The potential role of C-peptide in sexual and reproductive functions in type 1 diabetes mellitus: An update
Conclusion: C-peptide deficiency may be involved, at least partially, in the development of several pathological features associated with type 1 diabetes including sexual/reproductive dysfunction. Preliminary studies reported that C-peptide administration protects against diabetic micro- and macrovascular damages as well as sexual/reproductive dysfunction. Therefore, further studies are now needed to confirm these promising findings.PMID:34636302 | DOI:10.2174/1573399817666211005093434 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 12, 2021 Category: Endocrinology Authors: Roberta Pujia Samantha Maurotti Adriana Coppola Stefano Romeo Arturo Pujia Tiziana Montalcini Source Type: research

Management of Diabetic Foot Ulcers Using Topical Oxygen Therapy: A Case Series
Conclusion: NATROX therapy is an advanced topical oxygen delivery system compared to other conventional oxygen delivery systems; however, the study warrants further research to assess its potential applicability in DFU wound healing in large patients across and across the races.PMID:34636303 | DOI:10.2174/1573399817666211005094414 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 12, 2021 Category: Endocrinology Authors: Sinan F Tabanjeh Talal Al-Malki Abdulmajeed R Alhazzani Asirvatham A Robert Source Type: research

The potential role of C-peptide in sexual and reproductive functions in type 1 diabetes mellitus: An update
Conclusion: C-peptide deficiency may be involved, at least partially, in the development of several pathological features associated with type 1 diabetes including sexual/reproductive dysfunction. Preliminary studies reported that C-peptide administration protects against diabetic micro- and macrovascular damages as well as sexual/reproductive dysfunction. Therefore, further studies are now needed to confirm these promising findings.PMID:34636302 | DOI:10.2174/1573399817666211005093434 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 12, 2021 Category: Endocrinology Authors: Roberta Pujia Samantha Maurotti Adriana Coppola Stefano Romeo Arturo Pujia Tiziana Montalcini Source Type: research

Management of Diabetic Foot Ulcers Using Topical Oxygen Therapy: A Case Series
Conclusion: NATROX therapy is an advanced topical oxygen delivery system compared to other conventional oxygen delivery systems; however, the study warrants further research to assess its potential applicability in DFU wound healing in large patients across and across the races.PMID:34636303 | DOI:10.2174/1573399817666211005094414 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 12, 2021 Category: Endocrinology Authors: Sinan F Tabanjeh Talal Al-Malki Abdulmajeed R Alhazzani Asirvatham A Robert Source Type: research

The potential role of C-peptide in sexual and reproductive functions in type 1 diabetes mellitus: An update
Conclusion: C-peptide deficiency may be involved, at least partially, in the development of several pathological features associated with type 1 diabetes including sexual/reproductive dysfunction. Preliminary studies reported that C-peptide administration protects against diabetic micro- and macrovascular damages as well as sexual/reproductive dysfunction. Therefore, further studies are now needed to confirm these promising findings.PMID:34636302 | DOI:10.2174/1573399817666211005093434 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 12, 2021 Category: Endocrinology Authors: Roberta Pujia Samantha Maurotti Adriana Coppola Stefano Romeo Arturo Pujia Tiziana Montalcini Source Type: research

Management of Diabetic Foot Ulcers Using Topical Oxygen Therapy: A Case Series
Conclusion: NATROX therapy is an advanced topical oxygen delivery system compared to other conventional oxygen delivery systems; however, the study warrants further research to assess its potential applicability in DFU wound healing in large patients across and across the races.PMID:34636303 | DOI:10.2174/1573399817666211005094414 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 12, 2021 Category: Endocrinology Authors: Sinan F Tabanjeh Talal Al-Malki Abdulmajeed R Alhazzani Asirvatham A Robert Source Type: research

The potential role of C-peptide in sexual and reproductive functions in type 1 diabetes mellitus: An update
Conclusion: C-peptide deficiency may be involved, at least partially, in the development of several pathological features associated with type 1 diabetes including sexual/reproductive dysfunction. Preliminary studies reported that C-peptide administration protects against diabetic micro- and macrovascular damages as well as sexual/reproductive dysfunction. Therefore, further studies are now needed to confirm these promising findings.PMID:34636302 | DOI:10.2174/1573399817666211005093434 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 12, 2021 Category: Endocrinology Authors: Roberta Pujia Samantha Maurotti Adriana Coppola Stefano Romeo Arturo Pujia Tiziana Montalcini Source Type: research

Management of Diabetic Foot Ulcers Using Topical Oxygen Therapy: A Case Series
Conclusion: NATROX therapy is an advanced topical oxygen delivery system compared to other conventional oxygen delivery systems; however, the study warrants further research to assess its potential applicability in DFU wound healing in large patients across and across the races.PMID:34636303 | DOI:10.2174/1573399817666211005094414 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 12, 2021 Category: Endocrinology Authors: Sinan F Tabanjeh Talal Al-Malki Abdulmajeed R Alhazzani Asirvatham A Robert Source Type: research

The potential role of C-peptide in sexual and reproductive functions in type 1 diabetes mellitus: An update
Conclusion: C-peptide deficiency may be involved, at least partially, in the development of several pathological features associated with type 1 diabetes including sexual/reproductive dysfunction. Preliminary studies reported that C-peptide administration protects against diabetic micro- and macrovascular damages as well as sexual/reproductive dysfunction. Therefore, further studies are now needed to confirm these promising findings.PMID:34636302 | DOI:10.2174/1573399817666211005093434 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 12, 2021 Category: Endocrinology Authors: Roberta Pujia Samantha Maurotti Adriana Coppola Stefano Romeo Arturo Pujia Tiziana Montalcini Source Type: research

Management of Diabetic Foot Ulcers Using Topical Oxygen Therapy: A Case Series
Conclusion: NATROX therapy is an advanced topical oxygen delivery system compared to other conventional oxygen delivery systems; however, the study warrants further research to assess its potential applicability in DFU wound healing in large patients across and across the races.PMID:34636303 | DOI:10.2174/1573399817666211005094414 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 12, 2021 Category: Endocrinology Authors: Sinan F Tabanjeh Talal Al-Malki Abdulmajeed R Alhazzani Asirvatham A Robert Source Type: research

The potential role of C-peptide in sexual and reproductive functions in type 1 diabetes mellitus: An update
Conclusion: C-peptide deficiency may be involved, at least partially, in the development of several pathological features associated with type 1 diabetes including sexual/reproductive dysfunction. Preliminary studies reported that C-peptide administration protects against diabetic micro- and macrovascular damages as well as sexual/reproductive dysfunction. Therefore, further studies are now needed to confirm these promising findings.PMID:34636302 | DOI:10.2174/1573399817666211005093434 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 12, 2021 Category: Endocrinology Authors: Roberta Pujia Samantha Maurotti Adriana Coppola Stefano Romeo Arturo Pujia Tiziana Montalcini Source Type: research

Management of Diabetic Foot Ulcers Using Topical Oxygen Therapy: A Case Series
Conclusion: NATROX therapy is an advanced topical oxygen delivery system compared to other conventional oxygen delivery systems; however, the study warrants further research to assess its potential applicability in DFU wound healing in large patients across and across the races.PMID:34636303 | DOI:10.2174/1573399817666211005094414 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 12, 2021 Category: Endocrinology Authors: Sinan F Tabanjeh Talal Al-Malki Abdulmajeed R Alhazzani Asirvatham A Robert Source Type: research

The potential role of C-peptide in sexual and reproductive functions in type 1 diabetes mellitus: An update
Conclusion: C-peptide deficiency may be involved, at least partially, in the development of several pathological features associated with type 1 diabetes including sexual/reproductive dysfunction. Preliminary studies reported that C-peptide administration protects against diabetic micro- and macrovascular damages as well as sexual/reproductive dysfunction. Therefore, further studies are now needed to confirm these promising findings.PMID:34636302 | DOI:10.2174/1573399817666211005093434 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 12, 2021 Category: Endocrinology Authors: Roberta Pujia Samantha Maurotti Adriana Coppola Stefano Romeo Arturo Pujia Tiziana Montalcini Source Type: research

Management of Diabetic Foot Ulcers Using Topical Oxygen Therapy: A Case Series
Conclusion: NATROX therapy is an advanced topical oxygen delivery system compared to other conventional oxygen delivery systems; however, the study warrants further research to assess its potential applicability in DFU wound healing in large patients across and across the races.PMID:34636303 | DOI:10.2174/1573399817666211005094414 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 12, 2021 Category: Endocrinology Authors: Sinan F Tabanjeh Talal Al-Malki Abdulmajeed R Alhazzani Asirvatham A Robert Source Type: research

The potential role of C-peptide in sexual and reproductive functions in type 1 diabetes mellitus: An update
Conclusion: C-peptide deficiency may be involved, at least partially, in the development of several pathological features associated with type 1 diabetes including sexual/reproductive dysfunction. Preliminary studies reported that C-peptide administration protects against diabetic micro- and macrovascular damages as well as sexual/reproductive dysfunction. Therefore, further studies are now needed to confirm these promising findings.PMID:34636302 | DOI:10.2174/1573399817666211005093434 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 12, 2021 Category: Endocrinology Authors: Roberta Pujia Samantha Maurotti Adriana Coppola Stefano Romeo Arturo Pujia Tiziana Montalcini Source Type: research

Management of Diabetic Foot Ulcers Using Topical Oxygen Therapy: A Case Series
Conclusion: NATROX therapy is an advanced topical oxygen delivery system compared to other conventional oxygen delivery systems; however, the study warrants further research to assess its potential applicability in DFU wound healing in large patients across and across the races.PMID:34636303 | DOI:10.2174/1573399817666211005094414 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 12, 2021 Category: Endocrinology Authors: Sinan F Tabanjeh Talal Al-Malki Abdulmajeed R Alhazzani Asirvatham A Robert Source Type: research

The potential role of C-peptide in sexual and reproductive functions in type 1 diabetes mellitus: An update
Conclusion: C-peptide deficiency may be involved, at least partially, in the development of several pathological features associated with type 1 diabetes including sexual/reproductive dysfunction. Preliminary studies reported that C-peptide administration protects against diabetic micro- and macrovascular damages as well as sexual/reproductive dysfunction. Therefore, further studies are now needed to confirm these promising findings.PMID:34636302 | DOI:10.2174/1573399817666211005093434 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 12, 2021 Category: Endocrinology Authors: Roberta Pujia Samantha Maurotti Adriana Coppola Stefano Romeo Arturo Pujia Tiziana Montalcini Source Type: research

Management of Diabetic Foot Ulcers Using Topical Oxygen Therapy: A Case Series
Conclusion: NATROX therapy is an advanced topical oxygen delivery system compared to other conventional oxygen delivery systems; however, the study warrants further research to assess its potential applicability in DFU wound healing in large patients across and across the races.PMID:34636303 | DOI:10.2174/1573399817666211005094414 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 12, 2021 Category: Endocrinology Authors: Sinan F Tabanjeh Talal Al-Malki Abdulmajeed R Alhazzani Asirvatham A Robert Source Type: research

Heart Rate Variability And Respiratory Muscle Strength In Patients With Type Ii Diabetes Practicing Pilates: A Randomized Clinical Trial
CONCLUSION: The exercise protocol based on the Pilates method did not alter respiratory muscle strength but promoted changes in HRV, especially between the moments before and during exercise and during and after exercise.PMID:34602038 | DOI:10.2174/1573399817666210928143752 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 4, 2021 Category: Endocrinology Authors: Samara Sousa Vasconcelos Gouveia Guilherme Pertinni de Morais Gouveia Leydnaya Maria Souza Bruno Cunha da Costa Gustavo Henrique Melo Sousa Van ádia Almeida Pinho Samila Sousa Vasconcelos Antonia Tainara Dos Santos Souza Thamires da Silva Lopes Luiz Gonz Source Type: research

Inflammatory Biomarkers as Predictors of Infected Diabetic Foot Ulcer
Curr Diabetes Rev. 2021 Sep 28. doi: 10.2174/1573399817666210928144706. Online ahead of print.ABSTRACTDiabetic foot ulcer infection is a crucial complication associated with lower-limb amputation and postoperative mortality in individuals with diabetes mellitus. Deciding if a diabetic foot ulcer is infected in a community setting is challenging without validated point-of-care tests. Early detection of infected diabetic foot ulcers can reduce the frequency of hospitalizations, the occurrence of disability, and chances of mortality. Inflammatory biomarkers are predictors of infected diabetic foot ulcers and lower-limb amputa...
Source: Current Diabetes Reviews - October 4, 2021 Category: Endocrinology Authors: Mariya Dmitriyeva Zhanar Kozhakhmetova Saltanat Urazova Saken Kozhakhmetov Dulat Turebayev Medet Toleubayev Source Type: research

Heart Rate Variability And Respiratory Muscle Strength In Patients With Type Ii Diabetes Practicing Pilates: A Randomized Clinical Trial
CONCLUSION: The exercise protocol based on the Pilates method did not alter respiratory muscle strength but promoted changes in HRV, especially between the moments before and during exercise and during and after exercise.PMID:34602038 | DOI:10.2174/1573399817666210928143752 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 4, 2021 Category: Endocrinology Authors: Samara Sousa Vasconcelos Gouveia Guilherme Pertinni de Morais Gouveia Leydnaya Maria Souza Bruno Cunha da Costa Gustavo Henrique Melo Sousa Van ádia Almeida Pinho Samila Sousa Vasconcelos Antonia Tainara Dos Santos Souza Thamires da Silva Lopes Luiz Gonz Source Type: research

Inflammatory Biomarkers as Predictors of Infected Diabetic Foot Ulcer
Curr Diabetes Rev. 2021 Sep 28. doi: 10.2174/1573399817666210928144706. Online ahead of print.ABSTRACTDiabetic foot ulcer infection is a crucial complication associated with lower-limb amputation and postoperative mortality in individuals with diabetes mellitus. Deciding if a diabetic foot ulcer is infected in a community setting is challenging without validated point-of-care tests. Early detection of infected diabetic foot ulcers can reduce the frequency of hospitalizations, the occurrence of disability, and chances of mortality. Inflammatory biomarkers are predictors of infected diabetic foot ulcers and lower-limb amputa...
Source: Current Diabetes Reviews - October 4, 2021 Category: Endocrinology Authors: Mariya Dmitriyeva Zhanar Kozhakhmetova Saltanat Urazova Saken Kozhakhmetov Dulat Turebayev Medet Toleubayev Source Type: research

Heart Rate Variability And Respiratory Muscle Strength In Patients With Type Ii Diabetes Practicing Pilates: A Randomized Clinical Trial
CONCLUSION: The exercise protocol based on the Pilates method did not alter respiratory muscle strength but promoted changes in HRV, especially between the moments before and during exercise and during and after exercise.PMID:34602038 | DOI:10.2174/1573399817666210928143752 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 4, 2021 Category: Endocrinology Authors: Samara Sousa Vasconcelos Gouveia Guilherme Pertinni de Morais Gouveia Leydnaya Maria Souza Bruno Cunha da Costa Gustavo Henrique Melo Sousa Van ádia Almeida Pinho Samila Sousa Vasconcelos Antonia Tainara Dos Santos Souza Thamires da Silva Lopes Luiz Gonz Source Type: research

Inflammatory Biomarkers as Predictors of Infected Diabetic Foot Ulcer
Curr Diabetes Rev. 2021 Sep 28. doi: 10.2174/1573399817666210928144706. Online ahead of print.ABSTRACTDiabetic foot ulcer infection is a crucial complication associated with lower-limb amputation and postoperative mortality in individuals with diabetes mellitus. Deciding if a diabetic foot ulcer is infected in a community setting is challenging without validated point-of-care tests. Early detection of infected diabetic foot ulcers can reduce the frequency of hospitalizations, the occurrence of disability, and chances of mortality. Inflammatory biomarkers are predictors of infected diabetic foot ulcers and lower-limb amputa...
Source: Current Diabetes Reviews - October 4, 2021 Category: Endocrinology Authors: Mariya Dmitriyeva Zhanar Kozhakhmetova Saltanat Urazova Saken Kozhakhmetov Dulat Turebayev Medet Toleubayev Source Type: research

Heart Rate Variability And Respiratory Muscle Strength In Patients With Type Ii Diabetes Practicing Pilates: A Randomized Clinical Trial
CONCLUSION: The exercise protocol based on the Pilates method did not alter respiratory muscle strength but promoted changes in HRV, especially between the moments before and during exercise and during and after exercise.PMID:34602038 | DOI:10.2174/1573399817666210928143752 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 4, 2021 Category: Endocrinology Authors: Samara Sousa Vasconcelos Gouveia Guilherme Pertinni de Morais Gouveia Leydnaya Maria Souza Bruno Cunha da Costa Gustavo Henrique Melo Sousa Van ádia Almeida Pinho Samila Sousa Vasconcelos Antonia Tainara Dos Santos Souza Thamires da Silva Lopes Luiz Gonz Source Type: research

Inflammatory Biomarkers as Predictors of Infected Diabetic Foot Ulcer
Curr Diabetes Rev. 2021 Sep 28. doi: 10.2174/1573399817666210928144706. Online ahead of print.ABSTRACTDiabetic foot ulcer infection is a crucial complication associated with lower-limb amputation and postoperative mortality in individuals with diabetes mellitus. Deciding if a diabetic foot ulcer is infected in a community setting is challenging without validated point-of-care tests. Early detection of infected diabetic foot ulcers can reduce the frequency of hospitalizations, the occurrence of disability, and chances of mortality. Inflammatory biomarkers are predictors of infected diabetic foot ulcers and lower-limb amputa...
Source: Current Diabetes Reviews - October 4, 2021 Category: Endocrinology Authors: Mariya Dmitriyeva Zhanar Kozhakhmetova Saltanat Urazova Saken Kozhakhmetov Dulat Turebayev Medet Toleubayev Source Type: research

Heart Rate Variability And Respiratory Muscle Strength In Patients With Type Ii Diabetes Practicing Pilates: A Randomized Clinical Trial
CONCLUSION: The exercise protocol based on the Pilates method did not alter respiratory muscle strength but promoted changes in HRV, especially between the moments before and during exercise and during and after exercise.PMID:34602038 | DOI:10.2174/1573399817666210928143752 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 4, 2021 Category: Endocrinology Authors: Samara Sousa Vasconcelos Gouveia Guilherme Pertinni de Morais Gouveia Leydnaya Maria Souza Bruno Cunha da Costa Gustavo Henrique Melo Sousa Van ádia Almeida Pinho Samila Sousa Vasconcelos Antonia Tainara Dos Santos Souza Thamires da Silva Lopes Luiz Gonz Source Type: research

Inflammatory Biomarkers as Predictors of Infected Diabetic Foot Ulcer
Curr Diabetes Rev. 2021 Sep 28. doi: 10.2174/1573399817666210928144706. Online ahead of print.ABSTRACTDiabetic foot ulcer infection is a crucial complication associated with lower-limb amputation and postoperative mortality in individuals with diabetes mellitus. Deciding if a diabetic foot ulcer is infected in a community setting is challenging without validated point-of-care tests. Early detection of infected diabetic foot ulcers can reduce the frequency of hospitalizations, the occurrence of disability, and chances of mortality. Inflammatory biomarkers are predictors of infected diabetic foot ulcers and lower-limb amputa...
Source: Current Diabetes Reviews - October 4, 2021 Category: Endocrinology Authors: Mariya Dmitriyeva Zhanar Kozhakhmetova Saltanat Urazova Saken Kozhakhmetov Dulat Turebayev Medet Toleubayev Source Type: research

Heart Rate Variability And Respiratory Muscle Strength In Patients With Type Ii Diabetes Practicing Pilates: A Randomized Clinical Trial
CONCLUSION: The exercise protocol based on the Pilates method did not alter respiratory muscle strength but promoted changes in HRV, especially between the moments before and during exercise and during and after exercise.PMID:34602038 | DOI:10.2174/1573399817666210928143752 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 4, 2021 Category: Endocrinology Authors: Samara Sousa Vasconcelos Gouveia Guilherme Pertinni de Morais Gouveia Leydnaya Maria Souza Bruno Cunha da Costa Gustavo Henrique Melo Sousa Van ádia Almeida Pinho Samila Sousa Vasconcelos Antonia Tainara Dos Santos Souza Thamires da Silva Lopes Luiz Gonz Source Type: research

Inflammatory Biomarkers as Predictors of Infected Diabetic Foot Ulcer
Curr Diabetes Rev. 2021 Sep 28. doi: 10.2174/1573399817666210928144706. Online ahead of print.ABSTRACTDiabetic foot ulcer infection is a crucial complication associated with lower-limb amputation and postoperative mortality in individuals with diabetes mellitus. Deciding if a diabetic foot ulcer is infected in a community setting is challenging without validated point-of-care tests. Early detection of infected diabetic foot ulcers can reduce the frequency of hospitalizations, the occurrence of disability, and chances of mortality. Inflammatory biomarkers are predictors of infected diabetic foot ulcers and lower-limb amputa...
Source: Current Diabetes Reviews - October 4, 2021 Category: Endocrinology Authors: Mariya Dmitriyeva Zhanar Kozhakhmetova Saltanat Urazova Saken Kozhakhmetov Dulat Turebayev Medet Toleubayev Source Type: research

Heart Rate Variability And Respiratory Muscle Strength In Patients With Type Ii Diabetes Practicing Pilates: A Randomized Clinical Trial
CONCLUSION: The exercise protocol based on the Pilates method did not alter respiratory muscle strength but promoted changes in HRV, especially between the moments before and during exercise and during and after exercise.PMID:34602038 | DOI:10.2174/1573399817666210928143752 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 4, 2021 Category: Endocrinology Authors: Samara Sousa Vasconcelos Gouveia Guilherme Pertinni de Morais Gouveia Leydnaya Maria Souza Bruno Cunha da Costa Gustavo Henrique Melo Sousa Van ádia Almeida Pinho Samila Sousa Vasconcelos Antonia Tainara Dos Santos Souza Thamires da Silva Lopes Luiz Gonz Source Type: research

Inflammatory Biomarkers as Predictors of Infected Diabetic Foot Ulcer
Curr Diabetes Rev. 2021 Sep 28. doi: 10.2174/1573399817666210928144706. Online ahead of print.ABSTRACTDiabetic foot ulcer infection is a crucial complication associated with lower-limb amputation and postoperative mortality in individuals with diabetes mellitus. Deciding if a diabetic foot ulcer is infected in a community setting is challenging without validated point-of-care tests. Early detection of infected diabetic foot ulcers can reduce the frequency of hospitalizations, the occurrence of disability, and chances of mortality. Inflammatory biomarkers are predictors of infected diabetic foot ulcers and lower-limb amputa...
Source: Current Diabetes Reviews - October 4, 2021 Category: Endocrinology Authors: Mariya Dmitriyeva Zhanar Kozhakhmetova Saltanat Urazova Saken Kozhakhmetov Dulat Turebayev Medet Toleubayev Source Type: research

Exercise as Treatment for Neuropathy in the Setting of Diabetes and Pre-diabetic Metabolic Syndrome: a Review of Animal Models and Human Trials
CONCLUSION: Exercise is integrative therapy that potently reduces cellular inflammatory state and improves distal axonal oxidative metabolism to ameliorate features of neuropathy in metabolic syndrome. Intensity of exercise need not improve cardinal features of metabolic syndrome [e.g. weight, glucose control] to exert beneficial effects.PMID:34561989 | DOI:10.2174/1573399817666210923125832 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - September 25, 2021 Category: Endocrinology Authors: J Robinson Singleton Stormy Foster-Palmer Robin L Marcus Source Type: research

Exercise as Treatment for Neuropathy in the Setting of Diabetes and Pre-diabetic Metabolic Syndrome: a Review of Animal Models and Human Trials
CONCLUSION: Exercise is integrative therapy that potently reduces cellular inflammatory state and improves distal axonal oxidative metabolism to ameliorate features of neuropathy in metabolic syndrome. Intensity of exercise need not improve cardinal features of metabolic syndrome [e.g. weight, glucose control] to exert beneficial effects.PMID:34561989 | DOI:10.2174/1573399817666210923125832 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - September 25, 2021 Category: Endocrinology Authors: J Robinson Singleton Stormy Foster-Palmer Robin L Marcus Source Type: research

Exercise as Treatment for Neuropathy in the Setting of Diabetes and Pre-diabetic Metabolic Syndrome: a Review of Animal Models and Human Trials
CONCLUSION: Exercise is integrative therapy that potently reduces cellular inflammatory state and improves distal axonal oxidative metabolism to ameliorate features of neuropathy in metabolic syndrome. Intensity of exercise need not improve cardinal features of metabolic syndrome [e.g. weight, glucose control] to exert beneficial effects.PMID:34561989 | DOI:10.2174/1573399817666210923125832 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - September 25, 2021 Category: Endocrinology Authors: J Robinson Singleton Stormy Foster-Palmer Robin L Marcus Source Type: research

Exercise as Treatment for Neuropathy in the Setting of Diabetes and Pre-diabetic Metabolic Syndrome: a Review of Animal Models and Human Trials
CONCLUSION: Exercise is integrative therapy that potently reduces cellular inflammatory state and improves distal axonal oxidative metabolism to ameliorate features of neuropathy in metabolic syndrome. Intensity of exercise need not improve cardinal features of metabolic syndrome [e.g. weight, glucose control] to exert beneficial effects.PMID:34561989 | DOI:10.2174/1573399817666210923125832 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - September 25, 2021 Category: Endocrinology Authors: J Robinson Singleton Stormy Foster-Palmer Robin L Marcus Source Type: research

Exercise as Treatment for Neuropathy in the Setting of Diabetes and Pre-diabetic Metabolic Syndrome: a Review of Animal Models and Human Trials
CONCLUSION: Exercise is integrative therapy that potently reduces cellular inflammatory state and improves distal axonal oxidative metabolism to ameliorate features of neuropathy in metabolic syndrome. Intensity of exercise need not improve cardinal features of metabolic syndrome [e.g. weight, glucose control] to exert beneficial effects.PMID:34561989 | DOI:10.2174/1573399817666210923125832 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - September 25, 2021 Category: Endocrinology Authors: J Robinson Singleton Stormy Foster-Palmer Robin L Marcus Source Type: research

Exercise as Treatment for Neuropathy in the Setting of Diabetes and Pre-diabetic Metabolic Syndrome: a Review of Animal Models and Human Trials
CONCLUSION: Exercise is integrative therapy that potently reduces cellular inflammatory state and improves distal axonal oxidative metabolism to ameliorate features of neuropathy in metabolic syndrome. Intensity of exercise need not improve cardinal features of metabolic syndrome [e.g. weight, glucose control] to exert beneficial effects.PMID:34561989 | DOI:10.2174/1573399817666210923125832 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - September 25, 2021 Category: Endocrinology Authors: J Robinson Singleton Stormy Foster-Palmer Robin L Marcus Source Type: research

Exercise as Treatment for Neuropathy in the Setting of Diabetes and Pre-diabetic Metabolic Syndrome: a Review of Animal Models and Human Trials
CONCLUSION: Exercise is integrative therapy that potently reduces cellular inflammatory state and improves distal axonal oxidative metabolism to ameliorate features of neuropathy in metabolic syndrome. Intensity of exercise need not improve cardinal features of metabolic syndrome [e.g. weight, glucose control] to exert beneficial effects.PMID:34561989 | DOI:10.2174/1573399817666210923125832 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - September 25, 2021 Category: Endocrinology Authors: J Robinson Singleton Stormy Foster-Palmer Robin L Marcus Source Type: research

The Role of Oxidative Stress, Inflammation, and Advanced Glycation End Product in Skin Manifestations of Diabetes Mellitus
Curr Diabetes Rev. 2021 Sep 19. doi: 10.2174/1573399817666210920102318. Online ahead of print.ABSTRACTDiabetes mellitus is a metabolic disorder caused by an increase in insulin resistance, a decrease in insulin production, or both of them, resulting in a high level of blood glucose or hyperglycemia. An uncontrolled state of DM may cause complications, namely skin disorder. One or more skin disorders are found amongst 74% of T2DM patients, with the highest percentage is dry skin (47%), followed by infection (10%), diabetic hand (5%), hair loss and diabetic dermopathy (each 4%). In DM, the state of hyperglycemia and producti...
Source: Current Diabetes Reviews - September 21, 2021 Category: Endocrinology Authors: Lili Legiawati Source Type: research

The Role of Oxidative Stress, Inflammation, and Advanced Glycation End Product in Skin Manifestations of Diabetes Mellitus
Curr Diabetes Rev. 2021 Sep 19. doi: 10.2174/1573399817666210920102318. Online ahead of print.ABSTRACTDiabetes mellitus is a metabolic disorder caused by an increase in insulin resistance, a decrease in insulin production, or both of them, resulting in a high level of blood glucose or hyperglycemia. An uncontrolled state of DM may cause complications, namely skin disorder. One or more skin disorders are found amongst 74% of T2DM patients, with the highest percentage is dry skin (47%), followed by infection (10%), diabetic hand (5%), hair loss and diabetic dermopathy (each 4%). In DM, the state of hyperglycemia and producti...
Source: Current Diabetes Reviews - September 21, 2021 Category: Endocrinology Authors: Lili Legiawati Source Type: research

The Role of Oxidative Stress, Inflammation, and Advanced Glycation End Product in Skin Manifestations of Diabetes Mellitus
Curr Diabetes Rev. 2021 Sep 19. doi: 10.2174/1573399817666210920102318. Online ahead of print.ABSTRACTDiabetes mellitus is a metabolic disorder caused by an increase in insulin resistance, a decrease in insulin production, or both of them, resulting in a high level of blood glucose or hyperglycemia. An uncontrolled state of DM may cause complications, namely skin disorder. One or more skin disorders are found amongst 74% of T2DM patients, with the highest percentage is dry skin (47%), followed by infection (10%), diabetic hand (5%), hair loss and diabetic dermopathy (each 4%). In DM, the state of hyperglycemia and producti...
Source: Current Diabetes Reviews - September 21, 2021 Category: Endocrinology Authors: Lili Legiawati Source Type: research

The Role of Oxidative Stress, Inflammation, and Advanced Glycation End Product in Skin Manifestations of Diabetes Mellitus
Curr Diabetes Rev. 2021 Sep 19. doi: 10.2174/1573399817666210920102318. Online ahead of print.ABSTRACTDiabetes mellitus is a metabolic disorder caused by an increase in insulin resistance, a decrease in insulin production, or both of them, resulting in a high level of blood glucose or hyperglycemia. An uncontrolled state of DM may cause complications, namely skin disorder. One or more skin disorders are found amongst 74% of T2DM patients, with the highest percentage is dry skin (47%), followed by infection (10%), diabetic hand (5%), hair loss and diabetic dermopathy (each 4%). In DM, the state of hyperglycemia and producti...
Source: Current Diabetes Reviews - September 21, 2021 Category: Endocrinology Authors: Lili Legiawati Source Type: research

Structural Perspectives and Advancement of SGLT2 Inhibitors for the Treatment of Type 2 Diabetes
This article covers the reabsorption of glucose mechanism in the kidneys, the functional mechanism of various Sodium-Glucose Cotransporter 2 (SGLT2) inhibitors, their structure and driving profile, and a few SGLT2 inhibitors now accessible in the market as well as those in different periods of advancement. The advantages of SGLT2 inhibitors are dose-dependent glycemic regulation changes with a significant reduction both in the concentration of HbA1c and body weight clinically and statistically. A considerable number of SGLT2 inhibitors have been approved by the FDA, while a few others, still in preliminaries, have shown in...
Source: Current Diabetes Reviews - September 20, 2021 Category: Endocrinology Authors: Shivani Sharma Amit Mittal Shubham Kumar Anu Mittal Source Type: research

Structural Perspectives and Advancement of SGLT2 Inhibitors for the Treatment of Type 2 Diabetes
This article covers the reabsorption of glucose mechanism in the kidneys, the functional mechanism of various Sodium-Glucose Cotransporter 2 (SGLT2) inhibitors, their structure and driving profile, and a few SGLT2 inhibitors now accessible in the market as well as those in different periods of advancement. The advantages of SGLT2 inhibitors are dose-dependent glycemic regulation changes with a significant reduction both in the concentration of HbA1c and body weight clinically and statistically. A considerable number of SGLT2 inhibitors have been approved by the FDA, while a few others, still in preliminaries, have shown in...
Source: Current Diabetes Reviews - September 20, 2021 Category: Endocrinology Authors: Shivani Sharma Amit Mittal Shubham Kumar Anu Mittal Source Type: research

Lipid behavior in metabolic syndrome pathophysiology
Curr Diabetes Rev. 2021 Sep 14. doi: 10.2174/1573399817666210915101321. Online ahead of print.ABSTRACTUndeniably, lipid plays an extremely important role in the homeostasis balance, since lipid contributes to the regulation of the metabolic processes. The metabolic syndrome pathogenesis is multi-pathway that composes neurohormonal disorders, endothelial cell dysfunction, metabolic disturbance, genetic predisposition, in addition to gut commensal microbiota. The heterogenicity of the possible mechanisms gives the metabolic syndrome its complexity and limitation of therapeutic accesses. The main pathological link that lipid ...
Source: Current Diabetes Reviews - September 16, 2021 Category: Endocrinology Authors: Basheer Marzoog Source Type: research

Lipid behavior in metabolic syndrome pathophysiology
Curr Diabetes Rev. 2021 Sep 14. doi: 10.2174/1573399817666210915101321. Online ahead of print.ABSTRACTUndeniably, lipid plays an extremely important role in the homeostasis balance, since lipid contributes to the regulation of the metabolic processes. The metabolic syndrome pathogenesis is multi-pathway that composes neurohormonal disorders, endothelial cell dysfunction, metabolic disturbance, genetic predisposition, in addition to gut commensal microbiota. The heterogenicity of the possible mechanisms gives the metabolic syndrome its complexity and limitation of therapeutic accesses. The main pathological link that lipid ...
Source: Current Diabetes Reviews - September 16, 2021 Category: Endocrinology Authors: Basheer Marzoog Source Type: research

Lipid behavior in metabolic syndrome pathophysiology
Curr Diabetes Rev. 2021 Sep 14. doi: 10.2174/1573399817666210915101321. Online ahead of print.ABSTRACTUndeniably, lipid plays an extremely important role in the homeostasis balance, since lipid contributes to the regulation of the metabolic processes. The metabolic syndrome pathogenesis is multi-pathway that composes neurohormonal disorders, endothelial cell dysfunction, metabolic disturbance, genetic predisposition, in addition to gut commensal microbiota. The heterogenicity of the possible mechanisms gives the metabolic syndrome its complexity and limitation of therapeutic accesses. The main pathological link that lipid ...
Source: Current Diabetes Reviews - September 16, 2021 Category: Endocrinology Authors: Basheer Marzoog Source Type: research

Effects of alpha-lipoic acid supplementation on human diabetic nephropathy: A systematic review and meta-analysis
Curr Diabetes Rev. 2021 Sep 13. doi: 10.2174/1573399817666210914103329. Online ahead of print.ABSTRACTBACKGROUND: Diabetic nephropathy (DN) is a kidney dysfunction, which occurs due to elevated urine albumin excretion rate and reduced glomerular filtration rate. Studies in animals have shown that alpha-lipoic acid (ALA) supplementation can reduce the development of DN.OBJECTIVES: We performed a systematic review and meta-analysis to examine the effects of ALA supplementation on biological indices (albumin, creatinine etc.) indicative of human DN.METHODS: The searching procedure included the databases PubMed Central, Embase...
Source: Current Diabetes Reviews - September 15, 2021 Category: Endocrinology Authors: Elena Vakali Dimitrios Rigopoulos Andres E Carrillo Andreas D Flouris Petros C Dinas Source Type: research

Analysis of robustness of the landmark Cardiovascular outcome trials of antidiabetic drugs - A systematic review
Curr Diabetes Rev. 2021 Sep 13. doi: 10.2174/1573399817666210914114511. Online ahead of print.ABSTRACTBACKGROUND: It is essential for Randomized controlled trials [RCTs] to report its results in a comprehensive manner. Hence, it is necessary to assess the robustness of the trials with statistically significant and as well as non-significant results. Robustness can be evaluated using fragility index (FI) and reverse fragility index [RFI] is for trials with statistically significant and as well as non-significant results. The primary aim of this study was to calculate FI and RFI for cardiovascular outcome trials [CVOT].MATER...
Source: Current Diabetes Reviews - September 15, 2021 Category: Endocrinology Authors: Debdipta Bose Mahanjit Konwar Source Type: research