Panax ginseng Ameliorates Pituitary-Ovarian Dysfunction Induced by Radiofrequency Electromagnetic Radiation from Cell Phones via Upregulation of the CREM Signaling Pathway
CONCLUSION: The findings of this study indicate that P. ginseng extract shields against pituitary-ovarian impairment linked to RF-EMR exposure from cell phones by boosting antioxidant capacity and promoting the CREM-dependent pathway.PMID:38693729 | DOI:10.2174/0115701638279386240425050818 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - May 2, 2024 Category: Drugs & Pharmacology Authors: Oyetunji A Oyewopo Olabimpe C Badejogbin Isaac O Ajadi Linus A Enye Mary B Ajadi Ikponmwosa V Ebuwa Olutunmise V Owolabi Stephanie E Areloegbe Kehinde S Olaniyi Source Type: research
Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine
ConclusionsARG2 produces spermidine endogenously in the intestinal epithelium and has a palliative effect on ulcerative colitis. ARG2 and spermidine are potential novel therapeutic targets for UC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - May 2, 2024 Category: Gastroenterology Source Type: research
Phytomediated stress modulates antioxidant status, induces overexpression of < i > CYP6M2 < /i > , < i > Hsp70 < /i > , < i > α-esterase < /i > , and suppresses the < i > ABC transporter < /i > in < i > Anopheles gambiae < /i > ( < i > sensu stricto < /i > ) exposed to < i > Ocimum tenuiflorum < /i > extracts
by Harun K. Aremu, Christianah A. Dare, Idris A. Adekale, Bukunmi D. Adetunji, Dickson A. Musa, Luqmon A. Azeez, Olu I. Oyewole
The incorporation of phytoactive compounds in the management of malarial vectors holds promise for the development of innovative and efficient alternatives. Nevertheless, the molecular and physiological responses that these bioactive substances induce remain underexplored. This present study inves tigated the toxicity of different concentrations of aqueous and methanol extracts ofOcimum tenuiflorum against larvae ofAnopheles gambiae (sensu stricto) and unraveled the possible underlying molecular ...
Source: PLoS One - May 2, 2024 Category: Biomedical Science Authors: Harun K. Aremu Source Type: research
Molecules, Vol. 29, Pages 2113: Pleurotus sajor-caju (Fr.) Singer & beta;-1,3-Glucanoligosaccharide (Ps-GOS) Suppresses RANKL-induced Osteoclast Differentiation and Function in Pre-Osteoclastic RAW 264.7 Cells by Inhibiting the RANK/NF & kappa;B/cFOS/NFATc1 Signalling Pathway
Molecules, Vol. 29, Pages 2113: Pleurotus sajor-caju (Fr.) Singer β-1,3-Glucanoligosaccharide (Ps-GOS) Suppresses RANKL-induced Osteoclast Differentiation and Function in Pre-Osteoclastic RAW 264.7 Cells by Inhibiting the RANK/NFκB/cFOS/NFATc1 Signalling Pathway
Molecules doi: 10.3390/molecules29092113
Authors:
Purithat Rattajak
Aratee Aroonkesorn
Carl Smythe
Rapepun Wititsuwannakul
Thanawat Pitakpornpreecha
Edible grey oyster mushroom, Pleurotus sajor-caju, &beta; (1,3), (1,6) glucan possesses a wide range of biological activities, including anti-inflammation, anti-microorganism ...
Source: Molecules - May 2, 2024 Category: Chemistry Authors: Purithat Rattajak Aratee Aroonkesorn Carl Smythe Rapepun Wititsuwannakul Thanawat Pitakpornpreecha Tags: Article Source Type: research
Molecules, Vol. 29, Pages 2100: Research Progress in Pharmacological Effects and Mechanisms of Angelica sinensis against Cardiovascular and Cerebrovascular Diseases
This article reviews the main pharmacological effects and clinical research of A. sinensis on cardiovascular and cerebrovascular diseases in recent years, explores the effect of its chemical components on cardiovascular and cerebrovascular diseases by regulating the expression of functional proteins and inhibiting inflammation, anti-apoptosis, and antioxidant mechanisms. It provides a reference for further research on A. sinensis and the development of related drugs. It provides a new reference direction for the in-depth research and application of A. sinensis in the prevention, improvement, and treatment of cardiovascular...
Source: Molecules - May 2, 2024 Category: Chemistry Authors: Linlin Chen Bei Fan Fengzhong Wang Yang Song Xizhi Wang Ying Meng Yumin Chen Qing Xia Jing Sun Tags: Review Source Type: research
Molecules, Vol. 29, Pages 2101: Phenolic Compounds Profile and Antioxidant Capacity of Plant-Based Protein Supplements
owicz
The study aimed to determine the phenolic content and antioxidant capacity of five protein supplements of plant origin. The content and profile of phenolics were determined using the UHPLC-DAD-MS method, while antioxidant capacity (ABTS and DPPH assays) and total phenolic content (TPC) were evaluated using spectrophotometric tests. In the analyzed proteins, twenty-five polyphenols were detected, including eleven phenolic acids, thirteen flavonoids, and one ellagitannin. Hemp protein revealed the highest individual phenolics content and TPC value (1620 &mu;g/g and 1.79 mg GAE/g, respectively). Also, hemp p...
Source: Molecules - May 2, 2024 Category: Chemistry Authors: Tomasz Sawicki Monika Jab łońska Anna Danielewicz Katarzyna E. Przyby łowicz Tags: Article Source Type: research
Molecules, Vol. 29, Pages 2109: Extraction and In Vitro Skincare Effect Assessment of Polysaccharides Extract from the Roots of Abelmoschus manihot (L.)
In this study, polysaccharides are extracted from the discarded roots of Abelmoschus manihot (L.) by the high-efficiency ultrasound-assisted extraction (UAE). The optimized condition was determined as solid&ndash;liquid ratio SL ratio = 1:20, temperature T = 30 &deg;C and time T = 40 min, achieving an extraction yield of 13.41%. Composition analysis revealed that glucose (Glc, 44.65%), rhamnose (Rha, 26.30%), galacturonic acid (GalA, 12.50%) and galactose (Gal, 9.86%) are the major monosaccharides of the extract. The extract showed a low degree of esterification (DE) value of 40.95%, and its Fourier-transfo...
Source: Molecules - May 2, 2024 Category: Chemistry Authors: Junjie Wang Enhui Liao Zixuan Ren Qiong Wang Zenglai Xu Shufang Wu Chaoguang Yu Yunlong Yin Tags: Article Source Type: research
Aneuploidy is Linked to Neurological Phenotypes Through Oxidative Stress
AbstractAneuploidy, having an aberrant genome, is gaining increasing attention in neurodegenerative diseases. It gives rise to proteotoxic stress as well as a stereotypical oxidative shift which makes these cells sensitive to internal and environmental stresses. A growing body of research from numerous laboratories suggests that many neurodegenerative disorders, especially Alzheimer ’s disease and frontotemporal dementia, are characterised by neuronal aneuploidy and the ensuing apoptosis, which may contribute to neuronal loss. UsingDrosophila as a model, we investigated the effect of induced aneuploidy in GABAergic neuro...
Source: Journal of Molecular Neuroscience - May 2, 2024 Category: Neuroscience Source Type: research
Liensinine alleviates sepsis-induced acute liver injury by inhibiting the NF- κB and MAPK pathways in an Nrf2-dependent manner
Chem Biol Interact. 2024 Apr 29:111030. doi: 10.1016/j.cbi.2024.111030. Online ahead of print.ABSTRACTSepsis remains a serious public health issue that needs to be addressed globally. Severe liver injury caused by sepsis increases the risk of death in patients with sepsis. Liensinine (Lie) is one of the primary active components in Plumula nelumbinis and has anti-inflammatory and antioxidant effects. Nevertheless, the effects of Lie on septic liver injury are unclear. This research investigated the protective effect of Lie (10, 20 and 40 mg/kg) on liver damage via intraperitoneal administration of LPS (10 mg/kg) to C57BL/6...
Source: Chemico-Biological Interactions - May 1, 2024 Category: Molecular Biology Authors: Xiao Zhang Silong Yuan Hui Fan Wei Zhang Honggang Zhang Source Type: research
Short-term dietary teprenone improved thermal tolerance and mitigated liver damage caused by heat stress in juvenile largemouth bass (Micropterus salmoides)
This study offers theoretical support for applying teprenone in aquaculture to reduce financial losses caused by abiotic factors.PMID:38692348 | DOI:10.1016/j.cbpb.2024.110984 (Source: Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology.)
Source: Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology. - May 1, 2024 Category: Biochemistry Authors: Hongyun Li Feifei Chen Mu Qin Chenlei Liao Yaqi Shi Sihan Wu Keming Rong Xuezhen Zhang Source Type: research
Therapeutic administration of Luteolin protects against Escherichia coli-derived Lipopolysaccharide-triggered Inflammatory Response and Oxidative Injury
Acta Trop. 2024 Apr 29:107236. doi: 10.1016/j.actatropica.2024.107236. Online ahead of print.ABSTRACTEndometritis reduces reproductive effectiveness and leads to significant financial losses in the dairy sector. Luteolin is a natural phyto-flavonoid compound with many biological activities. However, the therapeutic effect of Luteolin against lipopolysaccharides (LPS)-induced endometritis has not yet been explored. A total of eighty female Kunming mice were randomly assigned into four treatment groups (n = 20). Following a successful initiation of the endometritis model by LPS, Luteolin was intraperitoneally administered th...
Source: Acta Tropica - May 1, 2024 Category: Infectious Diseases Authors: Aftab Shaukat Shahid Ali Rajput Mehboob Ali Rizwan Shukat Sana Hanif Mubashar Hassan Dalia Fouad Farid S Ataya Irfan Shaukat Arfan Yousaf Shadab Shaukat Renwei Su Source Type: research
Role of antioxidants in the neurobiology of drug addiction: An update
Biomed Pharmacother. 2024 Apr 30;175:116604. doi: 10.1016/j.biopha.2024.116604. Online ahead of print.ABSTRACTRelationships between protective enzymatic and non-enzymatic pro-antioxidant mechanisms and addictive substances use disorders (SUDs) are analyzed here, based on the results of previous research, as well as on the basis of our current own studies. This review introduces new aspects of comparative analysis of associations of pro-antixidant and neurobiological effects in patients taking psychoactive substances and complements very limited knowledge about relationships with SUDs from different regions, mainly Europe. ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Piotr Kami ński Ma łgorzata Lorek J ędrzej Baszyński Tadeusz Tadrowski Edward Jacek Gorzela ńczyk Julia Feit Halina Tkaczenko Jakub Owoc Alina Wo źniak Natalia Kurhaluk Source Type: research
Britanin - a beacon of hope against gastrointestinal tumors?
World J Clin Oncol. 2024 Apr 24;15(4):523-530. doi: 10.5306/wjco.v15.i4.523.ABSTRACTBritanin is a bioactive sesquiterpene lactone known for its potent anti-inflammatory and anti-oxidant properties. It also exhibits significant anti-tumor activity, suppressing tumor growth in vitro and in vivo. The current body of research on Britanin includes thirty papers predominantly related to neoplasms, the majority of which are gastrointestinal tumors that have not been summarized before. To drive academic debate, the present paper reviews the available research on Britanin in gastrointestinal tumors. It also outlines novel research ...
Source: Clinical Colorectal Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Agnieszka Kajdanek Damian Ko łat Lin-Yong Zhao Mateusz Kciuk Zbigniew Pasieka Żaneta Kałuzińska-Kołat Source Type: research
FGF10 protects against particulate matter-induced lung injury by inhibiting ferroptosis via Nrf2-dependent signaling
Int Immunopharmacol. 2024 Apr 30;134:112165. doi: 10.1016/j.intimp.2024.112165. Online ahead of print.ABSTRACTParticulate matter (PM) is considered the fundamental component of atmospheric pollutants and is associated with the pathogenesis of many respiratory diseases. Fibroblast growth factor 10 (FGF10) mediates mesenchymal-epithelial signaling and has been linked with the repair process of PM-induced lung injury (PMLI). However, the pathogenic mechanism of PMLI and the specific FGF10 protective mechanism against this injury are still undetermined. PM was administered in vivo into murine airways or in vitro to human bronc...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Yao Qian Qiangqiang Shi Wanting Zhou Baiqi He Haibo Xu Bin Liu Wanqi Miao Saverio Bellusci Chengshui Chen Nian Dong Source Type: research
Unlocking renal Restoration: Mesaconine from Aconitum plants restore mitochondrial function to halt cell apoptosis in acute kidney injury
This study explored mesaconine, derived from processed Fuzi, as a promising low-toxicity alternative for AKI treatment. In this study, we assessed the protective effects of mesaconine in gentamicin (GM)-induced NRK-52E cells and AKI rat models in vitro and in vivo, respectively. Mesaconine promotes the proliferation of damaged NRK-52E cells and down-regulates intracellular transforming growth factor β1 (TGF-β1) and kidney injury molecule 1 (KIM-1) to promote renal cell repair. Concurrently, mesaconine restored mitochondrial morphology and permeability transition pores, reversed the decrease in mitochondrial membrane pote...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Yixin Rui Xiumeng Zhang Xinran Min Hongxiao Xie Xiuying Ma Funeng Geng Rong Liu Source Type: research
