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Melatonin prevents pulmonary fibrosis caused by PM 2.5 exposure by targeting epithelial-mesenchymal transition
Toxicol Appl Pharmacol. 2024 Apr 28:116949. doi: 10.1016/j.taap.2024.116949. Online ahead of print.ABSTRACTPulmonary fibrosis is a lung disorder characterized by the accumulation of abnormal extracellular matrix, scar tissue formation, and tissue stiffness. Type II alveolar epithelial cells (AEII) play a critical role in repairing lung tissue after injury, and repeated injury to these cells is a key factor in the development of pulmonary fibrosis. Chronic exposure to PM2.5, a type of air pollution, has been shown to increase the incidence and severity of pulmonary fibrosis by enhancing the activation of EMT in lung epithel...
Source: Toxicology and Applied Pharmacology - April 30, 2024 Category: Toxicology Authors: Po-Chun Chen Ming-Hong Yen Sheng-Yen Hsiao Wan-Chen Kao Mei-Ting Wang Pei-Chen Chiou Chia-Chia Chao Source Type: research

Cyanidin-3-O-glucoside protects Zearalenone-induced in vitro maturation disorders of porcine oocytes by alleviating NOX4-dependent oxidative stress and endoplasmic reticulum stress in cumulus cells
In conclusion, C3G promoted in vitro maturation of porcine oocytes exposed to ZEN via mitigating NOX4-dependent oxidative stress and ERS in cumulus cells. These results contribute to our comprehension of the molecular mechanisms underlying the protective effects of C3G against ZEN toxicity in porcine oocytes, and they provide a novel theoretical foundation and strategy for future applications of C3G in the improvement of female reproduction.PMID:38688352 | DOI:10.1016/j.chemosphere.2024.142153 (Source: Chemosphere)
Source: Chemosphere - April 30, 2024 Category: Chemistry Authors: Xiuxiu Li Yu Tian Ning Zuo Jiatian Tang Shunfeng Cheng Lan Li Jinghe Tan Jianxin Zhang Wei Shen Source Type: research

Antioxidant and Antimicrobial Potential of Peptide from Rabbit Meat Hydrolysate Prepared by Trypsin and Zingibain
Conclusion: The combination zingibain enzyme and trypsin is feasible for hydrolyzing rabbit meat and the optimum hydrolysis time was 24 hrs with IC50 52.45 ppm, although accompanied by reduction in antibacterial activities.PMID:38686737 | DOI:10.3923/pjbs.2024.152.159 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - April 30, 2024 Category: Biomedical Science Authors: Eka Wulandari Wendry Setiyadi Putranto Andry Pratama Jajang Gumilar Rani Maharani Source Type: research

Antioxidant and Antibacterial Properties of 1,3-Dihydroxy-,2', 2'-Dimethylpyrano-(5,6)-Xanthone from Streptomyces sp. SU84
Conclusion: The findings suggested that compounds of Streptomyces sp. SU84 displayed antibacterial and antioxidant properties without cytotoxic activity. Extensive studies of compound 1 may be useful for the advancement of improved methods for avoidance, control and management of bacterial infections and metabolic-related free radical contribution.PMID:38686735 | DOI:10.3923/pjbs.2024.132.141 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - April 30, 2024 Category: Biomedical Science Authors: Thongchai Taechowisan Thanaporn Chuen-Im Waya S Phutdhawong Source Type: research

Evaluation of Melatonin and its Nanostructures Effects on Skin Disorders Focused on Wound Healing
Mini Rev Med Chem. 2024 Apr 29. doi: 10.2174/0113895575299255240422055203. Online ahead of print.ABSTRACTSkin is the largest organ of the human body functioning as a great primitive defensive barrier against different harmful environmental factors. However, it is damaged through varying injuries such as different wounds, burns, and skin cancers that cause disruption in internal organs and essential mechanisms of the body through inflammation, oxidation, coagulation problems, infection, etc. Melatonin is the major hormone of the pineal gland that is also effective in skin disorders due to strong antioxidant and anti-inflamm...
Source: Mini Reviews in Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Seyedeh Mohaddeseh Mousavi Leila Etemad Davood Yari Maryam Hashemi Zahra Salmasi Source Type: research

Expression of human dCTP pyrophosphatase 1 (DCTPP1) and its association with cisplatin resistance characteristics in ovarian cancer
In this study, we aimed to understand the role of DCTPP1 in cancer progression and cisplatin response. Using publicly available databases, we analysed the expression and clinical significance of DCTPP1 in ovarian cancer. Our bioinformatics analysis confirmed that DCTPP1 is significantly overexpressed in ovarian cancer and is closely associated with tumour progression and poor prognosis after cisplatin treatment. We also found that DCTPP1 located in oxidoreductase complex and may be involved in various biological processes related to cisplatin resistance, including pyrimidine nucleotide metabolism, the P53 signalling pathwa...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Yu Wang Xiangyun Chen Qiduan Chen Tiancai Liu Yingsong Wu Liping Huang Yao Chen Source Type: research

Glutathione peroxidase 4 restrains temporomandibular joint osteoarthritis progression by inhibiting ferroptosis
In conclusion, GPX4 and ferroptosis regulated the progression of TMJOA. Targeting ferroptosis might be an effective therapeutic strategy for TMJOA patients in the clinic.PMID:38686488 | PMC:PMC11058612 | DOI:10.1111/jcmm.18377 (Source: J Cell Mol Med)
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Chunyan Pang Hongmei Zhang Yi Liu Na Tang Kun Tian Yandong Mu Xue Li Li Xiao Source Type: research

Anti-viral Effects of Pavetta indica Methanolic Extract and Acyclovir on Behavioral and Biochemical Parameters in Streptozotocin-induced Alzheimer's Disease in Rats
CONCLUSION: In a dose-dependent manner, acyclovir and Pavetta indica methanolic extract treatments abrogated the streptozotocin-induced behavioral and neurological abnormalities in rats. The potential therapeutic effects of PIME and acyclovir administration in intracerebroventricular-streptozotocin-treated rats may be attributed to its potential antiviral, antioxidant, and anti-inflammatory effects. The current study suggests that Pavetta indica methanolic extract and acyclovir are promising therapeutic targets against Alzheimer's disease.PMID:38685761 | DOI:10.2174/0118715303273145240110100341 (Source: Endocrine, Metaboli...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Drugs & Pharmacology Authors: Deepak Kumar Govind Singh None Tarun Meenakshi Dhanawat Sumeet Gupta Mohamed A Morsy Anroop B Nair Asmaa I Matouk Source Type: research

Anti-viral Effects of Pavetta indica Methanolic Extract and Acyclovir on Behavioral and Biochemical Parameters in Streptozotocin-induced Alzheimer's Disease in Rats
CONCLUSION: In a dose-dependent manner, acyclovir and Pavetta indica methanolic extract treatments abrogated the streptozotocin-induced behavioral and neurological abnormalities in rats. The potential therapeutic effects of PIME and acyclovir administration in intracerebroventricular-streptozotocin-treated rats may be attributed to its potential antiviral, antioxidant, and anti-inflammatory effects. The current study suggests that Pavetta indica methanolic extract and acyclovir are promising therapeutic targets against Alzheimer's disease.PMID:38685761 | DOI:10.2174/0118715303273145240110100341 (Source: Herpes)
Source: Herpes - April 30, 2024 Category: Infectious Diseases Authors: Deepak Kumar Govind Singh None Tarun Meenakshi Dhanawat Sumeet Gupta Mohamed A Morsy Anroop B Nair Asmaa I Matouk Source Type: research

Nrf2 expression, mitochondrial fission, and neuronal apoptosis in the prefrontal cortex of methamphetamine abusers and rats
Brain Res. 2024 Apr 27;1837:148973. doi: 10.1016/j.brainres.2024.148973. Online ahead of print.ABSTRACTMethamphetamine (MA), a representative amphetamine-type stimulant, is one of the most abused drugs worldwide. Studies have shown that MA-induced neurotoxicity is strongly associated with oxidative stress and apoptosis. While nuclear factor E2-related factor 2 (Nrf2), an antioxidant transcription factor, is known to exert neuroprotective effects, its role in MA-induced dopaminergic neuronal apoptosis remains incompletely understood. In the present study, we explored the effects of MA on the expression levels of Nrf2, dynam...
Source: Brain Research - April 30, 2024 Category: Neurology Authors: Qian-Yun Nie Gen-Meng Yang Peng Zhang Wen-Juan Dong Di Jing Zhen-Ping Hou Yan-Xia Peng Yang Yu Li-Hua Li Shi-Jun Hong Source Type: research

Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell
The objectives of this research were investigating the effects of these compounds on the pathogenesis and progress of Alzheimer's disease in cells modeled by formaldehyde. MTT, flow cytometry, and RT-PCR were used to investigate the toxicity, survival rate and apoptosis of the cells, and the expression level of PP2A, GSK3, NMDAR, BACE1, and APP genes, respectively. Also, the total antioxidant capacity of the modeled cells was measured. The results showed that the two compounds as well as the plants extract and essential oil were able to increase the percentage of cell survival; among them, Thymus vulgaris essential oil had...
Source: Brain Research - April 30, 2024 Category: Neurology Authors: Saba Foroughi Kahin Shahanipour Ramesh Monajemi Ali Mohammad Ahadi Source Type: research

Anti-viral Effects of Pavetta indica Methanolic Extract and Acyclovir on Behavioral and Biochemical Parameters in Streptozotocin-induced Alzheimer's Disease in Rats
CONCLUSION: In a dose-dependent manner, acyclovir and Pavetta indica methanolic extract treatments abrogated the streptozotocin-induced behavioral and neurological abnormalities in rats. The potential therapeutic effects of PIME and acyclovir administration in intracerebroventricular-streptozotocin-treated rats may be attributed to its potential antiviral, antioxidant, and anti-inflammatory effects. The current study suggests that Pavetta indica methanolic extract and acyclovir are promising therapeutic targets against Alzheimer's disease.PMID:38685761 | DOI:10.2174/0118715303273145240110100341 (Source: Endocrine, Metaboli...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Endocrinology Authors: Deepak Kumar Govind Singh None Tarun Meenakshi Dhanawat Sumeet Gupta Mohamed A Morsy Anroop B Nair Asmaa I Matouk Source Type: research

Protective effects of gallic acid against nickel-induced kidney injury: impact of antioxidants and transcription factor on the incidence of nephrotoxicity
This study investigated the mechanism by which gallic acid (GA) protects mice kidneys against renal damage induced by Nickel oxide nanoparticles (NiO-NPs). Forty male Swiss albino mice were randomly assigned into four groups, each consisting of ten mice (n = 10/group): Group I the control group, received no treatment; Group II, the GA group, was administrated GA at a dosage of 110 mg/kg/day body weight; Group III, the NiO-NPs group, received injection of NiO-NPs at a concentration of 20 mg/kg body weight for 10 consecutive days; Group IV, the GA + NiO-NPs group, underwent treatment with both GA and NiO-NPs. The results sho...
Source: Renal Failure - April 30, 2024 Category: Urology & Nephrology Authors: Areej I Alhazmi Mohamed F El-Refaei Eman A A Abdallah Source Type: research

Dual stress factors adaptive evolution for high EPA production in Schizochytrium sp. and metabolomics mechanism analysis
This study provides a novel pathway for promoting EPA biosynthesis in Schizochytrium.PMID:38687387 | DOI:10.1007/s00449-024-03013-4 (Source: Bioprocess and Biosystems Engineering)
Source: Bioprocess and Biosystems Engineering - April 30, 2024 Category: Biomedical Engineering Authors: Ying Ou Yu Qin Shoushuai Feng Hailin Yang Source Type: research