Excessive intragastric alcohol administration exacerbates hepatic encephalopathy and provokes neuronal cell death in male rats with chronic liver disease
J Neurosci Res. 2024 May;102(5):e25337. doi: 10.1002/jnr.25337.ABSTRACTHepatic encephalopathy (HE) is defined as decline in neurological function during chronic liver disease (CLD). Alcohol is a major etiological factor in the pathogenesis of fibrosis/cirrhosis and has also been documented to directly impact the brain. However, the role of alcohol in the development of HE in CLD remains unclear. Here, we investigated the impact of excessive alcohol administration on neurological deterioration in rats with CLD. Starting day 7 post-BDL surgery, rats were administered alcohol twice daily (51% v/v ethanol, 3 g/kg, via gavage) ...
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Farzaneh Tamnanloo Xiaoru Chen Mariana M Oliveira M élanie Tremblay Christopher F Rose Source Type: research
Pharmacotherapeutic Potential of Bitter Gourd ( < em > Momordica charantia < /em > ) in Age-related Neurological Diseases
J Integr Neurosci. 2024 Apr 23;23(4):86. doi: 10.31083/j.jin2304086.ABSTRACTDue to the growth of the elderly population, age-related neurological disorders are an increasing problem. Aging begins very gradually and later leads to several neurological issues such as lower neurotransmitter levels, oxidative stress, neuronal inflammation, and continual neuronal loss. These changes might contribute to brain disorders such as Alzheimer's disease (AD), dementia or mild cognitive impairment, and epilepsy and glioma, and can also aggravate these disorders if they were previously present. Momordica charantia (bitter gourd), a membe...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Seyed Mohammad Hosein Hosseini Adarmanabadi Orod Jalali Khalil Abadi Amirhossein Amiri Rozhina Tamannaeifar Sahar Balanian Mehdi Rasekhjam Mohammad Sadra Samiazar Sara Hasanpour Samira Peiravi Dorsa Alijanzadeh Mohadeseh Poudineh Hamidreza Amiri Seyed Ami Source Type: research
Methyl jasmonate ameliorates pain ‐induced learning and memory impairments through regulating the expression of genes involved in neuroinflammation
ConclusionsThese findings highlight the notable antinociceptive potential of MeJA and its ability to inhibit pain-induced learning and memory dysfunction through its anti-inflammatory effect. (Source: Brain and Behavior)
Source: Brain and Behavior - April 29, 2024 Category: Neurology Authors: Fatemeh Mohammadinia,
Saeed Esmaeili ‐Mahani,
Mehdi Abbasnejad,
Manijeh Dogani,
Ali Mohammad Poorrahimi Tags: ORIGINAL ARTICLE Source Type: research
Tinospora cordifolia-assisted synthesis of silver ferrite nanoparticles: a multifunctional approach to photocatalytic degradation of reactive blue-13 dye, anti-bacterial efficacy, and antioxidant properties
. (Source: International Journal of Environmental Analytical Chemistry)
Source: International Journal of Environmental Analytical Chemistry - April 29, 2024 Category: Chemistry Authors: Sana JavaidMuhammad Shahid KhanMuhammad Babar TajHina AfzalIqra BatoolAfaf AlmasoudiMishayyam GhaznaviTariq JavedSharif QureshiWaqar Azeema Institute of Physics, The Islamia University Bahawalpur, Bahawalpur, Pakistanb Institute of Chemistry, The Islamia Source Type: research
Thermal decomposition characteristics of BHT and its peroxide (BHTOOH)
2,6-Di-tert-butyl-4-methylphenol (BHT) is an excellent antioxidant that is easily oxidized to 2,6-di-tert-butyl-4-hydroperoxyl-4-methyl-2,5-cyclohexadienone (BHTOOH). For the safety of BHT production and usage... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - April 29, 2024 Category: Chemistry Authors: Suyi Dai, Min Liang, Haijun Cheng, Chang Yu, Weiguang Li, Fang Lai, Li Ma and Xiongmin Liu Tags: Research Source Type: research
The associations of oxidative stress and inflammatory markers with obesity in Iranian population: MASHAD cohort study
Low-grade inflammation and stress oxidative condition play a role in the pathogenesis of obesity, and the serum levels of these markers, such as pro-oxidant-antioxidant balance (PAB), high-sensitivity C-reacti... (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - April 29, 2024 Category: Endocrinology Authors: Hamideh Ghazizadeh, Amin Mansoori, Toktam Sahranavard, Mohamad Nasrabadi, Kaveh Hadiloo, Nazanin Sheikh Andalibi, Marzyeh Azmon, Shima Tavallaei, Ameneh Timar, Gordon A Ferns and Majid Ghayour-Mobarhan Tags: Research Source Type: research
Enhancing nerve regeneration in infraorbital nerve injury rat model: effects of vitamin B complex and photobiomodulation
AbstractOrofacial nerve injuries may result in temporary or long-term loss of sensory function and decreased quality of life in patients. B vitamins are required for DNA synthesis and the repair and maintenance of phospholipids. In particular, vitamins B1, B6, and B12 are essential for neuronal function. Deficiency in vitamin B complex (VBC) has been linked to increased oxidative stress, inflammation and demyelination. Photobiomodulation (PBM) has antioxidant activity and is neuroprotective. In addition, a growing literature attests to the positive effects of PBM on nerve repair. To assess the effect of PBM and VBC on rege...
Source: Lasers in Medical Science - April 29, 2024 Category: Laser Surgery Source Type: research
Molecules, Vol. 29, Pages 2055: Valorisation of Agri-Food Waste for Bioactive Compounds: Recent Trends and Future Sustainable Challenges
Mahanta
Bishnoi
Worldwide, a massive amount of agriculture and food waste is a major threat to the environment, the economy and public health. However, these wastes are important sources of phytochemicals (bioactive), such as polyphenols, carotenoids, carnitine, coenzymes, essential oils and tocopherols, which have antioxidant, antimicrobial and anticarcinogenic properties. Hence, it represents a promising opportunity for the food, agriculture, cosmetics, textiles, energy and pharmaceutical industries to develop cost effective strategies. The value of agri-food wastes has been extracted from various valuable bioac...
Source: Molecules - April 29, 2024 Category: Chemistry Authors: Yadav Malik Moore Kamboj Malik Malik Arya Singh Mahanta Bishnoi Tags: Review Source Type: research
Molecules, Vol. 29, Pages 2045: Comprehensive Analysis of Physicochemical Properties and Volatile Compounds in Different Strawberry Wines under Various Pre-Treatments
Jiechao Liu
Pre-fermentation treatment has an important impact on the color, aroma, taste, and other characteristics of fruit wine. To discover suitable pre-treatment techniques and conditions that yield strawberry wine of excellent quality, the influences of juice fermentation, pulp maceration, thermovinification, and enzymatic hydrolysis pre-treatments on the basic chemical composition, color, antioxidant capacity, and volatile organic compounds in strawberry wines were investigated. The results showed that the color, antioxidant properties, and volatile aroma of strawberry wines fermented with juice were different...
Source: Molecules - April 29, 2024 Category: Chemistry Authors: Zhenzhen Lv Hui Liu Wenbo Yang Qiang Zhang Dalei Chen Zhonggao Jiao Jiechao Liu Tags: Article Source Type: research
Molecules, Vol. 29, Pages 2053: Antioxidant and Cytotoxic Properties of Berberis vulgaris (L.) Stem Bark Dry Extract
asela Elena Gîrd
Berberis vulgaris (L.) has remarkable ethnopharmacological properties and is widely used in traditional medicine. The present study investigated B. vulgaris stem bark (Berberidis cortex) by extraction with 50% ethanol. The main secondary metabolites were quantified, resulting in a polyphenols content of 17.6780 &plusmn; 3.9320 mg Eq tannic acid/100 g extract, phenolic acids amount of 3.3886 &plusmn; 0.3481 mg Eq chlorogenic acid/100 g extract and 78.95 &micro;g/g berberine. The dried hydro-ethanolic extract (BVE) was thoroughly analyzed using Ultra-High-Performance Liquid Chrom...
Source: Molecules - April 29, 2024 Category: Chemistry Authors: Ionu ț Mădălin Ivan Octavian Tudorel Olaru Violeta Popovici Carmen Lidia Chi țescu Liliana Popescu Emanuela Alice Lu ță Elena Iuliana Ilie Lorelei Irina Bra șoveanu Camelia Mia Hotnog George Mihai Ni țulescu Rica Boscencu Cerasela Elena G îrd Tags: Article Source Type: research
Cobalt protoporphyrin modulates antioxidant enzyme activity in the hypothalamus and motor cortex of female rats
This study aimed to delve into CoPP's impact on the activities of crucial antioxidant enzymes: superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione-S-transferase (GST) across seven distinct brain regions (hippocampus, hypothalamus, prefrontal cortex, motor cortex, striatum, midbrain, and cerebellum), as well as in the liver and kidneys. Female Wistar rats weighing 180 to 200 grams received a single subcutaneous dose of 25 μmol/kg CoPP. After six days, brain tissue was extracted to assess the activities of antioxidant enzymes and quantify malondialdehyde levels. Ou...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Norma Serrano-Garc ía Ra úl Pinete-Sánchez Omar Noel Medina-Campos Minerva Adriana Ramos-Santander Jos é Pedraza-Chaverri Marisol Orozco-Ibarra Source Type: research
Nervonic acid alleviates MPTP-induced Parkinson's disease via MEK/ERK pathway
This study mainly explored whether NA is involved in regulating oxidative stress and apoptosis in MPTP-induced mouse model and MPP-induced cell model. Through behavior tests, we proved that MPTP-induced motor dysfunction in mice was recovered by NA treatment. NA can reduce MPTP-induced neuronal damage, manifested by elevated levels of TH and dopamine, as well as decreased levels of α-syn. In the in vitro model, we observed from CCK8 assay and flow cytometry that the induction of MPP markedly suppressed cell activity and enhanced cell apoptosis, but these functions were all reversed by NA. Furthermore, NA administration re...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Xinru Zhang Donglei Wu Zengwei Yin Source Type: research
Research progress of vitiligo repigmentation: from oxidative stress to autoimmunity
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):147-151. doi: 10.14715/cmb/2024.70.4.23.ABSTRACTVitiligo belongs to a frequent chronic autoimmune skin disease with the features of pigmented plaques on the diseased skin along with potential damage of melanocytes. There are many factors underlying the pathogenesis of vitiligo, among which oxidative stress is extensively regarded to be the critical factor leading to the loss of melanocytes. The changed redox state resulting from oxidative stress, containing ROS overproduction along with the reduced activity of the skin's antioxidant system, makes melanocytes less resistant ...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Tingting Yu Yan Wu Zhenzhong Lu Source Type: research
Effect and mechanism of Yiqing decoction on hyperuricemia rats
This study aimed to experimentally compare the uric acid-lowering effect and renal protection of Yiqing Fang in a rat model of hyperuricemia. Additionally, we used network pharmacology to predict the potential active components, targets, and pathways of Yiqing Fang. Male SD rats were randomly divided into control, model, Yiqing Fang, allopurinol, and probenecid groups. Serum creatinine (Scr), blood urea nitrogen (BUN), serum uric acid (UA), alanine transaminase (ALT), complete blood count, and urinary NAG enzyme levels were measured. Standard pathology and electron microscopy samples were prepared from the left kidney to o...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Yajie Xu Pan Chen Long Sun None Yan Zou None Lixing Zhang None Wanghai Tang None Tingji Zhang Jinlin Huo Jin Zhou Source Type: research
Cobalt protoporphyrin modulates antioxidant enzyme activity in the hypothalamus and motor cortex of female rats
This study aimed to delve into CoPP's impact on the activities of crucial antioxidant enzymes: superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione-S-transferase (GST) across seven distinct brain regions (hippocampus, hypothalamus, prefrontal cortex, motor cortex, striatum, midbrain, and cerebellum), as well as in the liver and kidneys. Female Wistar rats weighing 180 to 200 grams received a single subcutaneous dose of 25 μmol/kg CoPP. After six days, brain tissue was extracted to assess the activities of antioxidant enzymes and quantify malondialdehyde levels. Ou...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Norma Serrano-Garc ía Ra úl Pinete-Sánchez Omar Noel Medina-Campos Minerva Adriana Ramos-Santander Jos é Pedraza-Chaverri Marisol Orozco-Ibarra Source Type: research
