Fever during pregnancy as a risk factor for neurodevelopmental disorders: results from a systematic review and meta-analysis
ConclusionAdditional evidence supported the association between fever during pregnancy and increased risk for NDD in offspring. Careful monitoring should be considered for children born from mothers with a febrile episode during pregnancy (specifically during the first trimester). (Source: Molecular Autism)
Source: Molecular Autism - September 18, 2021 Category: Molecular Biology Source Type: research

Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman Syndrome
ConclusionsDespite a few observed effects of IGF-2, our results taken together indicate that IGF-2 treatment does not profoundly improve behavioral deficits in mouse or rat models of AS. These findings shed cautionary light on the potential utility of acute systemic IGF-2 administration in the treatment of AS. (Source: Molecular Autism)
Source: Molecular Autism - September 15, 2021 Category: Molecular Biology Source Type: research

Correction to: Biological motion perception in autism spectrum disorder: a meta-analysis
(Source: Molecular Autism)
Source: Molecular Autism - August 20, 2021 Category: Molecular Biology Source Type: research

Non-verbal IQ and change in restricted and repetitive behavior throughout childhood in autism: a longitudinal study using the Autism Diagnostic Interview-Revised
ConclusionsThese results confirm that specific RRB are differentially linked to age and NVIQ. Studying RRB individually is a promising approach to better understanding how RRB change over the development of autistic children and are linked to other developmental domains. (Source: Molecular Autism)
Source: Molecular Autism - August 14, 2021 Category: Molecular Biology Source Type: research

Improving the measurement of alexithymia in autistic adults: a psychometric investigation of the 20-item Toronto Alexithymia Scale and generation of a general alexithymia factor score using item response theory
ConclusionsThese results indicate the potential of the GAFS-8 to robustly measure alexithymia in both autistic and non-autistic adults. A free online score calculator has been created to facilitate the use of norm-referenced GAFS-8 latent trait scores in research applications (available athttps://asdmeasures.shinyapps.io/alexithymia). (Source: Molecular Autism)
Source: Molecular Autism - August 10, 2021 Category: Molecular Biology Source Type: research

The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project design and methodologies: a dimensional approach to understanding neurobiological and genetic aetiology
ConclusionThe MAGNET project will be the first large-scale family study to take a transdiagnostic approach to ASD-ADHD, utilising deep phenotyping across behavioural, neurocognitive, brain imaging and genetic measures. (Source: Molecular Autism)
Source: Molecular Autism - August 5, 2021 Category: Molecular Biology Source Type: research

Abnormal sleep physiology in children with 15q11.2-13.1 duplication (Dup15q) syndrome
ConclusionsWe have identified three quantitative EEG biomarkers of sleep disruption in Dup15q syndrome, a genetic condition highly penetrant for ASD. Insights from this study not only promote a greater mechanistic understanding of the pathophysiology defining Dup15q syndrome, but also lay the foundation for studies that investigate the association between sleep and cognition. Abnormal sleep physiology may undermine healthy cognitive development and may serve as a quantifiable and modifiable target for behavioral and pharmacological interventions. (Source: Molecular Autism)
Source: Molecular Autism - August 3, 2021 Category: Molecular Biology Source Type: research

MEK inhibition ameliorates social behavior phenotypes in a Spred1 knockout mouse model for RASopathy disorders
ConclusionsThese results demonstrate for the first time that social behavior phenotypes in a mouse model for RASopathies (Spred1-/-) can be acutely reversed. This highlights a key role for Ras-MAPK dysregulation in mediating social behavior phenotypes in mouse models for ASD, suggesting that proper regulation of Ras-MAPK signaling is important for social behavior. (Source: Molecular Autism)
Source: Molecular Autism - July 26, 2021 Category: Molecular Biology Source Type: research

Initial action output and feedback-guided motor behaviors in autism spectrum disorder
ConclusionsWe identify reduced accuracy of initial motor output in ASD that was specific to the oculomotor system implicating deficient feedforward control that may be mitigated during slower occurring behaviors executed in the periphery. Individuals with ASD showed increased continuous force variability but similar levels of trial-to-trial saccade accuracy variability suggesting that feedback-guided refinement of motor commands is deficient specifically when adjustments occur rapidly during continuous behavior. We also document reduced lateralization of grip strength in ASD implicating atypical hemispheric specialization....
Source: Molecular Autism - July 10, 2021 Category: Molecular Biology Source Type: research

Maternal steroid levels and the autistic traits of the mother and infant
ConclusionMaternal steroid factors during pregnancy are associated with autistic traits in mothers and their infants. (Source: Molecular Autism)
Source: Molecular Autism - July 8, 2021 Category: Molecular Biology Source Type: research

Autism-associated biomarkers: test –retest reliability and relationship to quantitative social trait variation in rhesus monkeys
ConclusionsThese findings indicate that cerebrospinal fluid arginine vasopressin concentration is a stable trait-like measure and that it is linked to quantitative social trait variation in male rhesus monkeys. (Source: Molecular Autism)
Source: Molecular Autism - July 8, 2021 Category: Molecular Biology Source Type: research

Modulation of striatal functional connectivity differences in adults with and without autism spectrum disorder in a single-dose randomized trial of cannabidivarin
ConclusionIn conclusion, here we show atypical striatal FC with regions commonly associated with ASD symptoms. We further provide preliminary proof of concept that, in the adult autistic brain, acute CBDV administration can modulate atypical striatal circuitry towards neurotypical function. Future studies are required to determine whether modulation of striatal FC is associated with a change in ASD symptoms.Trial registrationclinicaltrials.gov, Identifier: NCT03537950. Registered May 25th, 2018 —Retrospectively registered,https://clinicaltrials.gov/ct2/show/NCT03537950?term=NCT03537950&draw=2&rank=1. (Source: Molecular Autism)
Source: Molecular Autism - July 1, 2021 Category: Molecular Biology Source Type: research

Neurite orientation dispersion and density imaging reveals white matter microstructural alterations in adults with autism
ConclusionsOur results suggest that NODDI measures might be useful as imaging biomarkers to diagnose autism in adults and assess its behavioral characteristics. Furthermore, NODDI allows interpretation of previous findings on changes in WM diffusion tensor metrics in individuals with autism. (Source: Molecular Autism)
Source: Molecular Autism - June 30, 2021 Category: Molecular Biology Source Type: research

Autism symptoms in anorexia nervosa: a comparative study with females with autism spectrum disorder
ConclusionsThe results suggest similarities in scores on both self-report and clinical interview measures in AN and ASD. However, individual ADOS-2 item analyses also revealed subtle differences, particularly in reciprocal social interaction. ASD symptoms may be a combination of both state and trait features in AN. (Source: Molecular Autism)
Source: Molecular Autism - June 30, 2021 Category: Molecular Biology Source Type: research

Development and validation of the suicidal behaviours questionnaire - autism spectrum conditions in a community sample of autistic, possibly autistic and non-autistic adults
ConclusionsThe SBQ-ASC is a brief self-report suicidality assessment tool, developed and validated with and for autistic adults, without co-occurring intellectual disability. The SBQ-ASC is appropriate for use in research to identify suicidal thoughts and behaviours in autistic and possibly autistic people, and model associations with risk and protective factors. (Source: Molecular Autism)
Source: Molecular Autism - June 21, 2021 Category: Molecular Biology Source Type: research

Correction to: Hans Asperger, National Socialism, and “race hygiene” in Nazi-era Vienna
An amendment to this paper has been published and can be accessed via the original article. (Source: Molecular Autism)
Source: Molecular Autism - June 21, 2021 Category: Molecular Biology Source Type: research

Correction to: Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder
(Source: Molecular Autism)
Source: Molecular Autism - June 16, 2021 Category: Molecular Biology Source Type: research

Genetic and morphological estimates of androgen exposure predict social deficits in multiple neurodevelopmental disorder cohorts
AbstractBackgroundNeurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD) display a strong male bias. Androgen exposure is profoundly increased in typical male development, but it also varies within the sexes, and previous work has sought to connect morphological proxies of androgen exposure, including digit ratio and facial morphology, to neurodevelopmental outcomes. The results of these studies have been mixed, and the relationships between androgen exposure and behavior remain unclear.MethodsHere, we measured both digit ratio masculinity (DRM) and facial landmark masculinity (FLM) in the same neurodev...
Source: Molecular Autism - June 9, 2021 Category: Molecular Biology Source Type: research

Psychometric validation and refinement of the Interoception Sensory Questionnaire (ISQ) in adolescents and adults on the autism spectrum
ConclusionThe ISQ-8 shows promise as a reliable and valid measure of interoception in adolescents and adults on the autism spectrum, but additional work is needed to examine its psychometrics in this population. A free online score calculator has been created to facilitate the use of ISQ-8 latent trait scores for further studies of autistic adolescents and adults (available athttps://asdmeasures.shinyapps.io/ISQ_score/). (Source: Molecular Autism)
Source: Molecular Autism - June 7, 2021 Category: Molecular Biology Source Type: research

Germline nuclear-predominant Pten murine model exhibits impaired social and perseverative behavior, microglial activation, and increased oxytocinergic activity
ConclusionsThe nuclear-predominantPtenY68H/+ model has clarified that Pten dysfunction links to microglial pathology and this associates with increased Akt signaling. We also demonstrate that Pten dysfunction associates with changes in the oxytocin system, an important connection between a prominent ASD risk gene and a potent neuroendocrine regulator of social behavior. These cellular and molecular pathologies may related to the observed changes in social behavior. Ultimately, the findings from this work may reveal important biomarkers and/or novel therapeutic modalities that could be explored in individuals with germline ...
Source: Molecular Autism - June 4, 2021 Category: Molecular Biology Source Type: research

Retraction Note to: Improving the measurement of alexithymia in autistic adults: a psychometric investigation and refinement of the twenty-item Toronto Alexithymia Scale
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13229-021-00446-6 (Source: Molecular Autism)
Source: Molecular Autism - May 30, 2021 Category: Molecular Biology Source Type: research

Using the big data approach to clarify the structure of restricted and  repetitive behaviors across the most commonly used autism spectrum disorder measures
ConclusionsReported findings offer promise for capturing important RRB domains using general ASD measures and highlight the need for measurement development. (Source: Molecular Autism)
Source: Molecular Autism - May 27, 2021 Category: Molecular Biology Source Type: research

Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder
AbstractBackgroundSulforaphane (SF), an isothiocyanate in broccoli, has potential benefits relevant to autism spectrum disorder (ASD) through its effects on several metabolic and immunologic pathways. Previous clinical trials of oral SF demonstrated positive clinical effects on behavior in young men and changes in urinary metabolomics in children with ASD.MethodsWe conducted a 15-week randomized parallel double-blind placebo-controlled clinical trial with 15-week open-label treatment and 6-week no-treatment extensions in 57 children, ages 3 –12 years, with ASD over 36 weeks. Twenty-eight were assigned SF an...
Source: Molecular Autism - May 25, 2021 Category: Molecular Biology Source Type: research

The Comprehensive Autistic Trait Inventory (CATI): development and validation of a new measure of autistic traits in the general population
ConclusionsThe CATI is a reliable and economical new measure that provides observations across a wide range of trait dimensions associated with autism, potentially precluding the need to administer multiple measures, and to our knowledge, the CATI is also the first broad measure of autistic traits to have dedicated subscales for social camouflage and sensory sensitivity. (Source: Molecular Autism)
Source: Molecular Autism - May 17, 2021 Category: Molecular Biology Source Type: research

Prospective and detailed behavioral phenotyping in DDX3X syndrome
ConclusionThis study, representing a first, prospective, detailed characterization of DDX3X syndrome, extends our understanding of the neurobehavioral phenotype. Gold-standard diagnostic approaches demonstrated high rates of ID, ASD, and ADHD. In addition, sensory deficits were observed to be a key part of the syndrome. Even with a modest sample, we observe evidence for genotype –phenotype correlations with missense variants/in-frame deletions generally associated with more severe phenotypes. (Source: Molecular Autism)
Source: Molecular Autism - May 16, 2021 Category: Molecular Biology Source Type: research

Bayonet-shaped language development in autism with regression: a retrospective study
ConclusionsFor autistic individuals with ELR and a normal level of non-verbal intelligence, language development follows a “bayonet shape” trajectory: early first words followed by regression, a plateau with limited progress, and then language catch up. (Source: Molecular Autism)
Source: Molecular Autism - May 13, 2021 Category: Molecular Biology Source Type: research

Single-participant structural similarity matrices lead to greater accuracy in classification of participants than function in autism in MRI
ConclusionThis study provides a simple means of feature extraction for inputting large numbers of structural MRIs into machine learning models. Our methods revealed a unique emphasis of the deep learning model on the structure of the bilateral Heschl ’s gyrus when characterizing autism. (Source: Molecular Autism)
Source: Molecular Autism - May 10, 2021 Category: Molecular Biology Source Type: research

An investigation of the diet, exercise, sleep, BMI, and health outcomes of autistic adults
ConclusionsAutistic adults are less likely to meet minimal health recommendations for diet, exercise, and sleep —and these unhealthy behaviors may relate to excess risk of cardiovascular conditions. Although the present study can only provide preliminary, correlational evidence, our findings suggest that diet, exercise, and sleep should be considered and further investigated as key targets for reducing the now widely reported and dramatically increased risks of health comorbidity and premature death among autistic individuals compared to others. Physicians should work cooperatively with patients to provide health edu...
Source: Molecular Autism - May 8, 2021 Category: Molecular Biology Source Type: research

Examining a stepped-care telehealth program for parents of young children with autism: a proof-of-concept trial
AbstractBackgroundIntervention during the first years of life for children with autism spectrum disorder (ASD) may have the strongest impact on long-term brain development and functioning. Yet, barriers such as a shortage of trained professionals contribute to significant delays in service. The goal of this proof-of-concept study was to explore strategies that support timely and equitable deployment of ASD-specific interventions.MethodsThis 15-week, randomized proof-of-concept study explored the acceptability of a digital parent mediated intervention online reciprocal imitation training (RIT; a naturalistic developmental b...
Source: Molecular Autism - May 8, 2021 Category: Molecular Biology Source Type: research

Correction to: Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life
An amendment to this paper has been published and can be accessed via the original article. (Source: Molecular Autism)
Source: Molecular Autism - May 8, 2021 Category: Molecular Biology Source Type: research

Extremely preterm birth and autistic traits in young adulthood: the EPICure study
AbstractBackgroundA high prevalence of autism spectrum disorder is reported in children born extremely preterm (EP), but an even larger proportion of survivors are affected by subclinical difficulties than meet diagnostic criteria. The aims of this study were to investigate autistic traits associated with the broader autism phenotype in a cohort of young adults born EP, and explore how these traits relate to emotion recognition, empathy and autism symptom presentation in childhood. The prevalence of autism diagnoses was also investigated.MethodsOne hundred and twenty-nine young adults born before 26  weeks of gestatio...
Source: Molecular Autism - May 6, 2021 Category: Molecular Biology Source Type: research

Shifted phase of EEG cross-frequency coupling in individuals with Phelan-McDermid syndrome
AbstractBackgroundPhelan-McDermid Syndrome (PMS) is a rare condition caused by deletion or mutation of theSHANK3 gene. Individuals with PMS frequently present with intellectual disability, autism spectrum disorder, and other neurodevelopmental challenges. Electroencephalography (EEG) can provide a window into network-level function in PMS.MethodsHere, we analyze EEG data collected across multiple sites in individuals with PMS (n  = 26) and typically developing individuals (n = 15). We quantify oscillatory power, alpha-gamma phase-amplitude coupling strength, and phase bias, a measure of the phas...
Source: Molecular Autism - April 28, 2021 Category: Molecular Biology Source Type: research

New guidance to seekers of autism biomarkers: an update from studies of identical twins
ConclusionBiomarkers identified on the basis of association with clinical symptom severity in ASD may reflecteffects rather thancauses of autism. The search for biomarkers of pathogenesis may benefit from a greater focus on traits that predict autism recurrence, among both clinical and general populations. In case –control studies, salient developmental liabilities should be systematically measured in both cases and controls, to avoid the erosion in statistical power (i.e., to detect differences) that can occur if control subjects carry sub-clinical aggregations of the same unmeasured traits that exert ca u...
Source: Molecular Autism - April 19, 2021 Category: Molecular Biology Source Type: research

Imitation and recognition of facial emotions in autism: a computer vision approach
ConclusionsGroup differences in emotion recognition, imitation and their interrelationships highlight potential for treatment of social interaction problems in individuals with autism. (Source: Molecular Autism)
Source: Molecular Autism - April 6, 2021 Category: Molecular Biology Source Type: research

Tactile cortical responses and association with tactile reactivity in young children on the autism spectrum
AbstractBackgroundUnusual behavioral reactions to sensory stimuli are frequently reported in individuals on the autism spectrum (AS). Despite the early emergence of sensory features (
Source: Molecular Autism - April 1, 2021 Category: Molecular Biology Source Type: research

Neuroanatomy and behavior in mice with a haploinsufficiency of AT-rich interactive domain 1B (ARID1B) throughout development
ConclusionsThis study represents a full validation and investigation of a novel model ofArid1b+/ − haploinsufficiency throughout development and highlights the importance of examining both sexes throughout development in NDDs. (Source: Molecular Autism)
Source: Molecular Autism - March 23, 2021 Category: Molecular Biology Source Type: research

A profile and review of findings from the Early Markers for Autism study: unique contributions from a population-based case –control study in California
ConclusionsResults across EMA studies support the importance of the prenatal and neonatal periods in ASD etiology, and provide evidence for the role of the maternal immune response during pregnancy. Future directions for EMA, and the field of ASD in general, include interrogation of mechanistic pathways and examination of combined effects of exposures. (Source: Molecular Autism)
Source: Molecular Autism - March 18, 2021 Category: Molecular Biology Source Type: research

Hippocampal neurons isolated from rats subjected to the valproic acid model mimic in vivo synaptic pattern: evidence of neuronal priming during early development in autism spectrum disorders
ConclusionsOur study suggests microglial role is not determinant for developing neuronal alterations or counteracting neuronal outcome in the hippocampus and highlights the crucial role of hippocampal neurons and structural plasticity in the establishment of the synaptic alterations in the VPA rat model. (Source: Molecular Autism)
Source: Molecular Autism - March 6, 2021 Category: Molecular Biology Source Type: research

The psychological impact of the COVID-19 pandemic on adults with autism: a survey study across three countries
ConclusionsResults highlight the psychological burden of the pandemic on adults with autism and shed light on how to support them during this COVID-19 pandemic, which is especially important now that the pandemic is likely to have a prolonged course. There is a need for accessible, affordable (continued) support from health services. Guidance may focus on the maintenance of a social network, and adjusting routines to the rapid ongoing changes. Finally, we may learn from the COVID-19 pandemic-related changes experienced as pleasant by adults with autism to build a more autism-friendly society post-pandemic. (Source: Molecular Autism)
Source: Molecular Autism - March 3, 2021 Category: Molecular Biology Source Type: research

Evaluating the latent structure of the non-social domain of autism in autistic adults
ConclusionsThis study provided evidence for the multidimensional nature of the non-social domain of autism. Given only two of the four criteria within the non-social domain need to be endorsed for a diagnosis of autism, there is room for substantial variation across individuals, who will have a unique profile within the non-social domain. The results have implications for our understanding of the heterogeneous nature of autistic traits, as well as for how we conceptualise autism as a diagnostic category. This is important for the provision of diagnosis and support within research and clinical practice. (Source: Molecular Autism)
Source: Molecular Autism - March 3, 2021 Category: Molecular Biology Source Type: research

Improving the measurement of alexithymia in autistic adults: a psychometric investigation and refinement of the twenty-item Toronto Alexithymia Scale
ConclusionsThese results indicate the potential of the TAS-8 as a psychometrically robust tool to measure alexithymia in both autistic and non-autistic adults. A free online score calculator has been created to facilitate the use of norm-referenced TAS-8 latent trait scores in research applications (available athttp://asdmeasures.shinyapps.io/TAS8_Score). (Source: Molecular Autism)
Source: Molecular Autism - March 2, 2021 Category: Molecular Biology Source Type: research

Towards robust and replicable sex differences in the intrinsic brain function of autism
AbstractBackgroundMarked sex differences in autism prevalence accentuate the need to understand the role of biological sex-related factors in autism. Efforts to unravel sex differences in the brain organization of autism have, however, been challenged by the limited availability of female data.MethodsWe addressed this gap by using a large sample of males and females with autism and neurotypical (NT) control individuals (ABIDE; Autism: 362 males, 82 females; NT: 409 males, 166 females; 7 –18 years). Discovery analyses examined main effects of diagnosis, sex and their interaction across five resting-state fMRI (R-...
Source: Molecular Autism - March 1, 2021 Category: Molecular Biology Source Type: research

Increased aperiodic gamma power in young boys with Fragile X Syndrome is associated with better language ability
ConclusionsResting-state EEG measures from this study in young boys with FXS identified similar increases in gamma power previously reported in adults and mouse models. The observed positive association between resting state aperiodic gamma power and language development supports hypotheses that alterations in some EEG measures may reflect ongoing compensatory mechanisms. (Source: Molecular Autism)
Source: Molecular Autism - February 25, 2021 Category: Molecular Biology Source Type: research

Sleep disorders in rare genetic syndromes: a meta-analysis of prevalence and profile
ConclusionsDiffering prevalence rates between types of sleep disorder suggest differing causal mechanisms, such as cranio-facial morphology in Down and Prader –Willi syndromes and the build-up of mucopolysaccharides in MPS disorders. Priorities for clinical assessment and intervention for sleep disorders are discussed. (Source: Molecular Autism)
Source: Molecular Autism - February 25, 2021 Category: Molecular Biology Source Type: research

Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development
ConclusionsTogether, these findings identify important, dosage-sensitive functions for CHD8 in p53 pathway repression, neurodevelopmental gene expression and neural progenitor fate in the embryonic neocortex. We conclude that brain development is acutely sensitive to reduced CHD8 expression and that the varying sensitivities of different progenitor populations and cellular processes to CHD8 dosage result in non-linear effects on gene transcription and brain growth.Shaun Hurley, Conor Mohan and Philipp Suetterlin have contributed equally to this work. (Source: Molecular Autism)
Source: Molecular Autism - February 24, 2021 Category: Molecular Biology Source Type: research

Oxytocin-induced increase in N , N -dimethylglycine and time course of changes in oxytocin efficacy for autism social core symptoms
ConclusionOur findings demonstrate an association ofN,N-dimethylglycine upregulation with the time-course change in the efficacy of oxytocin on autistic social deficits. Furthermore, the current findings support the involvement of theN-methyl-D-aspartate receptor and neural plasticity to the time-course change in oxytocin ’s efficacy.Trial registration: A multi-center, parallel-group, placebo-controlled, double-blind, confirmatory trial of intranasal oxytocin in participants with autism spectrum disorders (the date registered: 30 October 2014; UMIN Clinical Trials Registry:https://upload.umin.ac.jp/cgi-open-bin/ctr_e...
Source: Molecular Autism - February 23, 2021 Category: Molecular Biology Source Type: research

Modulation of atypical brain activation during executive functioning in autism: a pharmacological MRI study of tianeptine
ConclusionsOur findings provide the first evidence that tianeptine can shift atypical brain activation during EF in adults with ASD towards control levels. Future studies should investigate whether this shift in the biology of ASD is maintained after prolonged treatment with tianeptine and whether it improves clinical symptoms. (Source: Molecular Autism)
Source: Molecular Autism - February 19, 2021 Category: Molecular Biology Source Type: research

Is social camouflaging associated with anxiety and depression in autistic adults?
ConclusionsThe findings suggest that camouflaging is a risk factor for mental health problems in autistic adults without intellectual disability, regardless of gender. We also identified levels of camouflaging at which risk of mental health problems is highest, suggesting clinicians should be particularly aware of mental health problems in those who score at or above these levels. (Source: Molecular Autism)
Source: Molecular Autism - February 16, 2021 Category: Molecular Biology Source Type: research

Analysis of common genetic variation and rare CNVs in the Australian Autism Biobank
ConclusionsWe report on common genetic variation and rare CNVs within the AAB. Prediction analyses using currently available GWAS summary statistics are largely consistent with expected relationships based on published studies. As the size of publicly-available GWAS summary statistics grows, the phenotypic depth of the AAB dataset will provide many opportunities for analyses of autism profiles and co-occurring conditions, including when integrated with other omics datasets generated from AAB biospecimens (blood, urine, stool, hair). (Source: Molecular Autism)
Source: Molecular Autism - February 10, 2021 Category: Molecular Biology Source Type: research

Modified CBT for social anxiety and social functioning in young adults with autism spectrum disorder
AbstractBackgroundThere is a strong research imperative to investigate effective treatment options for adolescents and adults with autism spectrum disorder (ASD). Elevated social anxiety, difficulties with social functioning and poor mental health have all been identified as core treatment targets for this group. While theoretical models posit a strong bidirectionality between social anxiety and ASD social functioning deficits, few interventions have targeted both domains concurrently. Of the two group interventions previously conducted with adolescents and adults with ASD, significant results have only been observed in ei...
Source: Molecular Autism - February 8, 2021 Category: Molecular Biology Source Type: research