Distinguish response of low-dose radiation with different dose-rate on gene expression of human coronary artery endothelial cells: a bioinformatic study based on transcriptomic sequencing
CONCLUSIONS: We demonstrated that 100 mGy low-dose radiation could alter gene expression and molecular signaling pathways at the low-dose-rate and the high-dose-rate differently. Our findings provide evidence for further research on the potential impact of low-dose radiation on cardiovascular function.PMID:38489594 | DOI:10.1080/09553002.2024.2324470 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 15, 2024 Category: Radiology Authors: Soo-Ho Lee Yeonghoon Son Kyu Jin Choi Chang Geun Lee Hae-June Lee Source Type: research

Construction of dose prediction model and identification of sensitive genes for space radiation based on single-sample networks under spaceflight conditions
CONCLUSIONS: The topology structures of SSNs effectively predicted radiation doses under spaceflight conditions, and the SSNs revealed the gene regulatory patterns within the organisms under space stressors.PMID:38471034 | DOI:10.1080/09553002.2024.2327393 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 12, 2024 Category: Radiology Authors: Yan Zhang Xiaohui Du Lei Zhao Yeqing Sun Source Type: research

Early effects of different brain radiotherapy modalities on circulating leucocyte subpopulations in rodents
CONCLUSIONS: Leucocyte subpopulations reacted differently to X-ray or proton brain irradiation. This difference could be partly explained by LN exposure to radiation dose. Further researches and analyses on other biological processes and interactions between leucocyte subpopulations are ongoing. The various mechanisms underlying leucocyte subpopulation changes under different irradiation modalities may have implications for the choice of radiotherapy modalities and their combination with immunotherapy in brain cancer treatment.PMID:38466699 | DOI:10.1080/09553002.2024.2324471 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 11, 2024 Category: Radiology Authors: Thao-Nguyen Pham Julie Coupey J érôme Toutain Serge M Cand éias Ga ël Simonin Marc Rousseau Omar Touzani Juliette Thariat Samuel Valable Source Type: research

Production of specialized metabolites in plant cell and organo-cultures: the role of gamma radiation in eliciting secondary metabolism
CONCLUSIONS: Research on the application of gamma radiation with plants has contributed a lot to microbial decontamination of seeds, and the promotion of physiological processes such as seed germination, seedling vigor, plant growth, and development. Various studies have demonstrated the influence of gamma rays on the morphology, physiology, and biochemistry of plants. Recent research efforts have also shown that low-dose gamma (5-100 Gy) irradiation can be utilized as an expedient solution to alleviate the deleterious effect of abiotic stresses and to obtain better yields of plants. Inducing mutagenesis using gamma irradi...
Source: International Journal of Radiation Biology - March 7, 2024 Category: Radiology Authors: Hosakatte Niranjana Murthy Kadanthottu Sebastian Joseph Kee Yoeup Paek So Young Park Source Type: research

Kaplan lecture 2023: lymphopenia in particle therapy
CONCLUSIONS: There is nowadays an overwhelming evidence that particle therapy reduces significantly the radiotherapy-induced lymphopenia in several tumor sites. Because lymphopenia turns down the immune response to checkpoint inhibitors, it can be predicted that particle therapy may be the ideal partner for combined radiation and immunotherapy treatment and should be selected for patients where severe lymphopenia is expected after X-rays.PMID:38442137 | DOI:10.1080/09553002.2024.2324472 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 5, 2024 Category: Radiology Authors: Marco Durante Source Type: research

Taraxasterol enhanced bladder cancer cells radiosensitivity via inhibiting the COX-2/PGE2/JAK2/STAT3/MMP pathway
CONCLUSIONS: Our data support that Tara can improve the radiosensitivity of BCa cells by targeting COX-2/PGE2. The mechanism may involve regulating STAT3 phosphorylation, DNA damage response protein activation, and expression of MMP2/MMP9.PMID:38442139 | DOI:10.1080/09553002.2024.2324475 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 5, 2024 Category: Radiology Authors: Quanxin Wang Ruiqi Zhang Yijun He Guangmin Mao Zhaolu Kong Source Type: research

TGF- β3 increases the severity of radiation-induced oral mucositis and salivary gland fibrosis in a mouse model
CONCLUSIONS: When repeatedly administered during fractionated RT at the current dose, TGF-β3 treatment increased acute H&N radiation toxicities and increased mortality. Furthermore, TGF-β3 treatment may increase the severity of radiation-induced salivary gland fibrosis.PMID:38442208 | DOI:10.1080/09553002.2024.2324476 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 5, 2024 Category: Radiology Authors: Ingunn Hanson Inga Solg ård Juvkam Olga Zlygosteva Tine Merete S øland Hilde Kanli Galtung Eirik Malinen Nina Frederike Jeppesen Edin Source Type: research

ATR signaling controls the bystander responses of human chondrosarcoma cells by promoting RAD51-dependent DNA repair
CONCLUSION: Our results indicate that HTB94 cells were likely more efficient in DNA repair than AG01522 cells, specifically via ATR signaling, which inhibited the bystander signal-induced MN formation. This study highlights the significance of DNA repair efficiency in bystander cell responses.PMID:38442236 | DOI:10.1080/09553002.2024.2324479 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 5, 2024 Category: Radiology Authors: Nho Cong Luong Hidemasa Kawamura Hiroko Ikeda Reiko T Roppongi Atsushi Shibata Jiaxuan Hu Jinmeng G Jiang David S Yu Kathryn D Held Source Type: research

Kaplan lecture 2023: lymphopenia in particle therapy
CONCLUSIONS: There is nowadays an overwhelming evidence that particle therapy reduces significantly the radiotherapy-induced lymphopenia in several tumor sites. Because lymphopenia turns down the immune response to checkpoint inhibitors, it can be predicted that particle therapy may be the ideal partner for combined radiation and immunotherapy treatment and should be selected for patients where severe lymphopenia is expected after X-rays.PMID:38442137 | DOI:10.1080/09553002.2024.2324472 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 5, 2024 Category: Radiology Authors: Marco Durante Source Type: research