An Examination of Radon Awareness, Risk Communication, and Radon Risk Reduction in a Hispanic Community.
Conclusion:Individual and community understanding of the risks of exposure to radiation sources such as radon is dependent upon communication that informs and spurs appropriate action. This study demonstrates the need for culturally appropriate radon risk communication strategies targeted to a Hispanic population. Successful communication will raise awareness and knowledge that can lead to better public health protection. PMID: 32052674 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - February 15, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Calculation of the initial DNA damage induced by alpha particles in comparison with protons and electrons using Geant4-DNA.
Conclusion: There was a reasonable agreement in terms of trend and value between DSB yield results from this work and the available experimental data. The yield results, represented as a function of LET∞, suggested independence from particle type and converge to some extent at high values of LET∞, which manifests the dominant contribution of secondary electrons. PMID: 32052675 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - February 15, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Effects of radiofrequency fields on RAS and ERK kinases activity in live cells using the Bioluminescence Resonance Energy Transfer technique.
Conclusion: Our results indicate that RF exposure decreases the efficiency of the cascade of events, which, from the binding of PMA to its receptor(s), leads to the activation of RAS and ERK kinases. PMID: 32052678 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - February 15, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Regorafenib sensitizes human breast cancer cells to radiation by inhibiting multiple kinases and inducing DNA damage.
Conclusions: Our findings demonstrate that Regorafenib enhanced radiosensitivity of breast cancer cells by inhibiting the expression of multiple receptor tyrosine kinases, VEGF-mediated angiogenesis and DNA damage response in TNBC. Therefore, combining Regorafenib with radiation and antiangiogenic agents will be beneficial and effective in controlling TNBC. PMID: 32052681 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - February 15, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Comparative Studies on the Potential Use of 177Lu-Based Radiopharmaceuticals for the Palliative Therapy of Bone Metastases.
Conclusions: According to the results of the calculations, 177Lu-EDTMP and 177Lu-MDP demonstrate the best results for the palliative therapy of bone metastases. PMID: 32043915 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - February 13, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Single high dose irradiation induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cells through the Ras/Raf/MEK/ERK pathways.
Conclusions: Our results suggest that irradiation applied in SBRT, particularly single high dose irradiation, mediates its anti-tumor effects by inducing cell cycle arrest and apoptosis via modulation of the Ras/Raf/MEK/ERK signaling pathway. PMID: 32039644 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - February 11, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

A scanning and image processing system with integrated design for automated micronucleus scoring.
Conclusions - The results verify that the fully automatic mode of Radometer MN-Series is suitable for triage purposes. The performance of the user interacted semi-automatic mode is comparable with the reference manual scoring. Its performance reaches up to other non-fluorescent automatic systems and offers a compact and cost-effective alternative. PMID: 32023139 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - February 7, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Morphological features of pulmonary fibrosis in workers occupationally exposed to alpha radiation.
Conclusions. The study found qualitative and quantitative morphological features specific for PuPF compared to non-PuPF. The study demonstrated that hyper-production of collagen type V plays a key role in PuPF. The collagen type V content in fibrotic foci in lung tissue specimens from workers with PuPF was found to be increased. PMID: 31985334 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 29, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Antibiotic susceptibility variations of Methicillin-resistant Staphylococcus aureus after gamma irradiation.
Conclusion: It is shown that bacteria's resistance against antibiotics changes after being irradiated, by knowing the mechanism of actions for each antibiotic, and knowing how radiation changed bacteria's susceptibilities, we concluded how radiation might have affected the bacterium's cell. PMID: 31985341 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 29, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Role of Telomeric RAP1 in radiation sensitivity modulation and its interaction with CSC marker KLF4 in Colorectal cancer.
Authors: Anuja K, Kar M, Chowdhury AR, Shankar G, Padhi S, Roy S, Akhter Y, Rath AK, Banerjee B Abstract Aims: Radiotherapy is predominantly used as one of the treatment modalities to treat local tumor in colorectal cancer (CRC). Hindrance in disease treatment can be attributed to radio-tolerance of cancer stem cells (CSCs) subsistence in the tumor. Understanding the radio-resistant property of CSCs might help in the accomplishment of targeted radiotherapy treatment and increased disease-free survival. Telomeric RAP1 contributes in modulation of various transcription factors leading to aberrant cell proliferation a...
Source: International Journal of Radiation Biology - January 29, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Monte Carlo dosimetry using Fluka code and experimental dosimetry with Gafchromic EBT2, XR-RV3 of self-built experimental setup for radiobiological studies with low-energy X-rays.
Conclusions: Influence of specially constructed Petri dish on absorbed dose was determined using simulations that showed that low-energy photons, emitted as characteristic line from borosilicate glass forming component of Petri dish, were source of increase in dose absorbed by cells. This experimental setup will be used to conduct radiobiological research. Highlights:A low-energy X-ray system constructed for radiobiological studies was used.Dosimetry was based on a Monte Carlo simulation using Fluka 2011 code version 2c.4.A specially-designed rotating Petri dish ensured the uniformity of the radiation distribution.Gafchrom...
Source: International Journal of Radiation Biology - January 29, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Survival genes expression analysis following ionizing radiation to LiCl treated KG1a cells.
Conclusion: This is the first study with respect to global genetic expression upon LiCl treatment to radiation exposed cells. Our results suggest considering repurposing of LiCl as a protective agent for radiation injury. PMID: 31985347 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 29, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Uncertainty calculation methods in dose assessment for dicentric chromosome assay.
Conclusions: The Modified Crow and Gardner method should be preferred over the Garwood method for Poisson exact confidence intervals. The unlimited simultaneous calibration interval did not lose its property to preserve the coverage at 95% applying a regression coverage factor of value 2.02 at the point of doses studied in the simulation. PMID: 31986065 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 29, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Non-linearities in the cellular response to ionizing radiation and the role of p53 therein.
Authors: Murray D, Mirzayans R Abstract Many aspects of the cellular response to agents such as ionizing radiation that cause genotoxic and/or oxidative stress exhibit a non-linear relationship to the applied stress level. These include elements of the antioxidant response and of the damage-signaling pathways that determine cell fate decisions. The wild-type p53 protein, which is mutated in many cancers, coordinates these responses and is a key determinant of this non-linearity. Indeed, p53 has been referred to as a "cellular rheostat" that favors antioxidant/cytoprotective functions at low stress levels ...
Source: International Journal of Radiation Biology - January 29, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Protective effect of N-acetyl cysteine against radiotherapy-induced cardiac damage.
Conclusion: Our findings suggested that NAC may be a potential radioprotector which is capable of preventing cardiac damage. PMID: 31990607 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 29, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Analysis of elements secreted by CHO-K1 cells exposed to gamma radiation under different treatments.
Conclusions: The results showed that a statistically significant difference occured in elemental concentrations for media in contact with the cells at the temperatures used. From Principal Component Analysis (PCA), it was observed that the concentrations of elements such as Al, K, Ca, Zn, Br were similar to each other, in contrast to the concentrations of P, Cl, S, both with contact and without contact with cells. A high correlation between the treatment of media within the group at doses of 0.25 Gy and for the group with 0.5 and 5 Gy doses was confirmed. Numerous correlations were observed between the concen...
Source: International Journal of Radiation Biology - January 26, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Combination of agents modifying effects in hadrontherapy Modelisation of the role of HO ° free radicals.
Combination of agents modifying effects in hadrontherapy Modelisation of the role of HO° free radicals. Int J Radiat Biol. 2020 Jan 24;:1-16 Authors: Usami N, Hirayama R, Kobayashi K, Furusawa Y, Le Sech C Abstract Purpose: A study is presented of the irradiation of cancerous cervical cell line HeLa loaded with a platinum salt, betamethasone and deoxyglucose. The presence of the platinum increases the free-radical concentration and augments the cell death rate, whereas betamethasone or deoxyglucose induces radiosensitization by the alteration of metabolic pathways. Two by two combinations of these ...
Source: International Journal of Radiation Biology - January 26, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

The Russian Radiobiological Human Tissue Repository: Characteristics of biological specimens donated by nuclear workers with lung cancer.
Conclusions. Today biological specimens donated by 343 registrants with lung cancer are available at the RHTR. Among them, 255 donors (74%) are Mayak PA workers hired at the main facilities (reactors, plutonium production and radiochemical plants) in 1948-1982. These workers donated about 6024 specimens of lung tissues (tumor and tumor-free) stored mostly as formalin-fixed paraffin-embedded tissue blocks (31%) and histology slides (64%); in addition they donated 1800 specimens of blood/blood components, buccal epithelium cells and sputum. Among histologic types identified for these lung cancer cases, adenocarcinoma and sma...
Source: International Journal of Radiation Biology - January 26, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Mitochondrial Reactive Oxygen Species: The effects of Mitochondrial Ascorbic Acid vs untargeted and Mitochondria-targeted antioxidants.
Conclusions: Antioxidants that are not specifically targeted to mitochondria fail to accumulate in significant amounts in critical sites of mitochondrial ROS production and may eventually interfere with the ensuing physiological signaling. Mitochondria-targeted antioxidants are more effective, but are expected to interfere with the mitochondrial ROS-dependent physiologic signaling. AA promotes multiple beneficial effects in mitochondria. The complex regulation of vitamin C uptake in these organelles likely contributes to its versatile antioxidant response, thereby providing a central role to the vitamin for adequate contro...
Source: International Journal of Radiation Biology - January 26, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

The role of radiation induced oxidative stress as a regulator of radio-adaptive responses.
Conclusion: In conclusion, RIOS considerably contributes to radiation induced adaptive responses. Other possible molecular adaptors modulating RIOS-induced responses are yet to be divulged in future studies. PMID: 31976798 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 26, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Radiation metabolomics in the quest of cardiotoxicity biomarkers: the review.
Conclusions: Available literature indicates that radiation exposure affects metabolites associated with: energy production, degradation of proteins and cell membranes, expression of proteins and stress response. Such effects are common for both animal and human studies. However, the specific metabolic response depends on several factors, including the examined organ. Radiation metabolomics can be used to explain the mechanisms of development of radiation-induced heart disease and to find an organ-specific biomarker of radiation exposure. The main aim of this review was to collect the information on the human cardiotoxicity...
Source: International Journal of Radiation Biology - January 26, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

A review on the efficacy and safety of iodine-125 seed implantation in unresectable pancreatic cancers.
Conclusion: It may be employed either alone or in combination with cryotherapy, existing chemotherapy, bypass surgery or radiations to achieve the optimal results in these patients. Nevertheless, there is a need to formulate a uniform dose and procedure to achieve homogeneity and develop references for clinical practices. PMID: 31977258 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 26, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Cost of Fear and Radiation Protection Actions: Washington County, Utah and Fukushima, Japan {Comparing Case Histories}.
CONCLUSIONS: When evacuation is being considered, great care must be taken when any regulatory actions are initiated based on radiation limits. It is necessary to consider total impact and optimize the actions to limit radiation exposure while minimizing the social, economic, and health impacts. Optimization can help ensure that the protective measures result in more good than harm. It seems clear that organizations who recommend radiation protection guidelines need to revisit the past and current guides in light of the significant Fukushima experience. PMID: 31977266 [PubMed - as supplied by publisher] (Source: Intern...
Source: International Journal of Radiation Biology - January 26, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Effectiveness and feasibility of external beam radiotherapy for hepatocellular carcinoma with inferior vena cava and/or right atrium involvement: a multicenter trial in Korea (KROG 17-10).
Conclusion: EBRT can yield favorable local control in HCC with IVC and/or RA involvement. Systemic treatment may be more indicated as factors reflecting tumor aggressiveness were significant, and first distant failure is common. PMID: 31977276 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 26, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Occam's broom* and the dirty DSB: cytogenetic perspectives on cellular response to changes in track structure and ionization density.
Authors: Cornforth MN Abstract Given equal doses, it is well-known that densely ionizing radiations are more potent in causing a number of biological effects compared to sparsely ionizing radiations, such as x- or gamma rays. According to classical models of radiation action, this results from differences in the spatial distribution of lesions along charged particle tracks. In recent years investigators have been barraged with the alternative narrative that this is instead due to 'qualitative' differences in the types of molecular lesions that each type of radiation produces. The present review discusses, mainly fr...
Source: International Journal of Radiation Biology - January 25, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Correction to: Effects of culturing technique on human peripheral blood lymphocytes response to proton and X-ray radiation.
Authors: PMID: 31935165 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 15, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Ionizing radiation induces ferroptosis in granulocyte-macrophage hematopoietic progenitor cells of murine bone marrow.
Conclusions: These findings suggest that radiation-induced hemorrhage in the bone marrow causes ferroptosis in granulocyte-macrophage hematopoietic progenitor cells, and anti-ferroptosis has the potential to be a radioprotective strategy to ameliorate radiation-induced hematopoietic injury. PMID: 31906761 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 9, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Effects of Electron Beam Irradiation on Proteins and Exopolysaccharide Production and Changes in Microcystis aeruginosa.
Conclusions:2-5 kGy radiation could control the algae growth and produced obvious effect. The respiration rate decreased obviously that made M. aeruginosa lose activity in a short time. The results proved that irradiation could change the algae growth and affect its life characteristic efficiently in a short time. PMID: 31906777 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 9, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Gamma ray induced in-vitro cell migration via EGFR/ERK/Akt/p38 activation is prevented by olaparib pre-treatment.
Conclusions-This data implicates that olaparib treatment in combination with gamma therapy could be promising in protecting patients from gamma-induced metastasis. PMID: 31914341 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 9, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

The effects of DNA repair polymorphisms on chromosome aberrations in the population of Kazakhstan.
Conclusions: The age of donors, smoking and the ATM rs1801516 polymorphism significantly affect the frequency of chromosome aberrations among individuals inhabiting contaminated area around the Semipalatinsk nuclear weapon test site, as well as among those inhabiting ecologically favourable zones of Kazakhstan. PMID: 31914346 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 9, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Data independent acquisition mass spectrometry of irradiated mouse lung endothelial cells reveals a STAT-associated inflammatory response.
Authors: Philipp J, Sievert W, Azimzadeh O, von Toerne C, Metzger F, Posch A, Hladik D, Subedi P, Multhoff G, Atkinson MJ, Tapio S Abstract PURPOSE: Pulmonary inflammation is an adverse consequence of radiation therapy in breast cancer. The aim of this study was to elucidate biological pathways leading to this pathology. MATERIALS AND METHODS: Lung endothelial cells were isolated 24 hours after thorax-irradiation (sham or 10 Gy X-ray) from female C57Bl/6 mice and cultivated for 6 days. RESULTS: Quantitative proteomic analysis of lung endothelial cells was done using data independent acquisitio...
Source: International Journal of Radiation Biology - January 9, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Sensitivity analysis of parameters and methodological choices used in calculation of radiation detriment for solid cancer.
Conclusion: These results could have implications for radiation protection standards, and they should help define priorities for future research in the field of low radiation dose and dose rate research. The present sensitivity analysis is part of a global effort of ICRP to review the bases of radiation detriment calculation and assess potential evolutions to improve the radiation protection system. PMID: 31914349 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 9, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Effects of culturing technique on human peripheral blood lymphocytes response to proton and X-ray radiation.
Conclusions: The results showed different effects of the culturing techniques on the response of human peripheral blood lymphocytes to radiation. The MNi frequency and excess PCC fragments were significantly higher when lymphocytes were cultured after being isolated. After irradiation, no differences were seen in the NDI between the lymphocytes of the two culturing techniques; however, there were differences in the PPC index. When planning or performing cytogenetic studies, the possibility of such effects and their potential to impact the variability of the results of human biomonitoring studies should be considered import...
Source: International Journal of Radiation Biology - January 9, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Mechanism of Asbt (Slc10a2)-Related Bile Acid Malabsorption in Diarrhea after Pelvic Radiation.
This study aimed to investigate the potential mechanism of diarrhea after pelvic radiotherapy in rats based on the effect of radiation on bile acid homeostasis and sodium-dependent bile acid transporter (Asbt).Methods In this experimental study, male Sprague-Dawley rats were divided into the following groups - pelvic irradiation, cholestyramine-concurrent radiation, and control groups. The rats in the pelvic irradiation group were irradiated in the pelvic region with 2 Gy per day for 5 consecutive days. The total bile acid (TBA) levels in the ileum, colon, and feces were measured using automatic biochemical analyzer...
Source: International Journal of Radiation Biology - January 5, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

A Potential New Role of ATM Inhibitor in Radiotherapy: Suppressing Ionizing Radiation-Activated EGFR.
Conclusion: Our study demonstrates that ATMi can function like EGFRi in human tumor cells to inhibit tumor cell growth and sensitize the tumor cells to IR, suggesting that ATMi treatment as an alternative approach may exert anticancer effects on EGFRi-resistant tumor cells and facilitate radiotherapy. PMID: 31859574 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - December 22, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Radiation biology of a serious tropical pigeon pea pest, Maruca vitrata (Fabricius) (Lepidoptera: Crambidae) and potential of radiation mediated 'Inherited (F1) Sterility technique' for the pest suppression.
Conclusion: The present study indicated the potential use of a dose of 150 Gy to apply the 'F1 sterility' technique for parabiological suppression of the pigeon pea pod borer. The present findings and reproductive performance of the irradiated moths in F2 generation along with other compatible biorational pest control tactics (that are in progress), might help in formulating an effective integrated pest management module, including the F1 sterility technique as an integral component. PMID: 31859577 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - December 22, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Radiation induces an inflammatory response that results in STAT3-dependent changes in cellular plasticity and radioresistance of breast cancer stem-like cells.
Conclusions: Radiation-induced changes in cellular plasticity are STAT3 dependent and may be a potential target to reduce radioresistance in TNBC and improve treatment outcome. PMID: 31850822 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - December 20, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Establishing mechanisms affecting the individual response to ionising radiation.
Authors: Averbeck D, Candéias S, Chandna S, Foray N, Friedl A, Haghdoost S, Jeggo PA, Lumniczky K, Paris F, Quintens R, Sabatier L Abstract Purpose: Humans are increasingly exposed to ionising radiation (IR). Both low (
Source: International Journal of Radiation Biology - December 20, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Effects of the total dose and duration of γ-irradiation on the growth responses and induced SNPs of a Cymbidium hybrid.
Conclusions: These results indicate the irradiation duration affects PLB growth in response to γ-rays. Moreover, the mutations induced by a short-term treatment may be similar to those induced by a treatment over a longer period. PMID: 31852368 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - December 20, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Effect of Light Intensity on Survival, Growth and Physiology of Rohu, Labeo rohita (Cyprinidae) Fry.
Conclusions: A 2-5% mortality of rohu was recorded in L3 and L4 treatments. The average weight and specific growth rate were significantly (P 
Source: International Journal of Radiation Biology - December 20, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Radiation effects on Toxoplasma antigens: Different immune responses of irradiated intact tachyzoites or soluble antigens in experimental mice models.
Conclusions: Our data suggest that, MHCI pathway appears seem to be used by RH0.25kGy to generate cytotoxic cells while STag1.5kGy uses an MHCII pathway for B-cell memory, but both induce sufficient immune response for protection in mice without any adjuvant. Irradiation of soluble protein extracts enhances their immune response, allowing similar protection against T. gondii in mice as compared to irradiated intact parasites. PMID: 31855098 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - December 20, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

5-HT2A and 5-HT3 receptors contribute to the exacerbation of targeted and non-targeted effects of ionizing radiation-induced cell death in human colon carcinoma cells.
Conclusions: Our findings demonstrate a definitive role for 5-HT in the exacerbation of cell death following ionizing radiation exposure in colon carcinoma cells and highlight 5-HTRs as potential markers for predicting cellular radiosensitivity. PMID: 31846381 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - December 19, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Mitochondrial DNA damage in the hair bulb: can it be used as a non-invasive biomarker of local exposure to low LET ionizing radiation?
Conclusions: Our results suggest that the unspecified lesion frequency and proportion of large deletions of mtDNA in hair bulbs are not suitable biomarkers of exposure to ionizing radiation. PMID: 31846382 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - December 19, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

A Case Example of a Radiation-Relevant Adverse Outcome Pathway to Lung Cancer.
Conclusion: Overall, the AOP framework provided an effective means to organize the scientific knowledge surrounding the KERs and identify those with strong dose-response relationships and those with inconsistencies. This case study is an example of how the AOP methodology can be applied to sources of radiation to help support areas of risk assessment. PMID: 31846388 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - December 19, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Roadmap for Research on Individual Radiosensitivity and Radiosusceptibility - The MELODI View on Research Needs.
Authors: Salomaa S, Jung T PMID: 31825712 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - December 13, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

FLASH Radiotherapy: Ultra-High Dose Rates to Spare Healthy Tissue.
Conclusion This review will present an overview of the investigations into FLASH radiotherapy to date. PMID: 31829765 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - December 13, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Evaluation of 99mTc-HYNIC-(Ser)3-LTVPWY peptide for glioblastoma tumor imaging.
Conclusion: The results of this study showed that the 99mTc-HYNIC-(Ser)3-LTVPWY peptide specifically accumulates in glioma tumor and is therefore a promising probe for the diagnosis of glioma tumor. PMID: 31829777 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - December 13, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

The hunt for radiation biomarkers: current situation.
We described briefly recent advances in radiation genomics and metabolomics, giving particular emphasis to proteomic analysis. The majority of studies were performed on animal models (rats, mice, and non-human primates). They have provided much beneficial information, but the most relevant tests have been done on human (oncological) patients. By inspecting the radiaiton biodosimetry literate of the last 10 years, we identified a panel of candidate markers for each -omic approach involved. CONSLUSIONS: We reviewed different methodological approaches and various biological materials, which can be exploited for dose-effec...
Source: International Journal of Radiation Biology - December 13, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Correction to: Impact of gamma irradiation pretreatment on the growth of common vetch (Vicia sativa L.) seedlings grown under salt and drought stress.
Authors: PMID: 31774343 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - November 29, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Search for Tumor-Specific Frequencies of Amplitude-Modulated 27  MHz Electromagnetic Fields in Mice with Hepatocarcinoma Xenografted Tumors.
Conclusion: No tumor-related frequencies were found, neither using systematic scans of frequencies nor published specific frequencies. There might obviously be differences between animal and human models, but our approach did not confirm the physiological data of the human Pasche group data. PMID: 31746658 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - November 22, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research