Nervonic acid alleviates MPTP-induced Parkinson's disease via MEK/ERK pathway
This study mainly explored whether NA is involved in regulating oxidative stress and apoptosis in MPTP-induced mouse model and MPP-induced cell model. Through behavior tests, we proved that MPTP-induced motor dysfunction in mice was recovered by NA treatment. NA can reduce MPTP-induced neuronal damage, manifested by elevated levels of TH and dopamine, as well as decreased levels of α-syn. In the in vitro model, we observed from CCK8 assay and flow cytometry that the induction of MPP markedly suppressed cell activity and enhanced cell apoptosis, but these functions were all reversed by NA. Furthermore, NA administration re...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Xinru Zhang Donglei Wu Zengwei Yin Source Type: research
Research progress of vitiligo repigmentation: from oxidative stress to autoimmunity
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):147-151. doi: 10.14715/cmb/2024.70.4.23.ABSTRACTVitiligo belongs to a frequent chronic autoimmune skin disease with the features of pigmented plaques on the diseased skin along with potential damage of melanocytes. There are many factors underlying the pathogenesis of vitiligo, among which oxidative stress is extensively regarded to be the critical factor leading to the loss of melanocytes. The changed redox state resulting from oxidative stress, containing ROS overproduction along with the reduced activity of the skin's antioxidant system, makes melanocytes less resistant ...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Tingting Yu Yan Wu Zhenzhong Lu Source Type: research
Effect and mechanism of Yiqing decoction on hyperuricemia rats
This study aimed to experimentally compare the uric acid-lowering effect and renal protection of Yiqing Fang in a rat model of hyperuricemia. Additionally, we used network pharmacology to predict the potential active components, targets, and pathways of Yiqing Fang. Male SD rats were randomly divided into control, model, Yiqing Fang, allopurinol, and probenecid groups. Serum creatinine (Scr), blood urea nitrogen (BUN), serum uric acid (UA), alanine transaminase (ALT), complete blood count, and urinary NAG enzyme levels were measured. Standard pathology and electron microscopy samples were prepared from the left kidney to o...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Yajie Xu Pan Chen Long Sun None Yan Zou None Lixing Zhang None Wanghai Tang None Tingji Zhang Jinlin Huo Jin Zhou Source Type: research
A novel arylpiperazine derivative (LQFM181) protects against neurotoxicity induced by 3- nitropropionic acid in in vitro and in vivo models
Chem Biol Interact. 2024 Apr 26;395:111026. doi: 10.1016/j.cbi.2024.111026. Online ahead of print.ABSTRACTIn the pursuit of novel antioxidant therapies for the prevention and treatment of neurodegenerative diseases, three new arylpiperazine derivatives (LQFM181, LQFM276, and LQFM277) were synthesized through a molecular hybridization approach involving piribedil and butylated hydroxytoluene lead compounds. To evaluate the antioxidant and neuroprotective activities of the arylpiperazine derivatives, we employed an integrated approach using both in vitro (SH-SY5Y cells) and in vivo (neurotoxicity induced by 3-nitropropionic ...
Source: Chemico-Biological Interactions - April 28, 2024 Category: Molecular Biology Authors: Hericles Mesquita Campos Robbert Mota Pereira P âmela Yasmin de Oliveira Ferreira Nkaa Uchenna C ínthia Rio Branco da Silva Letizia Pruccoli Germ án Sanz Marcella Ferreira Rodrigues Boniek Gontijo Vaz B árbara Gonçalves Rivello Andr é Luís Batista Source Type: research
Cobalt protoporphyrin modulates antioxidant enzyme activity in the hypothalamus and motor cortex of female rats
This study aimed to delve into CoPP's impact on the activities of crucial antioxidant enzymes: superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione-S-transferase (GST) across seven distinct brain regions (hippocampus, hypothalamus, prefrontal cortex, motor cortex, striatum, midbrain, and cerebellum), as well as in the liver and kidneys. Female Wistar rats weighing 180 to 200 grams received a single subcutaneous dose of 25 μmol/kg CoPP. After six days, brain tissue was extracted to assess the activities of antioxidant enzymes and quantify malondialdehyde levels. Ou...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Norma Serrano-Garc ía Ra úl Pinete-Sánchez Omar Noel Medina-Campos Minerva Adriana Ramos-Santander Jos é Pedraza-Chaverri Marisol Orozco-Ibarra Source Type: research
Nervonic acid alleviates MPTP-induced Parkinson's disease via MEK/ERK pathway
This study mainly explored whether NA is involved in regulating oxidative stress and apoptosis in MPTP-induced mouse model and MPP-induced cell model. Through behavior tests, we proved that MPTP-induced motor dysfunction in mice was recovered by NA treatment. NA can reduce MPTP-induced neuronal damage, manifested by elevated levels of TH and dopamine, as well as decreased levels of α-syn. In the in vitro model, we observed from CCK8 assay and flow cytometry that the induction of MPP markedly suppressed cell activity and enhanced cell apoptosis, but these functions were all reversed by NA. Furthermore, NA administration re...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Xinru Zhang Donglei Wu Zengwei Yin Source Type: research
Research progress of vitiligo repigmentation: from oxidative stress to autoimmunity
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):147-151. doi: 10.14715/cmb/2024.70.4.23.ABSTRACTVitiligo belongs to a frequent chronic autoimmune skin disease with the features of pigmented plaques on the diseased skin along with potential damage of melanocytes. There are many factors underlying the pathogenesis of vitiligo, among which oxidative stress is extensively regarded to be the critical factor leading to the loss of melanocytes. The changed redox state resulting from oxidative stress, containing ROS overproduction along with the reduced activity of the skin's antioxidant system, makes melanocytes less resistant ...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Tingting Yu Yan Wu Zhenzhong Lu Source Type: research
Effect and mechanism of Yiqing decoction on hyperuricemia rats
This study aimed to experimentally compare the uric acid-lowering effect and renal protection of Yiqing Fang in a rat model of hyperuricemia. Additionally, we used network pharmacology to predict the potential active components, targets, and pathways of Yiqing Fang. Male SD rats were randomly divided into control, model, Yiqing Fang, allopurinol, and probenecid groups. Serum creatinine (Scr), blood urea nitrogen (BUN), serum uric acid (UA), alanine transaminase (ALT), complete blood count, and urinary NAG enzyme levels were measured. Standard pathology and electron microscopy samples were prepared from the left kidney to o...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Yajie Xu Pan Chen Long Sun None Yan Zou None Lixing Zhang None Wanghai Tang None Tingji Zhang Jinlin Huo Jin Zhou Source Type: research
A novel arylpiperazine derivative (LQFM181) protects against neurotoxicity induced by 3- nitropropionic acid in in vitro and in vivo models
Chem Biol Interact. 2024 Apr 26:111026. doi: 10.1016/j.cbi.2024.111026. Online ahead of print.ABSTRACTIn the pursuit of novel antioxidant therapies for the prevention and treatment of neurodegenerative diseases, three new arylpiperazine derivatives (LQFM181, LQFM276, and LQFM277) were synthesized through a molecular hybridization approach involving piribedil and butylated hydroxytoluene lead compounds. To evaluate the antioxidant and neuroprotective activities of the arylpiperazine derivatives, we employed an integrated approach using both in vitro (SH-SY5Y cells) and in vivo (neurotoxicity induced by 3-nitropropionic acid...
Source: Chemico-Biological Interactions - April 28, 2024 Category: Molecular Biology Authors: Hericles Mesquita Campos Robbert Mota Pereira P âmela Yasmin de Oliveira Ferreira Nkaa Uchenna C ínthia Rio Branco da Silva Letizia Pruccoli Germ án Sanz Marcella Ferreira Rodrigues Boniek Gontijo Vaz B árbara Gonçalves Rivello Andr é Luís Batista Source Type: research
Polygenic markers of survival and longevity in the antioxidant genes PON1, PON2, MTHFR, MSRA, SOD1, NQO1, and CAT in a 20-year follow-up study in the population from the Volga-Ural region
CONCLUSION: In our longitudinal 20-year study, we found the combinations of functional polymorphisms in antioxidant genes involved in longevity and survival in certain clinical phenotypes in the advanced age.PMID:38679184 | DOI:10.1016/j.gene.2024.148510 (Source: Gene)
Source: Gene - April 28, 2024 Category: Genetics & Stem Cells Authors: Vera Erdman Ilsia Tuktarova Timur Nasibullin Yanina Timasheva Anna Petintseva Gulnaz Korytina Source Type: research
Lipoic acid alters the microRNA signature in breast cancer cells
CONCLUSION: The outcome of this study provides further insights into the molecular mechanisms underlying the therapeutic benefit of LA. This in turn could assist the amelioration of LA-based anticancer therapies.PMID:38678851 | DOI:10.1016/j.prp.2024.155321 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 28, 2024 Category: Pathology Authors: Hoda Khalife Mohammad Fayyad-Kazan Hussein Fayyad-Kazan Elie Hadchity Nada Borghol Nader Hussein Bassam Badran Source Type: research
Cobalt protoporphyrin modulates antioxidant enzyme activity in the hypothalamus and motor cortex of female rats
This study aimed to delve into CoPP's impact on the activities of crucial antioxidant enzymes: superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione-S-transferase (GST) across seven distinct brain regions (hippocampus, hypothalamus, prefrontal cortex, motor cortex, striatum, midbrain, and cerebellum), as well as in the liver and kidneys. Female Wistar rats weighing 180 to 200 grams received a single subcutaneous dose of 25 μmol/kg CoPP. After six days, brain tissue was extracted to assess the activities of antioxidant enzymes and quantify malondialdehyde levels. Ou...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Norma Serrano-Garc ía Ra úl Pinete-Sánchez Omar Noel Medina-Campos Minerva Adriana Ramos-Santander Jos é Pedraza-Chaverri Marisol Orozco-Ibarra Source Type: research
Nervonic acid alleviates MPTP-induced Parkinson's disease via MEK/ERK pathway
This study mainly explored whether NA is involved in regulating oxidative stress and apoptosis in MPTP-induced mouse model and MPP-induced cell model. Through behavior tests, we proved that MPTP-induced motor dysfunction in mice was recovered by NA treatment. NA can reduce MPTP-induced neuronal damage, manifested by elevated levels of TH and dopamine, as well as decreased levels of α-syn. In the in vitro model, we observed from CCK8 assay and flow cytometry that the induction of MPP markedly suppressed cell activity and enhanced cell apoptosis, but these functions were all reversed by NA. Furthermore, NA administration re...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Xinru Zhang Donglei Wu Zengwei Yin Source Type: research
Research progress of vitiligo repigmentation: from oxidative stress to autoimmunity
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):147-151. doi: 10.14715/cmb/2024.70.4.23.ABSTRACTVitiligo belongs to a frequent chronic autoimmune skin disease with the features of pigmented plaques on the diseased skin along with potential damage of melanocytes. There are many factors underlying the pathogenesis of vitiligo, among which oxidative stress is extensively regarded to be the critical factor leading to the loss of melanocytes. The changed redox state resulting from oxidative stress, containing ROS overproduction along with the reduced activity of the skin's antioxidant system, makes melanocytes less resistant ...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Tingting Yu Yan Wu Zhenzhong Lu Source Type: research
Effect and mechanism of Yiqing decoction on hyperuricemia rats
This study aimed to experimentally compare the uric acid-lowering effect and renal protection of Yiqing Fang in a rat model of hyperuricemia. Additionally, we used network pharmacology to predict the potential active components, targets, and pathways of Yiqing Fang. Male SD rats were randomly divided into control, model, Yiqing Fang, allopurinol, and probenecid groups. Serum creatinine (Scr), blood urea nitrogen (BUN), serum uric acid (UA), alanine transaminase (ALT), complete blood count, and urinary NAG enzyme levels were measured. Standard pathology and electron microscopy samples were prepared from the left kidney to o...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Yajie Xu Pan Chen Long Sun None Yan Zou None Lixing Zhang None Wanghai Tang None Tingji Zhang Jinlin Huo Jin Zhou Source Type: research
