Overexpression of HSP27 accelerates stress-induced gastric ulcer healing via the CXCL12/CXCR4 axis
Clin Exp Pharmacol Physiol. 2024 May;51(5):e13857. doi: 10.1111/1440-1681.13857.ABSTRACTChronic stress often triggers gastrointestinal complications, including gastric injury and ulcers. Understanding the role of heat shock protein 27 (HSP27) in stress-induced gastric ulcers could unveil novel therapeutic targets. Here, we established a stress-induced gastric ulcer rat model using water immersion restraint stress and administered adenovirus-packaged HSP27 overexpression vector. Gastric ulcer severity was scored, and mucosal changes were assessed. Gastric epithelial and endothelial cells were treated with lipopolysaccharide...
Source: Clinical and Experimental Pharmacology and Physiology - April 3, 2024 Category: Drugs & Pharmacology Authors: Qiaoyan Lu Hua Tang Source Type: research
Overexpression of HSP27 accelerates stress-induced gastric ulcer healing via the CXCL12/CXCR4 axis
Clin Exp Pharmacol Physiol. 2024 May;51(5):e13857. doi: 10.1111/1440-1681.13857.ABSTRACTChronic stress often triggers gastrointestinal complications, including gastric injury and ulcers. Understanding the role of heat shock protein 27 (HSP27) in stress-induced gastric ulcers could unveil novel therapeutic targets. Here, we established a stress-induced gastric ulcer rat model using water immersion restraint stress and administered adenovirus-packaged HSP27 overexpression vector. Gastric ulcer severity was scored, and mucosal changes were assessed. Gastric epithelial and endothelial cells were treated with lipopolysaccharide...
Source: Clinical and Experimental Pharmacology and Physiology - April 3, 2024 Category: Drugs & Pharmacology Authors: Qiaoyan Lu Hua Tang Source Type: research
Comparative single-cell transcriptomic profile of hybrid immunity induced by adenovirus vector-based COVID-19 vaccines
Genes & Immunity, Published online: 03 April 2024; doi:10.1038/s41435-024-00270-xComparative single-cell transcriptomic profile of hybrid immunity induced by adenovirus vector-based COVID-19 vaccines (Source: Genes and Immunity)
Source: Genes and Immunity - April 3, 2024 Category: Genetics & Stem Cells Authors: Melissa Garc ía-Vega Hui Wan M ónica Reséndiz-Sandoval Diana Hinojosa-Trujillo Olivia Valenzuela Ver ónica Mata-Haro Freddy Dehesa-Canseco Mario Sol ís-Hernández Harold Marcotte Qiang Pan-Hammarstr öm Jes ús Hernández Source Type: research
RP105 Attenuates Ischemia/Reperfusion-Induced Oxidative Stress in the Myocardium via Activation of the Lyn/Syk/STAT3 Signaling Pathway
AbstractAlthough our previous studies have established the crucial role of RP105 in myocardial ischemia/reperfusion injury (MI/RI), its involvement in regulating oxidative stress induced by MI/RI remains unclear. To investigate this, we conducted experiments using a rat model of ischemia/reperfusion (I/R) injury. Adenovirus carrying RP105 was injected apically at multiple points, and after 72 h, the left anterior descending coronary artery was ligated for 30 min followed by 2 h of reperfusion.In vitro experiments were performed on H9C2 cells, which were transfected with recombinant adenoviral vectors for 48 h, subjec...
Source: Inflammation - April 3, 2024 Category: Allergy & Immunology Source Type: research
Oncolytic adenovirus encoding apolipoprotein A1 suppresses metastasis of triple-negative breast cancer in mice
Dysregulation of cholesterol metabolism is associated with the metastasis of triple-negative breast cancer (TNBC). Apolipoprotein A1 (ApoA1) is widely recognized for its pivotal role in regulating cholesterol ... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 3, 2024 Category: Cancer & Oncology Authors: Jie Dong, Lingkai Kong, Shiqun Wang, Mao Xia, Yenan Zhang, Jingyi Wu, Fuming Yang, Shuguang Zuo and Jiwu Wei Tags: Research Source Type: research
Shank3 deficiency elicits autistic-like behaviors by activating p38 α in hypothalamic AgRP neurons
ConclusionsThese results demonstrate that theShank3 deficiency caused autistic-like behaviors by activating p38 α signaling in AgRP neurons, suggesting that p38α signaling in AgRP neurons is a potential therapeutic target forShank3 mutant-related autism. (Source: Molecular Autism)
Source: Molecular Autism - April 3, 2024 Category: Molecular Biology Source Type: research
RP105 Attenuates Ischemia/Reperfusion-Induced Oxidative Stress in the Myocardium via Activation of the Lyn/Syk/STAT3 Signaling Pathway
AbstractAlthough our previous studies have established the crucial role of RP105 in myocardial ischemia/reperfusion injury (MI/RI), its involvement in regulating oxidative stress induced by MI/RI remains unclear. To investigate this, we conducted experiments using a rat model of ischemia/reperfusion (I/R) injury. Adenovirus carrying RP105 was injected apically at multiple points, and after 72 h, the left anterior descending coronary artery was ligated for 30 min followed by 2 h of reperfusion.In vitro experiments were performed on H9C2 cells, which were transfected with recombinant adenoviral vectors for 48 h, subjec...
Source: Inflammation - April 3, 2024 Category: Allergy & Immunology Source Type: research
NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence
In this study, we found that the expression of nuclear receptor subfamily 2 group F member 2 (NR2F2), a member of the steroid thyroid hormone superfamily of nuclear receptors, was reduced in both IPF and bleomycin-induced fibrotic lungs, markedly in bleomycin-induced senescent epithelial cells. Inhibition of NR2F2 expression increased the expression of senescence markers such as p21 and p16 in lung epithelial cells, and activated fibroblasts through epithelial-mesenchymal crosstalk, inversely overexpression of NR2F2 alleviated bleomycin-induced epithelial cell senescence and inhibited fibroblast activation. Subsequent mech...
Source: Cell Research - April 2, 2024 Category: Cytology Authors: Ruyan Wan Siqi Long Shuaichen Ma Peishuo Yan Zhongzheng Li Kai Xu Hui Lian Wenwen Li Yudi Duan Miaomiao Zhu Lan Wang Guoying Yu Source Type: research
Differential Contributions of Interferon Classes to Host Inflammatory Responses and Restricting Virus Progeny Production
J Proteome Res. 2024 Apr 2. doi: 10.1021/acs.jproteome.3c00826. Online ahead of print.ABSTRACTFundamental to mammalian intrinsic and innate immune defenses against pathogens is the production of Type I and Type II interferons, such as IFN-β and IFN-γ, respectively. The comparative effects of IFN classes on the cellular proteome, protein interactions, and virus restriction within cell types that differentially contribute to immune defenses are needed for understanding immune signaling. Here, a multilayered proteomic analysis, paired with biochemical and molecular virology assays, allows distinguishing host responses to IF...
Source: Cell Research - April 2, 2024 Category: Cytology Authors: Krystal K Lum Tavis J Reed Jinhang Yang Ileana M Cristea Source Type: research
Oncolytic adenovirus encoding apolipoprotein A1 suppresses metastasis of triple-negative breast cancer in mice
CONCLUSIONS: This study provides a promising oncolytic virus treatment strategy for TNBC based on targeting dysregulated cholesterol metabolism. It also establishes a basis for subsequent clinical trials of ADV-ApoA1 in the treatment of TNBC.PMID:38566092 | DOI:10.1186/s13046-024-03011-0 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 2, 2024 Category: Cancer & Oncology Authors: Jie Dong Lingkai Kong Shiqun Wang Mao Xia Yenan Zhang Jingyi Wu Fuming Yang Shuguang Zuo Jiwu Wei Source Type: research
Oncolytic adenovirus encoding apolipoprotein A1 suppresses metastasis of triple-negative breast cancer in mice
CONCLUSIONS: This study provides a promising oncolytic virus treatment strategy for TNBC based on targeting dysregulated cholesterol metabolism. It also establishes a basis for subsequent clinical trials of ADV-ApoA1 in the treatment of TNBC.PMID:38566092 | DOI:10.1186/s13046-024-03011-0 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 2, 2024 Category: Cancer & Oncology Authors: Jie Dong Lingkai Kong Shiqun Wang Mao Xia Yenan Zhang Jingyi Wu Fuming Yang Shuguang Zuo Jiwu Wei Source Type: research
Oncolytic adenovirus encoding apolipoprotein A1 suppresses metastasis of triple-negative breast cancer in mice
CONCLUSIONS: This study provides a promising oncolytic virus treatment strategy for TNBC based on targeting dysregulated cholesterol metabolism. It also establishes a basis for subsequent clinical trials of ADV-ApoA1 in the treatment of TNBC.PMID:38566092 | DOI:10.1186/s13046-024-03011-0 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 2, 2024 Category: Cancer & Oncology Authors: Jie Dong Lingkai Kong Shiqun Wang Mao Xia Yenan Zhang Jingyi Wu Fuming Yang Shuguang Zuo Jiwu Wei Source Type: research
Differential Contributions of Interferon Classes to Host Inflammatory Responses and Restricting Virus Progeny Production
J Proteome Res. 2024 Apr 2. doi: 10.1021/acs.jproteome.3c00826. Online ahead of print.ABSTRACTFundamental to mammalian intrinsic and innate immune defenses against pathogens is the production of Type I and Type II interferons, such as IFN-β and IFN-γ, respectively. The comparative effects of IFN classes on the cellular proteome, protein interactions, and virus restriction within cell types that differentially contribute to immune defenses are needed for understanding immune signaling. Here, a multilayered proteomic analysis, paired with biochemical and molecular virology assays, allows distinguishing host responses to IF...
Source: Herpes - April 2, 2024 Category: Infectious Diseases Authors: Krystal K Lum Tavis J Reed Jinhang Yang Ileana M Cristea Source Type: research
Clonal structure and the specificity of vaccine-induced T cell response to SARS-CoV-2 Spike protein
In conclusion, our study demonstrates the immunogenicity of the Ad5-nCoV adenoviral vaccine and highlights its ability to induce robust and durable T cell responses. These findings provide valuable insight into the efficacy of the vaccine against COVID-19 and provide critical information for ongoing efforts to control infectious diseases. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - April 2, 2024 Category: Allergy & Immunology Source Type: research
False positive findings associated with adenoviral vector-based vaccine underscore the regulatory necessity to eliminate abnormal toxicity test
In conclusion, ATT, which requires unnecessary animal usage and competes for resources which otherwise can be spent on innovative medicine research, should be deleted permanently as batch release test by regulatory authorities around the world.PMID:38561146 | DOI:10.1016/j.yrtph.2024.105617 (Source: Regulatory Toxicology and Pharmacology : RTP)
Source: Regulatory Toxicology and Pharmacology : RTP - April 1, 2024 Category: Toxicology Authors: Ryan Meng Mark van Ooij Yali Li Yunhai Zhang Jianxun Xie Source Type: research
