Effect of Non-Rotavirus Enteric Infections on Vaccine Efficacy in a ROTASIIL Clinical Trial
This study examined the relative proportion of enteric pathogens associated with severe gastroenteritis (GE) among children younger than 2 years in a phase III efficacy trial of the ROTASIIL® vaccine in India, evaluated the impact of co-infections on vaccine efficacy (VE), and characterized the association between specific pathogens and the clinical profile of severe GE. Stored stool samples collected from cases of severe GE in the phase III trial were tested by quantitative polymerase chain reaction using TaqMan™ Array Cards. Etiology was attributed by calculating the adjusted attributable fraction (AF) for each pathog...
Source: The American Journal of Tropical Medicine and Hygiene - April 16, 2024 Category: Tropical Medicine Authors: Dilip Abraham Prasanna Samuel Premkumar James A Platts-Mills Tushar Tewari Niranjan Bhat Revathi Rajendiran Hemavathi Gunalan Gagandeep Kang Source Type: research
Effect of Non-Rotavirus Enteric Infections on Vaccine Efficacy in a ROTASIIL Clinical Trial
This study examined the relative proportion of enteric pathogens associated with severe gastroenteritis (GE) among children younger than 2 years in a phase III efficacy trial of the ROTASIIL® vaccine in India, evaluated the impact of co-infections on vaccine efficacy (VE), and characterized the association between specific pathogens and the clinical profile of severe GE. Stored stool samples collected from cases of severe GE in the phase III trial were tested by quantitative polymerase chain reaction using TaqMan™ Array Cards. Etiology was attributed by calculating the adjusted attributable fraction (AF) for each pathog...
Source: Am J Trop Med Hyg - April 16, 2024 Category: Infectious Diseases Authors: Dilip Abraham Prasanna Samuel Premkumar James A Platts-Mills Tushar Tewari Niranjan Bhat Revathi Rajendiran Hemavathi Gunalan Gagandeep Kang Source Type: research
Necrotizing enterocolitis in a premature infant
We report a case of necrotizing enterocolitis in a 30 weeks old premature infant fed with breast milk. No ischemic etiology was present. Bacteriological and parasitological investigations were found to be negative. Only, a positive latex agglutination test for Adenoviruses was detected in stools collected the day of the bloody diarrhea. Detailed microbiological examinations are emphasized by this unusual finding because the role of pathogens in this disease deserves further understanding.PMID:38620191 | PMC:PMC7141009 | DOI:10.1016/S0399-077X(05)81185-0 (Source: Medecine et Maladies Infectieuses)
Source: Medecine et Maladies Infectieuses - April 15, 2024 Category: Infectious Diseases Authors: R Mettey G Agius C Cessans Source Type: research
Etude épidémiologique de gastroentérites infantiles d'origine virale dans la région amienoise
Med Mal Infect. 1981 Nov;11(11):576-580. doi: 10.1016/S0399-077X(81)80043-1. Epub 2005 May 26.ABSTRACTA systematic survey was carried on stools from 130 children suffering of acute gastroenteritis. Electron microscopy, enzymo-linked immunosorbent assay (ELISA) and counter electrophoresis were employed. This survey allowed to the detection by electron microscopy of Rotavirus (40 cases), Coronaviruses (3 cases), Astroviruses (2 cases), Adenoviruses (2 cases) and Small Round Viruses (1 case). Serological tests (complement fixation, ELISA and counter electrophoresis) done with 86 sera showed a good correlation with results obt...
Source: Medecine et Maladies Infectieuses - April 15, 2024 Category: Infectious Diseases Authors: F Lema A Roseto G Duverlie J Peries Ph Daniel Source Type: research
AAV-mediated gene therapies for glaucoma and uveitis: are we there yet?
Expert Rev Mol Med. 2024 Apr 15;26:e9. doi: 10.1017/erm.2024.4.ABSTRACTGlaucoma and uveitis are non-vascular ocular diseases which are among the leading causes of blindness and visual loss. These conditions have distinct characteristics and mechanisms but share a multifactorial and complex nature, making their management challenging and burdensome for patients and clinicians. Furthermore, the lack of symptoms in the early stages of glaucoma and the diverse aetiology of uveitis hinder timely and accurate diagnoses, which are a cause of poor visual outcomes under both conditions. Although current treatment is effective in mo...
Source: Molecular Medicine - April 15, 2024 Category: Molecular Biology Authors: Brenda Castro Jason C Steel Christopher J Layton Source Type: research
The crucial relationship between miRNA-27 and CSE/H < sub > 2 < /sub > S, and the mechanism of action of GLP-1 in myocardial hypertrophy
In this study, we aimed to investigate whether inhibition of miR-27a could protect against cardiac hypertrophy by modulating H2S signaling. We established a model of cardiac hypertrophy by obtaining hypertrophic tissue from mice subjected to transverse aortic constriction (TAC) and from cells treated with angiotensin-II. Molecular alterations in the myocardium were quantified using quantitative real time PCR (qRT-PCR), Western blotting, and ELISA. Morphological changes were characterized by hematoxylin and eosin (HE) staining and Masson's trichrome staining. Functional myocardial changes were assessed using echocardiograph...
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Shan Gao Ying Li Mei-Ming Liu Xue Xiong Chang-Peng Cui Qing-Ji Huo Ke-Xin Li Xun Sun Rong Zhang Di Wu Bai-Yan Li Source Type: research
AAV-mediated gene therapies for glaucoma and uveitis: are we there yet?
Expert Rev Mol Med. 2024 Apr 15;26:e9. doi: 10.1017/erm.2024.4.ABSTRACTGlaucoma and uveitis are non-vascular ocular diseases which are among the leading causes of blindness and visual loss. These conditions have distinct characteristics and mechanisms but share a multifactorial and complex nature, making their management challenging and burdensome for patients and clinicians. Furthermore, the lack of symptoms in the early stages of glaucoma and the diverse aetiology of uveitis hinder timely and accurate diagnoses, which are a cause of poor visual outcomes under both conditions. Although current treatment is effective in mo...
Source: Molecular Medicine - April 15, 2024 Category: Molecular Biology Authors: Brenda Castro Jason C Steel Christopher J Layton Source Type: research
The crucial relationship between miRNA-27 and CSE/H < sub > 2 < /sub > S, and the mechanism of action of GLP-1 in myocardial hypertrophy
In this study, we aimed to investigate whether inhibition of miR-27a could protect against cardiac hypertrophy by modulating H2S signaling. We established a model of cardiac hypertrophy by obtaining hypertrophic tissue from mice subjected to transverse aortic constriction (TAC) and from cells treated with angiotensin-II. Molecular alterations in the myocardium were quantified using quantitative real time PCR (qRT-PCR), Western blotting, and ELISA. Morphological changes were characterized by hematoxylin and eosin (HE) staining and Masson's trichrome staining. Functional myocardial changes were assessed using echocardiograph...
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Shan Gao Ying Li Mei-Ming Liu Xue Xiong Chang-Peng Cui Qing-Ji Huo Ke-Xin Li Xun Sun Rong Zhang Di Wu Bai-Yan Li Source Type: research
