Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac Hypertrophy
CONCLUSIONS: Paracrine and autocrine secretions of VEGF-B induce expansion of a specific endocardium-derived endothelial cell population with distinct angiogenic markers. However, autocrine VEGF-B signaling fails to promote VEGF-B-induced endothelial cell migration and contribution to myocardial capillaries, predisposing to septal defects and inducing a mismatch between angiogenesis and myocardial growth, which results in pathological cardiac hypertrophy.PMID:38655691 | DOI:10.1161/CIRCRESAHA.123.324136 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Ibrahim Sultan Markus Ramste Pim Peletier Karthik Amudhala Hemanthakumar Deepak Ramanujam Annakaisa Tirronen Ylva von Wright Salli Antila Pipsa Saharinen Lauri Eklund Eero Mervaala Seppo Yl ä-Herttuala Stefan Engelhardt Riikka Kivel ä Kari Alitalo Source Type: research
Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac Hypertrophy
CONCLUSIONS: Paracrine and autocrine secretions of VEGF-B induce expansion of a specific endocardium-derived endothelial cell population with distinct angiogenic markers. However, autocrine VEGF-B signaling fails to promote VEGF-B-induced endothelial cell migration and contribution to myocardial capillaries, predisposing to septal defects and inducing a mismatch between angiogenesis and myocardial growth, which results in pathological cardiac hypertrophy.PMID:38655691 | DOI:10.1161/CIRCRESAHA.123.324136 (Source: Circulation Research)
Source: Circulation Research - April 24, 2024 Category: Cardiology Authors: Ibrahim Sultan Markus Ramste Pim Peletier Karthik Amudhala Hemanthakumar Deepak Ramanujam Annakaisa Tirronen Ylva von Wright Salli Antila Pipsa Saharinen Lauri Eklund Eero Mervaala Seppo Yl ä-Herttuala Stefan Engelhardt Riikka Kivel ä Kari Alitalo Source Type: research
Phosphorylation of AS160-Serine 704 is Not Essential for Exercise-increase in Insulin-stimulated Glucose Uptake by Skeletal Muscles from Female or Male Rats
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00010.2024. Online ahead of print.ABSTRACTOne exercise session can increase subsequent insulin-stimulated glucose uptake (ISGU) by skeletal muscle from rodents and humans of both sexes. We recently found that concurrent mutation of three key sites to prevent their phosphorylation (Ser588, Thr642, and Ser704) on Akt substrate of 160 kDa (AS160; also known as TBC1D4) reduced the magnitude of the enhancement of postexercise ISGU (PEX-ISGU) by muscle from male, but not female rats. However, we did not test the role of individual phosphorylation sites on PEX-ISGU....
Source: Am J Physiol Endocri... - April 24, 2024 Category: Endocrinology Authors: Haiyan Wang Seong Eun Kwak Amy Zheng Edward B Arias Xiufang Pan Dongsheng Duan Gregory D Cartee Source Type: research
Phosphorylation of AS160-Serine 704 is Not Essential for Exercise-increase in Insulin-stimulated Glucose Uptake by Skeletal Muscles from Female or Male Rats
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00010.2024. Online ahead of print.ABSTRACTOne exercise session can increase subsequent insulin-stimulated glucose uptake (ISGU) by skeletal muscle from rodents and humans of both sexes. We recently found that concurrent mutation of three key sites to prevent their phosphorylation (Ser588, Thr642, and Ser704) on Akt substrate of 160 kDa (AS160; also known as TBC1D4) reduced the magnitude of the enhancement of postexercise ISGU (PEX-ISGU) by muscle from male, but not female rats. However, we did not test the role of individual phosphorylation sites on PEX-ISGU....
Source: American Journal of Physiology. Endocrinology and Metabolism - April 24, 2024 Category: Physiology Authors: Haiyan Wang Seong Eun Kwak Amy Zheng Edward B Arias Xiufang Pan Dongsheng Duan Gregory D Cartee Source Type: research
Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac Hypertrophy
CONCLUSIONS: Paracrine and autocrine secretions of VEGF-B induce expansion of a specific endocardium-derived endothelial cell population with distinct angiogenic markers. However, autocrine VEGF-B signaling fails to promote VEGF-B-induced endothelial cell migration and contribution to myocardial capillaries, predisposing to septal defects and inducing a mismatch between angiogenesis and myocardial growth, which results in pathological cardiac hypertrophy.PMID:38655691 | DOI:10.1161/CIRCRESAHA.123.324136 (Source: Circulation Research)
Source: Circulation Research - April 24, 2024 Category: Cardiology Authors: Ibrahim Sultan Markus Ramste Pim Peletier Karthik Amudhala Hemanthakumar Deepak Ramanujam Annakaisa Tirronen Ylva von Wright Salli Antila Pipsa Saharinen Lauri Eklund Eero Mervaala Seppo Yl ä-Herttuala Stefan Engelhardt Riikka Kivel ä Kari Alitalo Source Type: research
Phosphorylation of AS160-Serine 704 is Not Essential for Exercise-increase in Insulin-stimulated Glucose Uptake by Skeletal Muscles from Female or Male Rats
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00010.2024. Online ahead of print.ABSTRACTOne exercise session can increase subsequent insulin-stimulated glucose uptake (ISGU) by skeletal muscle from rodents and humans of both sexes. We recently found that concurrent mutation of three key sites to prevent their phosphorylation (Ser588, Thr642, and Ser704) on Akt substrate of 160 kDa (AS160; also known as TBC1D4) reduced the magnitude of the enhancement of postexercise ISGU (PEX-ISGU) by muscle from male, but not female rats. However, we did not test the role of individual phosphorylation sites on PEX-ISGU....
Source: Am J Physiol Endocri... - April 24, 2024 Category: Endocrinology Authors: Haiyan Wang Seong Eun Kwak Amy Zheng Edward B Arias Xiufang Pan Dongsheng Duan Gregory D Cartee Source Type: research
Phosphorylation of AS160-Serine 704 is Not Essential for Exercise-increase in Insulin-stimulated Glucose Uptake by Skeletal Muscles from Female or Male Rats
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00010.2024. Online ahead of print.ABSTRACTOne exercise session can increase subsequent insulin-stimulated glucose uptake (ISGU) by skeletal muscle from rodents and humans of both sexes. We recently found that concurrent mutation of three key sites to prevent their phosphorylation (Ser588, Thr642, and Ser704) on Akt substrate of 160 kDa (AS160; also known as TBC1D4) reduced the magnitude of the enhancement of postexercise ISGU (PEX-ISGU) by muscle from male, but not female rats. However, we did not test the role of individual phosphorylation sites on PEX-ISGU....
Source: American Journal of Physiology. Endocrinology and Metabolism - April 24, 2024 Category: Physiology Authors: Haiyan Wang Seong Eun Kwak Amy Zheng Edward B Arias Xiufang Pan Dongsheng Duan Gregory D Cartee Source Type: research
Phosphorylation of AS160-Serine 704 is Not Essential for Exercise-increase in Insulin-stimulated Glucose Uptake by Skeletal Muscles from Female or Male Rats
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00010.2024. Online ahead of print.ABSTRACTOne exercise session can increase subsequent insulin-stimulated glucose uptake (ISGU) by skeletal muscle from rodents and humans of both sexes. We recently found that concurrent mutation of three key sites to prevent their phosphorylation (Ser588, Thr642, and Ser704) on Akt substrate of 160 kDa (AS160; also known as TBC1D4) reduced the magnitude of the enhancement of postexercise ISGU (PEX-ISGU) by muscle from male, but not female rats. However, we did not test the role of individual phosphorylation sites on PEX-ISGU....
Source: Am J Physiol Endocri... - April 24, 2024 Category: Endocrinology Authors: Haiyan Wang Seong Eun Kwak Amy Zheng Edward B Arias Xiufang Pan Dongsheng Duan Gregory D Cartee Source Type: research
Phosphorylation of AS160-Serine 704 is Not Essential for Exercise-increase in Insulin-stimulated Glucose Uptake by Skeletal Muscles from Female or Male Rats
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00010.2024. Online ahead of print.ABSTRACTOne exercise session can increase subsequent insulin-stimulated glucose uptake (ISGU) by skeletal muscle from rodents and humans of both sexes. We recently found that concurrent mutation of three key sites to prevent their phosphorylation (Ser588, Thr642, and Ser704) on Akt substrate of 160 kDa (AS160; also known as TBC1D4) reduced the magnitude of the enhancement of postexercise ISGU (PEX-ISGU) by muscle from male, but not female rats. However, we did not test the role of individual phosphorylation sites on PEX-ISGU....
Source: American Journal of Physiology. Endocrinology and Metabolism - April 24, 2024 Category: Physiology Authors: Haiyan Wang Seong Eun Kwak Amy Zheng Edward B Arias Xiufang Pan Dongsheng Duan Gregory D Cartee Source Type: research
Phosphorylation of AS160-Serine 704 is Not Essential for Exercise-increase in Insulin-stimulated Glucose Uptake by Skeletal Muscles from Female or Male Rats
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00010.2024. Online ahead of print.ABSTRACTOne exercise session can increase subsequent insulin-stimulated glucose uptake (ISGU) by skeletal muscle from rodents and humans of both sexes. We recently found that concurrent mutation of three key sites to prevent their phosphorylation (Ser588, Thr642, and Ser704) on Akt substrate of 160 kDa (AS160; also known as TBC1D4) reduced the magnitude of the enhancement of postexercise ISGU (PEX-ISGU) by muscle from male, but not female rats. However, we did not test the role of individual phosphorylation sites on PEX-ISGU....
Source: Am J Physiol Endocri... - April 24, 2024 Category: Endocrinology Authors: Haiyan Wang Seong Eun Kwak Amy Zheng Edward B Arias Xiufang Pan Dongsheng Duan Gregory D Cartee Source Type: research
Phosphorylation of AS160-Serine 704 is Not Essential for Exercise-increase in Insulin-stimulated Glucose Uptake by Skeletal Muscles from Female or Male Rats
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00010.2024. Online ahead of print.ABSTRACTOne exercise session can increase subsequent insulin-stimulated glucose uptake (ISGU) by skeletal muscle from rodents and humans of both sexes. We recently found that concurrent mutation of three key sites to prevent their phosphorylation (Ser588, Thr642, and Ser704) on Akt substrate of 160 kDa (AS160; also known as TBC1D4) reduced the magnitude of the enhancement of postexercise ISGU (PEX-ISGU) by muscle from male, but not female rats. However, we did not test the role of individual phosphorylation sites on PEX-ISGU....
Source: American Journal of Physiology. Endocrinology and Metabolism - April 24, 2024 Category: Physiology Authors: Haiyan Wang Seong Eun Kwak Amy Zheng Edward B Arias Xiufang Pan Dongsheng Duan Gregory D Cartee Source Type: research
Phosphorylation of AS160-Serine 704 is Not Essential for Exercise-increase in Insulin-stimulated Glucose Uptake by Skeletal Muscles from Female or Male Rats
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00010.2024. Online ahead of print.ABSTRACTOne exercise session can increase subsequent insulin-stimulated glucose uptake (ISGU) by skeletal muscle from rodents and humans of both sexes. We recently found that concurrent mutation of three key sites to prevent their phosphorylation (Ser588, Thr642, and Ser704) on Akt substrate of 160 kDa (AS160; also known as TBC1D4) reduced the magnitude of the enhancement of postexercise ISGU (PEX-ISGU) by muscle from male, but not female rats. However, we did not test the role of individual phosphorylation sites on PEX-ISGU....
Source: Am J Physiol Endocri... - April 24, 2024 Category: Endocrinology Authors: Haiyan Wang Seong Eun Kwak Amy Zheng Edward B Arias Xiufang Pan Dongsheng Duan Gregory D Cartee Source Type: research
Phosphorylation of AS160-Serine 704 is Not Essential for Exercise-increase in Insulin-stimulated Glucose Uptake by Skeletal Muscles from Female or Male Rats
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00010.2024. Online ahead of print.ABSTRACTOne exercise session can increase subsequent insulin-stimulated glucose uptake (ISGU) by skeletal muscle from rodents and humans of both sexes. We recently found that concurrent mutation of three key sites to prevent their phosphorylation (Ser588, Thr642, and Ser704) on Akt substrate of 160 kDa (AS160; also known as TBC1D4) reduced the magnitude of the enhancement of postexercise ISGU (PEX-ISGU) by muscle from male, but not female rats. However, we did not test the role of individual phosphorylation sites on PEX-ISGU....
Source: American Journal of Physiology. Endocrinology and Metabolism - April 24, 2024 Category: Physiology Authors: Haiyan Wang Seong Eun Kwak Amy Zheng Edward B Arias Xiufang Pan Dongsheng Duan Gregory D Cartee Source Type: research
Phosphorylation of AS160-Serine 704 is Not Essential for Exercise-increase in Insulin-stimulated Glucose Uptake by Skeletal Muscles from Female or Male Rats
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00010.2024. Online ahead of print.ABSTRACTOne exercise session can increase subsequent insulin-stimulated glucose uptake (ISGU) by skeletal muscle from rodents and humans of both sexes. We recently found that concurrent mutation of three key sites to prevent their phosphorylation (Ser588, Thr642, and Ser704) on Akt substrate of 160 kDa (AS160; also known as TBC1D4) reduced the magnitude of the enhancement of postexercise ISGU (PEX-ISGU) by muscle from male, but not female rats. However, we did not test the role of individual phosphorylation sites on PEX-ISGU....
Source: Am J Physiol Endocri... - April 24, 2024 Category: Endocrinology Authors: Haiyan Wang Seong Eun Kwak Amy Zheng Edward B Arias Xiufang Pan Dongsheng Duan Gregory D Cartee Source Type: research
GSE246610 Conditionally Replicative Adenovirus as a Therapy for Malignant Peripheral Nerve Sheath Tumors
CONCLUSIONS: CRAds demonstrate selective binding and efficient replication in MPNST cells, leading to tumor cell lysis while sparing non-cancerous cells. These results suggest that oncolytic adenoviruses may have the potential as novel agents for MPNST therapy and thus warrant further investigation. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Mus musculus Source Type: research
