Swimming impacts on pancreatic inflammatory cytokines, miR-146a and NF- кB expression levels in type-2 diabetic rats.
CONCLUSION: Our results indicated a significant increase in expression levels of miR-146, NF-κB and inflammatory cytokines (IL-6, TNF-α, and IL-1β) while a significant decrease in pancreatic expression levels of TRAF6 and IRAK1 in diabetic group as compared to the control group. In contrast, swimming exercise resulted in a significant decrease in expression levels of miR-146a, NF-кB and inflammatory cytokines and a significant increase in expression levels of TRAF6 and IRAK1 in the exercise-diabetic group compared to the diabetic group. PMID: 31733638 [PubMed - as supplied by publisher] (Source: Curr...
Source: Current Diabetes Reviews - November 15, 2019 Category: Endocrinology Authors: Alipour MR, Yousefzade N, Bavil FM, Naderi R, Ghiasi R Tags: Curr Diabetes Rev Source Type: research

Real-World Clinical Effectiveness and Tolerability of Hydroxychloroquine 400 Mg in Uncontrolled Type 2 Diabetes Subjects who are not Willing to Initiate Insulin Therapy (HYQ-Real-World Study).
The objective of this observational study was to investigate the effectiveness and tolerability of hydroxychloroquine (HCQ) in T2DM patients uncontrolled on multiple OHA and despite high sugar level not willing to initiate insulin therapy in a real-world clinical setting. METHODS: A prospective, investigator-initiated, observational, single-centred study was conducted where 250 patients (18-65 years) with T2DM for more than 5 years, with uncontrolled glycemia despite on a combination of multiple OHA, HbA1c between ≥7% and 130 mg/dL or PPG>180 mg/dL and BMI between>25 and
Source: Current Diabetes Reviews - November 14, 2019 Category: Endocrinology Authors: Gupta A Tags: Curr Diabetes Rev Source Type: research

Chronic Stress And Diabetes Mellitus: Interwoven Pathologies.
Abstract Stress threatens the homeostasis and mobilizes a plethora of adaptive physiological and behavioral changes via the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system. The HPA axis influences pituitary gland, hypothalamus and adrenal gland via a complex set of positive and negative feedback system. The feedback system operates in a well regulated neuroendocrine manner to reestablish the threatened body equilibrium. The HPA axis secreted major product is glucocorticoid (cortisol) which is kept within a physiologically optimal range and serve to accomplish the various physiological ...
Source: Current Diabetes Reviews - November 11, 2019 Category: Endocrinology Authors: Sharma VK, Singh TG Tags: Curr Diabetes Rev Source Type: research

Impact of SGLT inhibitors on multiple organ defects in diabetes.
CONCLUSION: The use of SGLT inhibitor in the treatment of type 2 diabetes should be considered with the perspective of general health state of the patient. In fact, SGLT inhibitors promote pleiotropic effects, among which some are beneficial for certain organs while some are deleterious. PMID: 31702506 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - November 5, 2019 Category: Endocrinology Authors: Asrih M, Gariani K Tags: Curr Diabetes Rev Source Type: research

African plants with antidiabetic potentials: Beyond glycaemic control to central nervous system benefits.
CONCLUSION: While the neurobehavioural and neuromorphological effects of some of these plants had been investigated in animal models of DM; their possible roles in the prevention or amelioration of the neurological complications of DM are yet to be established. PMID: 31702529 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - November 5, 2019 Category: Endocrinology Authors: Onaolapo AY, Onaolapo OJ Tags: Curr Diabetes Rev Source Type: research

Diabetes, diabetic complications, and phosphate toxicity: a scoping review.
This article presents a scoping review and synthesis of research findings investigating the toxic cellular accumulation of dysregulated inorganic phosphate-phosphate toxicity-as a pathophysiological determinant of diabetes and diabetic complications. Phosphorus, an essential micronutrient, is closely linked to the cellular metabolism of glucose for energy production, and serum inorganic phosphate is often transported into cells along with glucose during insulin therapy. Mitochondrial dysfunction and apoptosis, endoplasmic reticulum stress, neuronal degeneration, and pancreatic cancer are associated with dysregulated levels...
Source: Current Diabetes Reviews - November 3, 2019 Category: Endocrinology Authors: Brown RB Tags: Curr Diabetes Rev Source Type: research

Coexistence of Type-1 Diabetes Mellitus and Papillary Thyroid Carcinoma.
Conclusion: Patients with type 1 DM should be examined for thyroid diseases, and patients with suspected thyroid disease should be evaluated with a thyroid ultrasound. Type 1 DM and PTC coexistence albeit very rare; It should be known that type 1 diabetes can be seen together with thyroid cancer. PMID: 31686641 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - November 3, 2019 Category: Endocrinology Authors: Calapkulu M, Sencar ME, Duger H, Bayram SM, Unsal IO, Cakal E, Ozbek M Tags: Curr Diabetes Rev Source Type: research

Improved Clinical Outcomes With Dulaglutide as Add-on Medication to Oral Antidiabetic Drugs With or Without Insulin in Overweight Indian Patients With Type 2 Diabetes Mellitus: Retrospective Study in a Real-World Setting.
This study retrospectively evaluates the real-world clinical effectiveness of dulaglutide as an add-on therapy in overweight patients with inadequately controlled type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: This single-center study included overweight adult patients (N, 85; women, 45) with inadequately controlled T2DM (mean glycated hemoglobin [HbA1c] (standard deviation [SD]), 7.55 [0.43] %; and body mass index [BMI] [SD], 29.01 [2.30] kg/m2) treated with dulaglutide (1.5 mg) once weekly as an add-on therapy. Follow-up improvements in outcomes were analyzed using the paired t-test. Subgroup analysis was p...
Source: Current Diabetes Reviews - November 3, 2019 Category: Endocrinology Authors: Ghosh A, Nair R Tags: Curr Diabetes Rev Source Type: research

Reduction of Resting Energy Expenditure and Sarcopenic Obesity in Adults with Overweight and Obesity: A Brief Report.
CONCLUSION: SO appears to be present in a high proportion of treatment-seeking adults with overweight or obesity of both genders, and it seems to be associated with a reduced REE, compared with those without SO. Future studies are needed to clarify whether this may influence clinical outcomes. PMID: 31663844 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 29, 2019 Category: Endocrinology Authors: Tannir H, Kreidieh D, Itani L, El Masri D, El Ghoch M Tags: Curr Diabetes Rev Source Type: research

Predictive Equations based on Body Composition for Resting Energy Expenditure estimation in adults with obesity.
CONCLUSION: We suggest Huang and Horie-Waitzberg equations for accurate REE estimation in females; however, new validated REE estimation equations for males in this population are still needed. PMID: 31663845 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 29, 2019 Category: Endocrinology Authors: El Masri D, Itani L, Kreidieh D, Tannir H, El Ghoch M Tags: Curr Diabetes Rev Source Type: research

Uncommon association between diabetic ketoacidosis, thyrotoxicosis, cutaneous abscess and acute pericarditis in an immunocompetent patient: a single case report and literature review.
CONCLUSION: To our knowledge, this uncommon association is described for the first time. Few studies have analyzed the implications of HTLV-1 infection in thyroiditis and diabetes mellitus. We did not find any reports describing the association of pericarditis with HTLV-1 infection. Additional studies are necessary to understand the role of HTLV-1 in endocrine and cardiac disorders. PMID: 31654516 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 25, 2019 Category: Endocrinology Authors: Amelie M, Magalie D, Liliane T, Merzaka B, Florin S, Maryvonne D, Jelena V, Henry D, Nadia S Tags: Curr Diabetes Rev Source Type: research

Is it worth CANVASing for CREDENCE? A benefit-risk analysis.
CONCLUSION: The outcome benefits were in favour of canagliflozin in comparison to all reported adverse events, when hHF& renal composite were under consideration, in both the individual & pooled LHH analysis. However, the MACE benefits were overwhelmed by amputation risk in the pooled analysis. PMID: 31652114 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 24, 2019 Category: Endocrinology Authors: Sinha B, Ghosal S Tags: Curr Diabetes Rev Source Type: research

A molecular approach on the protective effects of mangiferin against diabetes and diabetes-related complications.
CONCLUSION: This study concludes that mangiferin has the potential to treat diabetes and it can be developed as a therapeutic agent for diabetes and the complications caused by diabetes. PMID: 31584372 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - October 4, 2019 Category: Endocrinology Authors: Aswal S, Kumar A, Chauhan A, Semwal RB, Kumar A, Semwal DK Tags: Curr Diabetes Rev Source Type: research

Mapping Of Type 1 Diabetes Mellitus.
Abstract Type 1 diabetes mellitus (T1DM), an autoimmune disorder, is becoming widespread with approximately 97,700 children in India and 490,000 children worldwide affected. There are various etiological factors contributing to the expansion of its incidence on different geographical locations. Hence, the articles published in reputed journals were studies and data was collected for analyzing etiology and prevention of T1DM. It has been observed that hybrid insulin peptides act as key antigens for the autoreactive T cells and causes loss of self-tolerance in humans. The association of coxsackievirus B has been obs...
Source: Current Diabetes Reviews - October 4, 2019 Category: Endocrinology Authors: Desai S, Deshmukh A Tags: Curr Diabetes Rev Source Type: research

Prevalence and Associates of Foot Deformities among Patients with Diabetes in Jordan.
Abstract OBJECTIVES: To determine the prevalence of, and factors associated with, people with foot deformities, among patients with diabetes in Jordan. METHODS: A cross-sectional study was conducted on 1000 diabetic participants recruited from the National Center for Diabetes, Endocrinology, and Genetics in Jordan. Participants had their feet clinically examined to detect the following foot deformity outcomes: Hallux valgus, claw/hammer toe, prominent metatarsal heads, limited joint mobility, pes cavus, Charcot foot, and amputations. Sociodemographic and health variables were also collected from participants'...
Source: Current Diabetes Reviews - September 30, 2019 Category: Endocrinology Authors: Ababneh A, Bakri FG, Khader Y, Lazzarini P, Ajlouni K Tags: Curr Diabetes Rev Source Type: research

Water Soluble Vitamins and their Role in Diabetes and its Complications.
CONCLUSION: Water-soluble vitamins like B1, B3, B6, B7, B9 and B12 have notable effects in diabetes mellitus and its related complications like nephropathy, neuropathy, retinopathy and cardiomyopathy. PMID: 31526351 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - September 16, 2019 Category: Endocrinology Authors: Deshmukh SV, Prabhakar B, Kulkarni YA Tags: Curr Diabetes Rev Source Type: research

Fasting insulin and risk of cancer related mortality in non-diabetic adults: A dose-response meta-analysis of cohort studies.
CONCLUSION: This dose-response meta-analysis showed a direct significant association between fasting insulin level and cancer mortality in men. PMID: 31490761 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - September 6, 2019 Category: Endocrinology Authors: Ghanavati M, Rahmani J, Rinaldi G, Zand H Tags: Curr Diabetes Rev Source Type: research

Dietary phytonutrients in prevention of diabetes related complications.
CONCLUSION: Our study thus highlights the abundance of clinical evidence of the efficiency of phytonutrients, and at the same time, the scarcity of clinically approved and marketed phytonutrients, as drugs, for the management of diabetes and related complications. PMID: 31490762 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - September 6, 2019 Category: Endocrinology Authors: Jha P, Kumari S, Jobby R, Desai N, Ali A Tags: Curr Diabetes Rev Source Type: research

Characteristics and Outcomes of Children with Type-I Diabetes Mellitus Hospitalized for Ketoacidosis.
CONCLUSION: The observed patient characteristics are typical of those reported in many studies and standard resources. Despite no mortality was documented, the need for early diagnosis and management should not be overlooked. Further study, with large sample size, is recommended to point-out the real characteristics difference among new and known type-I diabetes mellitus patients admitted for ketoacidosis. PMID: 31490763 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - September 6, 2019 Category: Endocrinology Authors: Ababulgu RZ, Tesfaye BT Tags: Curr Diabetes Rev Source Type: research

Insulin Sensitivity Indices in Patients with Polycystic Ovary Syndrome with Different Body Mass Index Categories.
CONCLUSION: Insulin resistance is prevalent among women with PCOS. The detection rate of insulin resistance varies according to the insulin sensitivity index used. Menstrual irregularity was the most common presentation of PCOS. Women with PCOS has significantly higher levels of AMH levels compared to women in the control group. PMID: 31441729 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - August 23, 2019 Category: Endocrinology Authors: Shahin L, Hyassat D, Batieha A, Khader Y, El-Khateeb M, Ajlouni K Tags: Curr Diabetes Rev Source Type: research

Association of Inflammatory markers with Diabetic retinopathy in Type 2 Diabetic patients- A Cross Sectional Study.
CONCLUSION: The study concluded that, inflammation was associated with the severe diabetic retinopathy in patients with well controlled diabetes. A possible relationship was provided between the risk factors and biomarkers which are responsible for Diabetic retinopathy. Hence, modifying the risk factors risk and development of severe diabetic retinopathy can be reduced. PMID: 31441730 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - August 23, 2019 Category: Endocrinology Authors: Mathala N, Akula A, Hegde S, Bitra R, Sachedev V Tags: Curr Diabetes Rev Source Type: research

A Systematic Review On Synthetic Drugs And Phytopharmaceuticals Used To Manage Diabetes.
CONCLUSION: Oral antihyperglycemics which are used to treat diabetes can cause many adverse effects and if given in combination can lead to drug-drug interactions. The combination of various phytochemicals with synthetic drugs can overcome the challenge faced by the synthetic drug treatment. Herbal and nutraceuticals therapy and the use of probiotics and prebiotics is a more holistic therapy due to its natural origin and traditional use. PMID: 31438829 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - August 22, 2019 Category: Endocrinology Authors: Banerjee M, Khursheed R, Yadav AK, Singh SK, Gulati M, Pandey DK, Prabhakar PK, Kumar R, Porwal O, Awasthi A, Kumari Y, Kaur G, Ayinkamiye C, Prashar R, Mankotia D, Pandey NK Tags: Curr Diabetes Rev Source Type: research

Nutritional Interventions and Considerations for the development of low calorie or sugar free foods.
Abstract Diabetes is a globally prevalent chronic metabolic disease characterized by more than normal blood glucose levels. Sugar, a common constituent of diet, is also a major factor often responsible for elevating the glucose level in diabetic patients. However, diabetic patients are more prone to eat sweets amongst the human population. Therefore, we find a popular consumption of zero or low-calorie sweeteners both natural and artificial. But, the uses of these sweeteners have proved to be controversial. Thus, the purpose of this review is to critically analyze and highlight the considerations needed for the de...
Source: Current Diabetes Reviews - August 7, 2019 Category: Endocrinology Authors: Singh J, Rasane P, Kaur S, Kumar V, Dhawan K, Mahato DK, Malhotra S, Sarma C, Kaur D, Bhattacharya J Tags: Curr Diabetes Rev Source Type: research

The effects of Smoking Cessation on Diabetes Mellitus Patients.
CONCLUSION: The result of this review did not estblish a clear relationship between smoking cessation and diabates Limitations: Compared to other studies examining the implication of smoking on chronic diseases, this study identified a very small number of trials evaluating the effect of smoking cessation on diabetes. The small number of studies implies that the results may not be suitable for generalization. IMPLICATION: Results from the review can help in the development of a tailored intervention for effective management of diabetes in smoking patients. PMID: 31362677 [PubMed - as supplied by publisher] (Sourc...
Source: Current Diabetes Reviews - July 29, 2019 Category: Endocrinology Authors: Alshahrani A Tags: Curr Diabetes Rev Source Type: research

Pulmonary Pathology Among Patients with Type 2 Diabetes Mellitus: An Updated Systematic Review and Meta-analysis.
Conclusion and implications of key findings: This review affirms the existing evidence of restrictive pathology among patients with T2DM. The future study could be conducted to see the effect of various rehabilitation protocols on pulmonary function among patients with T2DM. PMID: 31333139 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - July 16, 2019 Category: Endocrinology Authors: Saini M, Kulandaivelan S, Bansal VK, Saini V, Sharma S, Kaur J, Sondh A Tags: Curr Diabetes Rev Source Type: research

Diabetes and Parkinson ´s disease: Debating the link through Ca2+/cAMP signalling.
CONCLUSION: Considering our previous reports about Ca2+/cAMP signalling, I herein discussed the putative contribution of Ca2+/cAMP signalling in this link (between diabetes and PD). PMID: 31291877 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - July 11, 2019 Category: Endocrinology Authors: Bergantin LB Tags: Curr Diabetes Rev Source Type: research

The Association of Transcription Factor 7 like 2 Gene Polymorphism with Diabetic Nephropathy in patients with type 2 diabetes mellitus.
CONCLUSION: rs12255372 TCF7L2 gene polymorphism was strongly associated with type 2 diabetes mellitus and DN. The association between rs12255372 polymorphism and DN was a mere reflection of a complicated diabetes mellitus rather than a direct independent association. PMID: 31288725 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - July 9, 2019 Category: Endocrinology Authors: Morgan MF, Salam RF, Rady NH, Alnaggar ARLR, Ammar SH, Ghanem NS Tags: Curr Diabetes Rev Source Type: research

Self-Care in Adults with Type 2 Diabetes Mellitus: A Systematic Review.
CONCLUSION: The studies indicated a poor adherence of the population to good self-care practices, reflected by the increase in complications related to DM. PMID: 31267873 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - July 2, 2019 Category: Endocrinology Authors: da Rocha RB, Silva CS, Cardoso VS Tags: Curr Diabetes Rev Source Type: research

The Role of Adiponectin in Maintaining Metabolic Homeostasis.
Abstract Adiponectin is an adipocyte-derived cytokine, which has recently become closely associated with obesity, altered body fat distribution, insulin resistance and atherosclerosis. Although research efforts on adiponectin mostly aim towards its endocrine functions, these adipocyte-derived signals have also profound autocrine and paracrine functions. Furthermore, evidence from both animal and human studies demonstrate that adiponectin plays an important role in the pathophysiology of carbohydrate and lipid metabolism. The proper identification of these roles is of great importance, for which is a potential way ...
Source: Current Diabetes Reviews - July 2, 2019 Category: Endocrinology Authors: Adiyaman SC, Ozer M, Saydam BO, Akinci B Tags: Curr Diabetes Rev Source Type: research

Prevalence and Risk Factors for Diabetes Mellitus in a State in South East Nigeria: Results of a Population Based House To House Survey.
CONCLUSION: The prevalence of DM in this study was 3.3%. A BMI>25 kg/m2, WHR>0.85, family history of DM, HC, and older age were associated with significantly higher prevalence. PMID: 31250762 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - June 19, 2019 Category: Endocrinology Authors: Ezeani IU, Chukwuonye II, Onyeonoro UU, Chuku A, Ogah OS Tags: Curr Diabetes Rev Source Type: research

A Prospective Study of the Clinical and Demographic Profile of Type 2 Diabetes Mellitus Patients Receiving Antidiabetic Drug Combinations.
Conclusion A combination of metformin with sulfonylurea was the preferred first-line treatment; insulin was added when the HbA1c was>9. Patients who received dose escalation had a longer duration of the disease and higher FBG and HbA1c. PMID: 31250763 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - June 19, 2019 Category: Endocrinology Authors: Gadgade A, Shenoy A, Kamath A, Kamath P, Adhikari P, Rs N, Hadigal S, N S, Shenoy N, Chowta MN Tags: Curr Diabetes Rev Source Type: research

Impact of Glycemic Variability and Hypoglycemia on the Mortality and Length of Hospital Stay among Elderly Patients in Brazil.
This study aimed to investigate the association between GV, hypoglycemia, and the 90-day mortality and length of hospital stay (LOS) among non-critically ill hospitalized elderly patients. METHODS: The medical records of 2,237 elderly patients admitted to the Zilda Arns Elderly Hospital over a 2.5-year period were reviewed. Hypoglycemia was defined as a glucose level
Source: Current Diabetes Reviews - June 19, 2019 Category: Endocrinology Authors: Bruginski D, Précoma DB, Sabbag A, Olandowski M Tags: Curr Diabetes Rev Source Type: research

An insight of Alpha-amylase inhibitors as a Valuable Tool in the Management of Type 2 Diabetes Mellitus.
CONCLUSION: Herein we discuss various potential antidiabetic agents which are strategically target alpha amylase enzyme. These are having lesser side effects as compared to other antidiabetic agents. These are proposed to prevent the digestion and absorption of glucose leading to decrease the blood glucose level. PMID: 31237215 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - June 17, 2019 Category: Endocrinology Authors: Bashary R, Vyas M, Nayak SK, Suttee A, Verma S, Narang R, Khatik GL Tags: Curr Diabetes Rev Source Type: research

New Insight into Diabetes Management: from Glycemic Index to Dietary Insulin Index.
CONCLUSION: Choosing foods based on carbohydrate counting, glycemic index or glycemic load are common guides to control glycemia in diabetic patients, but neglect the insulin response, so meet with failure in diabetes management. Therefore, paying attention to insulinemic response along with glycemic response seems to be more effective in managing diabetes. PMID: 31203801 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - June 14, 2019 Category: Endocrinology Authors: Yari Z, Behrouz V, Zand H, Pourvali K Tags: Curr Diabetes Rev Source Type: research

Liraglutide as adjunct to insulin treatment in patients with type 1 diabetes: A systematic review and meta-analysis.
CONCLUSION: In patients with T1D, liraglutide might offer as adjunct to insulin, improving glycemic control, inducing body weight loss and decreasing exogenous insulin requirements and severe hypoglycemia. PMID: 31203802 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - June 14, 2019 Category: Endocrinology Authors: Dimitrios P, Michael D, Vasilios K, Konstantinos S, Konstantinos I, Ioanna Z, Konstantinos P, Spyridon B, Asterios K Tags: Curr Diabetes Rev Source Type: research

Not a Painless Condition: Rheumatological and Musculoskeletal Symptoms in Type 2 Diabetes, and the Implications for Exercise Participation.
DISCUSSION: Recommendations for future research are provided. PMID: 31146662 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - May 30, 2019 Category: Endocrinology Authors: Cox ER, Coombes JS, Keating SE, Burton NW, Coombes BK Tags: Curr Diabetes Rev Source Type: research

Evaluation of Glycated Haemoglobin (HbA1c) Level in Type 2 Diabetic chronic HCV non cirrhotic treatment-na ïve Egyptian patients eradicated with sofosbuvir plus daclatasvir.
Evaluation of Glycated Haemoglobin (HbA1c) Level in Type 2 Diabetic chronic HCV non cirrhotic treatment-naïve Egyptian patients eradicated with sofosbuvir plus daclatasvir. Curr Diabetes Rev. 2019 May 30;: Authors: Hussein HA, Allam AS, Moaty ASA Abstract Background /Introduction: A high prevalence of type 2 diabetes mellitus (T2DM) was seen in association with hepatitis C virus infection; moreover, risk of development of T2DM is increased about 11 folds in patients with risk factors for metabolic syndrome in the presence of chronic hepatitis C virus (HCV) infection. There is a few available data...
Source: Current Diabetes Reviews - May 30, 2019 Category: Endocrinology Authors: Hussein HA, Allam AS, Moaty ASA Tags: Curr Diabetes Rev Source Type: research

Clinical Utility of the Ankle-Brachial Index and Toe Brachial Index in Patients with Diabetic Foot Ulcers.
In conclusion, it is recommend both the ABI and TBI to be used as screening tests for PAD in diabetic foot ulcer patients. PMID: 31146664 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - May 30, 2019 Category: Endocrinology Authors: Ababneh M, Al Ayed MY, Robert AA, Al Dawish MA Tags: Curr Diabetes Rev Source Type: research

The Worrying Trend of Diabetes Mellitus in Saudi Arabia: An Urgent Call to Action.
Abstract From last few years, the pervasiveness of diabetes mellitus (DM), in Saudi Arabia, is growing at a frightening rate. Overall, one fourth of the adult population is affected by DM, which is further predicted to rise to more than double by the year 2030. The most alarming is possibly the escalation propensity of diabetes, in recent years, where a nearly ten-fold increase has been witnessed over the past thirty years in Saudi Arabia. However, the number of research arbitrations on the prevalence and incidence of DM is woefully inadequate, as compared to developed countries. Apart from this, most of the exist...
Source: Current Diabetes Reviews - May 30, 2019 Category: Endocrinology Authors: Robert AA, Al Dawish MA Tags: Curr Diabetes Rev Source Type: research

A Clinical decision support system for assessing the risk of cardiovascular diseases in the diabetic hemodialysis patients.
CONCLUSION: The results of the system were largely similar to the patients' records and showed that the designed system can be used to help physicians to assess the risk of cardiovascular diseases and to improve the quality of care services for diabetic patients undergoing hemodialysis. By predicting the risk of the disease and classifying patients in different risk groups, it is possible to provide them with better care plans. PMID: 31146666 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - May 30, 2019 Category: Endocrinology Authors: Boni TTA, Ayatollahi H, Langarizadeh M Tags: Curr Diabetes Rev Source Type: research

Gene-environment interaction on the risk of type 2 diabetes among ethnic minority populations living in Europe and North America: A systematic review.
CONCLUSION: There is a need for more studies on GEI among ethnicities, broadening the spectrum of ethnic minority groups being investigated, performing more discovery using genome-wide approaches, larger sample sizes for these studies by collaborating efforts such as the InterConnect approach, and developing a more standardized method of reporting GEI studies are discussed. PMID: 31146667 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - May 30, 2019 Category: Endocrinology Authors: Zafarmand MH, Tajik P, Spijker R, Agyemang C Tags: Curr Diabetes Rev Source Type: research

Effect Of Supervised Exercise Program On Individuals In Peripheral Arterial Disease With Type 2 Diabetes Mellitus - A Systematic Review.
Conclusion - In conclusion, the data evaluating the supervised exercise program in PAD with T2DM is inadequate to determine its effect on this population. Future large-scale studies can be conducted on both subjective and objective outcomes of PAD with T2DM to have a better understanding of the condition and for a universally acceptable exercise program for these individuals which the healthcare practitioners can use in their practice. PMID: 31124423 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - May 23, 2019 Category: Endocrinology Authors: Arora E, Maiya AG, Bhat R, Devasia T, Kamath G Tags: Curr Diabetes Rev Source Type: research

A Comprehensive Review on Preclinical Diabetic Models.
CONCLUSION: This review encompasses the wide pathophysiological and molecular mechanisms associated with diabetes, particularly focusing on the challenges associated with the evaluation and predictive validation of these models as ideal animal models for preclinical assessments and discovering new drugs and therapeutic agents for translational application in humans. This review may further contribute to discover a novel drug to treat diabetes more efficaciously with minimum or no side effects. Furthermore, it also highlights ongoing research and considers the future perspectives in the field of diabetes. PMID: 3107437...
Source: Current Diabetes Reviews - May 10, 2019 Category: Endocrinology Authors: Shakya A, Chaudary SK, Garabadu D, Bhat HR, Kakoti BB, Ghosh SK Tags: Curr Diabetes Rev Source Type: research

Knowledge and Awareness of Oral Manifestations of Diabetes Mellitus and Oral Health Assessment among Diabetes Mellitus Patients- A Cross Sectional Study.
The objectives of our study was to assess the knowledge and awareness of type 2 diabetes mellitus patients about oral manifestations of diabetes, their risk for developing oral diseases as complications associated with diabetes mellitus and at same instance perform an oral examination to detect these oral symptoms if any present, along with recording of Decayed Missing Filled Teeth Index (DMFT) and Community Periodontal Index (CPI) index. METHODOLOGY: Structured questionnaires consisting of 12 different statements on the knowledge base of oral manifestations of diabetes mellitus were distributed to 447 Type 2 diabetes...
Source: Current Diabetes Reviews - May 2, 2019 Category: Endocrinology Authors: Parakh MK, Kasi A, Ayappan V, Prabhu S Tags: Curr Diabetes Rev Source Type: research

The Emerging role of Branch Chain Amino Acids in the Prediction of Diabetes: A Brief Review.
CONCLUSION: The research findings related to BCAA signaling pathways and metabolism broaden our understanding of this topic. However, it remains unclear how increased levels of BCAAs will assist in the prediction of future insulin resistance or type 2 diabetes. Future research needs to determine whether BCAAs are a causative factor for insulin resistance and type 2 diabetes, or just a biomarker of impaired insulin action. PMID: 31057117 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - May 2, 2019 Category: Endocrinology Authors: Nawaz SS, Siddiqui K Tags: Curr Diabetes Rev Source Type: research

GLP-1 Receptor Agonists in Type 2 Diabetes Mellitus.
CONCLUSION: The significant potency and appreciable safety of GLP-1 RAs manifested their potential as a logical approach for the management of type 2 diabetes. PMID: 31057118 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - May 2, 2019 Category: Endocrinology Authors: Dahiya L, Kaur R, Kumar R, Kumar M, Palta K Tags: Curr Diabetes Rev Source Type: research

Perceptions in Type 1 Diabetes Mellitus with or without the use of Insulin Pump: An online study.
DISCUSSION: Negative perceptions of MDI users in treatment control, illness comprehensibility, representations of control, body image and sex life with the insulin pump, differentiate CSII and MDI therapy groups to a significant degree. According to the research, these parameters seem to interfere with accepting CSII therapy for MDI users and discourage them. PMID: 31057119 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - May 2, 2019 Category: Endocrinology Authors: Benioudakis ES Tags: Curr Diabetes Rev Source Type: research

Charcot neuroarthropathy: From the laboratory to the bedside.
CONCLUSIONS: The review concludes with the comprehensive summary of the major promising therapeutic strategies, including conservative treatment involving orthopedic devices, pharmacological approach, and the most common surgical techniques currently employed in the diagnosis and treatment of this acute disease. PMID: 31057120 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - May 2, 2019 Category: Endocrinology Authors: Pitocco D, Scavone G, Di Leo M, Vitiello R, Rizzi A, Tartaglione L, Costantini F, Flex A, Galli M, Caputo S, Ghirlanda G, Pontecorvi A Tags: Curr Diabetes Rev Source Type: research

Primary hypertriglyceridemia: A look back on the clinical classification and genetics of the disease.
CONCLUSION: The current review has summarized the case definition, epidemiology, pathophysiology, clinical presentation, classification, associated genetic factors, and scope of genetic screening in the diagnosis of primary HTG. PMID: 31057121 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - May 2, 2019 Category: Endocrinology Authors: Musambil M, Al-Rubeaan K, Al-Qasim S, Al Naqeb D, Al-Soghayer A Tags: Curr Diabetes Rev Source Type: research

The Etiology and Treatment of LADA: An Update.
Abstract PMID: 30990133 [PubMed - in process] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - April 18, 2019 Category: Endocrinology Authors: Grill V Tags: Curr Diabetes Rev Source Type: research