Comparative study of Micronucleus assays and Dicentric plus ring chromosomes for dose assessment in particular cases of partial-body exposure.
CONCLUSIONS: Dicentric chromosomes continue to prove to be the best biological marker for dose assessment. However exposure scenarios of partial-body estimation, overdispersion and zero-inflation may not occur, it being a critical point not only for dose assessment, but also to confirm partial-body exposure. MN could be used as alternative assays for partial-body dose estimation, but only in case when we have sure about the accident. PMID: 31008687 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - April 23, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Role of Nrf2-antioxidant in radioprotection by root extract of Inula racemosa.
CONCLUSIONS: The aqueous extract of roots of I. racemosa enhanced the survival of irradiated NKE cells and rescued C57BL/6 mice against WBI-induced mortality. The radiation modulation efficacy was mediated through cumulative activation of HO-1 and NQO1 downstream of Nrf2 translocation in NKE cells. PMID: 30998083 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - April 19, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Why is the multiple stressor concept of relevance to radioecology?
Conclusions: Following severe nuclear events, releases can be described as a massive multiple stressor exposure containing radionuclides combined with other stressors. Thus, advanced characterization technologies are needed for parameterization of the mixed stressor source term as input to ecosystem transport, dose and impact models. To reduce uncertainties in assessments of these complex exposures, advanced technologies and computational efforts to link internal distributions to responses are also needed to understand how multiple stressor exposure could affect toxicokinetics and toxicodynamics, and why combined exposures...
Source: International Journal of Radiation Biology - April 12, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Autophagy suppresses radiation damage by activating PARP-1 and attenuating reactive oxygen species in hepatoma cells.
CONCLUSION: Autophagy upregulates the expression of PARP-1 and relieves radiation damage by reducing the generation of ROS. PMID: 30964366 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - April 11, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Recent discussions toward regulatory implementation of the new occupational equivalent dose limit for the lens of the eye and related studies in Japan.
CONCLUSIONS: In Japan, the Radiation Council established a Subcommittee in July 2017 to discuss the feasibility of implementing the new occupational lens dose limit. In March 2018, the Radiation Council requested all relevant government ministries and agencies to take necessary actions toward implementation of the new occupational lens dose limit, considering a series of discussions made by the Subcommittee. According to the currently available information, the new occupational lens dose limit (20 mSv/year, averaged over defined periods of 5 years, with no single year exceeding 50 mSv) will be implemented into regulations ...
Source: International Journal of Radiation Biology - April 11, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Utility of TRAP markers to determine indel mutation frequencies induced by gamma-ray irradiation of faba bean (Vicia faba L.) seeds.
CONCLUSIONS: The optimal gamma dose was 100-150 Gy on the basis of survival percentage and morphological response analysis. The TRAP markers distinguished mutant lines and showed association between mutation frequency and gamma doses. This study will be useful for faba bean mutation breeding and may be applicable to other crops. PMID: 30964373 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - April 11, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Cancer stem cells in radiation response: current views and future perspectives in radiation oncology.
CONCLUSION: Evidence from both, experimental and clinical studies demonstrates that the probability of achieving local tumor control by radiation therapy depends on the complete eradication of CSC populations. The number, properties and molecular signature of CSCs are highly predictive for clinical outcome of radiotherapy, whereas targeted therapies against CSCs combined with conventional treatment are expected to provide an improved clinical response and prevent tumor relapse. In this review, we discuss the modern methods to study CSCs in radiation biology, the role of CSCs in personalized cancer therapy as well as future...
Source: International Journal of Radiation Biology - March 23, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Big data in radiation biology and epidemiology; an overview of the historical and contemporary landscape of data and biomaterial archives.
CONCLUSIONS: We find evidence for the ongoing utility of legacy datasets and biological materials, but that the availability of these resources depends on uncoordinated, often institutional, initiatives to curate and archive them. The importance of open data from contemporary experiments and studies is also very clear, and yet there are few stable platforms for their preservation, sharing, and reuse. We discuss the development of the ERA and STORE data sharing platforms for the scientific community, and their contribution to FAIR sharing of data. The contribution of funding agency and journal policies to the support of dat...
Source: International Journal of Radiation Biology - March 20, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Harnessing epigenetics and metabolism to modulate tissue response to radiotherapy.
Authors: Koturbash I, Griffin RJ PMID: 30856046 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 13, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Reflections on the Coming Year: IJRB 2019.
Authors: Woloschak GE PMID: 30860952 [PubMed - in process] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 13, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Radioprotective effects of Mistletoe extract in Zebrafish embryos in vivo.
Authors: Rim CH, Koun S, Park HC, Lee S, Kim CY Abstract INTRODUCTION: Radioprotectors can enhance the efficacy of cancer radiotherapy, but their clinical use remains uncommon. The present study aimed to assess the radioprotective potential of mistletoe extract (commercial name: Abnoba Viscum), a well-known complementary cancer medicine, in zebrafish larvae. MATERIALS AND METHODS: Wild-type AB zebrafish embryos at 4 hours-post-fertilization were exposed to 5 Gy 9-MeV electron beam irradiation after being treated for 1 h with 4 mMl/L amifostine or 0.2 mg/ml Abnoba Viscum A, F, ...
Source: International Journal of Radiation Biology - March 7, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

In Memoriam: Peggy Louise Olive 1948-2018.
Authors: Minchinton A, Benniwith K, Hill R PMID: 30836046 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 7, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

The Million Person Study, Whence it Came and Why.
CONCLUSIONS: The MPS is designed to answer the major unanswered question in radiation risk understanding: What is the level of health effects when exposure is gradual overtime and not delivered briefly. The MPS will provide scientific understandings of prolonged exposure which will improve guidelines to protect workers and the public; improve compensation schemes for workers, veterans and the public; provide guidance for policy and decision makers; and provide evidence for or against the continued use of the linear nonthreshold dose-response model in radiation protection. PMID: 30831042 [PubMed - as supplied by publish...
Source: International Journal of Radiation Biology - March 6, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Radiation protection biology then and now.
CONCLUSIONS: While radiobiological investigations started immediately after the discovery of X-rays, the qualitative approach dominated until the end of World War II. After 1945 the nuclear weapons race and nuclear energy programs initiated quantitative radiobiological research. Radiation protection biology does not provide results from which radiation risks can be directly derived. Rather, it provides data that is necessary for understanding the nature of risks. Most recent years have seen, especially in Europe, a growing interest in coordinated studies on the effects of low radiation doses. PMID: 30831044 [PubMed - a...
Source: International Journal of Radiation Biology - March 6, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Cardiovascular and Growth Outcomes of C57Bl/6J Mice Offspring Exposed to Maternal Stress and Ionizing Radiation During Pregnancy.
CONCLUSIONS: Overall, there were minimal effects on cardiovascular measures or offspring weight due to irradiation except at 1000 mGy. The presence of maternal stress, a known trigger of developmental programming, may have confounded any potential irradiation effects. PMID: 30831046 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 6, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Icariin protects against radiation-induced mortality and damage in vitro and in vivo.
CONCLUSION: These results suggest that icariin has significant protective effects against radiation-induced damages partly through its anti-oxidative and anti-apoptotic properties. PMID: 30831047 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 6, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

The Million Person Study Relevance to Space Exploration and Mars.
CONCLUSIONS: The MPS provides a more representative group (healthy men and women) for risk estimates than the 1945 Japanese population exposed briefly to the atomic bombs. The permissible career exposure limit set by NASA for each astronaut is a 3% risk of exposure-induced death (REID) from cancer at a 95% confidence level to account for uncertainties in risk projections. Because the MPS is ten times larger than the LSS, the 95% confidence levels will be narrower and thus allow more time in space, all things being equal. Sex-specific differences in radiation risk can be examined more fully in the MPS with over 250,000 wome...
Source: International Journal of Radiation Biology - March 6, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Proliferation Saturation Index in an adaptive Bayesian approach to predict patient-specific radiotherapy responses.
CONCLUSION: The PSI model may be suited to forecast treatment response for individual patients and offers actionable decision points for mid-treatment protocol adaptation. The presented work provides an actionable image-derived biomarker prior to and during therapy to personalize and adapt radiotherapy. PMID: 30831050 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 6, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Targets, Pools, Shoulders and Communication - A Reflection on the evolution of Low Dose Radiobiology.
CONCLUSIONS: The major conclusion from this study is that ideas concerning survival curves and radiation dose responses evolved and (epi)mutated gradually, driven in a large part by the techniques available for studying radiobiological processes. The illusion of abrupt paradigm shifts is not really borne out by the history when primary references are studied rather than textbooks or reviews. The textbooks necessarily simplify and distil complex data to provide a "take-home message" while reviews are usually very personal collations selected among the vast amount of scientific literature. Primary references reveal...
Source: International Journal of Radiation Biology - March 4, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Direct and bystander effects in human blood lymphocytes exposed to 241Am alpha particles and the relative biological effectiveness using chromosomal aberration and micronucleus assay.
CONCLUSION: The magnitude of low fluence α-particle induced RIBE is higher than in low LET (linear energy transfer) radiation. The RBE also varies depending upon the endpoints used and adds up to targeted effects. Since the endpoint of CA is considered as important and early marker of risk prediction, the RIBE and RBE using CA as a marker are relevant for radiation protection purposes. PMID: 30821557 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 4, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Correlation between expression of CatSper1,2 and sperm parameters in the gamma irradiated adult mouse testis.
In this study, we investigated the effects of gamma radiation on the expression of CatSper1 and CatSper2 genes. Materials and Methods- Twenty-one male NMRI mice were divided into three groups: a control group without gamma radiation, and two experimental groups; Group 1 treated with 1Gy of gamma radiation, and Group 2 treated with a higher dose of 2Gy gamma radiation. Testes were removed from all groups of animals 35 days following irradiation and the testicular tissue, processed and embedded in paraffin blocks for sectioning and histological examination. Sperm samples were also taken from the epididymis for microscopic. S...
Source: International Journal of Radiation Biology - March 4, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Effects of gamma radiation ( γ) on biochemical and antioxidant properties in Black gram (Vigna mungo L. Hepper).
CONCLUSION: The present result concludes that cellular metabolites and the antioxidant enzymes increased and these alterations of metabolism due to the effect of gamma rays which induced free radical production in seeds and plants grown under irradiation stress. These results confirm that the exposure of gamma irradiation produced free radicals as well as counteract by antioxidant enzymes and in addition to that accumulation and alteration of primary metabolites. PMID: 30821568 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 4, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

The Warburg effect: Essential part of metabolic reprogramming and central contributor to cancer progression.
CONCLUSIONS: There is clear evidence that mitochondria are not defective in most cancers. Aerobic glycolysis, a key metabolic feature of the Warburg phenotype, is caused by active metabolic reprogramming required to support sustained cancer cell proliferation and malignant progression. This metabolic switch is directed by altered growth factor signaling, hypoxic or normoxic activation of HIF-1α- transcription, oncogene activation or loss-of-function of suppressor genes, and is implemented in the hostile tumor microenvironment. The "selfish" reprogramming includes (a) overexpression of glucose transporters a...
Source: International Journal of Radiation Biology - March 4, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

A Small Fish Model for Quantitative Analysis of Radiation Effects Using Visualized Thymus Responses in GFP Transgenic Medaka.
CONCLUSION: A biomonitoring system to detect the effects of radiation in real time was established. Using this system, the threshold doses for the induction of thymic atrophy by acute X-rays and Fe ions were 2-5 Gy and 0.5-1 Gy, respectively. The Relative Biological Effectiveness (RBE) of Fe-ion to X-rays was estimated to be around 3. This system may be used to evaluate the risk from concurrent exposure to hazards, such as chemicals and radiation, and for aging research. PMID: 30822211 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 4, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Combination of static magnetic field and cisplatin in order to reduce drug resistance in cancer cell lines.
CONCLUSION: Results showed that A2780 cells were more sensitive to cisplatin than A2780-CP. Studies have shown that SMF can increase the effect of cisplatin on cell viability percent and decrease the resistance of A2780-CP cells by producing large, verruca shaped structures at the surface of the cell membrane. PMID: 30822212 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 4, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Saving Normal Tissues - A Goal for the Ages.
CONCLUSIONS: Limiting the survey solely to articles appearing within International Journal of Radiation Biology likely reduced the number of translational studies interrogated given the basic science tenor of this particular publication. In addition, by taking 'snapshots' rather than considering the entire breadth of the journal's history in this field, important papers that were published during the interim periods were omitted, for which we apologize. Nonetheless, since the journal's inception, we observed that, during the chosen periods, the majority of studies undertaken in the field of normal tissue countermeasures, w...
Source: International Journal of Radiation Biology - March 4, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Effect of cobalt-60 gamma radiation on Total haemocyte content and Biochemical parameters in Macrobrachium rosenbergii (De Man, 1879).
CONCLUSIONS: Hence, this study concludes that even low level of ionizing radiation (60Co gamma) can cause acute damages in gills, hepatopancreas and muscles in irradiated groups. PMID: 30822214 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 4, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Long - term exposure of cockroach Blaptica dubia (Insecta: Blaberidae) nymphs to magnetic fields of different characteristics: Effects on antioxidant biomarkers and nymphal gut mass.
CONCLUSION: The applied magnetic fields could be considered a potential stressor influencing gut mass, as well as examined antioxidative biomarkers. PMID: 30822251 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 4, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Cohort Profile - MSK Radiation Workers: a Feasibility Study to Establish a Deceased Worker Sub-Cohort as part of a Multicenter Medical Radiation Worker Component in the Million Person Study of Low-Dose Radiation Health Effects.
CONCLUSIONS: MSK has pioneered the use of novel radiation diagnostic and therapeutic approaches over time (including initial work with x-rays, radium and radon), with workplace safety in mind, resulting in a variety of radiation worker exposure scenarios. The results of this feasibility sub-cohort of deceased radiation workers, and associated lessons learned may potentially be applied to an expanded multicenter study of about 170,000 medical radiation worker component of the MPS. PMID: 30810447 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 1, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Exploring the legacy and impact of historical IJRB articles and contributions to ICRP publications and Radiation Research articles through graphical reference mapping.
Authors: Rusin A, Hamada N Abstract The International Journal of Radiation Biology (IJRB) celebrates its sixtieth birthday this year. Ahead of this very special issue, we wanted to produce strong representations of the journal's publication history in order to celebrate the current status of the journal and to look forward to its future. This was accomplished using "reference maps". Reference data was used from 1959 onward from the highest-cited paper in IJRB, for each respective year, to create a figure displaying when those articles were cited in IJRB since their publication. This was done to show the r...
Source: International Journal of Radiation Biology - February 27, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Mapping the research trends on the biological effects of radiation less than 100 mSv: A bibliometric analysis for 30 years publication.
CONCLUSIONS: Continuous studies in large programs of low dose radiation led to the increment of research achievements in accordance with societal needs in radiation safety regulation for health protection. Our findings can surely help radiation researchers to gain insights and penetration in low dose risk research for radiation protection, and establish the further research direction. PMID: 30753094 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - February 14, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Radiation induced DNA damage response and resistance in colorectal cancer stem-like cells.
CONCLUSION: This study highlighted the presence of CSC phenotype in clonospheres having increased DNA repair capacity. Differential expression of developmental marker, CSC markers and telomeric components between parental and clonospheres may contribute in radio-resistance property of CSCs. PMID: 30753097 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - February 14, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Long-term immune effects of high level natural radiation on Yangjiang inhabitants in China.
CONCLUSION: Immune function was found to be affected in humans exposed to long-term low dose radiation. Specifically, we observed an increase in CD8+T lymphocyte numbers and an up-regulation of inflammatory biomarkers, including IFN-γ, MCP-1, sIL-6R, EGFR, CRP. PMID: 30753115 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - February 14, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Applying a multiscale systems biology approach to study the effect of chronic low-dose exposure to uranium in rat kidneys.
CONCLUSION: Our results showed changes in multi-omic profiles of rats exposed to low doses of uranium contamination, compared with controls. These changes involved gene expression as well as modifications in the transcriptome and the metabolome. The metabolomic profile confirmed that the main molecular targets of uranium in kidney cells are the metabolism of nicotinate-nicotinamide and the biosynthesis of unsaturated fatty acids. Additionally, gene expression analysis showed that the metabolism of fatty acids is targeted by processes associated with cell function. These results demonstrate that multiscale systems biology i...
Source: International Journal of Radiation Biology - February 6, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

G2-lymphocyte Chromosomal Radiosensitivity in Patients with LPS Responsive Beige-Like Anchor Protein (LRBA) Deficiency.
This study was undertaken to evaluate radiation sensitivity in 11 LRBA-deficient patients. Therefore, stimulated lymphocytes of the studied subjects were exposed to a low dose γ-radiation (100cGy) in the G2 phase of the cell cycle and chromosomal aberrations were scored. Lymphocytes of age-sex matched healthy individuals used in the same way as controls. Based on the G2-assay, six (54.5%) of the patients had higher radiosensitivity score comparing to the healthy control group, forming the radiosensitive LRBA-deficient patients. This chromosomal radiosensitivity showed that these patients are predisposed to autoimmuni...
Source: International Journal of Radiation Biology - February 6, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Quantification of DNA damage in patients undergoing non-contrast & contrast enhanced whole body PET/CT investigations using comet assay and micronucleus assay.
CONCLUSION: The patients undergoing contrast-enhanced WB PET/CT investigations have demonstrated higher DNA damage. The DNA damage was also observed to be more in heavier patients. The other baseline parameters of patients like age, sex, CBG, serum creatinine did not show any correlation with DNA damage. PMID: 30707050 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - February 3, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Radiation databases and archives - examples and comparisons.
CONCLUSIONS: By preserving all of these data and tissue sets, radiation biologists can combine databases and conduct large-scale analyses of detailed existing data and perform new assays with cutting edge scientific approaches. PMID: 30676164 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 25, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

History of radiation genetics: light and darkness.
CONCLUSION: Although powerful methods such as whole-genome-sequencing techniques have become available to detect radiation effects in human germ cells, the mutation induction rate in the genome now appears to be much lower than was previously thought. Consequently, detecting radiation effects in human germ cells still remains a difficult task. PMID: 30676167 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 25, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Ionizing radiation affects miRNA composition in both young and old mice.
CONCLUSIONS: The results of our study demonstrate that both radiation and aging can influence the global expression of miRNAs, while low dose radiation modulates the expression of miRNAs in a dose-, time-, and age- dependent manner. PMID: 30676169 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 25, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

International Coordination of Research: EPRI International Dose Effect Alliance.
CONCLUSIONS: Significant advances are being achieved through the IDEA program, and the Osaka workshop held in Japan in March 2018 has further contributed to the initiative. PMID: 30676170 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 25, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Differential Radio-Adaptive Responses in BALB/c and C57BL/6 Mice: Pivotal Role of Calcium and Nitric Oxide Signalling.
CONCLUSIONS: These results suggest that low dose induced differential induction of Ca2+ and NO signaling along with MAPK was responsible for contrasting RAR with respect to immune system of BALB/c and C57BL/6 mice. PMID: 30676176 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 25, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Epidemiological Studies of Atomic Bomb Radiation at the Radiation Effects Research Foundation.
CONCLUSIONS: Epidemiological studies have observed increased radiation risks for malignant diseases among survivors including those exposed in utero, and possible risks for some noncancer diseases. No increased risks due to parental exposure to radiation have been observed for malignancies or other diseases in F1, but continuing investigations are required. PMID: 30676179 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 25, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Is Stereotactic Body Radiotherapy for Ultra-central Lung Tumor a Feasible Option? A Systemic Review and Meta-analysis.
Conclusions SBRT for UC tumors confers efficient LC, although the risk of complications was not negligible. Control of possible risk factors of hemorrhage and dose optimization through further studies are warranted. PMID: 30676182 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 25, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Neutrons are forever! Historical perspectives.
CONCLUSIONS: Neutron radiobiology has continued as a vigorous field of study throughout the past eighty four years. Main driving forces have included concern for protection from the harmful effects of neutrons, exploitation and optimisation for cancer therapy (fast beam therapy, brachytherapy and boron capture therapy), and scientific curiosity about the mechanisms of radiation action. Effort has fluctuated as emphasis has shifted from time to time, but all three areas remain active today. Whatever the future holds for the various types of neutron therapy, the health protection aspects will remain with us permanently becau...
Source: International Journal of Radiation Biology - January 24, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Chronic Low Dose Exposure of Hospital Workers to Ionizing Radiation Leads to Increased Micronuclei Frequency and Reduced Antioxidants in Their Peripheral Blood Lymphocytes.
Authors: Siama Z, Zosangzuali M, Vanlalruati A, Jagetia GC, Pau KS, Kumar NS Abstract PURPOSE: The regular low dose occupational exposure to ionizing radiation may induce deleterious health effects, which may be of particular interest to medical radiation workers who daily handle X-ray machines. Human peripheral blood lymphocytes are able to retain the signature of radiation-induced DNA damage, therefore present study was undertaken to investigate the DNA damage and antioxidants status in hospital workers occupationally exposed to low doses of X-rays. MATERIALS AND METHODS: The peripheral blood lymphocytes of t...
Source: International Journal of Radiation Biology - January 24, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Infrared Spectroscopic Demonstration of Magnetic Orientation in SH-SY5Y Neuronal-Like Cells Induced by Static or 50  Hz Magnetic Fields.
CONCLUSIONS: These findings can be easily explained assuming that proteins α-helices and lipids contents in cellular membrane aligned towards the direction of the applied magnetic field after exposure, inducing an increasing of ions flux across cellular membrane channels after exposure to a magnetic field, changing cellular functions. PMID: 30668250 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 24, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Chemical Radiosensitizers: The Journal History.
CONCLUSION: The development of an agent that would differentially sensitize tumors to irradiation remains a "holy grail" of clinically-oriented radiobiology. Approaches to this goal have been a major feature of the Journal since its first decade, but we have yet to find such an agent. Perhaps we should be discouraged, but personally I remain optimistic that we (or our students) will succeed. PMID: 30657352 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 20, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Assessment of Lead tolerance in gamma exposed Aspergillus niger Van Tieghem. & Penicillium cyclopium Westling.
CONCLUSION: The outcomes of this study exhibit a light towards a new step of heavy metal bioremediation. PMID: 30648900 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 18, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Verification of a dose rate-responsive dynamic equilibrium model on radiation-induced mutation frequencies in mice.
CONCLUSIONS: As a result of comparison between experimental and theoretical data, the certainty of the WAM model was confirmed in mice and it was shown that the genetic influence varies depending on the dose-rate. PMID: 30648901 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 18, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Early Authors: R. H. Mole.
Conclusions: RH Mole made significant contributions to radiobiology and is particularly associated with studies of the effects of low dose exposures on the reproductive health of mammals. Many of his ideas are still debated and remain controversial. PMID: 30649982 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 18, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research