A, Rompaey BV, Maamri A Tags: Curr Diabetes Rev Source Type: research

Value of Sodium Glucose co Transporter 2 Inhibitor Versus Traditional Medication In Microalbuminuric Diabetic Patients.
Abstract BACKGROUND: Sodium glucose co transporter 2 inhibitor (SGLT2i) is a new arment in the prevention and treatment of diabetic kidney disease with a potential effect on reducing and preventing chronic kidney disease (CKD) progression. OBJECTIVE: To evaluate the effect of SGLT2 inhibitor in comparison to traditional medication in diabetic patients with microalbuminuria. PATIENTS AND METHODS: 60 diabetic patients with microalbuminuria were divided into group I: 30 patients were treated by traditional medications (RAAS blockers) and group II: 30 patients for whom Dapagliflozin was added to the traditio...
Source: Current Diabetes Reviews - November 10, 2020 Category: Endocrinology Authors: Hussein N, Abdelrahman F, Khedr A, Aref H, Halawa MR, ELSharkawy M Tags: Curr Diabetes Rev Source Type: research

A Review on Cellular and Molecular Mechanisms Linked to the Development of Diabetes Complications.
Abstract Modern lifestyle, changing eating habits and reduced physical work have been known to culminate into making diabetes a global pandemic. Hyperglycemia during the course of diabetes is an important causative factor for the development of both microvascular (retinopathy, nephropathy and neuropathy) and macrovascular (coronary artery disease, stroke and peripheral artery disease) complications. In this article, we summarize several mechanisms accountable for the development of both microvascular and macrovascular complications of diabetes. Several metabolic and cellular events are linked to the augmentation o...
Source: Current Diabetes Reviews - November 3, 2020 Category: Endocrinology Authors: Babel RA, Dandekar MP Tags: Curr Diabetes Rev Source Type: research

Diabetes and its complications: Therapies Available, Anticipated and Aspired.
Abstract Diabetes Mellitus is characterized as a set of metabolic disorders that have hyperglycemia in common, caused by defects in the action and / or in the secretion of insulin. It is a noncommunicable disease, considered one of the main public health problems and of widespread growth in the world, a difficult condition to treat and expensive to manage. Metabolic surgery is a safe treatment, regulated by the Federal Council of Medicine and indicated for the treatment of people with a Body Mass Index above 30, who are not successful in controlling pathologies associated with obesity, especially type 2 diabetes. ...
Source: Current Diabetes Reviews - November 3, 2020 Category: Endocrinology Authors: Grover A, Sharma K, Gautam S, Gautam S, Gulati M, Singh SK Tags: Curr Diabetes Rev Source Type: research

Hepatic mediators of lipid metabolism and ketogenesis: focus on fatty liver and diabetes.
CONCLUSION: A better understanding of the molecular mediators involved in lipid synthesis and ketogenesis can lead to new treatments for metabolic disorders in the liver, such as NAFLD. PMID: 33143628 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - November 3, 2020 Category: Endocrinology Authors: Fernandes GW, Bocco BMLC Tags: Curr Diabetes Rev Source Type: research

The Impact of a New Best Practice Advisory on the Management of Diabetic Ketoacidosis.
CONCLUSIONS: The BPA introduced in our DKA management algorithm successfully reduced total time on insulin and the incidence of hypoglycemia. PMID: 33143629 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - November 3, 2020 Category: Endocrinology Authors: Alawneh D, Younis M, Hamarshi MS Tags: Curr Diabetes Rev Source Type: research

Glucolipotoxicity-induced oxidative stress is related to mitochondrial dysfunction and apoptosis of pancreatic β-cell.
Glucolipotoxicity-induced oxidative stress is related to mitochondrial dysfunction and apoptosis of pancreatic β-cell. Curr Diabetes Rev. 2020 Nov 03;: Authors: Vela-Guajardo JE, Garza-González S, García N Abstract Glucolipotoxicity-induced oxidative stress and mitochondrial dysfunction of pancreatic β-cells are one of the mechanisms that have been related to the low insulin secretion and cell death during diabetes development. In early or non-chronic stages, the pancreatic β-cells respond to hyperglycemia or hyperlipidemia, stimulating insulin secretion. However, the chro...
Source: Current Diabetes Reviews - November 3, 2020 Category: Endocrinology Authors: Vela-Guajardo JE, Garza-González S, García N Tags: Curr Diabetes Rev Source Type: research

Diabetic Neuropathy Pain Management: A Global Challenge.
CONCLUSION: In the end, we propose to consider the altered skin structure, function and microenvironmental factors in diabetic population for devising smart, targeted, stimuli-responsive treatment options to attain maximum pain relief with minimum side effects. PMID: 33143631 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - November 3, 2020 Category: Endocrinology Authors: Qureshi Z, Ali MN Tags: Curr Diabetes Rev Source Type: research

Herbal medicines for diabetes management and its secondary complications.
Abstract Diabetic Mellitus (DM) is a metabolic disorder that has attracted worldwide concern. DM is caused due to lack of insulin or ineffective production of insulin in the pancreas. A total of 463 million people have diabetes mellitus in 2019 and it was predictedto raise upto 578 million by 2030 and 700 million by 2045. High blood sugar gives rise to many complications like diabetic retinopathy, diabetic nephropathy, atherosclerosis, hypercoagulability, cardiovascular disease, coronary heart disease, abdominal obesity, hypertension, hyperlipidemia, cerebrovascular disease, coronary artery disease, foot damage, s...
Source: Current Diabetes Reviews - November 3, 2020 Category: Endocrinology Authors: Kumar S, Mittal A, Babu D, Mittal A Tags: Curr Diabetes Rev Source Type: research

Treatment Strategies Against Diabetic Foot Ulcer: Success so far and Road Ahead.
Conclusion: DFU has become one of the most common complications in patients having more than ten years of diabetes. Hence, understanding the root cause and its successful treatment is a big challenge because it depends upon multiple factors such as judicious selection of drug as well as proper control of blood sugar level. Most of the drugs that have been used so far either belong to the category of antibiotics, antihyperglycaemics or, they have been repositioned. Moreover, in clinical practice, much focus has been given towards dressings that have been used to cover the ulcer. The complete treatment of DFU is still a farf...
Source: Current Diabetes Reviews - November 2, 2020 Category: Endocrinology Authors: Awasthi A, Singh SK, Kumar B, Gulati M, Kumar R, Wadhwa S, Khursheed R, Corrie L, Arya Kr, Kumar R, Patni P, Kaur J, Vishwas S, Yadav A Tags: Curr Diabetes Rev Source Type: research

Identifying the Predictors of Self-Management Behaviors in Patients with Diabetes Based on Ecological Approach: A Systematic Review.
CONCLUSION: Self-management of diabetes is necessary for controlling it because 95% of care is done by the patient. When designing self-management interventions, factors based on the individual level that increasing self-management behaviors should be taken into account. PMID: 33106146 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 26, 2020 Category: Endocrinology Authors: Davari M, Moghaddam HR, Soola AH Tags: Curr Diabetes Rev Source Type: research

Understanding the Concept of Chronotherapeutics in the Management of Diabetes Mellitus.
Abstract The circadian rhythms have been controlled with the aid of a circadian clock in hypothalamus part which is known as suprachiasmatic nucleus. Chronotherapeutics, a branch of pharmacotherapeutics plays a mandate part in the treatment of various disorders, as delivering the drug in correct schedule, correct site, and in correct extent and provides benefit to the patients. The chronopharmacological aspects are very much important in the treatment of diabetes mellitus during daytime as the patients timing of activities of body and medicine treatment has an impact on the increase in the glucose levels in the bl...
Source: Current Diabetes Reviews - October 22, 2020 Category: Endocrinology Authors: Kashyap S, Bala R, Behl T Tags: Curr Diabetes Rev Source Type: research