Delayed M50/M100 evoked response component latency in minimally verbal/nonverbal children who have autism spectrum disorder
AbstractAbnormal auditory neuromagnetic M50 and M100 responses, reflecting primary/secondary auditory cortex processing, have been reported in children who have autism spectrum disorder (ASD). Some studies have reported an association between delays in these responses and language impairment. However, as most prior research has focused onverbal individuals with ASDwithout cognitive impairment, rather little is known about neural activity during auditory processing in minimally verbal or nonverbal children who have ASD (ASD-MVNV) —children with little or no speech and often significant cognitive impairment. To underst...
Source: Molecular Autism - August 15, 2019 Category: Molecular Biology Source Type: research

Impact of on-site clinical genetics consultations on diagnostic rate in children and young adults with autism spectrum disorder
ConclusionBased on the diagnostic rate observed in this cohort, we suggest that a stepwise procedure be considered, first screening pathogenic CNVs and a limited number of disease genes in a much larger number of patients, especially those with syndromic ASD and intellectual disability. (Source: Molecular Autism)
Source: Molecular Autism - August 7, 2019 Category: Molecular Biology Source Type: research

Behavioral characteristics of autism spectrum disorder in very preterm birth children
AbstractBackgroundLower gestational age may increase autism spectrum disorder (ASD) vulnerability; however, the incidence of ASD diagnosis through a direct assessment on every very preterm birth child on the population base remains unclear. Moreover, the behavioral characteristics of preterm birth ASD are unknown.MethodsEvery very preterm birth child (gestational age
Source: Molecular Autism - July 22, 2019 Category: Molecular Biology Source Type: research

Integrated genetic and methylomic analyses identify shared biology between autism and autistic traits
AbstractPrevious studies have identified differences in DNA methylation in autistic individuals compared to neurotypical individuals. Yet, it is unclear if this extends to autistic traits —subclinical manifestation of autism features in the general population. Here, we investigate the association between DNA methylation at birth (cord blood), and scores on the Social and Communication Disorders Checklist (SCDC), a measure of autistic traits, in 701 8-year-olds, by conducting a meth ylome-wide association study (MWAS). We did not identify significant CpGs associated with SCDC. The most significant CpG site was cg...
Source: Molecular Autism - July 17, 2019 Category: Molecular Biology Source Type: research

Neuropsychiatric phenotypes and a distinct constellation of ASD features in 3q29 deletion syndrome: results from the 3q29 registry
AbstractBackgroundThe 1.6 Mb 3q29 deletion is associated with neurodevelopmental and psychiatric phenotypes, including increased risk for autism spectrum disorder (ASD) and a 20 to 40-fold increased risk for schizophrenia. However, the phenotypic spectrum of the deletion, particularly with respect to ASD, remains poorly described.MethodsWe ascertained individuals with 3q29 deletion syndrome (3q29Del, “cases,”n = 93, 58.1% male) and typically developing controls (n = 64, 51.6% male) through the 3q29 registry (https://3q29deletion.patientcrossroads.org). Self-report of neuropsychiatric...
Source: Molecular Autism - July 16, 2019 Category: Molecular Biology Source Type: research

Mechanisms underlying the EEG biomarker in Dup15q syndrome
ConclusionsOur results suggest a critical role for GABAergic transmission in the Dup15q syndrome beta EEG phenotype, which cannot be explained byUBE3A dysfunction alone. If this mechanism is confirmed, the phenotype may be used as a marker of GABAergic pathology in clinical trials for Dup15q syndrome. (Source: Molecular Autism)
Source: Molecular Autism - July 3, 2019 Category: Molecular Biology Source Type: research

Visual attention to faces in children with autism spectrum disorder: are there sex differences?
ConclusionsThis study has implications for how the field understands core social deficits in children with ASD, which should ideally be benchmarked against same-sex peers (male and female). Social attention in ASD females fell on a continuum —greater than their ASD male peers, but not as great as TD females. Overall, their social attention mirrored that of TD males. Improved understanding of the female social phenotype in ASD will enhance early screening and diagnostic efforts and will guide the development of sex-sensitive experiment al paradigms and social interventions. (Source: Molecular Autism)
Source: Molecular Autism - June 28, 2019 Category: Molecular Biology Source Type: research

Generalizability and reproducibility of functional connectivity in autism
ConclusionOverall, functional connectivity features predictive of autism demonstrated limited generalizability across sites, with consistent results only for large samples. Different types of functional connectivity features do not consistently predict different symptoms of autism. Rather, specific features that predict autism symptoms are distributed across feature types. (Source: Molecular Autism)
Source: Molecular Autism - June 24, 2019 Category: Molecular Biology Source Type: research

CYFIP1 overexpression increases fear response in mice but does not affect social or repetitive behavioral phenotypes
ConclusionOverall, this research identifies the behavioral and molecular consequences ofCYFIP1 overexpression and how they contribute to the variable phenotype seen in Dup15q syndrome and in ASD patients with excess CYFIP1. (Source: Molecular Autism)
Source: Molecular Autism - June 7, 2019 Category: Molecular Biology Source Type: research

Autistic traits in adults who have attempted suicide
ConclusionsThe findings suggest that high levels of autistic traits may frequently be present in adults who have attempted suicide, and that AQ scores are higher in those with a history of more than one suicide attempt. It may be possible to better identify suicide risk by screening autistic adults with mental health conditions  for suicidal thoughts and behaviours, and by screening people with suicidal thoughts and/or behaviours for autism. (Source: Molecular Autism)
Source: Molecular Autism - June 7, 2019 Category: Molecular Biology Source Type: research

The distribution of autistic traits across the autism spectrum: evidence for discontinuous dimensional subpopulations underlying the autism continuum
ConclusionThe results provide insight into the continuum nature of the distribution of autistic traits, support the complementary role of both categorical and dimensional approaches to autism spectrum condition, and underscore the importance of analyzing samples that reflect the epidemiological prevalence of the condition. Owing to its flexibility to represent a wide variety of distributions, the Weibull distribution might be better suited for latent structure studies, within enriched and prevalence-true samples. (Source: Molecular Autism)
Source: Molecular Autism - May 27, 2019 Category: Molecular Biology Source Type: research

Delayed loss of UBE3A reduces the expression of Angelman syndrome-associated phenotypes
ConclusionsTaken together, these results emphasize that UBE3A critically impacts early brain development, but plays a more limited role in adulthood. Our findings provide important considerations for upcoming clinical trials in which UBE3A gene expression is reactivated and suggest that even transient UBE3A reinstatement during a critical window of early development is likely to prevent most adverse Angelman syndrome phenotypes. However, sustained UBE3A expression into adulthood is probably needed for optimal clinical benefit. (Source: Molecular Autism)
Source: Molecular Autism - May 22, 2019 Category: Molecular Biology Source Type: research

Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events?
AbstractBackgroundAutism spectrum disorders (ASD) are characterized by abnormal neurodevelopment, genetic, and environmental risk factors, as well as immune dysfunctions. Several lines of evidence suggest alterations in innate immune responses in children with ASD. To address this question in adults with high-functioning ASD (hf-ASD), we sought to investigate the role of natural killer (NK) cells in the persistence of ASD.MethodsNK cells from 35 adults with hf-ASD were compared to that of 35 healthy controls (HC), selected for the absence of any immune dysfunctions, at different time-points, and over a 2-year follow-up per...
Source: Molecular Autism - May 15, 2019 Category: Molecular Biology Source Type: research

Incomplete silencing of full mutation alleles in males with fragile X syndrome is associated with autistic features
This study determined if completeFMR1 mRNA silencing from FM alleles and/or levels ofFMR1 mRNA (if present) in blood are associated with intellectual functioning and autism features in FXS.MethodsThe study cohort included 98 participants (70.4% male) with FXS (FM-only and PM/FM mosaic) aged 1 –43 years. A control group of 14 females were used to establish controlFMR1 mRNA reference range. Intellectual functioning and autism features were assessed using the Mullen Scales of Early Learning or an age-appropriate Wechsler Scale and the Autism Diagnostic Observation Schedule-2nd Edition (ADOS-2), respectively.FMR1 mR...
Source: Molecular Autism - May 3, 2019 Category: Molecular Biology Source Type: research

Autistic traits, resting-state connectivity, and absolute pitch in professional musicians: shared and distinct neural features
ConclusionsResults show both shared and distinct neural features between AP and autistic traits. Differences in the beta range were associated with higher autistic traits in the same population. In general, AP musicians exhibit a widely underconnected brain with reduced functional integration and reduced small-world property during resting state. This might be partly related to autism-specific brain connectivity, while differences in path length and small-worldness reflect other ability-specific influences. This is further evidenced for different pathways in the acquisition and development of absolute pitch, likely influen...
Source: Molecular Autism - May 2, 2019 Category: Molecular Biology Source Type: research

Retinal alterations in a pre-clinical model of an autism spectrum disorder
ConclusionsThis study establishes that adolescent male mice of the VPA-induced ASD model have alterations in retinal function and protein expression compatible with those found in several brain areas of other autism models. These results support the view that synaptic disturbances with excitatory/inhibitory imbalance early in life are associated with ASD and point to the retina as a window to understand their subjacent mechanisms. (Source: Molecular Autism)
Source: Molecular Autism - April 15, 2019 Category: Molecular Biology Source Type: research

A ‘choice’, an ‘addiction’, a way ‘out of the lost’: exploring self-injury in autistic people without intellectual disability
ConclusionsAlexithymia, depression, anxiety and sensory differences may place some autistic individuals at especial risk of self-injury. Investigating the involvement of these variables and their utility for identification and treatment is of high importance, and the voices of participants offer guidance to practitioners confronted with NSSI  in their autistic clients. (Source: Molecular Autism)
Source: Molecular Autism - April 11, 2019 Category: Molecular Biology Source Type: research

Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer
ConclusionsComparisons of ASD and cancer differential gene expression meta-analysis results suggest that brain, kidney, thyroid, and pancreatic cancers are candidates for direct comorbid associations with ASD. On the other hand, lung and prostate cancers are candidates for inverse comorbid associations with ASD. Joint perturbations in a set of specific biological processes underlie these associations which include several pathways previously implicated in both cancer and ASD encompassing immune system alterations, impairments of energy metabolism, cell cycle, and signaling through PI3K and G protein-coupled receptors among...
Source: Molecular Autism - April 8, 2019 Category: Molecular Biology Source Type: research

The role of gender in the perception of autism symptom severity and future behavioral development
ConclusionsInvestigating parent ’s cognition about their child’s future behavioral development can provide additional information regarding delayed diagnosis of autistic girls. (Source: Molecular Autism)
Source: Molecular Autism - March 29, 2019 Category: Molecular Biology Source Type: research

Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity
ConclusionsScn2aKO/+ mice exhibit a spectrum of phenotypes commonly observed in models of schizophrenia and autism spectrum disorder. Treatment with the CX516 ampakine, which ameliorates hyperactivity in these mice, could be a potential therapeutic strategy to rescue some of the disease phenotypes. (Source: Molecular Autism)
Source: Molecular Autism - March 28, 2019 Category: Molecular Biology Source Type: research

Linguistic markers of autism in girls: evidence of a “blended phenotype” during storytelling
ConclusionThis study extends prior research on autistic children ’s storytelling by measuring sex differences in the narratives of a relatively large, well-matched sample of children with and without ASD. Importantly, prior research showing that autistic children use fewer cognitive process words is true for boys only, while object-focused language is a sex-neu tral linguistic marker of ASD. These findings suggest that sex-sensitive screening and diagnostic methods—preferably using objective metrics like natural language processing—may be helpful for identifying autistic girls, and could guide the develop...
Source: Molecular Autism - March 27, 2019 Category: Molecular Biology Source Type: research

Latent trajectories of adaptive behaviour in infants at high and low familial risk for autism spectrum disorder
ConclusionsFindings confirm the heterogeneity of trajectories of adaptive functioning in infancy, with a higher risk for ASD in toddlerhood linked to a plateau in the development of adaptive functioning after the first year of life. (Source: Molecular Autism)
Source: Molecular Autism - March 15, 2019 Category: Molecular Biology Source Type: research

The oxytocin receptor gene predicts brain activity during an emotion recognition task in autism
ConclusionsThis is one of the first studies to investigateOXTR and brain function in autism. The findings suggest a neurogenetic mechanism by whichOXTR-dependent activity within the rSMG is related to the aetiology of autism. (Source: Molecular Autism)
Source: Molecular Autism - March 12, 2019 Category: Molecular Biology Source Type: research

A multifaceted approach for analyzing complex phenotypic data in rodent models of autism
AbstractAutism (MIM 209850) is a multifactorial disorder with a broad clinical presentation. A number of high-confidence ASD risk genes are known; however, the contribution of non-genetic environmental factors towards ASD remains largely uncertain. Here, we present a bioinformatics resource of genetic and induced models of ASD developed using a shared annotation platform. Using this data, we depict the intricate trends in the research approaches to analyze rodent models of ASD. We identify the top 30 most frequently studied phenotypes extracted from rodent models of ASD based on 787 publications. As expected, many of these...
Source: Molecular Autism - March 12, 2019 Category: Molecular Biology Source Type: research

Atypical event-related potentials revealed during the passive parts of a Go-NoGo task in autism spectrum disorder: a case-control study
AbstractBackgroundThe core features of autism spectrum disorder (ASD) are easily recognizable in non-structured clinical and real-life situations. The features are often difficult to capture in structured laboratory settings, and the results from tests do not necessarily reflect symptom severity. We investigated neurophysiological processing in thepassive parts of a cued Go-NoGo task, using theactive parts of the test as a comparator.MethodsForty-nine adolescents diagnosed with ASD and 49 typically developing (TD) adolescents (age 12 –21 years) were included. Daily life executive function was assessed with the...
Source: Molecular Autism - March 5, 2019 Category: Molecular Biology Source Type: research

Selection bias on intellectual ability in autism research: a cross-sectional review and meta-analysis
ConclusionsWe found selection bias against ID throughout all fields of autism research. We recommend transparent reporting about ID and strategies for inclusion for this much marginalised group. (Source: Molecular Autism)
Source: Molecular Autism - March 1, 2019 Category: Molecular Biology Source Type: research

The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice
ConclusionsOur findings demonstrate that deleting a single neurexin gene (Nrxn2 α) induces atypical structural connectivity within socially relevant brain regions. More generally, our combined within-subject DTI and CLARITY approach presents a new, more sensitive method of revealing hitherto undetectable differences in the autistic brain. (Source: Molecular Autism)
Source: Molecular Autism - February 28, 2019 Category: Molecular Biology Source Type: research

Autism prevalence in China is comparable to Western prevalence
ConclusionsResults from Jilin City, where both mainstream and special school data were available, revealed a similar prevalence of autism in China to the West, at around 1%. Results from Shenzhen and Jiamusi cities, where only mainstream data were available, prevalence is also in line with Western estimates. In all three cities, new cases of autism were identified by the study in mainstream schools, reflecting current under-diagnosis. Non-significant variation across different cities is seen indicating the need to explore potential variation of autism across diverse Chinese regions with large sample sizes to achieve a full...
Source: Molecular Autism - February 28, 2019 Category: Molecular Biology Source Type: research

Haploinsufficiency of autism causative gene Tbr1 impairs olfactory discrimination and neuronal activation of the olfactory system in mice
ConclusionsTbr1 regulates neural circuits and activity in the olfactory system to control olfaction.Tbr1+/ − mice can serve as a suitable model for revealing how an autism causative gene controls neuronal circuits, neural activity, and autism-related behaviors. (Source: Molecular Autism)
Source: Molecular Autism - February 11, 2019 Category: Molecular Biology Source Type: research

Rigor in science and science reporting: updated guidelines for submissions to Molecular Autism
(Source: Molecular Autism)
Source: Molecular Autism - February 4, 2019 Category: Molecular Biology Source Type: research

Sensory over-responsivity: parent report, direct assessment measures, and neural architecture
ConclusionsThis study identified cut-off scores for AOR and TOR using the SSP parent report and SP-3D:A observation. A combination of questionnaire and direct observation measures should be used in clinical and research settings. The SSP parent report and SP-3D:A direct observation ratings overlapped moderately for sensory related behaviors. Based on these preliminary structural neuroimaging results, we suggest a putative neural network may contribute to AOR. (Source: Molecular Autism)
Source: Molecular Autism - February 4, 2019 Category: Molecular Biology Source Type: research

Intestinal dysmotility in a zebrafish ( Danio rerio ) shank3a;shank3b mutant model of autism
AbstractBackground and aimsAutism spectrum disorder (ASD) is currently estimated to affect more than 1% of the world population. For people with ASD, gastrointestinal (GI) distress is a commonly reported but a poorly understood co-occurring symptom. Here, we investigate the physiological basis for GI distress in ASD by studying gut function in a zebrafish model of Phelan-McDermid syndrome (PMS), a condition caused by mutations in theSHANK3 gene.MethodsTo generate a zebrafish model of PMS, we used CRISPR/Cas9 to introduce clinically related C-terminal frameshift mutations inshank3a andshank3b zebrafish paralogues (shank3ab ...
Source: Molecular Autism - January 31, 2019 Category: Molecular Biology Source Type: research

Lower circulating endocannabinoid levels in children with autism spectrum disorder
AbstractBackgroundThe endocannabinoid system (ECS) is a major regulator of synaptic plasticity and neuromodulation. Alterations of the ECS have been demonstrated in several animal models of autism spectrum disorder (ASD). In some of these models, activating the ECS rescued the social deficits. Evidence for dysregulations of the ECS in human ASD are emerging, but comprehensive assessments and correlations with disease characteristics have not been reported yet.MethodsSerum levels of the main endocannabinoids,N-arachidonoylethanolamine (AEA or anandamide) and 2-arachidonoylglycerol (2-AG), and their related endogenous compou...
Source: Molecular Autism - January 30, 2019 Category: Molecular Biology Source Type: research

Autism spectrum disorders, endocrine disrupting compounds, and heavy metals in amniotic fluid: a case-control study
ConclusionsThe presence of PFAS and heavy metals in AF indicates that they can cross the placenta. The inverse association between levels of PFAS congeners in AF and ASD risk might relate to the weak estrogenic activities and anti-androgenic activities of PFAS.The observed tendency of positive association between the ratio of combined androgenic effect to the combined estrogenic effect and ASD risk needs further studies to explore whether EDCs together with endogenous hormones play a role in the development of ASD. (Source: Molecular Autism)
Source: Molecular Autism - January 9, 2019 Category: Molecular Biology Source Type: research

Functional MRI connectivity of children with autism and low verbal and cognitive performance
AbstractBackgroundFunctional neuroimaging research in autism spectrum disorder has reported patterns of decreased long-range, within-network, and interhemispheric connectivity. Research has also reported increased corticostriatal connectivity and between-network connectivity for default and attentional networks. Past studies have excluded individuals with autism and low verbal and cognitive performance (LVCP), so connectivity in individuals more significantly affected with autism has not yet been studied. This represents a critical gap in our understanding of brain function across the autism spectrum.MethodsUsing behaviora...
Source: Molecular Autism - December 27, 2018 Category: Molecular Biology Source Type: research

Neuroglia in the autistic brain: evidence from a preclinical model
ConclusionsNeuroglial pathological phenotype in autism spectrum disorder rat model appears to be rather mild with little signs of widespread and chronic neuroinflammation. (Source: Molecular Autism)
Source: Molecular Autism - December 27, 2018 Category: Molecular Biology Source Type: research

Autism-associated CHD8 deficiency impairs axon development and migration of cortical neurons
ConclusionOur findings indicate an important role for CHD8 in dendritic and axon development and neuronal migration and thus offer novel insights to further dissect the underlying molecular and circuit mechanisms of ASD caused by CHD8 deficiency. (Source: Molecular Autism)
Source: Molecular Autism - December 19, 2018 Category: Molecular Biology Source Type: research

Modeling the quantitative nature of neurodevelopmental disorders using Collaborative Cross mice
ConclusionsThese findings show that the CC can move animal model studies beyond comparative single gene-single background designs, and point out which type of behavioral phenotypes are most suitable to quantify the effect of developmental etiologies across multiple genetic backgrounds. (Source: Molecular Autism)
Source: Molecular Autism - December 13, 2018 Category: Molecular Biology Source Type: research

Diffusional kurtosis imaging of the corpus callosum in autism
ConclusionDecreased DKI metrics suggested that ASD may be associated with axonal deficits such as reduced axonal caliber and density in the corpus callosum, especially in the mid and posterior callosal areas. These data suggest that impaired interhemispheric connectivity may contribute to decreased processing speed in ASD participants. (Source: Molecular Autism)
Source: Molecular Autism - December 13, 2018 Category: Molecular Biology Source Type: research

Inherited and multiple de novo mutations in autism/developmental delay risk genes suggest a multifactorial model
ConclusionsWe identify new risk genes and transmission of deleterious mutations in genes primarily associated with DNMs. The fact that parental carriers show milder phenotypes and patients with multiple hits are more severe supports a multifactorial model of risk. (Source: Molecular Autism)
Source: Molecular Autism - December 13, 2018 Category: Molecular Biology Source Type: research

The valproic acid rat model of autism presents with gut bacterial dysbiosis similar to that in human autism
ConclusionsOur data on the microbiota of the VPA rat model of autism indicate that this model, in addition to behaviorally and anatomically mimicking the autistic brain as previously shown, also mimics the microbiome features of autism, making it one of the best-suited rodent models for the study of autism and ASD. (Source: Molecular Autism)
Source: Molecular Autism - December 10, 2018 Category: Molecular Biology Source Type: research

A pilot dose finding study of pioglitazone in autistic children
Conclusions and relevancePioglitazone is well-tolerated and shows a potential signal in measures of social withdrawal, repetitive, and externalizing behaviors. Randomized controlled trials using the confirmed dose are warranted.Trial registrationClinicalTrials.gov,NCT01205282. Registration date: September 20, 2010.   (Source: Molecular Autism)
Source: Molecular Autism - November 26, 2018 Category: Molecular Biology Source Type: research

Brain hyperserotonemia causes autism-relevant social deficits in mice
ConclusionsThese findings reveal aSert gene dose-dependent effect on brain hyperserotonemia and related behavioral sequelae in ASD and a possible therapeutic target to normalize brain hyperserotonemia and ASD-relevant social deficits. (Source: Molecular Autism)
Source: Molecular Autism - November 26, 2018 Category: Molecular Biology Source Type: research

Assessing subtypes of restricted and repetitive behaviour using the Adult Repetitive Behaviour Questionnaire-2 in autistic adults
ConclusionsThe RBQ-2A is a reliable and valid self-report measure of RRBs in the present sample of autistic adults. As one of the few measures of RRBs aimed at adults, it is suitable for adults with the ability to read and complete a self-report questionnaire. Results build on previous work with children using the Repetitive Behaviour Questionnaire-2 (RBQ-2). (Source: Molecular Autism)
Source: Molecular Autism - November 26, 2018 Category: Molecular Biology Source Type: research

Intranasal administration of exosomes derived from mesenchymal stem cells ameliorates autistic-like behaviors of BTBR mice
AbstractAutism spectrum disorders (ASD) are neurodevelopmental disorders characterized by three core symptoms that include social interaction deficits, cognitive inflexibility, and communication disorders. They have been steadily increasing in children over the past several years, with no effective treatment. BTBR T+tf/J (BTBR) mice are an accepted model of evaluating autistic-like behaviors as they present all core symptoms of ASD. We have previously shown that transplantation of human bone marrow mesenchymal stem cells (MSC) to the lateral ventricles of BTBR mice results in long lasting improvement in their autistic beha...
Source: Molecular Autism - November 21, 2018 Category: Molecular Biology Source Type: research

Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model
ConclusionsIn this study,QPRT was causally related to in vitro neuronal differentiation of SH-SY5Y cells and affected the regulation of genes and gene networks previously implicated in ASD. Thus, our data suggest thatQPRT may play an important role in the pathogenesis of ASD in Chr16p11.2 deletion carriers. (Source: Molecular Autism)
Source: Molecular Autism - November 6, 2018 Category: Molecular Biology Source Type: research

A cross-cultural study of autistic traits across India, Japan and the UK
AbstractBackgroundThere is a global need for brief screening instruments that can identify key indicators for autism to support frontline professionals in their referral decision-making. Although a universal set of conditions, there may be subtle differences in expression, identification and reporting of autistic traits across cultures. In order to assess the potential for any measure for cross-cultural screening use, it is important to understand the relative performance of such measures in different cultures. Our study aimed to identify the items on the Autism Spectrum Quotient (AQ)-Child that are most predictive of an a...
Source: Molecular Autism - November 5, 2018 Category: Molecular Biology Source Type: research

Does stereopsis account for the link between motor and social skills in adults?
ConclusionsMediation analyses suggested that whilst fine motor skill and coordination explained the relationship between stereopsis and social skill to some extent, stereopsis nonetheless exerted a substantial direct effect upon social skill. This is the first study to demonstrate that the functional significance of stereopsis is not limited to motor ability and may directly impact upon social functioning. (Source: Molecular Autism)
Source: Molecular Autism - October 24, 2018 Category: Molecular Biology Source Type: research

Subcellular organization of UBE3A in human cerebral cortex
ConclusionsBy highlighting the subcellular compartments in which UBE3A is likely to function in the human neocortex, our data provide insight into the diverse functional capacities of this E3 ligase. These anatomical data may help to elucidate the role of UBE3A in Angelman syndrome and autism spectrum disorder. (Source: Molecular Autism)
Source: Molecular Autism - October 19, 2018 Category: Molecular Biology Source Type: research

Savant syndrome has a distinct psychological profile in autism
ConclusionsThese results reveal a unique cognitive and behavioural profile in autistic adults with savant syndrome that is distinct from autistic adults without a savant skill. (Source: Molecular Autism)
Source: Molecular Autism - October 12, 2018 Category: Molecular Biology Source Type: research